{"id":55891,"date":"2024-02-07T05:44:33","date_gmt":"2024-02-07T05:44:33","guid":{"rendered":"https:\/\/medsname.com\/brom\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"brom","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/brom\/","title":{"rendered":"Brom"},"content":{"rendered":"

<\/p>\n

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Brom<\/strong> je peror\u00e1ln\u00ed bromokriptin<\/strong> (2,5 mg) tableta \u2014 ergotov\u00fd deriv\u00e1t s dopaminergn\u00edm \u00fa\u010dinkem<\/strong> s troj\u00edm indika\u010dn\u00edm spektrem: Parkinsonova choroba<\/strong> (zejm\u00e9na jako dopl\u0148kov\u00e1 terapie p\u0159i v\u00fdskytu motorick\u00fdch fluktuac\u00ed p\u0159i l\u00e9\u010db\u011b levodopou), hyperprolaktin\u00e9mii<\/strong> (vysok\u00e1 hladina prolaktinu zp\u016fsobuj\u00edc\u00ed neplodnost, amenoreu, galaktoreu nebo n\u00edzkou hladinu testosteronu), a akromegalie<\/strong> (nadbytek r\u016fstov\u00e9ho hormonu). P\u0159\u00edmo stimuluje dopaminov\u00e9 D2 receptory a (v hypof\u00fdze) potla\u010duje sekreci prolaktinu. D\u016fle\u017eit\u00e9:<\/strong> ergotov\u00e9 agonist\u00e9 mohou zp\u016fsobit fibr\u00f3zu srde\u010dn\u00edch chlopn\u00ed<\/em> a pleur\u00e1ln\u00ed\/perikardi\u00e1ln\u00ed\/retroperitone\u00e1ln\u00ed fibr\u00f3zu<\/em> p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed vysok\u00fdch d\u00e1vek \u2014 probl\u00e9m, kter\u00fd se nevyskytuje u neergotov\u00fdch agonist\u016f (ropinirol, pramipexol, piribedil). U dlouhodob\u00fdch u\u017eivatel\u016f se doporu\u010duje echokardiografick\u00fd screening.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Brom?<\/h2>\n

Brom je peror\u00e1ln\u00ed tableta obsahuj\u00edc\u00ed bromokriptin 2,5 mg<\/strong>. Bromokriptin je p\u016fvodn\u00ed ergotov\u00fd dopaminov\u00fd agonista, kter\u00fd je na trhu od 70. let 20. stolet\u00ed pod n\u00e1zvem Parlodel<\/strong>. M\u00e1 t\u0159i klasick\u00e9 indikace:<\/p>\n

    \n
  • Parkinsonova choroba<\/strong> \u2014 symptomatick\u00e1 \u00faleva, samostatn\u011b nebo jako dopln\u011bk k levodop\u011b.<\/li>\n
  • Hyperprolaktin\u00e9mie<\/strong> \u2014 prolaktinom hypof\u00fdzy, idiopatick\u00e1 hyperprolaktin\u00e9mie, l\u00e9ky vyvolan\u00e1 hyperprolaktin\u00e9mie: zp\u016fsobuje amenoreu, neplodnost, galaktoreu, hypogonadismus.<\/li>\n
  • Akromegalie<\/strong> \u2014 potla\u010duje sekreci r\u016fstov\u00e9ho hormonu (m\u00e9n\u011b \u00fa\u010dinn\u00e9 ne\u017e analogy somatostatinu, ale u n\u011bkter\u00fdch pacient\u016f u\u017eite\u010dn\u00e9).<\/li>\n<\/ul>\n

    Brom je vyr\u00e1b\u011bn ve v\u00fdrobn\u00edm za\u0159\u00edzen\u00ed certifikovan\u00e9m WHO-GMP a je bioekvivalentn\u00ed origin\u00e1ln\u00ed zna\u010dce v d\u00e1vce 2,5 mg.<\/p>\n

