{"id":55951,"date":"2024-02-07T05:47:17","date_gmt":"2024-02-07T05:47:17","guid":{"rendered":"https:\/\/medsname.com\/busiron\/"},"modified":"2026-04-30T10:24:42","modified_gmt":"2026-04-30T10:24:42","slug":"busiron","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/busiron\/","title":{"rendered":"Busiron"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Busiron (Buspiron 5 \/ 10 mg) je parci\u00e1ln\u00ed agonista 5-HT1A receptor\u016f pro l\u00e9\u010dbu generalizovan\u00e9 \u00fazkostn\u00e9 poruchy. Nesedativn\u00ed, nezp\u016fsobuje z\u00e1vislost ani zneu\u017e\u00edv\u00e1n\u00ed \u2014 ale m\u00e1 pomal\u00fd n\u00e1stup \u00fa\u010dinku (3\u20136 t\u00fddn\u016f). Vhodn\u00fd, kdy\u017e jsou benzodiazepiny nevhodn\u00e9.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Busiron na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Busiron a jak funguje<\/h2>\n

Busiron je tableta obsahuj\u00edc\u00ed 5 \/ 10 mg buspironu dod\u00e1van\u00e1 spole\u010dnost\u00ed Intas. Buspiron je parci\u00e1ln\u00ed agonista serotoninov\u00fdch receptor\u016f 5-HT1A a slab\u00fd antagonista D2. \u00da\u010dinek na 5-HT1A receptory sni\u017euje \u00fazkost po t\u00fddnech pod\u00e1v\u00e1n\u00ed; absence interakce s GABA-A receptory vysv\u011btluje, pro\u010d buspiron nezp\u016fsobuje sedaci, amn\u00e9zii ani z\u00e1vislost \u2014 co\u017e jej v\u00fdrazn\u011b odli\u0161uje od benzodiazepin\u016f.<\/p>\n

\nPomal\u00fd n\u00e1stup \u00fa\u010dinku je vlastnost\u00ed l\u00e9ku \u2014 nikoli selh\u00e1n\u00edm<\/strong><\/p>\n

Buspiron dosahuje pln\u00e9ho anxiolytick\u00e9ho \u00fa\u010dinku za 3\u20136 t\u00fddn\u016f. Nep\u016fsob\u00ed jako prost\u0159edek pro PRN (podle pot\u0159eby) a nevyvol\u00e1v\u00e1 okam\u017eit\u00e9 zklidn\u011bn\u00ed. Pacienti, kte\u0159\u00ed o\u010dek\u00e1vaj\u00ed \u00falevu podobnou benzodiazepin\u016fm ji\u017e v prvn\u00edm t\u00fddnu, mohou usoudit, \u017ee buspiron \u201cnefunguje\u201d, a p\u0159estanou jej u\u017e\u00edvat. Je d\u016fle\u017eit\u00e9 stanovit o\u010dek\u00e1v\u00e1n\u00ed p\u0159edem.<\/p>\n<\/div>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Generalizovan\u00e1 \u00fazkostn\u00e1 porucha<\/td>\n5 mg 2\u20133\u00d7 denn\u011b<\/td>\n20\u201330 mg\/den ve 2\u20133 d\u00e1vk\u00e1ch<\/td>\n60 mg<\/td>\n<\/tr>\n
SSRI sexu\u00e1ln\u00ed dysfunkce (mimo indikaci)<\/td>\n10 mg 2\u00d7 denn\u011b<\/td>\n20 mg 2\u00d7 denn\u011b<\/td>\n\u2014<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed<\/td>\n5 mg 2\u00d7 denn\u011b<\/td>\n15\u201320 mg\/den<\/td>\n\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

U\u017e\u00edvejte pravideln\u011b s j\u00eddlem nebo bez j\u00eddla (j\u00eddlo sni\u017euje variabilitu). Vyhn\u011bte se grapefruitov\u00e9 \u0161\u0165\u00e1v\u011b (inhibice CYP3A4).<\/p>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nCYP3A4 substr\u00e1t<\/strong><\/p>\n

Buspiron je v\u00fdrazn\u011b metabolizov\u00e1n CYP3A4. Siln\u00e9 inhibitory (klarithromycin, itrakonazol, ketokonazol, ritonavir, grapefruitov\u00fd d\u017eus) zvy\u0161uj\u00ed hladiny 5\u201310\u00d7 \u2014 za\u010dn\u011bte s 2,5 mg 2\u00d7 denn\u011b. Siln\u00e9 induktory (rifampicin, karbamazepin, fenytoin, t\u0159ezalka te\u010dkovan\u00e1) sni\u017euj\u00ed hladiny a mohou zru\u0161it \u00fa\u010dinnost.<\/p>\n<\/div>\n

\nMAOI<\/strong><\/p>\n

14denn\u00ed vy\u0159azen\u00ed p\u0159i ka\u017ed\u00e9 zm\u011bn\u011b; sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed riskuje hypertenzn\u00ed krizi.<\/p>\n<\/div>\n

\n\u017d\u00e1dn\u00fd potenci\u00e1l zneu\u017eit\u00ed, \u017e\u00e1dn\u00e1 z\u00e1vislost<\/strong><\/p>\n

Buspiron je l\u00e9k bez omezen\u00ed ve v\u0161ech hlavn\u00edch regula\u010dn\u00edch z\u00f3n\u00e1ch. Nevyvol\u00e1v\u00e1 euforii, netoleranci, abstinen\u010dn\u00ed p\u0159\u00edznaky a je vhodn\u00fd pro pacienty s anamn\u00e9zou u\u017e\u00edv\u00e1n\u00ed n\u00e1vykov\u00fdch l\u00e1tek nebo ty, kte\u0159\u00ed se mus\u00ed vyhnout omezen\u00ed (\u0159idi\u010di, piloti, obsluha stroj\u016f, chirurgov\u00e9).<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n