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Ezedoc<\/strong> obsahuje cholestyramine (colestyramine)<\/strong> (4 g cholestyramine (approximate \u2014 verify label) per sachet), a non-absorbed bile acid sequestrant resin<\/strong>. It works entirely in the gut lumen — binding bile acids so they are excreted in stool rather than reabsorbed. This forces the liver to pull cholesterol from the bloodstream to make new bile acids, lowering LDL by ~15–30%. Pou\u017eit\u00ed:<\/strong> (1) hypercholesterolaemia in statin-intolerant patients or as statin add-on; (2) itch (pruritus) due to cholestasis<\/strong> — the main modern indication, often more useful than the lipid effect; (3) bile acid diarrhoea (BAD)<\/strong> — chronic diarrhoea after gallbladder surgery, ileal resection, or idiopathic; (4) some C. difficile<\/em>-related and ileal-resection diarrhoea. Dose: 1 sachet (4 g) 1–4 times daily, mixed with water or juice. Binds many oral drugs<\/strong> — take other medicines 1 hour before or 4 hours after.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Choltran Sachet is a bile acid sequestrant<\/strong> supplied as 4 g cholestyramine (approximate \u2014 verify label)-sachets containing cholestyramine resin, to be mixed with water or juice before swallowing. Manufactured by WHO-GMP certified manufacturer. Supplied as 30, 60, 90 or 180 sachets. Cholestyramine is a non-absorbed, high-molecular-weight anion-exchange resin — it stays entirely in the gut lumen and has no systemic absorption.<\/p>\n Originator brands: Questran<\/strong> (Bristol-Myers Squibb, 1970s) and Olestyr<\/strong>. Cholestyramine is on the WHO Essential Medicines List.<\/p>\n In lipid management, cholestyramine has been displaced by statins and ezetimibe for most patients, but it remains important for cholestatic itch and bile acid diarrhoea, where no other drug matches it.<\/p>\n Cholestyramine is a large positively-charged polymer (strong anion-exchange resin). In the intestinal lumen it binds anionic bile acids<\/strong> via electrostatic interaction, forming an insoluble complex that is excreted in the stool.<\/p>\n The downstream effects:<\/p>\n Hypercholesterolaemia:<\/strong> 1 sachet (4 g) 1–2 times daily initially; titrate up to 1 sachet 3–4 times daily (maximum 24 g\/day) over 2–4 weeks.<\/p>\n Cholestatic pruritus:<\/strong> 1 sachet 2–4 times daily; the first dose often given at breakfast when bile acid delivery to the gut is highest. Effect on itch usually within 2–4 days.<\/p>\n Bile acid diarrhoea:<\/strong> 1 sachet 1–3 times daily, titrated to effect. Many patients respond to a single sachet once daily.<\/p>\n Mixing:<\/strong> empty the sachet contents into a glass, add at least 120 mL of water, juice, or another non-carbonated liquid; stir until uniform; drink and rinse with more liquid. Never swallow the dry powder<\/strong> — it can cause oesophageal irritation or obstruction.<\/p>\n CRITICAL — drug interaction timing:<\/strong> cholestyramine binds many oral drugs (thyroid hormone, warfarin, digoxin, thiazides, statins, ezetimibe, fat-soluble vitamins, NSAIDs, many more). Take all other oral medicines at least 1 hour BEFORE or 4 hours AFTER cholestyramine<\/strong>, otherwise absorption may be impaired.<\/p>\n Vitamin considerations:<\/strong> long-term use can reduce absorption of fat-soluble vitamins (A, D, E, K). Supplementation may be needed, particularly for vitamin K (monitor INR in warfarin patients) and D.<\/p>\n Cholestyramine does not enter the bloodstream, so systemic side effects are minimal. The main issues are gastrointestinal tolerability.<\/p>\n \u010cast\u00e9:<\/strong><\/p>\n M\u00e9n\u011b \u010dast\u00e9:<\/strong><\/p>\n Cholestyramine has many clinically important drug interactions by binding<\/strong>. Always dose other oral drugs 1 hour before or 4 hours after<\/strong> cholestyramine. Particularly important:<\/p>\n The short answer: if you are on multiple oral medicines, time cholestyramine carefully and tell your pharmacist.<\/p>\n Store Choltran Sachet below 25°C in a dry place. Keep sachets sealed until use. Do not use after the expiry date. Keep out of reach of children.<\/p>\n Yes — both are cholestyramine sachets. Choltran Sachet is a bioequivalent formulation to the originator Questran (BMS).