    Jak funguje Brom (Bromokriptin)?<\/h2>\n

    Bromokriptin je p\u0159\u00edm\u00fd agonista D2 dopaminov\u00fdch receptor\u016f<\/strong> se slab\u00fdm antagonismem D1, odvozen\u00fd z rodiny ergotov\u00fdch alkaloid\u016f. Jeho \u00fa\u010dinky:<\/p>\n

      \n
    • Mozek (baz\u00e1ln\u00ed ganglia):<\/strong> napodobuje dopamin na striat\u00e1ln\u00edch D2 receptorech, \u010d\u00e1ste\u010dn\u011b kompenzuje ztr\u00e1tu dopamin produkuj\u00edc\u00edch neuron\u016f u Parkinsonovy choroby.<\/li>\n
    • Laktotropn\u00ed bu\u0148ky hypof\u00fdzy:<\/strong> dopamin je hlavn\u00edm inhibitorem uvol\u0148ov\u00e1n\u00ed prolaktinu. Bromokriptin stimuluje D2 receptory na t\u011bchto bu\u0148k\u00e1ch a b\u011bhem n\u011bkolika hodin zastavuje sekreci prolaktinu; p\u0159i dlouhodob\u00e9 l\u00e9\u010db\u011b m\u016f\u017ee tak\u00e9 zmen\u0161it prolaktinomy.<\/li>\n
    • Somatotropn\u00ed bu\u0148ky hypof\u00fdzy:<\/strong> u akromegalie paradoxn\u00ed stimulace D2 potla\u010duje uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu.<\/li>\n<\/ul>\n

      Proto\u017ee bromokriptin je ergot, v\u00e1\u017ee se tak\u00e9 na 5-HT2B serotoninov\u00e9 receptory<\/strong> na srde\u010dn\u00edch chlopn\u00edch a pojivov\u00e9 tk\u00e1ni \u2014 co\u017e je z\u00e1klad vz\u00e1cn\u00fdch, ale z\u00e1va\u017en\u00fdch fibrotick\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f.<\/p>\n

      Pro koho je Brom ur\u010den?<\/h2>\n

      Parkinsonova choroba:<\/strong> historicky agonist dopaminu prvn\u00ed volby; v\u011bt\u0161ina neurolog\u016f dnes za\u010d\u00edn\u00e1 neergotov\u00fdm agonistou (ropinirol, pramipexol) kv\u016fli riziku fibr\u00f3zy. Bromokriptin z\u016fst\u00e1v\u00e1 u\u017eite\u010dn\u00fd, kdy\u017e jsou nov\u011bj\u0161\u00ed agonist\u00e9 nesnesiteln\u00ed, nedostupn\u00ed nebo p\u0159\u00edli\u0161 draz\u00ed, a jako dopln\u011bk k levodop\u011b u pacient\u016f s fluktuacemi.<\/p>\n

      Hyperprolaktin\u00e9mie \/ prolaktinom:<\/strong> st\u00e1le \u0161iroce pou\u017e\u00edv\u00e1n. Kabergolin je nyn\u00ed obvykle preferov\u00e1n (d\u00e1vkov\u00e1n\u00ed dvakr\u00e1t t\u00fddn\u011b, m\u00e9n\u011b gastrointestin\u00e1ln\u00edch \u00fa\u010dink\u016f), ale bromokriptin z\u016fst\u00e1v\u00e1 \u00fa\u010dinn\u00fd a je standardn\u00ed volbou v t\u011bhotenstv\u00ed, proto\u017ee m\u00e1 nejdel\u0161\u00ed z\u00e1znam o bezpe\u010dnosti.<\/p>\n

      Akromegalie:<\/strong> druh\u00e1 volba, p\u0159edev\u0161\u00edm pro pacienty, kte\u0159\u00ed nesn\u00e1\u0161ej\u00ed nebo si nemohou dovolit analogy somatostatinu (oktreotid, lanreotid).<\/p>\n

      Potla\u010den\u00ed laktace po mrtv\u00e9m porodu nebo p\u0159i mate\u0159sk\u00e9 kontraindikaci kojen\u00ed:<\/strong> historicky pou\u017e\u00edv\u00e1n, ale nyn\u00ed z\u0159\u00eddka doporu\u010dov\u00e1n<\/em> kv\u016fli p\u0159\u00edpad\u016fm mrtvice, hypertenze a z\u00e1chvat\u016f \u2014 nefarmakologick\u00e1 opat\u0159en\u00ed a kabergolin jsou obvykle preferov\u00e1ny.<\/p>\n

