{"id":55940,"date":"2024-02-07T05:46:49","date_gmt":"2024-02-07T05:46:49","guid":{"rendered":"https:\/\/medsname.com\/bupron-xl\/"},"modified":"2026-04-30T10:24:42","modified_gmt":"2026-04-30T10:24:42","slug":"bupron-xl","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/bupron-xl\/","title":{"rendered":"Bupron XL"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Bupron XL?<\/h3>\n<p style=\"margin:0;\"><strong>Bupron XL<\/strong> je prodlou\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed <strong>bupropion hydrochlorid<\/strong> tableta pou\u017e\u00edvan\u00e1 k l\u00e9\u010db\u011b <strong>hlavn\u00ed depresivn\u00ed porucha (MDD)<\/strong>, <strong>sez\u00f3nn\u00ed afektivn\u00ed porucha (SAD)<\/strong>, a jako pomoc p\u0159i <strong>odvyk\u00e1n\u00ed kou\u0159en\u00ed<\/strong>. K dispozici v <strong>150 mg a 300 mg<\/strong> vhodn\u00e9 pro jednodenn\u00ed d\u00e1vkov\u00e1n\u00ed. Na rozd\u00edl od SSRI bupropion <strong>nezp\u016fsobuje sexu\u00e1ln\u00ed dysfunkci ani p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze<\/strong>, a \u010dasto <strong>sni\u017euje chu\u0165 k j\u00eddlu<\/strong>. Vyr\u00e1b\u011bno jako generick\u00fd ekvivalent p\u0159\u00edpravku Wellbutrin XL od GSK<sup>\u00ae<\/sup> a Zyban<sup>\u00ae<\/sup>.<\/p>\n<\/div>\n<p><strong>Bupron XL<\/strong> je <strong>prodlou\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed bupropion hydrochloridu<\/strong> tableta pou\u017e\u00edvan\u00e1 k l\u00e9\u010db\u011b <strong>deprese<\/strong> a pom\u00e1h\u00e1 lidem <strong>p\u0159estat kou\u0159it<\/strong>. Ka\u017ed\u00e1 tableta obsahuje 150 mg nebo 300 mg bupropionu v matrici s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm ur\u010den\u00e9 k pod\u00e1v\u00e1n\u00ed jednou denn\u011b po dobu 24 hodin. Vyr\u00e1b\u00ed spole\u010dnost Sun Pharma, Bupron XL je generick\u00fd ekvivalent p\u0159\u00edpravku od GSK <strong>Wellbutrin XL<sup>\u00ae<\/sup><\/strong> (pro depresi) a <strong>Zyban<sup>\u00ae<\/sup><\/strong> (pro odvyk\u00e1n\u00ed kou\u0159en\u00ed) \u2014 za zlomek ceny.<\/p>\n<p>Bupropion je <strong>atypick\u00fd antidepresivum<\/strong> klasifikovan\u00e9 jako <strong>inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed noradrenalinu a dopaminu (NDRI)<\/strong>. Li\u0161\u00ed se od SSRI t\u00edm, \u017ee m\u00e1 odli\u0161n\u00fd profil vedlej\u0161\u00edch \u00fa\u010dink\u016f: \u017e\u00e1dn\u00e9 sexu\u00e1ln\u00ed dysfunkce, \u017e\u00e1dn\u00fd n\u00e1r\u016fst hmotnosti (a \u010dasto m\u00edrn\u00fd \u00fabytek hmotnosti), minim\u00e1ln\u00ed sedace a m\u00edrn\u00fd stimula\u010dn\u00ed \u00fa\u010dinek u mnoha pacient\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Co je Bupron XL?<\/h2>\n<p>Bupron XL je p\u0159edpisov\u00fd l\u00e9k <strong>NDRI<\/strong> kter\u00fd selektivn\u011b inhibuje zp\u011btn\u00e9 vychyt\u00e1v\u00e1n\u00ed <strong>noradrenalinu<\/strong> a <strong>dopaminu<\/strong> v neuronech centr\u00e1ln\u00ed nervov\u00e9 soustavy. Na rozd\u00edl od SSRI m\u00e1 bupropion minim\u00e1ln\u00ed vliv na serotonin \u2014 co\u017e vysv\u011btluje jeho \u010dist\u00fd profil v oblasti sexu\u00e1ln\u00ed funkce, hmotnosti a sp\u00e1nku.