{"id":55973,"date":"2024-02-07T05:47:52","date_gmt":"2024-02-07T05:47:52","guid":{"rendered":"https:\/\/medsname.com\/tegrital\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"tegrital","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/tegrital\/","title":{"rendered":"Tegrital 100 mg \u017ev\u00fdkac\u00ed tablety (karbamazepin) \u2014 trigemin\u00e1ln\u00ed neuralgie a z\u00e1chvaty"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;font-size:18px;color:#1a1a1a;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p><strong>Tegrital 100 mg chewable tablets<\/strong> obsahuje <strong>karbamazepin<\/strong>, a sodium-channel-blocking anticonvulsant that has been first-line for <strong>trigeminal neuralgia since 1962<\/strong> and remains a workhorse anti-epileptic for partial-onset seizures and bipolar mood stabilisation. The chewable formulation is well-suited to children, patients with swallowing difficulty, and adults who prefer not to swallow whole tablets. Treatment starts low (100 mg once or twice daily) and titrates up slowly because carbamazepine induces its own metabolism over 2\u20134 weeks. <strong>Asian-ancestry patients should be tested for HLA-B*1502 before starting<\/strong> \u2014 this allele identifies a high risk of Stevens-Johnson syndrome.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2>What Is Tegrital?<\/h2>\n<p>Tegrital is an Indian-manufactured generic of <strong>karbamazepin<\/strong>, available as a 100 mg chewable tablet. Carbamazepine is a tricyclic compound structurally related to imipramine but pharmacologically classified as an anti-epileptic. The chewable formulation can be chewed, broken, or swallowed whole with water \u2014 convenient for children and patients with dysphagia.<\/p>\n<h2>How Carbamazepine Works<\/h2>\n<p>Carbamazepine binds <strong>voltage-gated sodium channels<\/strong> in their inactivated state, preventing the channel from returning to its resting state and so blocking repetitive high-frequency neuronal firing while sparing normal physiological signalling. This mechanism explains its efficacy in:<\/p>\n<ul>\n<li><strong>Focal (partial) seizures<\/strong> \u2014 sustained suppression of epileptogenic firing<\/li>\n<li><strong>Neuralgie trojklann\u00e9ho nervu<\/strong> \u2014 blocks paroxysmal nerve discharges in the trigeminal ganglion<\/li>\n<li><strong>Mood stabilisation<\/strong> \u2014 reduces neuronal excitability and limbic hyperactivity<\/li>\n<\/ul>\n<h2>Indikace<\/h2>\n<ul>\n<li><strong>Neuralgie trojklann\u00e9ho nervu<\/strong> \u2014 first-line per NICE, EFNS, and AAN guidelines<\/li>\n<li><strong>Partial-onset seizures<\/strong> with or without secondary generalisation<\/li>\n<li><strong>Generalised tonic-clonic seizures<\/strong> \u2014 second-line<\/li>\n<li><strong>Bipolar disorder<\/strong> \u2014 mood stabiliser, particularly mixed and rapid-cycling presentations<\/li>\n<li><strong>Glossopharyngeal neuralgia<\/strong> \u2014 analogous use to trigeminal neuralgia<\/li>\n<li><strong>Diabetic neuropathy<\/strong> \u2014 second-line option when gabapentinoids fail or are contraindicated<\/li>\n<li><strong>Alcohol withdrawal<\/strong> \u2014 selected cases under specialist supervision<\/li>\n<\/ul>\n<h2>D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n<table>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Indikace<\/th>\n<th>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\n<th>Titrace<\/th>\n<th>Udr\u017eovac\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Neuralgie trojklann\u00e9ho nervu<\/td>\n<td>100 mg once or twice daily<\/td>\n<td>+100\u2013200 mg every 2 days<\/td>\n<td>200\u2013400 mg three times daily<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Partial seizures (adult)<\/td>\n<td>100\u2013200 mg once or twice daily<\/td>\n<td>+100\u2013200 mg weekly<\/td>\n<td>800\u20131200 mg\/day in 2\u20134 doses<\/td>\n<\/tr>\n<tr>\n<td>Bipolar disorder<\/td>\n<td>200 mg dvakr\u00e1t denn\u011b<\/td>\n<td>+200 mg every 3\u20134 days<\/td>\n<td>400\u20131600 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Children (epilepsy)<\/td>\n<td>10\u201320 mg\/kg\/day<\/td>\n<td>Odborn\u00e9 doporu\u010den\u00ed<\/td>\n<td>15\u201330 mg\/kg\/day in divided doses<\/td>\n<\/tr>\n<tr>\n<td>Star\u0161\u00ed pacienti<\/td>\n<td>100 mg dvakr\u00e1t denn\u011b<\/td>\n<td>Cautious titration<\/td>\n<td>Lower of typical adult range<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>HLA-B*1502 testing before starting<\/strong> Patients of Han Chinese, Thai, Malay, Vietnamese, Filipino, Indonesian, and South Indian ancestry have a much higher carrier rate of HLA-B*1502 \u2014 an allele strongly associated with Stevens-Johnson syndrome and toxic epidermal necrolysis on carbamazepine. Test before initiation in these populations and choose an alternative if positive. HLA-A*3101 is a similar but lower-risk marker in European and Japanese ancestry.