{"id":56116,"date":"2024-02-07T05:53:44","date_gmt":"2024-02-07T05:53:44","guid":{"rendered":"https:\/\/medsname.com\/orzine\/"},"modified":"2026-04-30T10:24:40","modified_gmt":"2026-04-30T10:24:40","slug":"orzine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/orzine\/","title":{"rendered":"Orzine"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Orzine (Chlorpromazine 10 \/ 100 mg) je antipsychotikum prvn\u00ed generace ze skupiny fenothiazin\u016f. Pou\u017e\u00edv\u00e1 se p\u0159i l\u00e9\u010db\u011b schizofrenie, t\u011b\u017ek\u00e9 agitovanosti, nezvladateln\u00e9 \u0161kytavky, siln\u00e9 nevolnosti\/zvracen\u00ed a k p\u0159edanestetick\u00e9 sedaci. Typick\u00e1 antipsychotika (FGA) jsou nyn\u00ed obecn\u011b druhou volbou po atypick\u00fdch antipsychotik\u00e1ch.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Orzine na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Orzine a jak funguje<\/h2>\n

Orzine je tableta Chlorpromazinu dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: 10 \/ 100 mg<\/strong>.<\/p>\n

Chlorpromazin byl prvn\u00edm antipsychotikem (1952) a st\u00e1le je u\u017eite\u010dn\u00fd p\u0159i t\u011b\u017ek\u00e9 agitovanosti, nezvladateln\u00e9 \u0161kytavce a akutn\u00ed psych\u00f3ze. P\u016fvodn\u00ed fenothiazin \u2013 siln\u00e1 sedace, siln\u00fd anticholinergn\u00ed \u00fa\u010dinek, siln\u00e1 blok\u00e1da \u03b11 a v\u00fdznamn\u00e9 riziko EPS\/pozdn\u00ed dyskineze.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Schizofrenie (dosp\u011bl\u00ed)<\/td>\n25\u201350 mg TID<\/td>\n200\u2013800 mg\/den<\/td>\n1000 mg<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e1 agitovanost (IM)<\/td>\n25\u201350 mg IM<\/td>\n\u2014<\/td>\n3 d\u00e1vky\/24h<\/td>\n<\/tr>\n
Nezvladateln\u00e1 \u0161kytavka<\/td>\n25\u201350 mg TID\u2013QID peror\u00e1ln\u011b<\/td>\n\u2014<\/td>\n50 mg QID<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e1 nevolnost\/zvracen\u00ed<\/td>\n10\u201325 mg ka\u017ed\u00e9 4\u20136 hodiny peror\u00e1ln\u011b<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n
Star\u0161\u00ed pacienti\/demence (mimo indikaci, jako posledn\u00ed volba)<\/td>\n10 mg p\u0159ed span\u00edm<\/td>\n10\u201325 mg\/den<\/td>\ndle sn\u00e1\u0161enlivosti<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA varov\u00e1n\u00ed pro demenci (\u010dern\u00e1 sk\u0159\u00ed\u0148ka)<\/strong><\/p>\n

Stejn\u011b jako atypick\u00e1 antipsychotika, v\u0161echna antipsychotika nesou varov\u00e1n\u00ed ohledn\u011b mortality spojen\u00e9 s psych\u00f3zou u demence.<\/p>\n<\/div>\n

\nProdlou\u017een\u00ed QT intervalu, EPS, tardivn\u00ed dyskineze<\/strong><\/p>\n

Chlorpromazin prodlu\u017euje QT interval (m\u00e9n\u011b ne\u017e thioridazin). EPS a tardivn\u00ed dyskineze jsou \u010dast\u011bj\u0161\u00ed ne\u017e u atypick\u00fdch antipsychotik. Kumulativn\u00ed riziko TD je p\u0159ibli\u017en\u011b 5 %\/rok expozice.<\/p>\n<\/div>\n

\nAnticholinergn\u00ed z\u00e1t\u011b\u017e, sedace, ortostatick\u00e1 hypotenze<\/strong><\/p>\n

V\u0161echny fenothiaziny maj\u00ed v\u00fdznamnou anticholinergn\u00ed, antihistaminovou a \u03b11-blokuj\u00edc\u00ed aktivitu. Zvl\u00e1\u0161t\u011b problematick\u00e9 u star\u0161\u00edch pacient\u016f \u2013 \u010dast\u00e9 jsou p\u00e1dy, delirium, retence mo\u010di a z\u00e1cpa. Vyvarovat se u demence, BPH, uzav\u0159en\u00e9ho \u00fahlu glaukomu, t\u011b\u017ek\u00e9ho jatern\u00edho onemocn\u011bn\u00ed.<\/p>\n<\/div>\n

\nFotosenzitivita a pigmentace k\u016f\u017ee<\/strong><\/p>\n

Fenothiaziny zp\u016fsobuj\u00ed fotosenzitivitu (t\u011b\u017ek\u00e9 sp\u00e1len\u00ed sluncem) a p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed modro\u0161edou pigmentaci k\u016f\u017ee, vz\u00e1cn\u011b i pigmentaci \u010do\u010dky\/rohovky (zejm\u00e9na chlorpromazin). Nutn\u00e1 ochrana p\u0159ed sluncem.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n