<\/p>\n<p>Bupron XL se nej\u010dast\u011bji pou\u017e\u00edv\u00e1 pro:<\/p>\n<ul>\n<li><strong>Hlavn\u00ed depresivn\u00ed porucha (MDD)<\/strong> \u2014 v\u010detn\u011b deprese nereaguj\u00edc\u00ed na SSRI nebo \u0161patn\u011b sn\u00e1\u0161en\u00e9<\/li>\n<li><strong>Sez\u00f3nn\u00ed afektivn\u00ed porucha (SAD)<\/strong> \u2014 prevence depresivn\u00edch epizod na podzim\/zimu u osob s anamn\u00e9zou SAD<\/li>\n<li><strong>Odvyk\u00e1n\u00ed kou\u0159en\u00ed<\/strong> \u2014 sni\u017euje chu\u0165 na nikotin a abstinen\u010dn\u00ed p\u0159\u00edznaky; dvojn\u00e1sobn\u011b vy\u0161\u0161\u00ed \u00fasp\u011b\u0161nost ne\u017e placebo<\/li>\n<li><strong>Pomocn\u00e1 l\u00e9\u010dba sexu\u00e1ln\u00ed dysfunkce zp\u016fsoben\u00e9 SSRI<\/strong> \u2014 neschv\u00e1len\u00e9 indikace, ale b\u011b\u017en\u011b u\u017e\u00edv\u00e1no proti SSRI-indukovan\u00e9 anorgasmii a n\u00edzk\u00e9mu libidu<\/li>\n<li><strong>ADHD u dosp\u011bl\u00fdch<\/strong> \u2014 neschv\u00e1len\u00e9 indikace, v\u011bdecky podlo\u017een\u00e1 alternativa pro dosp\u011bl\u00e9, kte\u0159\u00ed nemohou u\u017e\u00edvat stimulancia<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Jak Bupron XL funguje?<\/h2>\n<p>Bupropion p\u016fsob\u00ed jako <strong>selektivn\u00ed inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed noradrenalinu a dopaminu<\/strong> v centr\u00e1ln\u00edch synaps\u00edch:<\/p>\n<ul>\n<li>Blokuje <strong>transport\u00e9r noradrenalinu (NET)<\/strong> a <strong>dopaminov\u00fd transport\u00e9r (DAT)<\/strong>, zvy\u0161uje synaptick\u00e9 koncentrace obou monoamin\u016f<\/li>\n<li>Toto zvy\u0161uje aktivitu v oblastech mozku spojen\u00fdch s <strong>motivac\u00ed, odm\u011bnou a pozornost\u00ed<\/strong> \u2014 zejm\u00e9na v prefront\u00e1ln\u00edm kortexu a mezolimbick\u00e9m syst\u00e9mu<\/li>\n<li>Bupropion a jeho aktivn\u00ed metabolit <strong>hydroxybupropion<\/strong> tak\u00e9 nekompetitivn\u011b blokuj\u00ed nikotinov\u00e9 acetylcholinov\u00e9 receptory, co\u017e vysv\u011btluje jeho u\u017eite\u010dnost p\u0159i odvyk\u00e1n\u00ed kou\u0159en\u00ed<\/li>\n<li>M\u00e1 <strong>t\u00e9m\u011b\u0159 \u017e\u00e1dn\u00fd vliv na serotonin<\/strong>, proto jsou sexu\u00e1ln\u00ed funkce, hmotnost a sp\u00e1nek obvykle zachov\u00e1ny<\/li>\n<\/ul>\n<p>N\u00e1stup antidepresivn\u00edho \u00fa\u010dinku je obvykle patrn\u00fd do <strong>2 t\u00fddny<\/strong> a pln\u00fd \u00fa\u010dinek do <strong>4\u20136 t\u00fddnech<\/strong>. Pro odvyk\u00e1n\u00ed kou\u0159en\u00ed se Bupron XL za\u010d\u00edn\u00e1 u\u017e\u00edvat <strong>1\u20132 t\u00fddny p\u0159ed pl\u00e1novan\u00fdm dnem ukon\u010den\u00ed kou\u0159en\u00ed<\/strong>, proto\u017ee stabiln\u00ed hladiny l\u00e9ku se vytv\u00e1\u0159ej\u00ed pr\u00e1v\u011b tak dlouho.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Hlavn\u00ed depresivn\u00ed porucha (MDD)<\/strong> \u2014 prvn\u00ed volba v mnoha doporu\u010den\u00edch, zejm\u00e9na pro pacienty, kte\u0159\u00ed nesn\u00e1\u0161ej\u00ed sexu\u00e1ln\u00ed nebo hmotnostn\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky SSRI<\/li>\n<li><strong>Sez\u00f3nn\u00ed afektivn\u00ed porucha (SAD)<\/strong> \u2014 preventivn\u00ed u\u017e\u00edv\u00e1n\u00ed za\u010d\u00ednaj\u00edc\u00ed koncem l\u00e9ta \/ za\u010d\u00e1tkem podzimu p\u0159ed sez\u00f3nn\u00edm poklesem<\/li>\n<li><strong>Odvyk\u00e1n\u00ed kou\u0159en\u00ed<\/strong> \u2014 7\u201312 t\u00fddenn\u00ed k\u00fary; lze kombinovat s n\u00e1hradn\u00ed nikotinovou terapi\u00ed (NRT)<\/li>\n<li><strong>Sexu\u00e1ln\u00ed dysfunkce vyvolan\u00e1 SSRI<\/strong> \u2014 p\u0159id\u00e1v\u00e1 se v d\u00e1vce 150\u2013300 mg denn\u011b k ji\u017e u\u017e\u00edvan\u00e9mu SSRI<\/li>\n<li><strong>ADHD u dosp\u011bl\u00fdch<\/strong> \u2014 mimo schv\u00e1len\u00e9 indikace u pacient\u016f, u nich\u017e jsou stimulancia kontraindikov\u00e1na nebo \u0161patn\u011b sn\u00e1\u0161ena<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a