{"id":56303,"date":"2024-02-07T06:00:17","date_gmt":"2024-02-07T06:00:17","guid":{"rendered":"https:\/\/medsname.com\/endoxan\/"},"modified":"2026-04-30T10:24:38","modified_gmt":"2026-04-30T10:24:38","slug":"endoxan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/endoxan\/","title":{"rendered":"Endoxan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Endoxan?<\/h3>\n<p style=\"margin:0;\"><strong>Endoxan<\/strong> je peror\u00e1ln\u00ed tableta od spole\u010dnosti Baxter obsahuj\u00edc\u00ed <strong>cyklofosfamid 50 mg<\/strong> \u2014 alkyla\u010dn\u00ed cytotoxick\u00e9 \u010dinidlo (deriv\u00e1t dus\u00edkat\u00e9ho yperitu) pou\u017e\u00edvan\u00e9 pro <strong>hematologick\u00e9 malignity, karcinom prsu (re\u017eimy CMF \/ AC), z\u00e1va\u017en\u00e1 autoimunitn\u00ed onemocn\u011bn\u00ed (lupusov\u00e1 nefritida, ANCA vaskulitida) a p\u0159\u00edprava kostn\u00ed d\u0159en\u011b<\/strong>. Standardn\u00ed n\u00edzkod\u00e1vkov\u00e9 peror\u00e1ln\u00ed re\u017eimy: 1\u20133 mg\/kg\/den nebo pulzn\u00ed t\u00fddenn\u00ed cykly, p\u0159edepsan\u00e9 specialistou. Povinn\u00e9 sledov\u00e1n\u00ed: <strong>, mo\u010d na hemoragickou cystitidu, diskuse o zachov\u00e1n\u00ed fertility p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby.<\/strong>, mo\u010d na hemoragickou cystitidu, diskuse o zachov\u00e1n\u00ed plodnosti p\u0159ed zah\u00e1jen\u00edm. <strong>(3 l\/den b\u011bhem aktivn\u00edho d\u00e1vkov\u00e1n\u00ed) k proplachov\u00e1n\u00ed mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e a prevenci hemoragick\u00e9 cystitidy zp\u016fsoben\u00e9 metabolitem akroleinem. Kontraindikace v t\u011bhotenstv\u00ed; gonadotoxick\u00fd s rizikem trval\u00e9 neplodnosti \u2014 nab\u00eddnout mo\u017enosti zachov\u00e1n\u00ed fertility u pacient\u016f v reproduk\u010dn\u00edm v\u011bku.<\/strong> (3 l\/den b\u011bhem aktivn\u00edho d\u00e1vkov\u00e1n\u00ed) k propl\u00e1chnut\u00ed mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e a prevenci hemoragick\u00e9 cystitidy z metabolitu akroleinu. Kontraindikace v t\u011bhotenstv\u00ed; gonadotoxick\u00fd s rizikem trval\u00e9 neplodnosti \u2014 nab\u00eddn\u011bte zachov\u00e1n\u00ed plodnosti u pacient\u016f v reproduk\u010dn\u00edm v\u011bku.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">Endoxan jsou peror\u00e1ln\u00ed tablety od spole\u010dnosti Baxter obsahuj\u00edc\u00ed<\/h2>\n<p>Endoxan je peror\u00e1ln\u00ed tableta od spole\u010dnosti Baxter obsahuj\u00edc\u00ed <strong>cyklofosfamid 50 mg<\/strong>. Cyklofosfamid je prol\u00e9\u010divo, alkyla\u010dn\u00ed cytotoxick\u00e1 l\u00e1tka (ze skupiny dus\u00edkat\u00fdch yperit\u016f). V j\u00e1trech se metabolizuje na aktivn\u00ed 4-hydroxycyklofosfamid a toxick\u00fd metabolit akrolein. Pou\u017e\u00edv\u00e1 se u mnoha hematologick\u00fdch n\u00e1dor\u016f, solidn\u00edch n\u00e1dor\u016f a t\u011b\u017ek\u00fdch autoimunitn\u00edch onemocn\u011bn\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Hematologick\u00e9:<\/strong> chronick\u00e1 lymfocyt\u00e1rn\u00ed leuk\u00e9mie, n\u00edzkostup\u0148ov\u00fd non-Hodgkin\u016fv lymfom, mnoho\u010detn\u00fd myelom, Waldenstr\u00f6mova makroglobulin\u00e9mie, kondicionov\u00e1n\u00ed p\u0159ed transplantac\u00ed kmenov\u00fdch bun\u011bk<\/li>\n<li><strong>Solidn\u00ed n\u00e1dory:<\/strong> karcinom