{"id":56240,"date":"2024-02-07T05:58:02","date_gmt":"2024-02-07T05:58:02","guid":{"rendered":"https:\/\/medsname.com\/ecopril\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"ecopril","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ecopril\/","title":{"rendered":"Ecopril"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Ecopril?<\/h3>\n<p style=\"margin:0;\"><strong>Ecopril<\/strong> is 75 mg clopidogrel tablets from a WHO-GMP certified manufacturer &mdash; antiplatelet (irreversible P2Y12 ADP receptor antagonist). Clopidogrel was introduced by Sanofi\/BMS in 1997 as <strong>Plavix<\/strong>. CAPRIE (1996) established superiority over aspirin for secondary prevention (8.7% relative risk reduction vs aspirin). CURE and COMMIT established dual antiplatelet therapy (DAPT) in ACS. prodrug activated by CYP2C19 to an active metabolite that irreversibly blocks the P2Y12 ADP receptor on platelets. CYP2C19 poor metabolisers (up to 30% of East Asian populations, ~5% of European) have reduced clopidogrel effect &mdash; the FDA carries a boxed warning on this. Dosing: Maintenance 75 mg once daily. ACS loading 300-600 mg single dose. Bleeding risk similar to aspirin monotherapy; DAPT doubles bleeding risk. Anticoagulant and antiplatelet selection is individualised to diagnosis, bleeding risk, renal function, and drug interactions. Specialist or family-physician supervision is standard.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What Is Ecopril?<\/h2>\n<p>Ecopril is 75 mg clopidogrel tablets from a WHO-GMP certified manufacturer, supplied in 30-180 tablets. Clopidogrel was introduced by Sanofi\/BMS in 1997 as <strong>Plavix<\/strong>. CAPRIE (1996) established superiority over aspirin for secondary prevention (8.7% relative risk reduction vs aspirin). CURE and COMMIT established dual antiplatelet therapy (DAPT) in ACS.<\/p>\n<h2 class=\"wp-block-heading\">Jak klopidogrel funguje<\/h2>\n<p>Clopidogrel prodrug activated by CYP2C19 to an active metabolite that irreversibly blocks the P2Y12 ADP receptor on platelets. CYP2C19 poor metabolisers (up to 30% of East Asian populations, ~5% of European) have reduced clopidogrel effect &mdash; the FDA carries a boxed warning on this.<\/p>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 indikace<\/h2>\n<ul>\n<li><strong>Akutn\u00ed koron\u00e1rn\u00ed syndrom<\/strong> &mdash; dual antiplatelet therapy with aspirin (CURE, COMMIT trials) &mdash; 12 months standard after ACS or PCI<\/li>\n<li><strong>Sekund\u00e1rn\u00ed prevence<\/strong> post-stroke, post-MI, PAD &mdash; aspirin alternative (CAPRIE) or add-on<\/li>\n<li><strong>Elective PCI<\/strong> &mdash; DAPT 6-12 months depending on stent type and bleeding risk<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed<\/h2>\n<p>Maintenance 75 mg once daily. ACS loading 300-600 mg single dose.<\/p>\n<h2 class=\"wp-block-heading\">Riziko krv\u00e1cen\u00ed a monitorov\u00e1n\u00ed<\/h2>\n<p>Bleeding risk similar to aspirin monotherapy; DAPT doubles bleeding risk.<\/p>\n<p><strong>Rutinn\u00ed monitorov\u00e1n\u00ed krve nen\u00ed vy\u017eadov\u00e1no.<\/strong> CYP2C19 genotyping is not standard but may be used after a major breakthrough event (stent thrombosis on treatment) to confirm poor-metaboliser status before switching to prasugrel or ticagrelor.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Bleeding (similar to aspirin in monotherapy)<\/li>\n<li>GI upset, diarrhoea<\/li>\n<li>Vyr\u00e1\u017eka<\/li>\n<li>Thrombotic thrombocytopenic purpura (very rare)<\/li>\n<li>Reduced effect in CYP2C19 poor metabolisers<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Aktivn\u00ed patologick\u00e9 krv\u00e1cen\u00ed<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost<\/li>\n<li>Concurrent use of proton pump inhibitors &mdash; omeprazole and esomeprazole specifically reduce clopidogrel activation; use pantoprazole or rabeprazole instead<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Omeprazole, esomeprazole &mdash; CRITICAL.<\/strong> Reduce CYP2C19 activation of clopidogrel and blunt antiplatelet effect. Switch to pantoprazole or rabeprazole.<\/li>\n<li><strong>Other CYP2C19 inhibitors<\/strong> (fluconazole, fluvoxamine) &mdash; reduce clopidogrel effect.<\/li>\n<li><strong>NSAIDs, SSRIs, anticoagulants<\/strong> &mdash; additive bleeding risk.<\/li>\n<li><strong>Repaglinide<\/strong> &mdash; clopidogrel raises repaglinide levels (CYP2C8).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Store Ecopril below 25&deg;C. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Do I need blood tests on Ecopril?