      Nevhodn\u00e9 pro:<\/strong> nekontrolovanou hypertenzi, t\u011b\u017ek\u00e9 koron\u00e1rn\u00ed nebo perifern\u00ed c\u00e9vn\u00ed onemocn\u011bn\u00ed, anamn\u00e9zu chlopenn\u00edho srde\u010dn\u00edho onemocn\u011bn\u00ed, sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed ergotov\u00fdch alkaloid\u016f (ergotamin, methysergid).<\/p>\n

      D\u00e1vkov\u00e1n\u00ed a titrace<\/h2>\n\n\n\n\n\n\n\n
      Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nUdr\u017eovac\u00ed d\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
      Parkinsonova choroba<\/strong><\/td>\n1,25 mg dvakr\u00e1t denn\u011b s j\u00eddlem (polovina tablety 2,5 mg)<\/td>\n10\u201340 mg\/den v rozd\u011blen\u00fdch d\u00e1vk\u00e1ch; v\u00fdjime\u010dn\u011b a\u017e 100 mg\/den<\/td>\nZvy\u0161ujte o 2,5 mg\/den ka\u017ed\u00e9 2\u20134 t\u00fddny<\/td>\n<\/tr>\n
      Hyperprolaktin\u00e9mie<\/strong><\/td>\n1,25 mg p\u0159ed span\u00edm s j\u00eddlem<\/td>\n2,5\u201315 mg\/den; obvykle 5\u20137,5 mg<\/td>\nTitrujte podle hladiny prolaktinu ka\u017ed\u00e9 2\u20134 t\u00fddny<\/td>\n<\/tr>\n
      Akromegalie<\/strong><\/td>\n1,25\u20132,5 mg p\u0159ed span\u00edm<\/td>\n20\u201330 mg\/den v rozd\u011blen\u00fdch d\u00e1vk\u00e1ch<\/td>\nVy\u0161\u0161\u00ed ne\u017e u prolaktinomu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      U\u017e\u00edvat s j\u00eddlem.<\/strong> Tablety v\u017edy polykejte s j\u00eddlem, abyste sn\u00ed\u017eili nevolnost. Prvn\u00ed d\u00e1vku je nejlep\u0161\u00ed u\u017e\u00edt p\u0159ed span\u00edm.<\/p>\n

      \u26a0 Hypotenze po prvn\u00ed d\u00e1vce<\/strong> Bromokriptin m\u016f\u017ee zp\u016fsobit v\u00fdrazn\u00fd pokles krevn\u00edho tlaku b\u011bhem 30\u201360 minut po prvn\u00ed d\u00e1vce \u2014 n\u011bkdy natolik z\u00e1va\u017en\u00fd, \u017ee zp\u016fsob\u00ed synkopu. Prvn\u00ed d\u00e1vku byste m\u011bli v\u017edy u\u017e\u00edt s j\u00eddlem, vle\u017ee a za p\u0159\u00edtomnosti dal\u0161\u00ed osoby. N\u00e1sledn\u00e9 d\u00e1vky jsou l\u00e9pe sn\u00e1\u0161eny, jak si pacient zvykne.<\/div>\n
      \u26a0 Riziko dlouhodob\u00e9ho u\u017e\u00edv\u00e1n\u00ed ergotu \u2014 srde\u010dn\u00ed a ser\u00f3zn\u00ed fibr\u00f3za<\/strong> P\u0159i chronick\u00e9m u\u017e\u00edv\u00e1n\u00ed vysok\u00fdch d\u00e1vek bromokriptinu (zejm\u00e9na >30 mg\/den po n\u011bkolik let) existuje mal\u00e9, ale re\u00e1ln\u00e9 riziko: <\/p>\n
        \n
      • Fibr\u00f3za srde\u010dn\u00edch chlopn\u00ed<\/strong> (mitr\u00e1ln\u00ed, aort\u00e1ln\u00ed, trikuspid\u00e1ln\u00ed regurgitace) \u2014 zp\u016fsoben\u00e1 agonismem 5-HT2B receptor\u016f.<\/li>\n
      • Pleur\u00e1ln\u00ed a perikardi\u00e1ln\u00ed v\u00fdpotky a fibr\u00f3za.<\/strong><\/li>\n
      • Retroperitone\u00e1ln\u00ed fibr\u00f3za<\/strong> \u2014 bolest v boc\u00edch, otoky nohou, obstrukce mo\u010dovodu.<\/li>\n<\/ul>\n