prsu (CMF, AC re\u017eimy), malobun\u011b\u010dn\u00fd karcinom plic, karcinom vaje\u010dn\u00edk\u016f, neuroblastom, sarkom (vysokod\u00e1vkovan\u00fd IV)<\/li>\n<li><strong>Z\u00e1va\u017en\u00e9 autoimunitn\u00ed onemocn\u011bn\u00ed:<\/strong> lupusov\u00e1 nefritida, ANCA-asociovan\u00e1 vaskulitida (granulomat\u00f3za s polyangiitidou, mikroskopick\u00e1 polyangiitida), refraktern\u00ed revmatoidn\u00ed artritida<\/li>\n<li><strong>Mimo indikaci:<\/strong> nefrotick\u00fd syndrom (steroid-rezistentn\u00ed), pemphigus vulgaris<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<p>Peror\u00e1ln\u00ed re\u017eimy se li\u0161\u00ed podle indikace; pouze specializovan\u00e9 p\u0159edepisov\u00e1n\u00ed. P\u0159\u00edklady pro dosp\u011bl\u00e9:<\/p>\n<ul>\n<li><strong>N\u00edzkod\u00e1vkovan\u00e1 kontinu\u00e1ln\u00ed peror\u00e1ln\u00ed l\u00e9\u010dba:<\/strong> 1\u20133 mg\/kg\/den<\/li>\n<li><strong>Pulzn\u00ed peror\u00e1ln\u00ed cyklofosfamid<\/strong> pro vaskulitidu: 50\u2013200 mg\/den<\/li>\n<\/ul>\n<ol>\n<li>U\u017e\u00edvejte r\u00e1no s dostate\u010dn\u00fdm mno\u017estv\u00edm tekutin \u2013 c\u00edlem je alespo\u0148 3 litry p\u0159\u00edjmu tekutin denn\u011b b\u011bhem aktivn\u00edho d\u00e1vkov\u00e1n\u00ed, aby se vyplavil mo\u010dov\u00fd m\u011bch\u00fd\u0159 od akroleinu a sn\u00ed\u017eilo se riziko hemoragick\u00e9 cystitidy.<\/li>\n<li>\u010casto mo\u010dte. Zva\u017ete profylaxi mesnou p\u0159i vy\u0161\u0161\u00edch kumulativn\u00edch d\u00e1vk\u00e1ch pod odborn\u00fdm dohledem.<\/li>\n<li>U\u017e\u00edvejte s j\u00eddlem, pokud se objev\u00ed nevolnost. Antiemetikum (ondansetron) 1 hodinu p\u0159edem v p\u0159\u00edpad\u011b pot\u0159eby.<\/li>\n<li>Polykejte tablety cel\u00e9. NEROZDRC\u00c1VEJTE. Osoby manipuluj\u00edc\u00ed s tabletami si mus\u00ed um\u00fdt ruce.<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> Krevn\u00ed obraz (FBC) ka\u017ed\u00fdch 1\u20132 t\u00fddny; mo\u010dov\u00e1 anal\u00fdza m\u011bs\u00ed\u010dn\u011b (hematurie); jatern\u00ed testy m\u011bs\u00ed\u010dn\u011b; z\u00e1kladn\u00ed + pr\u016fb\u011b\u017en\u00e9 hodnocen\u00ed ren\u00e1ln\u00ed funkce.<\/li>\n<li><strong>Zachov\u00e1n\u00ed fertility:<\/strong> diskutujte p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby u pacient\u016f v reproduk\u010dn\u00edm v\u011bku. Cyklofosfamid je gonadotoxick\u00fd \u2014 m\u011bla by b\u00fdt nab\u00eddnuta mo\u017enost spermabanky, kryokonzervace oocyt\u016f\/embry\u00ed nebo ochrana vaje\u010dn\u00edk\u016f pomoc\u00ed agonist\u016f GnRH.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> nevolnost, zvracen\u00ed (lze p\u0159edch\u00e1zet antiemetiky), alopecie, anorexie, mukozitida, \u00fanava.<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Myelosuprese<\/strong> \u2014 nejni\u017e\u0161\u00ed hodnoty v 7.