pod\u00e1v\u00e1n\u00ed Bupron XL<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indikace<\/th>\n<th>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\n<th>C\u00edlov\u00e1 \/ maxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>z\u00e1va\u017en\u00e1 depresivn\u00ed porucha<\/strong><\/td>\n<td>150 mg jednou denn\u011b (r\u00e1no) \u00d7 4 dny<\/td>\n<td>300 mg jednou denn\u011b; max. 450 mg\/denn\u011b v rozd\u011blen\u00fdch d\u00e1vk\u00e1ch<\/td>\n<\/tr>\n<tr>\n<td><strong>Sez\u00f3nn\u00ed afektivn\u00ed porucha<\/strong><\/td>\n<td>150 mg jednou denn\u011b po dobu 7 dn\u016f za\u010d\u00ednaj\u00edc\u00ed na podzim<\/td>\n<td>300 mg jednou denn\u011b b\u011bhem zimy; postupn\u011b vysazovat na ja\u0159e<\/td>\n<\/tr>\n<tr>\n<td><strong>Odvyk\u00e1n\u00ed kou\u0159en\u00ed<\/strong><\/td>\n<td>150 mg jednou denn\u011b po dobu 3 dn\u016f<\/td>\n<td>150 mg dvakr\u00e1t denn\u011b (nebo 300 mg XL jednou denn\u011b) po dobu 7\u201312 t\u00fddn\u016f<\/td>\n<\/tr>\n<tr>\n<td><strong>Star\u0161\u00ed pacienti nebo pacienti s n\u00edzkou t\u011blesnou hmotnost\u00ed<\/strong><\/td>\n<td>Zpo\u010d\u00e1tku 150 mg obden<\/td>\n<td>Titrovat podle odpov\u011bdi; ni\u017e\u0161\u00ed strop<\/td>\n<\/tr>\n<tr>\n<td><strong>Lehk\u00e9 a\u017e st\u0159edn\u00ed po\u0161kozen\u00ed jater<\/strong><\/td>\n<td>Sn\u00ed\u017eit d\u00e1vku a\/nebo frekvenci<\/td>\n<td>Pe\u010dliv\u00e9 sledov\u00e1n\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C)<\/strong><\/td>\n<td>150 mg ka\u017ed\u00fd druh\u00fd den<\/td>\n<td>Max. 150 mg ka\u017ed\u00fd druh\u00fd den<\/td>\n<\/tr>\n<tr>\n<td><strong>Porucha funkce ledvin<\/strong><\/td>\n<td>Zv\u00e1\u017eit ni\u017e\u0161\u00ed po\u010d\u00e1te\u010dn\u00ed d\u00e1vku<\/td>\n<td>Aktivn\u00ed metabolity se kumuluj\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>Maxim\u00e1ln\u00ed denn\u00ed d\u00e1vka<\/strong><\/td>\n<td>450 mg (pouze v rozd\u011blen\u00fdch IR d\u00e1vk\u00e1ch)<\/td>\n<td>XL formulace: max. 300 mg jednou denn\u011b<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Bupron XL<\/h3>\n<ul>\n<li>Tabletu polykejte <strong>vcelku<\/strong> \u2014 tabletu XL NEROZKRACUJTE, NEROZ\u017dV\u00ddKEJTE a NEROZP\u016eLTE. Poru\u0161en\u00ed matrice uvoln\u00ed celou d\u00e1vku najednou a zvy\u0161uje riziko z\u00e1chvat\u016f<\/li>\n<li>U\u017eijte <strong>r\u00e1no<\/strong> \u2014 ve\u010dern\u00ed d\u00e1vkov\u00e1n\u00ed m\u016f\u017ee zp\u016fsobit nespavost<\/li>\n<li>Lze u\u017e\u00edvat s j\u00eddlem i bez j\u00eddla<\/li>\n<li>Po\u010dkejte <strong>2 t\u00fddny<\/strong> pro \u010dasnou antidepresivn\u00ed odpov\u011b\u010f a <strong>4\u20136 t\u00fddnech<\/strong> pro pln\u00fd \u00fa\u010dinek<\/li>\n<li>Pro <strong>odvyk\u00e1n\u00ed kou\u0159en\u00ed<\/strong>, stanovte datum ukon\u010den\u00ed a za\u010dn\u011bte u\u017e\u00edvat Bupron XL <strong>1\u20132 t\u00fddny p\u0159ed<\/strong> t\u00edmto datem<\/li>\n<li>Nep\u0159est\u00e1vejte <strong>nep\u0159est\u00e1vejte n\u00e1hle<\/strong> po dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed \u2014 postupn\u011b vysazujte po dobu 2\u20134 t\u00fddn\u016f pod l\u00e9ka\u0159sk\u00fdm dohledem<\/li>\n<li>Po\u010dkejte <strong>14 dn\u00ed<\/strong> mezi vysazen\u00edm MAOI a zah\u00e1jen\u00edm u\u017e\u00edv\u00e1n\u00ed bupropionu a naopak<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky Bupron XL<\/h2>\n<p>Bupropion m\u00e1 specifick\u00fd profil vedlej\u0161\u00edch \u00fa\u010dink\u016f \u2014 m\u00e9n\u011b sexu\u00e1ln\u00edch a v\u00e1hov\u00fdch \u00fa\u010dink\u016f ne\u017e SSRI, ale v\u00edce aktiva\u010dn\u00edch \u00fa\u010dink\u016f, nespavosti a rizika z\u00e1chvat\u016f p\u0159i nespr\u00e1vn\u00e9m d\u00e1vkov\u00e1n\u00ed.