        Dlouhodob\u00ed u\u017eivatel\u00e9 (zejm\u00e9na pacienti s Parkinsonovou chorobou u\u017e\u00edvaj\u00edc\u00ed >30 mg\/den) by m\u011bli m\u00edt z\u00e1kladn\u00ed echokardiografii a opakovat ji ka\u017ed\u00fdch 6\u201312 m\u011bs\u00edc\u016f. Nov\u011b vznikl\u00e9 du\u0161nost, otoky nebo bolesti v boc\u00edch vy\u017eaduj\u00ed okam\u017eit\u00e9 vy\u0161et\u0159en\u00ed.<\/p><\/div>\n

        B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n

        \u010cast\u00e9 (>10%):<\/strong> nevolnost, bolest hlavy, z\u00e1vrat\u011b, ortostatick\u00e1 hypotenze, \u00fanava, nosn\u00ed kongesce, z\u00e1cpa.<\/p>\n

        M\u00e9n\u011b \u010dast\u00e9:<\/strong> vizu\u00e1ln\u00ed halucinace, zmatenost (\u010dast\u011bj\u0161\u00ed u star\u0161\u00edch pacient\u016f s Parkinsonovou chorobou), vazospazmus prst\u016f na rukou\/nohou (Raynaud\u016fv fenom\u00e9n), erytromelalgie (bolestiv\u00e9 zarudl\u00e9 otoky nohou), perifern\u00ed otoky, bolesti b\u0159icha.<\/p>\n

        Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9:<\/strong> regurgitace srde\u010dn\u00edch chlopn\u00ed, pleur\u00e1ln\u00ed\/perikardi\u00e1ln\u00ed\/retroperitone\u00e1ln\u00ed fibr\u00f3za, c\u00e9vn\u00ed mozkov\u00e1 p\u0159\u00edhoda (zejm\u00e9na p\u0159i potla\u010den\u00ed laktace po porodu), z\u00e1chvaty, t\u011b\u017ek\u00e1 hypertenze. Poruchy impulzivn\u00ed kontroly \u2014 gambling, hypersexualita, z\u00e1chvatov\u00e9 p\u0159ej\u00edd\u00e1n\u00ed \u2014 se mohou vyskytnout, i kdy\u017e m\u00e9n\u011b \u010dasto ne\u017e u neergotov\u00fdch agonist\u016f.<\/p>\n

        Interakce s l\u00e9\u010divy<\/h2>\n
          \n
        • Dal\u0161\u00ed ergotov\u00e9 alkaloidy<\/strong> (ergotamin, methysergid) \u2014 aditivn\u00ed vazokonstrikce, kontraindikov\u00e1no.<\/li>\n
        • Siln\u00e9 inhibitory CYP3A4<\/strong> (klarithromycin, erytromycin, ritonavir, ketokonazol, itrakonazol) \u2014 v\u00fdrazn\u011b zvy\u0161uj\u00ed hladiny bromokriptinu. Vyvarujte se nebo sni\u017ete d\u00e1vku.<\/li>\n
        • Antagonist\u00e9 dopaminu<\/strong> (haloperidol, risperidon, metoklopramid, prochlorperazin) \u2014 farmakologick\u00e1 antagonie. Pro nevolnost pou\u017eijte rad\u011bji domperidon.<\/li>\n
        • Antihypertenziva<\/strong> \u2014 aditivn\u00ed hypotenze. Vst\u00e1vejte pomalu.<\/li>\n
        • Alkohol<\/strong> \u2014 m\u016f\u017ee zesilovat vedlej\u0161\u00ed \u00fa\u010dinky; hl\u00e1\u0161eny reakce s n\u00e1valy horka.<\/li>\n
        • Sympatomimetika, triptany<\/strong> \u2014 teoreticky aditivn\u00ed vazokonstrikce; pou\u017e\u00edvejte opatrn\u011b.<\/li>\n<\/ul>\n