\u201310. dni; pln\u00e9 zotaven\u00ed do 21. dne<\/li>\n<li><strong>Hemorrhagick\u00e1 cystitida<\/strong> \u2014 d\u016fsledek toxicity akroleinu na mo\u010dov\u00fd m\u011bch\u00fd\u0159; prevence vysok\u00fdm p\u0159\u00edjmem tekutin (3 l\/den) a \u010dast\u00fdm vyprazd\u0148ov\u00e1n\u00edm mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e; mesna u vysokod\u00e1vkov\u00fdch re\u017eim\u016f<\/li>\n<li><strong>Trval\u00e1 neplodnost<\/strong> \u2014 gonadotoxick\u00fd; p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby by m\u011bla b\u00fdt pacient\u016fm v reproduk\u010dn\u00edm v\u011bku nab\u00eddnuta spermabanka a kryokonzervace oocyt\u016f<\/li>\n<li>Rakovina mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e (dlouhodob\u00fd, d\u00e1vkov\u011b z\u00e1visl\u00fd \u00fa\u010dinek)<\/li>\n<li>Sekund\u00e1rn\u00ed leuk\u00e9mie\/myelodysplastick\u00fd syndrom<\/li>\n<li>Kardiotoxicita (p\u0159edev\u0161\u00edm u vysokod\u00e1vkov\u00fdch IV re\u017eim\u016f)<\/li>\n<li>Plicn\u00ed fibr\u00f3za (vz\u00e1cn\u011b)<\/li>\n<li>SIADH a intoxikace vodou (vysokod\u00e1vkov\u00e9 IV pod\u00e1n\u00ed)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> teratogenn\u00ed a abortivn\u00ed \u00fa\u010dinek. D\u016fsledn\u00e1 antikoncepce po celou dobu l\u00e9\u010dby + 12 m\u011bs\u00edc\u016f po l\u00e9\u010db\u011b u \u017een, 6 m\u011bs\u00edc\u016f u mu\u017e\u016f.<\/li>\n<li><strong>Kojen\u00ed:<\/strong> kontraindikov\u00e1no.<\/li>\n<li><strong>T\u011b\u017ek\u00e9 jatern\u00ed nebo ren\u00e1ln\u00ed posti\u017een\u00ed:<\/strong> sn\u00ed\u017eit d\u00e1vku, pod odborn\u00fdm dohledem.<\/li>\n<li><strong>\u017div\u00e9 vakc\u00edny:<\/strong> kontraindikov\u00e1no.<\/li>\n<li><strong>Aktivn\u00ed infekce mo\u010dov\u00fdch cest:<\/strong> l\u00e9\u010dit p\u0159ed zah\u00e1jen\u00edm terapie.<\/li>\n<li><strong>Pe\u010dovatel\u00e9:<\/strong> pou\u017e\u00edvejte rukavice p\u0159i manipulaci s tabletami nebo kontaminovan\u00fdmi t\u011bln\u00edmi tekutinami; okam\u017eit\u011b om\u00fdvejte exponovanou poko\u017eku.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Allopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zvy\u0161uje myelotoxicitu cyklofosfamidu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sledujte krevn\u00ed obraz pravideln\u011b.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kol\u00eds\u00e1n\u00ed INR<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte INR t\u00fddn\u011b.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u017div\u00e9 vakc\u00edny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diseminovan\u00e1 infekce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindikov\u00e1no.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Jin\u00e1 imunosupresiva<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed riziko infekce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dohled specialisty.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibitory\/induktory CYP3A4<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Modifikace aktivace cyklofosfamidov\u00e9ho prol\u00e9\u010diva<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Konzultace specialistou.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>P\u0159i pokojov\u00e9 teplot\u011b, 15\u201325\u00b0C, v p\u016fvodn\u00edm blistru.<\/li>\n<li>Mimo dosah d\u011bt\u00ed, \u017een v reproduk\u010dn\u00edm v\u011bku, dom\u00e1c\u00edch zv\u00ed\u0159at.<\/li>\n<li>O\u0161et\u0159uj\u00edc\u00ed person\u00e1l mus\u00ed pou\u017e\u00edvat rukavice p\u0159i manipulaci.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temotero\/\"><strong>Temotero (temozolomid 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\"><strong>Lomoother (lomustin 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Pro\u010d pot\u0159ebuji tolik tekutin p\u0159i u\u017e\u00edv\u00e1n\u00ed Endoxanu?