<\/p>\n<table>\n<thead>\n<tr>\n<th>Z\u00e1va\u017enost<\/th>\n<th>Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>B\u011b\u017en\u00e9 (\u22651 z 10)<\/strong><\/td>\n<td>Sucho v \u00fastech, nespavost, bolest hlavy, nevolnost<\/td>\n<\/tr>\n<tr>\n<td><strong>B\u011b\u017en\u00e9 (\u22651 ze 100)<\/strong><\/td>\n<td>Nepokoj, \u00fazkost, t\u0159es, z\u00e1vrat\u011b, z\u00e1cpa, pocen\u00ed, tinnitus, rozmazan\u00e9 vid\u011bn\u00ed, zm\u011bny chuti, sn\u00ed\u017een\u00e1 chu\u0165 k j\u00eddlu \/ m\u00edrn\u00fd \u00fabytek hmotnosti<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00e9n\u011b \u010dast\u00e9<\/strong><\/td>\n<td>Tachykardie, zv\u00fd\u0161en\u00fd krevn\u00ed tlak, vyr\u00e1\u017eka, kop\u0159ivka, palpitace<\/td>\n<\/tr>\n<tr>\n<td><strong>Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9<\/strong><\/td>\n<td>Z\u00e1chvaty (z\u00e1visl\u00e9 na d\u00e1vce), syndrom podobn\u00fd s\u00e9rov\u00e9 nemoci, Stevens-Johnson\u016fv syndrom, t\u011b\u017ek\u00e1 hypertenze, sebevra\u017eedn\u00e9 my\u0161lenky (zejm\u00e9na u mlad\u00fdch dosp\u011bl\u00fdch), psych\u00f3za nebo m\u00e1nie u n\u00e1chyln\u00fdch pacient\u016f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Riziko z\u00e1chvat\u016f je nejv\u00fdznamn\u011bj\u0161\u00edm d\u00e1vkov\u011b z\u00e1visl\u00fdm vedlej\u0161\u00edm \u00fa\u010dinkem.<\/strong> P\u0159i d\u00e1vk\u00e1ch do 300 mg XL denn\u011b je v\u00fdskyt asi 0,1 % \u2014 srovnateln\u00fd s jin\u00fdmi antidepresivy. Nad 450 mg\/den nebo s rozdrcen\u00fdmi\/rozbit\u00fdmi tabletami se riziko prudce zvy\u0161uje. Nikdy nep\u0159ekra\u010dujte doporu\u010denou d\u00e1vku a nikdy nedr\u0165te ani nerozd\u011blujte XL formu.<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Riziko z\u00e1chvat\u016f<\/strong> je z\u00e1visl\u00e9 na d\u00e1vce. Nep\u0159ekra\u010dujte 300 mg XL jednou denn\u011b (nebo 450 mg celkem denn\u011b p\u0159i u\u017e\u00edv\u00e1n\u00ed IR). Vyvarujte se u pacient\u016f s jakoukoli anamn\u00e9zou z\u00e1chvat\u016f, poran\u011bn\u00ed mozku nebo faktor\u016f, kter\u00e9 sni\u017euj\u00ed pr\u00e1h z\u00e1chvat\u016f<\/li>\n<li><strong>Sebevra\u017eedn\u00e9 my\u0161lenky.<\/strong> Stejn\u011b jako v\u0161echna antidepresiva nese bupropion \u010dernou v\u00fdstrahu pro sebevra\u017eedn\u00e9 my\u0161lenky u pacient\u016f mlad\u0161\u00edch 25 let. Pe\u010dliv\u011b sledujte b\u011bhem prvn\u00edch 2\u20134 t\u00fddn\u016f l\u00e9\u010dby a po ka\u017ed\u00e9 zm\u011bn\u011b d\u00e1vky<\/li>\n<li><strong>Neuropsychiatrick\u00e9 p\u0159\u00edznaky p\u0159i odvyk\u00e1n\u00ed kou\u0159en\u00ed.<\/strong> Byly hl\u00e1\u0161eny p\u0159\u00edpady neklidu, depresivn\u00ed n\u00e1lady a vz\u00e1cn\u011b psych\u00f3zy. Pacienti by m\u011bli b\u00fdt varov\u00e1ni, aby takov\u00e9 p\u0159\u00edznaky neprodlen\u011b hl\u00e1sili<\/li>\n<li><strong>Hypertenze.<\/strong> Zkontrolujte krevn\u00ed tlak p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby a p\u0159i n\u00e1sledn\u00fdch kontrol\u00e1ch; m\u016f\u017ee zp\u016fsobit m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed TK, zejm\u00e9na v kombinaci s n\u00e1hradn\u00ed nikotinovou terapi\u00ed<\/li>\n<li><strong>Aktivace \/ \u00fazkost \/ nespavost.<\/strong> Za\u010dn\u011bte d\u00e1vkou 150 mg; pokud je nespavost v\u00fdrazn\u00e1, u\u017e\u00edvejte d\u0159\u00edve b\u011bhem dne nebo zva\u017ete kr\u00e1tkodobou podporu hypnotiky<\/li>\n<li><strong>Alkohol.