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Terapeutick\u00e9 monitorov\u00e1n\u00ed hladin l\u00e9\u010div<\/strong> Aim for a steady-state plasma level of 4\u201312 mg\/L (17\u201351 \u00b5mol\/L). Carbamazepine is a potent autoinducer \u2014 your daily requirement may rise over the first 2\u20134 weeks of treatment as hepatic CYP3A4 induction matures. Levels should be checked 5\u20137 days after each dose change.<\/div>\n<h2>B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Drowsiness, ataxia (especially during titration)<\/li>\n<li>Dizziness, blurred or double vision<\/li>\n<li>Nevolnost, zvracen\u00ed<\/li>\n<li>Bolest hlavy<\/li>\n<li>Mild rash (\u22485\u201310% of patients)<\/li>\n<li>Dry mouth, mild fluid retention<\/li>\n<li>Hyponatraemia (mild, especially in elderly)<\/li>\n<\/ul>\n<h2>Serious Side Effects \u2014 Stop and Seek Care<\/h2>\n<ul>\n<li><strong>Severe rash, blistering, mouth ulcers<\/strong> \u2014 possible Stevens-Johnson syndrome \/ TEN<\/li>\n<li><strong>Aplastic anaemia, agranulocytosis<\/strong> \u2014 full blood count monitoring during the first months<\/li>\n<li><strong>Hyponatraemia &lt;125 mmol\/L<\/strong> \u2014 confusion, seizures<\/li>\n<li><strong>Hepatitida<\/strong> \u2014 jaundice, dark urine, abdominal pain<\/li>\n<li><strong>DRESS syndrome<\/strong> \u2014 fever, lymphadenopathy, eosinophilia, multi-organ involvement<\/li>\n<li>Heart block (rare)<\/li>\n<li>Suicidal ideation (anti-epileptic class warning)<\/li>\n<\/ul>\n<h2>Kontraindikace<\/h2>\n<ul>\n<li>Known hypersensitivity to carbamazepine, oxcarbazepine, or tricyclic antidepressants<\/li>\n<li>Atrioventricular block (especially second- or third-degree)<\/li>\n<li>History of bone-marrow depression or acute intermittent porphyria<\/li>\n<li>Use of MAO inhibitors within the previous 14 days<\/li>\n<li>HLA-B*1502 positive (relative \u2014 alternative agent preferred)<\/li>\n<\/ul>\n<h2>Interakce s l\u00e9\u010divy<\/h2>\n<p>Carbamazepine is a powerful inducer of CYP3A4 and many other CYP enzymes. It accelerates the metabolism (and so reduces the plasma level and clinical effect) of:<\/p>\n<ul>\n<li>Combined oral contraceptives \u2014 alternative contraception is essential<\/li>\n<li>Warfarin and direct oral anticoagulants<\/li>\n<li>Many other anti-epileptics (lamotrigine, valproate, phenytoin)<\/li>\n<li>Antiretrovirals, immunosuppressants, calcium-channel blockers<\/li>\n<li>Statins (especially simvastatin), corticosteroids<\/li>\n<\/ul>\n<p>And its own level is raised dangerously by:<\/p>\n<ul>\n<li>Makrolidov\u00e1 antibiotika (erytromycin, klarithromycin)<\/li>\n<li>Diltiazem, verapamil, isoniazid, fluconazole, ketoconazole<\/li>\n<li>Grapefruitov\u00e1 \u0161\u0165\u00e1va<\/li>\n<\/ul>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<p>Store below 25 \u00b0C in a dry place. Protect from moisture (carbamazepine tablets can degrade in damp conditions). Keep in original blister packaging. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Is Tegrital the same as Tegretol?<\/h3>\n<p>Yes \u2014 both are brand names for carbamazepine. Tegrital is the Indian generic version; Tegretol is the original Novartis brand. Mechanism, dosing, and effect are identical at the same dose.<\/p>\n<h3>How fast does carbamazepine work for trigeminal neuralgia?<\/h3>\n<p>Most patients experience meaningful pain relief within 24\u201372 hours of reaching an effective dose. The challenge is reaching that dose \u2014 slow titration is required to limit dizziness and ataxia. About 70% of trigeminal neuralgia patients respond at carbamazepine doses of 200\u2013800 mg\/day.<\/p>\n<h3>Why does the dose need to go up over time?<\/h3>\n<p>Carbamazepine induces its own hepatic metabolism \u2014 autoinduction. Over the first 2\u20134 weeks the liver produces more CYP3A4 enzyme, accelerating drug clearance. Daily requirements typically rise 30\u201360% before plateauing.<\/p>\n<h3>What is HLA-B*1502 testing and do I need it?<\/h3>\n<p>HLA-B*1502 is a genetic marker strongly associated with Stevens-Johnson syndrome on carbamazepine. The FDA recommends pre-treatment testing for patients of Han Chinese, Thai, Malay, South Indian, Filipino, Indonesian, and Vietnamese ancestry. If positive, an alternative anticonvulsant should be used.<\/p>\n<h3>Can carbamazepine be used in pregnancy?<\/h3>\n<p>Carbamazepine is associated with neural tube defects (1% risk vs. 0.06% baseline) and other malformations. It is generally avoided in pregnancy when alternatives exist. If continued, high-dose folic acid (5 mg daily) is recommended before conception and through the first trimester.