<\/p>\n Not usually. Statins lower LDL by 30–60% and have far stronger cardiovascular outcome evidence. Cholestyramine lowers LDL by 15–30%, is less well tolerated (constipation, GI upset), and has many drug interactions. It is a reasonable option for patients who are truly statin-intolerant or when statin alternatives have failed, but it is not first-line.<\/p>\n In cholestatic liver disease (PBC, PSC, pregnancy cholestasis), bile acids accumulate and deposit in the skin, triggering intense itch. Cholestyramine removes these bile acids via stool excretion. Effect on itching is usually seen within 2–4 days. It is the first-line drug treatment<\/strong> for cholestatic pruritus in most guidelines.<\/p>\n Very likely. Post-cholecystectomy diarrhoea is often due to bile acid malabsorption (bile acids spill into the colon where they act as laxatives). Cholestyramine binds these bile acids and commonly produces rapid, near-complete relief — often at a single sachet per day. Discuss with your GP or gastroenterologist.<\/p>\n Yes — cholestyramine binds levothyroxine and many other oral drugs. Always take your other medicines at least 1 hour BEFORE or 4 hours AFTER<\/strong> your cholestyramine dose. If you are on warfarin, thyroid hormone, or digoxin, tell your prescriber\/pharmacist before starting.<\/p>\n Empty the sachet into a glass with at least 120 mL of water, juice, or another non-carbonated liquid. Stir until uniform (it does not fully dissolve — more like a suspension). Drink immediately; rinse the glass and drink that too, to get the full dose. Never swallow the dry powder<\/strong> — it can stick in the throat or oesophagus.<\/p>\n You can order Choltran Sachet (4 g cholestyramine (approximate \u2014 verify label) sachets) from MedsBase as 30, 60, 90 or 180 sachets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n Choltran Sachet is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. V\u00e1\u0161 popis transakce p\u0159i platb\u011b kartou zobrazuje regulovan\u00e9ho zpracovatele plateb (regulovan\u00e9ho zpracovatele plateb kartou), nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku.<\/p>\n <\/p>\n Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n \u2705 Lowers cholesterol levels Choltran Sachet contains Cholestyramine.<\/p>","protected":false},"featured_media":56134,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3953],"product_tag":[4060,4061],"class_list":{"0":"post-56133","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-high-cholesterol-treatments","9":"product_tag-cholestyramine","10":"product_tag-choltran","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56133"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56134"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56133"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56133"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56133"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
What Is Choltran Sachet?<\/h2>\n
What Is Choltran Sachet Used For?<\/h2>\n
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How Does Choltran Sachet Work?<\/h2>\n
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D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n
Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce s l\u00e9\u010divy<\/h2>\n
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Who Should Not Take Choltran Sachet?<\/h2>\n
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Skladov\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Is Choltran Sachet the same as Questran?<\/h3>\n
Can I use Choltran Sachet to lower cholesterol instead of a statin?<\/h3>\n
How does Choltran Sachet help with itching?<\/h3>\n
I have chronic diarrhoea after my gallbladder surgery — can Choltran Sachet help?<\/h3>\n
Will Choltran Sachet affect my thyroid tablets or other medicines?<\/h3>\n
How should I mix Choltran Sachet?<\/h3>\n
Where can I buy Choltran Sachet online?<\/h3>\n
Souvisej\u00edc\u00ed l\u00e9ky na cholesterol<\/h2>\n
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Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Souvisej\u00edc\u00ed alternativy<\/h3>\n
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\n\u2705 Sni\u017euje riziko srde\u010dn\u00edch onemocn\u011bn\u00ed
\n\u2705 Binds with bile acids
\n\u2705 Improves digestion
\n\u2705 Manages cholesterol levels<\/p>\n