<\/strong> Vyhn\u011bte se nadm\u011brn\u00e9mu pit\u00ed alkoholu \u2013 alkohol sni\u017euje pr\u00e1h z\u00e1chvat\u016f a m\u016f\u017ee vyvolat neuropsychiatrick\u00e9 \u00fa\u010dinky<\/li>\n<li><strong>T\u011bhotenstv\u00ed \/ kojen\u00ed.<\/strong> Pou\u017e\u00edvejte pouze v p\u0159\u00edpad\u011b, \u017ee p\u0159\u00ednosy jasn\u011b p\u0159eva\u017euj\u00ed nad riziky. Bupropion p\u0159ech\u00e1z\u00ed do mate\u0159sk\u00e9ho ml\u00e9ka v mal\u00e9m mno\u017estv\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace \u2013 Kdo by NEM\u011aL u\u017e\u00edvat Bupron XL<\/h2>\n<ul>\n<li><strong>Jak\u00e1koli anamn\u00e9za z\u00e1chvatov\u00e9 poruchy<\/strong><\/li>\n<li><strong>Sou\u010dasn\u00e1 nebo minul\u00e1 bulimie nebo ment\u00e1ln\u00ed anorexie<\/strong> \u2014 vy\u0161\u0161\u00ed riziko z\u00e1chvat\u016f u pacient\u016f s poruchou elektrolyt\u016f<\/li>\n<li><strong>Akutn\u00ed abstinen\u010dn\u00ed p\u0159\u00edznaky alkoholu nebo benzodiazepin\u016f<\/strong><\/li>\n<li><strong>U\u017e\u00edv\u00e1n\u00ed MAOI v posledn\u00edch 14 dnech<\/strong> (v\u010detn\u011b linezolidu, methylenov\u00e9 mod\u0159i)<\/li>\n<li><strong>Pou\u017eit\u00ed jin\u00e9ho p\u0159\u00edpravku obsahuj\u00edc\u00edho bupropion<\/strong> (kumulativn\u00ed riziko z\u00e1chvat\u016f)<\/li>\n<li><strong>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/strong> (pokud nen\u00ed d\u00e1vka sn\u00ed\u017eena podle doporu\u010den\u00ed specialisty)<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na bupropion nebo jakoukoli pomocnou l\u00e1tku<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table>\n<thead>\n<tr>\n<th>L\u00e9\u010divo \/ T\u0159\u00edda<\/th>\n<th>Interakce<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>MAOI (fenelzin, tranylcypromin, moklobemid, linezolid)<\/strong><\/td>\n<td><strong>Absolutn\u00ed kontraindikace<\/strong> \u2014 riziko serotoninov\u00e9ho\/noradrenergn\u00edho krize. 14denn\u00ed vy\u0159azen\u00ed v obou sm\u011brech<\/td>\n<\/tr>\n<tr>\n<td><strong>Dal\u0161\u00ed l\u00e9ky sni\u017euj\u00edc\u00ed pr\u00e1h pro z\u00e1chvaty<\/strong> (tramadol, theofylin, syst\u00e9mov\u00e9 kortikosteroidy, antipsychotika)<\/td>\n<td>Zv\u00fd\u0161en\u00e9 riziko z\u00e1chvat\u016f \u2014 pou\u017e\u00edvejte opatrn\u011b<\/td>\n<\/tr>\n<tr>\n<td><strong>Inhibitory CYP2B6 (tiklopidin, klopidogrel)<\/strong><\/td>\n<td>Zv\u00fd\u0161en\u00e9 hladiny bupropionu \u2014 m\u016f\u017ee b\u00fdt nutn\u00e1 \u00faprava d\u00e1vkov\u00e1n\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>Induktory CYP2B6 (karbamazepin, fenytoin, rifampicin, ritonavir)<\/strong><\/td>\n<td>Sn\u00ed\u017een\u00e9 hladiny bupropionu \u2014 m\u016f\u017ee sn\u00ed\u017eit \u00fa\u010dinnost<\/td>\n<\/tr>\n<tr>\n<td><strong>CYP2D6 substr\u00e1ty (tamoxifen, kodein, beta-blok\u00e1tory, mnoh\u00e1 antidepresiva, atomoxetin)<\/strong><\/td>\n<td>\u2014 substr\u00e1ty se hromad\u00ed. Klinicky v\u00fdznamn\u00e9 u tamoxifenu (sn\u00ed\u017een\u00ed \u00fa\u010dinnosti) a kodeinu (sn\u00ed\u017een\u00ed analgezie) <strong>Nikotinov\u00e9 n\u00e1plasti \/ \u017ev\u00fdka \/ vareniklin<\/strong> Mohou b\u00fdt kombinov\u00e1ny pro odvyk\u00e1n\u00ed kou\u0159en\u00ed \u2014 sledujte krevn\u00ed tlak<\/td>\n<\/tr>\n<tr>\n<td><strong>Sni\u017euje pr\u00e1h z\u00e1chvat\u016f \u2014 p\u0159\u00edsn\u011b omezte<\/strong><\/td>\n<td>Lze kombinovat pro odvyk\u00e1n\u00ed kou\u0159en\u00ed \u2014 sledujte krevn\u00ed tlak<\/td>\n<\/tr>\n<tr>\n<td><strong>Alkohol<\/strong><\/td>\n<td>Sni\u017euje pr\u00e1h z\u00e1chvatu \u2014 p\u0159\u00edsn\u011b omezte.