<\/h3>\n<p>Cyklofosfamid produkuje toxick\u00fd metabolit zvan\u00fd <strong>akrolein<\/strong> kter\u00fd se koncentruje v mo\u010dov\u00e9m m\u011bch\u00fd\u0159i a zp\u016fsobuje <strong>hemoragickou cystitidu<\/strong> \u2014 krv\u00e1cen\u00ed ze st\u011bny mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e. Agresivn\u00ed hydratace (minim\u00e1ln\u011b 3 litry tekutin denn\u011b b\u011bhem aktivn\u00edho d\u00e1vkov\u00e1n\u00ed) vyplavuje akrolein d\u0159\u00edve, ne\u017e po\u0161kod\u00ed mo\u010dov\u00fd m\u011bch\u00fd\u0159. Pravideln\u011b mo\u010dte a pokud mo\u017eno se vyhn\u011bte zadr\u017eov\u00e1n\u00ed mo\u010di p\u0159es noc. U vy\u0161\u0161\u00edch d\u00e1vek se p\u0159edepisuje mesna (thiolov\u00e1 l\u00e1tka neutralizuj\u00edc\u00ed akrolein).<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017ee Endoxan zp\u016fsobit neplodnost?<\/h3>\n<p>Ano \u2014 cyklofosfamid je gonadotoxick\u00fd a m\u016f\u017ee zp\u016fsobit <strong>trvalou neplodnost<\/strong>, zejm\u00e9na p\u0159i kumulativn\u00edch d\u00e1vk\u00e1ch &gt; 5\u20137 g\/m\u00b2 a u star\u0161\u00edch pacient\u016f v reproduk\u010dn\u00edm v\u011bku. <strong>Zachov\u00e1n\u00ed plodnosti by m\u011blo b\u00fdt nab\u00edzeno p\u0159ed zah\u00e1jen\u00edm.<\/strong> u ka\u017ed\u00e9ho pacienta v reproduk\u010dn\u00edm v\u011bku: kryokonzervace spermi\u00ed (mu\u017ei), kryokonzervace oocyt\u016f nebo embry\u00ed (\u017eeny) nebo ovari\u00e1ln\u00ed ochrana pomoc\u00ed GnRH agonisty b\u011bhem l\u00e9\u010dby. P\u0159ed prvn\u00ed d\u00e1vkou se pora\u010fte s onkologem.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 krevn\u00ed testy pot\u0159ebuji?<\/h3>\n<p>Povinn\u00e9: Kompletn\u00ed krevn\u00ed obraz ka\u017ed\u00fdch 1\u20132 t\u00fddny (nejni\u017e\u0161\u00ed hodnoty mezi 7.\u201310. dnem, obnova do 21. dne); mo\u010dov\u00e9 vy\u0161et\u0159en\u00ed m\u011bs\u00ed\u010dn\u011b (detekce hematurie); jatern\u00ed testy m\u011bs\u00ed\u010dn\u011b; z\u00e1kladn\u00ed a pr\u016fb\u011b\u017en\u00e9 vy\u0161et\u0159en\u00ed ren\u00e1ln\u00edch funkc\u00ed. Informujte sv\u00e9ho specialistu o jak\u00e9koli krvi v mo\u010di, hore\u010dce, v\u0159edech v \u00fastech nebo neobvykl\u00e9m krv\u00e1cen\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d je rakovina mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e dlouhodob\u00fdm rizikem?<\/h3>\n<p>Dlouhodob\u00e9 vystaven\u00ed cyklofosfamidu zvy\u0161uje riziko rakoviny mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e, a to v z\u00e1vislosti na d\u00e1vce a kumulativn\u00ed d\u00e1vce. Po l\u00e9\u010db\u011b cyklofosfamidem je rozumn\u00e9 prov\u00e1d\u011bt pravideln\u00e9 mo\u010dov\u00e9 vy\u0161et\u0159en\u00ed (minim\u00e1ln\u011b ro\u010dn\u011b) na hematurii; cystoskopii p\u0159i p\u0159etrv\u00e1vaj\u00edc\u00ed hematurii. P\u0159esta\u0148te kou\u0159it \u2014 kou\u0159en\u00ed dramaticky zvy\u0161uje riziko rakoviny mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e.<\/p>\n<h3 class=\"wp-block-heading\">Mohu ot\u011bhotn\u011bt p\u0159i u\u017e\u00edv\u00e1n\u00ed Endoxanu?