<\/h3>\n<p>Rutinn\u00ed krevn\u00ed testy pro hodnocen\u00ed \u00fa\u010dinnosti nejsou nutn\u00e9. Obecn\u00fd zdravotn\u00ed screening podle klinick\u00e9 indikace.<\/p>\n<h3 class=\"wp-block-heading\">What should I do if I cut myself while on Ecopril?<\/h3>\n<p>P\u0159ilo\u017ete pevn\u00fd p\u0159\u00edm\u00fd tlak po dobu 15-20 minut bez kontroly. V\u011bt\u0161ina drobn\u00fdch \u0159ez\u016f se norm\u00e1ln\u011b zastav\u00ed; krv\u00e1cen\u00ed trvaj\u00edc\u00ed d\u00e9le ne\u017e 20 minut nebo prosakuj\u00edc\u00ed p\u0159es v\u00edce obvaz\u016f vy\u017eaduje neodkladn\u00e9 l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed. Nahlaste jakoukoli \u010dernou nebo krvavou stolici, jasn\u011b \u010derven\u00e9 rekt\u00e1ln\u00ed krv\u00e1cen\u00ed, hematurii, nevysv\u011btliteln\u00e9 mod\u0159iny, krv\u00e1cen\u00ed z nosu trvaj\u00edc\u00ed d\u00e9le ne\u017e 15 minut nebo menstrua\u010dn\u00ed krv\u00e1cen\u00ed v\u00fdrazn\u011b siln\u011bj\u0161\u00ed ne\u017e obvykle.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Ecopril in pregnancy?<\/h3>\n<p>Discuss with your clinician; clopidogrel data in pregnancy are limited; discuss risks.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e pot\u0159ebuji operaci?<\/h3>\n<p>Informujte opera\u010dn\u00ed t\u00fdm s dostate\u010dn\u00fdm p\u0159edstihem. Rozhodnut\u00ed o pokra\u010dov\u00e1n\u00ed\/p\u0159eru\u0161en\u00ed antiagrega\u010dn\u00ed l\u00e9\u010dby z\u00e1vis\u00ed na typu v\u00fdkonu a riziku tromb\u00f3zy; po ned\u00e1vn\u00fdch stentech nep\u0159est\u00e1vejte bez odborn\u00e9ho posouzen\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Ecopril online?<\/h3>\n<p>You can buy Ecopril (clopidogrel 75 mg, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed kardiovaskul\u00e1rn\u00ed l\u00e9ky<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ambrican\/\">Ambrican \u2014 Ambrisentan 5 mg (ERA pro PAH)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/coq-forte\/\">Coq Forte \u2014 CoQ10 + lykopen + selen + omega-3<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ecosprin\/\">Ecosprin \u2014 Aspirin 75\/150 mg (antiagrega\u010dn\u00ed)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ivabrad\/\">Ivabrad \u2014 Ivabradine 7,5 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lonitab\/\">Lonitab \u2014 Minoxidil 5 mg (or\u00e1ln\u00ed vazodilat\u00e1tor)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rioci-1\/\">Rioci 1 \u2014 Riociguat 1 mg (stimul\u00e1tor sGC pro PAH)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/high-blood-pressure-medication\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na vysok\u00fd krevn\u00ed tlak<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed a arytmie vy\u017eaduj\u00ed diagn\u00f3zu, monitorov\u00e1n\u00ed a individu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed l\u00e9ka\u0159em \u2014 v\u017edy u\u017e\u00edvejte betablok\u00e1tory pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/metomac\/\">Metomac<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/olmesar\/\">Olmesar<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amlode\/\">Amlode<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/glynase\/\">Glynase<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/isentress\/\">Isentress<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Ecopril is clopidogrel 75 mg tablets \u2014 irreversible P2Y12 ADP receptor antagonist. Originally Plavix (Sanofi\/BMS 1997). Superior to aspirin for secondary prevention (CAPRIE 1996); standard DAPT partner after ACS and PCI (CURE 2001). Prodrug activated by CYP2C19 \u2014 poor metabolisers (up to 30% of East Asians, 5% Europeans) have reduced effect. Avoid omeprazole\/esomeprazole co-therapy (blunt activation); use pantoprazole or rabeprazole instead.<\/p>","protected":false},"featured_media":56241,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3342,3260,3356],"product_tag":[4081,4082],"class_list":{"0":"post-56240","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-general-health","9":"product_cat-heart-blood-pressure","10":"product_cat-high-blood-pressure-medication","11":"product_tag-clopidogrel","12":"product_tag-ecopril","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56240"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56241"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56240"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56240"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56240"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}