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>V\u017edy p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby p\u0159\u00edpravkem Bupron XL sd\u011blte sv\u00e9mu l\u00e9ka\u0159i \u00fapln\u00fd seznam v\u0161ech l\u00e9k\u016f na p\u0159edpis i voln\u011b prodejn\u00fdch, v\u010detn\u011b rekrea\u010dn\u00edch drog, bylinn\u00fdch dopl\u0148k\u016f a nikotinov\u00fdch produkt\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Co d\u011blat v p\u0159\u00edpad\u011b p\u0159ed\u00e1vkov\u00e1n\u00ed<\/h2>\n<p>Bupropion overdose can cause seizures, cardiac conduction abnormalities, severe hypertension, and altered consciousness. There is no specific antidote \u2014 management is supportive with airway protection, benzodiazepines for seizures, and cardiac monitoring. Contact your local poisons service or emergency department immediately if overdose is suspected.<\/p>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Nepou\u017eit\u00e9 tobolky zlikvidujte prost\u0159ednictv\u00edm l\u00e9k\u00e1rensk\u00e9ho zp\u011btn\u00e9ho odb\u011bru, je-li k dispozici<\/li>\n<li>Uchov\u00e1vejte v p\u016fvodn\u00edm blistrov\u00e9m obalu<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed<\/li>\n<li>Nepou\u017e\u00edvejte po datu expirace uveden\u00e9m na obalu<\/li>\n<li>Nepou\u017eit\u00e9 tablety likvidujte prost\u0159ednictv\u00edm l\u00e9k\u00e1rny, pokud je k dispozici<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Hled\u00e1te souvisej\u00edc\u00ed mo\u017enosti antidepresiv nebo odvyk\u00e1n\u00ed kou\u0159en\u00ed?<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/champix\/\" rel=\"noopener\">Champix<\/a> \u2014 varenicline, dal\u0161\u00ed mo\u017enost odvyk\u00e1n\u00ed kou\u0159en\u00ed, kter\u00e1 p\u016fsob\u00ed na nikotinov\u00e9 receptory<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mirtaz\/\" rel=\"noopener\">Mirtaz<\/a> \u2014 mirtazapin, atypick\u00e9 antidepresivum se siln\u00fdmi \u00fa\u010dinky na sp\u00e1nek a chu\u0165 k j\u00eddlu (opa\u010dn\u00fd profil ne\u017e bupropion)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sertima\/\" rel=\"noopener\">Sertima<\/a> \u2014 sertralin, b\u011b\u017en\u00e9 SSRI; \u010dasto se uva\u017euje spolu s bupropionem nebo v kombinaci s n\u00edm<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mental-health-and-psychiatric-medications\/\" rel=\"noopener\">Prohl\u00e9dnout v\u0161echny l\u00e9ky na du\u0161evn\u00ed zdrav\u00ed \u2192<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Jak dlouho trv\u00e1, ne\u017e Bupron XL za\u010dne \u00fa\u010dinkovat?<\/h3>\n<p>P\u0159i depresi v\u011bt\u0161ina lid\u00ed zaznamen\u00e1 po\u010d\u00e1te\u010dn\u00ed odezvu do <strong>2 t\u00fddny<\/strong> (energie, koncentrace, chu\u0165 k j\u00eddlu) s pln\u00fdm antidepresivn\u00edm \u00fa\u010dinkem do <strong>4\u20136 t\u00fddnech<\/strong>. Pro odvyk\u00e1n\u00ed kou\u0159en\u00ed je \u00fa\u010dinek sn\u00ed\u017een\u00ed chuti na cigaretu obvykle p\u0159\u00edtomen do dne ukon\u010den\u00ed kou\u0159en\u00ed, proto l\u00e9\u010dba za\u010d\u00edn\u00e1 <strong>1\u20132 t\u00fddny p\u0159ed<\/strong> p\u0159ed ukon\u010den\u00edm kou\u0159en\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Zp\u016fsobuje Bupron XL sexu\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky?<\/h3>\n<p><strong>Ne<\/strong> \u2014 to je jedna z hlavn\u00edch v\u00fdhod bupropionu oproti SSRI. Bupropion m\u00e1 minim\u00e1ln\u00ed vliv na serotonin a zachov\u00e1v\u00e1 libido, vzru\u0161en\u00ed a orgasmus. \u010casto je p\u0159edepisov\u00e1n speci\u00e1ln\u011b k potla\u010den\u00ed sexu\u00e1ln\u00ed dysfunkce vyvolan\u00e9 SSRI.