<\/h3>\n<p>Ne \u2014 cyklofosfamid je teratogenn\u00ed a abortivn\u00ed. Spolehliv\u00e1 antikoncepce po celou dobu l\u00e9\u010dby A alespo\u0148 12 m\u011bs\u00edc\u016f po posledn\u00ed d\u00e1vce (\u017eeny) nebo 6 m\u011bs\u00edc\u016f (mu\u017ei). Proberte pl\u00e1nov\u00e1n\u00ed rodiny se sv\u00fdm specialistou; zva\u017ete zachov\u00e1n\u00ed fertility p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby.<\/p>\n<h3 class=\"wp-block-heading\">Mohu dostat \u017eiv\u00e9 vakc\u00edny?<\/h3>\n<p>Ne \u2014 \u017eiv\u00e9 vakc\u00edny (MMR, \u017elut\u00e1 zimnice, BCG, or\u00e1ln\u00ed polio, varicella) jsou kontraindikov\u00e1ny b\u011bhem u\u017e\u00edv\u00e1n\u00ed cyklofosfamidu a po dobu 3\u20136 m\u011bs\u00edc\u016f po jeho ukon\u010den\u00ed. Inaktivovan\u00e9 vakc\u00edny (ka\u017edoro\u010dn\u00ed ch\u0159ipka, pneumokokov\u00e1, COVID-19) jsou nejen bezpe\u010dn\u00e9, ale doporu\u010den\u00e9.<\/p>\n<h3 class=\"wp-block-heading\">Na jak\u00e9 infekce bych si m\u011bl d\u00e1t pozor?<\/h3>\n<p>Cyklofosfamidem indukovan\u00e1 lymfopenie zvy\u0161uje riziko oportunn\u00edch infekc\u00ed. Vyhledejte l\u00e9ka\u0159skou pomoc je\u0161t\u011b tent\u00fd\u017e den p\u0159i jak\u00e9koli hore\u010dce &gt; 38\u00b0C, p\u0159etrv\u00e1vaj\u00edc\u00edm ka\u0161li, du\u0161nosti, siln\u00e9m pr\u016fjmu nebo nov\u00e9 vyr\u00e1\u017ece. Profylaxe PCP (ko-trimoxazol) m\u016f\u017ee b\u00fdt p\u0159edeps\u00e1na p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch nebo v transplanta\u010dn\u00edch re\u017eimech.<\/p>\n<h3 class=\"wp-block-heading\">P\u00e9\u010de o pacienty u\u017e\u00edvaj\u00edc\u00ed Endoxan \u2014 jak\u00e1 opat\u0159en\u00ed?<\/h3>\n<p>Ano \u2014 tablety cyklofosfamidu a t\u011bln\u00ed tekutiny pacienta (mo\u010d, zvratky) b\u011bhem prvn\u00edch 48 hodin po d\u00e1vce obsahuj\u00ed cytotoxick\u00e9 l\u00e1tky. Pe\u010dovatel\u00e9 by m\u011bli pou\u017e\u00edvat rukavice p\u0159i manipulaci s tabletami, kontaminovan\u00fdm pr\u00e1dlem nebo t\u011bln\u00edmi tekutinami; pot\u00e9 si um\u00fdt ruce; spl\u00e1chnout toaletu dvakr\u00e1t. T\u011bhotn\u00e9 pe\u010dovatelky by se m\u011bly manipulaci s cyklofosfamidem zcela vyhnout.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\">Celkeran (chlorambucil 2 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\">Lomoother (lomustin 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/folitrax\/\">Folitrax (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imutrex\/\">Imutrex (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 L\u00e9\u010d\u00ed r\u016fzn\u00e9 typy rakoviny<br \/>\n\u2705 Potla\u010duje imunitn\u00ed syst\u00e9m<br \/>\n\u2705 Kontroluje autoimunitn\u00ed onemocn\u011bn\u00ed<br \/>\n\u2705 Sni\u017euje z\u00e1n\u011bt<br \/>\n\u2705 L\u00e9\u010d\u00ed nefrotick\u00fd syndrom<\/p>\n<p>Endoxan obsahuje cyklofosfamid.<\/p>","protected":false},"featured_media":56304,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4095,4096],"class_list":{"0":"post-56303","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-cyclophosphamide","10":"product_tag-endoxan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56303"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56304"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56303"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56303"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56303"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}