          \u010casto kladen\u00e9 dotazy<\/h2>\n

          Pro\u010d se bromokriptin pou\u017e\u00edv\u00e1 u tolika r\u016fzn\u00fdch onemocn\u011bn\u00ed?<\/h3>\n

          V\u0161echny t\u0159i indikace \u2014 Parkinsonova choroba, vysok\u00fd prolaktin, akromegalie \u2014 jsou stavy, kde je terapeutick\u00e1 stimulace dopaminov\u00e9ho receptoru D2. V mozku zm\u00edr\u0148uje p\u0159\u00edznaky Parkinsonovy choroby; v hypof\u00fdze potla\u010duje uvol\u0148ov\u00e1n\u00ed prolaktinu (a slab\u011bji tak\u00e9 r\u016fstov\u00e9ho hormonu).<\/p>\n

          Pou\u017e\u00edv\u00e1 se bromokriptin st\u00e1le u Parkinsonovy choroby, nebo jej nahradily nov\u011bj\u0161\u00ed l\u00e9ky?<\/h3>\n

          V\u011bt\u0161ina neurolog\u016f nyn\u00ed za\u010d\u00edn\u00e1 s neergotov\u00fdm dopaminov\u00fdm agonistou (ropinirol, pramipexol, piribedil) u Parkinsonovy choroby, proto\u017ee se vyh\u00fdbaj\u00ed riziku fibr\u00f3zy. Bromokriptin z\u016fst\u00e1v\u00e1 u\u017eite\u010dn\u00fd, kdy\u017e nov\u011bj\u0161\u00ed agonist\u00e9 nejsou dostupn\u00ed, nesnesiteln\u00ed nebo cenov\u011b nedostupn\u00ed \u2014 a st\u00e1le se pou\u017e\u00edv\u00e1 jako dopln\u011bk k levodop\u011b u n\u011bkter\u00fdch pacient\u016f s kol\u00edsav\u00fdm pr\u016fb\u011bhem.<\/p>\n

          Jak rychle bromokriptin sni\u017euje prolaktin?<\/h3>\n

          Ji\u017e b\u011bhem n\u011bkolika hodin po prvn\u00ed d\u00e1vce doch\u00e1z\u00ed k v\u00fdrazn\u00e9mu poklesu prolaktinu. Trval\u00e9 potla\u010den\u00ed vy\u017eaduje 1\u20132 t\u00fddny pravideln\u00e9ho u\u017e\u00edv\u00e1n\u00ed. U prolaktinom\u016f je zmen\u0161ov\u00e1n\u00ed n\u00e1doru postupn\u00e9 \u2014 na MRI viditeln\u00e9 za 3\u20136 m\u011bs\u00edc\u016f, s maxim\u00e1ln\u00edm \u00fa\u010dinkem do 12 m\u011bs\u00edc\u016f.<\/p>\n

          M\u016f\u017eu u\u017e\u00edvat Brom b\u011bhem t\u011bhotenstv\u00ed?<\/h3>\n

          U prolaktinomu: bromokriptin m\u00e1 nejdel\u0161\u00ed bezpe\u010dnostn\u00ed z\u00e1znam ze v\u0161ech l\u00e9k\u016f sni\u017euj\u00edc\u00edch prolaktin v t\u011bhotenstv\u00ed. V\u011bt\u0161ina specialist\u016f jej vysazuje ihned po potvrzen\u00ed t\u011bhotenstv\u00ed (u mal\u00fdch adenom\u016f), ale u makroprolaktinom\u016f, kde je riziko expanze n\u00e1doru v t\u011bhotenstv\u00ed re\u00e1ln\u00e9, pokra\u010duj\u00ed v pod\u00e1v\u00e1n\u00ed pod pe\u010dliv\u00fdm dohledem. Proberte to se sv\u00fdm endokrinologem p\u0159ed po\u010det\u00edm.<\/strong> \u00dadaje o kabergolinu jsou tak\u00e9 uklid\u0148uj\u00edc\u00ed, ale nov\u011bj\u0161\u00ed.<\/p>\n