<\/p>\n<h3>Does Tegrital interact with the contraceptive pill?<\/h3>\n<p>Yes \u2014 strongly. Carbamazepine reduces oestrogen and progestogen levels via CYP3A4 induction, leading to contraceptive failure. Use a copper IUD, levonorgestrel IUD, or progestogen-only injection during treatment.<\/p>\n<h3>How long until I can come off carbamazepine?<\/h3>\n<p>For trigeminal neuralgia, many patients trial dose reduction every 6\u201312 months once pain is controlled. For epilepsy, withdrawal is considered only after 2\u20133 years seizure-free. Always taper \u2014 abrupt stop can precipitate seizures even in patients without epilepsy.<\/p>\n<h3>Jak\u00e9 krevn\u00ed testy jsou pot\u0159eba?<\/h3>\n<p>Baseline full blood count, liver function, urea and electrolytes, and pregnancy test where relevant. Repeat FBC and LFTs at 4 weeks, 3 months, then every 6\u201312 months. Carbamazepine plasma level 5\u20137 days after each dose change.<\/p>\n<h3>Can I drink alcohol on Tegrital?<\/h3>\n<p>Avoid or strictly limit alcohol. Both carbamazepine and alcohol depress the central nervous system; combining them increases sedation, falls risk, and raises seizure threshold variability.<\/p>\n<h3>Why is Tegrital chewable?<\/h3>\n<p>The chewable format makes the tablet easy to take for children, elderly patients, and anyone with swallowing difficulty. The bioavailability is comparable to standard tablets.<\/p>\n<h3>Is Tegrital effective for fibromyalgia?<\/h3>\n<p>Carbamazepine is not first-line for fibromyalgia \u2014 pregabalin, duloxetine, and amitriptyline are. Carbamazepine has a defined role in trigeminal neuralgia and partial seizures; for general nerve pain it is a later-line option.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka m\u00e1 pouze informativn\u00ed charakter a nenahrazuje odborn\u00e9 l\u00e9ka\u0159sk\u00e9 poradenstv\u00ed. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli l\u00e9ku se v\u017edy pora\u010fte s kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem, zejm\u00e9na pokud m\u00e1te jin\u00e9 zdravotn\u00ed pot\u00ed\u017ee, u\u017e\u00edv\u00e1te jin\u00e9 l\u00e9ky, jste t\u011bhotn\u00e1 nebo koj\u00edte, nebo je v\u00e1m v\u00edce ne\u017e 65 let.<\/div>\n<p class=\"medsbase-link-boost-2026-04-30\" data-marker=\"mb-link-boost-gabasign\">For trigeminal neuralgia patients who do not respond to or tolerate carbamazepine, <a href='\/cs\/gabasign\/'>Gabasign (gabapentin 100\/300\/400\/600\/800 mg)<\/a> is the standard second-line option per AAN\/EFNS guidelines and covers the broader range of neuropathic-pain indications.<\/p>\n<p data-mb-link-target=\"gabasign\" data-mb-anchor-variant=\"v2\" style=\"margin-top:1em;font-size:0.95em;color:#444;border-left:3px solid #2c7cb0;padding:0.5em 0.75em;background:#f4f8fb;\"><strong>Viz tak\u00e9:<\/strong> <a href=\"https:\/\/medsbase.com\/cs\/gabasign\/\"><strong>the gabapentin brand we stock<\/strong><\/a> \u2014 generikum gabapentinu od spole\u010dnosti Cipla \u2014 stejn\u00e1 molekula schv\u00e1len\u00e1 FDA, pln\u00e9 d\u00e1vkov\u00e1n\u00ed od po\u010d\u00e1te\u010dn\u00ed d\u00e1vky 300 mg po udr\u017eovac\u00ed d\u00e1vku 600 mg.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/calpol\/\">Calpol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/abana\/\">Abana<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/symbicort-turbohaler\/\">Symbicort Turbohaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/monit\/\">Monit<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/caberlin\/\">Caberlin<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Controls seizures<br \/>\n\u2705 L\u00e9\u010d\u00ed bipol\u00e1rn\u00ed poruchu<br \/>\n\u2705 Relieves nerve pain<br \/>\n\u2705 Manages trigeminal neuralgia<br \/>\n\u2705 Stabilizes mood<\/p>\n<p>Tegrital contains Carbamazepine.<\/p>","protected":false},"featured_media":55974,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3985],"product_tag":[4022,4023],"class_list":{"0":"post-55973","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neuropathic-pain-medication","9":"product_tag-carbamazepine","10":"product_tag-tegrital","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/55973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=55973"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/55974"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=55973"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=55973"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=55973"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=55973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}