<\/p>\n<h3 class=\"wp-block-heading\">Zp\u016fsobuje Bupron XL p\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze?<\/h3>\n<p><strong>Ne<\/strong> \u2014 a u mnoha pacient\u016f zp\u016fsobuje m\u00edrn\u00fd \u00fabytek hmotnosti (obvykle 2\u20135 lb \/ 1\u20132 kg). Sni\u017euje chu\u0165 k j\u00eddlu v prvn\u00edch t\u00fddnech a nezp\u016fsobuje metabolick\u00fd p\u0159\u00edr\u016fstek hmotnosti jako SSRI, tricyklick\u00e1 antidepresiva nebo mirtazapin.<\/p>\n<h3 class=\"wp-block-heading\">Je Bupron XL stejn\u00fd jako Wellbutrin a Zyban?<\/h3>\n<p>Ano, v \u00fa\u010dinn\u00fdch l\u00e1tk\u00e1ch \u2014 Bupron XL je hydrochlorid bupropionu s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm, identick\u00fd s Wellbutrin XL<sup>\u00ae<\/sup> (pro depresi) a Zyban<sup>\u00ae<\/sup> (pro odvyk\u00e1n\u00ed kou\u0159en\u00ed; obvykle krat\u0161\u00ed p\u016fsob\u00edc\u00ed SR forma). Klinicky ekvivalentn\u00ed, v\u00fdrazn\u011b ni\u017e\u0161\u00ed cena.<\/p>\n<h3 class=\"wp-block-heading\">Mohu rozd\u011blit nebo rozdrtit tablety Bupron XL?<\/h3>\n<p><strong>Ne, nikdy.<\/strong> Matrice s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm je z\u00e1sadn\u00ed. Rozlomen\u00ed, rozdrcen\u00ed nebo roz\u017ev\u00fdk\u00e1n\u00ed tablety uvoln\u00ed celou d\u00e1vku najednou a v\u00fdrazn\u011b zv\u00fd\u0161\u00ed riziko z\u00e1chvat\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Mohu kombinovat Bupron XL s SSRI?<\/h3>\n<p>Ano \u2014 tato kombinace je v klinick\u00e9 praxi b\u011b\u017en\u00e1 u pacient\u016f, kte\u0159\u00ed na SSRI reaguj\u00ed \u010d\u00e1ste\u010dn\u011b, ale maj\u00ed p\u0159etrv\u00e1vaj\u00edc\u00ed n\u00edzkou energii, motivaci nebo sexu\u00e1ln\u00ed dysfunkci. Riziko serotoninov\u00e9ho syndromu je velmi n\u00edzk\u00e9, proto\u017ee bupropion m\u00e1 malou serotonergn\u00ed aktivitu.<\/p>\n<h3 class=\"wp-block-heading\">Jak pou\u017e\u00edvat Bupron XL pro odvyk\u00e1n\u00ed kou\u0159en\u00ed?<\/h3>\n<p>Stanovte si datum ukon\u010den\u00ed kou\u0159en\u00ed 1\u20132 t\u00fddny dop\u0159edu. Za\u010dn\u011bte s Bupron XL 150 mg jednou denn\u011b po dobu 3 dn\u016f, pot\u00e9 150 mg dvakr\u00e1t denn\u011b (nebo 300 mg XL jednou denn\u011b). Pokra\u010dujte po dobu <strong>7\u201312 t\u00fddn\u016f<\/strong> celkem. Lze kombinovat s n\u00e1hradn\u00ed nikotinovou terapi\u00ed (n\u00e1plasti, \u017ev\u00fdka\u010dky, pastilky) pro vy\u0161\u0161\u00ed \u00fasp\u011b\u0161nost v odvyk\u00e1n\u00ed. Pokud do 7 t\u00fddn\u016f nekou\u0159en\u00ed nep\u0159estanete, l\u00e9\u010dbu lze prodlou\u017eit.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Bupron XL?<\/h3>\n<p>Nadm\u011brn\u00e9 pit\u00ed alkoholu by se m\u011blo vyvarovat \u2014 sni\u017euje pr\u00e1h pro z\u00e1chvaty a m\u016f\u017ee vyvolat neuropsychiatrick\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky. <strong>Akutn\u00ed abstinen\u010dn\u00ed p\u0159\u00edznaky alkoholu p\u0159i u\u017e\u00edv\u00e1n\u00ed bupropionu jsou nebezpe\u010dn\u00e9<\/strong> proto\u017ee se riziko z\u00e1chvat\u016f n\u00e1sob\u00ed. M\u00edrn\u00e9 spole\u010densk\u00e9 pit\u00ed je obvykle tolerov\u00e1no, ale proberte to se sv\u00fdm l\u00e9ka\u0159em.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00fd je rozd\u00edl mezi Bupron SR a Bupron XL?