          Pro\u010d pot\u0159ebuji echokardiogram?<\/h3>\n

          Bromokriptin se v\u00e1\u017ee na serotoninov\u00e9 receptory 5-HT2B na srde\u010dn\u00edch chlopn\u00edch \u2014 p\u0159i chronick\u00e9m u\u017e\u00edv\u00e1n\u00ed vysok\u00fdch d\u00e1vek to m\u016f\u017ee zp\u016fsobit fibr\u00f3zu chlopn\u00ed (mitr\u00e1ln\u00ed, aort\u00e1ln\u00ed, trikuspid\u00e1ln\u00ed nedostate\u010dnost). Riziko z\u00e1vis\u00ed na d\u00e1vce a d\u00e9lce u\u017e\u00edv\u00e1n\u00ed. Z\u00e1kladn\u00ed echokardiogram a jeho ka\u017edoro\u010dn\u00ed opakov\u00e1n\u00ed je standardem u dlouhodob\u011b l\u00e9\u010den\u00fdch Parkinsonov\u00fdch pacient\u016f s d\u00e1vkami > 30 mg\/den. P\u0159i kr\u00e1tkodob\u00e9 l\u00e9\u010db\u011b hyperprolaktinemie d\u00e1vkami 5\u20137,5 mg\/den je riziko velmi n\u00edzk\u00e9.<\/p>\n

          Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n

          Vezm\u011bte si l\u00e9k, jakmile si vzpomenete, pokud nen\u00ed bl\u00edzko dal\u0161\u00ed d\u00e1vky. Ned\u00e1vejte dvojitou d\u00e1vku. Vynech\u00e1n\u00ed jedn\u00e9 d\u00e1vky bromokriptinu u hyperprolaktinemie pravd\u011bpodobn\u011b nezp\u016fsob\u00ed probl\u00e9my; vynech\u00e1n\u00ed n\u011bkolika dn\u016f m\u016f\u017ee v\u00e9st k reboundu prolaktinu. U Parkinsonovy choroby m\u016f\u017ee vynech\u00e1n\u00ed d\u00e1vek zhor\u0161it p\u0159\u00edznaky \u2014 ale nikdy ned\u00e1vejte dvojitou d\u00e1vku, abyste to dohnali.<\/p>\n

          M\u016f\u017eu bromokriptin n\u00e1hle vysadit?<\/h3>\n

          U Parkinsonovy choroby ne \u2014 n\u00e1hl\u00e9 vysazen\u00ed jak\u00e9hokoli dopaminergn\u00edho \u010dinidla m\u016f\u017ee vyvolat syndrom podobn\u00fd neuroleptick\u00e9mu malign\u00edmu syndromu. Sni\u017eujte d\u00e1vku postupn\u011b po dobu 1\u20132 t\u00fddn\u016f. U hyperprolaktinemie m\u016f\u017ee prolaktin po vysazen\u00ed l\u00e9ku reboundovat, proto by m\u011blo b\u00fdt vysazov\u00e1n\u00ed pl\u00e1nov\u00e1no s pravideln\u00fdmi kontrolami hladiny prolaktinu.<\/p>\n

          M\u016f\u017ee bromokriptin zp\u016fsobit gamblerstv\u00ed nebo jin\u00e9 nutkav\u00e9 chov\u00e1n\u00ed?<\/h3>\n

          Ano \u2014 i kdy\u017e m\u00e9n\u011b \u010dasto ne\u017e neergotn\u00ed agonist\u00e9. Informujte sv\u00e9ho neurologa o jak\u00e9mkoli nov\u00e9m nutkav\u00e9m nakupov\u00e1n\u00ed, gamblerstv\u00ed, sexu\u00e1ln\u00edm chov\u00e1n\u00ed nebo z\u00e1chvatov\u00e9m p\u0159ej\u00edd\u00e1n\u00ed. Chov\u00e1n\u00ed obvykle vymiz\u00ed po sn\u00ed\u017een\u00ed d\u00e1vky.<\/p>\n

          Ovlivn\u00ed Brom m\u00e9 \u0159\u00edzen\u00ed?<\/h3>\n

          Zvl\u00e1\u0161t\u011b v prvn\u00edch t\u00fddnech mohou z\u00e1vrat\u011b a ospalost (a vz\u00e1cn\u011b n\u00e1hl\u00fd n\u00e1stup sp\u00e1nku) zhor\u0161it schopnost \u0159\u00eddit. Vyhn\u011bte se \u0159\u00edzen\u00ed, dokud nebudete alespo\u0148 2 t\u00fddny na stabiln\u00ed d\u00e1vce a nec\u00edt\u00edte se pln\u011b bd\u011bl\u00ed.<\/p>\n

          Pou\u017e\u00edv\u00e1 se bromokriptin st\u00e1le k potla\u010den\u00ed laktace?<\/h3>\n

          D\u0159\u00edve se pou\u017e\u00edval, ale vz\u00e1cn\u00e9 p\u0159\u00edpady poporodn\u00ed mrtvice, hypertenzn\u00ed krize a z\u00e1chvat\u016f vedly v\u011bt\u0161inu zem\u00ed k odebr\u00e1n\u00ed t\u00e9to indikace. Kabergolin (jednor\u00e1zov\u00e1 d\u00e1vka) je nyn\u00ed preferovan\u00fdm ergotem pro l\u00e9ka\u0159sk\u00e9 potla\u010den\u00ed laktace, pokud je indikov\u00e1no; nefarmakologick\u00e9 metody jsou obvykle prvn\u00ed volbou.<\/p>\n

          Jak MedsBase zas\u00edl\u00e1 Brom?<\/h3>\n

          Celosv\u011btov\u00e1 doprava v diskr\u00e9tn\u00edm balen\u00ed od v\u00fdrobce certifikovan\u00e9ho WHO-GMP. Tablety jsou dod\u00e1v\u00e1ny v origin\u00e1ln\u00edch uzav\u0159en\u00fdch blistrech. Sledujte svou objedn\u00e1vku ve sv\u00e9m \u00fa\u010dtu MedsBase.<\/p>\n

          Skladov\u00e1n\u00ed<\/h2>\n

          Skladujte p\u0159i pokojov\u00e9 teplot\u011b (15\u201330\u00b0C), chr\u00e1n\u011bn\u00e9 p\u0159ed teplem, vlhkost\u00ed a p\u0159\u00edm\u00fdm sv\u011btlem. Uchov\u00e1vejte v p\u016fvodn\u00edm obalu s pevn\u011b uzav\u0159en\u00fdm v\u00edkem. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed. Nepou\u017e\u00edvejte po uplynut\u00ed data exspirace uveden\u00e9ho na obalu.<\/p>\n

          L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed<\/h2>\n

          Tyto informace jsou poskytov\u00e1ny pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nenahrazuj\u00ed rady kvalifikovan\u00e9ho l\u00e9ka\u0159e. Parkinsonova choroba a parkinsonsk\u00e9 syndromy vy\u017eaduj\u00ed individu\u00e1ln\u00ed neurologickou p\u00e9\u010di. Proberte v\u0161echny l\u00e9ky, dopl\u0148ky stravy a st\u00e1vaj\u00edc\u00ed zdravotn\u00ed stav se sv\u00fdm l\u00e9ka\u0159em p\u0159ed zah\u00e1jen\u00edm, zm\u011bnou nebo ukon\u010den\u00edm l\u00e9\u010dby. N\u00e1hl\u00e9 vysazen\u00ed dopaminergn\u00ed terapie m\u016f\u017ee vyvolat neuroleptick\u00fd malign\u00ed syndrom.<\/p>\n

          <\/p>\n

          Souvisej\u00edc\u00ed alternativy<\/h3>\n

          Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n