<\/h3>\n<p>Oba obsahuj\u00ed bupropion HCl, ale li\u0161\u00ed se v uvol\u0148ov\u00e1n\u00ed. <strong>SR (sustained-release, prodlou\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed)<\/strong> se u\u017e\u00edv\u00e1 dvakr\u00e1t denn\u011b. <strong>XL (extended-release, prodlou\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed)<\/strong> se u\u017e\u00edv\u00e1 jednou denn\u011b. XL je preferovan\u00e1 forma pro pohodl\u00ed a vyrovnan\u011bj\u0161\u00ed hladinu v plazm\u011b.<\/p>\n<h3 class=\"wp-block-heading\">Je Bupron XL n\u00e1vykov\u00fd?<\/h3>\n<p><strong>Ne<\/strong> \u2014 bupropion nen\u00ed n\u00e1vykov\u00fd a nem\u00e1 potenci\u00e1l zneu\u017eit\u00ed navzdory sv\u00e9mu dopaminergn\u00edmu \u00fa\u010dinku, proto\u017ee zv\u00fd\u0161en\u00ed extracelul\u00e1rn\u00edho dopaminu je m\u00edrn\u00e9 a pomal\u00e9. Ve v\u011bt\u0161in\u011b zem\u00ed nen\u00ed kontrolovanou l\u00e1tkou.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu n\u00e1hle p\u0159estat u\u017e\u00edvat Bupron XL?<\/h3>\n<p>Kr\u00e1tk\u00e9 l\u00e9\u010debn\u00e9 k\u00fary (nap\u0159. 7\u201312t\u00fddenn\u00ed odvykac\u00ed k\u00fara kou\u0159en\u00ed) lze obvykle ukon\u010dit bez postupn\u00e9ho sni\u017eov\u00e1n\u00ed d\u00e1vky. P\u0159i l\u00e9\u010db\u011b deprese trvaj\u00edc\u00ed n\u011bkolik m\u011bs\u00edc\u016f je, <strong>doporu\u010deno sni\u017eovat d\u00e1vku po dobu 2\u20134 t\u00fddn\u016f<\/strong> aby se minimalizoval n\u00e1vrat depresivn\u00edch p\u0159\u00edznak\u016f nebo abstinen\u010dn\u00edch p\u0159\u00edznak\u016f. Proberte postup sni\u017eov\u00e1n\u00ed d\u00e1vky se sv\u00fdm l\u00e9ka\u0159em.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Bupron XL na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em <a href=\"https:\/\/medsbase.com\/cs\/loyalty-points\/\">v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Obecn\u00e9 zdrav\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/erythromycin\/\">Erythromycin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/orzine\/\">Orzine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/reglan\/\">Reglan<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dulcoflex\/\">Dulcoflex<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lurakem\/\">Lurakem<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Bupron XL (Bupropion 150\/300 mg XL) \u2014 NDRI antidepresivum pro l\u00e9\u010dbu t\u011b\u017ek\u00e9 deprese a odvyk\u00e1n\u00ed kou\u0159en\u00ed. jednou denn\u011b XL \u2014 bez sexu\u00e1ln\u00ed dysfunkce, neutr\u00e1ln\u00ed v\u016f\u010di hmotnosti.<\/p>","protected":false},"featured_media":55941,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[5684,4015,4014,5677,5681,5682,5683,5680,5678,5679],"class_list":{"0":"post-55940","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-atypical-antidepressant","10":"product_tag-bupron-xl","11":"product_tag-bupropion","12":"product_tag-bupropion-hcl","13":"product_tag-major-depression","14":"product_tag-mdd","15":"product_tag-ndri","16":"product_tag-smoking-cessation","17":"product_tag-wellbutrin-generic","18":"product_tag-zyban","20":"first","21":"instock","22":"shipping-taxable","23":"purchasable","24":"product-type-variable","25":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/55940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=55940"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/55941"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=55940"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=55940"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=55940"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=55940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}