{"id":56303,"date":"2024-02-07T06:00:17","date_gmt":"2024-02-07T06:00:17","guid":{"rendered":"https:\/\/medsname.com\/endoxan\/"},"modified":"2026-04-30T10:24:38","modified_gmt":"2026-04-30T10:24:38","slug":"endoxan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/endoxan\/","title":{"rendered":"Endoxan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Endoxan?<\/h3>\n<p style=\"margin:0;\"><strong>Endoxan<\/strong> is an oral tablet from Baxter containing <strong>cyclophosphamide 50 mg<\/strong> &mdash; an alkylating cytotoxic agent (nitrogen mustard derivative) used for <strong>haematological malignancies, breast cancer (CMF \/ AC regimens), severe autoimmune disease (lupus nephritis, ANCA vasculitis), and bone marrow conditioning<\/strong>. Standard low-dose oral regimens: 1&ndash;3 mg\/kg\/day or pulsed weekly cycles, prescribed by specialist. Mandatory monitoring: <strong>FBC every 1&ndash;2 weeks<\/strong>, urine for haemorrhagic cystitis, fertility preservation discussion before starting. <strong>Plenty of fluids<\/strong> (3 L\/day during active dosing) to flush bladder and prevent haemorrhagic cystitis from acrolein metabolite. Pregnancy contraindication; gonadotoxic with permanent infertility risk &mdash; offer fertility preservation in reproductive-age patients.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Endoxan?<\/h2>\n<p>Endoxan is an oral tablet from Baxter containing <strong>cyclophosphamide 50 mg<\/strong>. Cyclophosphamide is a prodrug alkylating cytotoxic agent (nitrogen mustard family). It is metabolised in the liver to active 4-hydroxycyclophosphamide and the toxic metabolite acrolein. Used in many haematological cancers, solid tumours and severe autoimmune diseases.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Hematologick\u00e9:<\/strong> chronic lymphocytic leukaemia, low-grade non-Hodgkin lymphoma, multiple myeloma, Waldenstr&ouml;m macroglobulinaemia, conditioning before stem cell transplant<\/li>\n<li><strong>Solid tumours:<\/strong> breast cancer (CMF, AC regimens), small-cell lung cancer, ovarian cancer, neuroblastoma, sarcoma (high-dose IV)<\/li>\n<li><strong>Severe autoimmune disease:<\/strong> lupus nephritis, ANCA-associated vasculitis (granulomatosis with polyangiitis, microscopic polyangiitis), refractory rheumatoid arthritis<\/li>\n<li><strong>Mimo indikaci:<\/strong> nephrotic syndrome (steroid-resistant), pemphigus vulgaris<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<p>Oral regimens vary by indication; specialist prescribing only. Examples for adults:<\/p>\n<ul>\n<li><strong>Low-dose continuous oral:<\/strong> 1&ndash;3 mg\/kg\/day<\/li>\n<li><strong>Pulsed oral cyclophosphamide<\/strong> for vasculitis: 50&ndash;200 mg\/day<\/li>\n<\/ul>\n<ol>\n<li>Take in the morning with plenty of fluid &mdash; aim for at least 3 L of fluid intake per day during active dosing to flush the bladder of acrolein and reduce haemorrhagic cystitis risk.<\/li>\n<li>Empty bladder frequently. Consider mesna prophylaxis at higher cumulative dose under specialist guidance.<\/li>\n<li>Take with food if nausea occurs. Antiemetic (ondansetron) 1 hour before if needed.<\/li>\n<li>Swallow tablets whole. Do NOT crush. Caregivers handling tablets should wash hands.<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> FBC every 1&ndash;2 weeks; urinalysis monthly (haematuria); LFTs monthly; baseline + ongoing renal function.<\/li>\n<li><strong>Fertility preservation:<\/strong> discuss before starting in reproductive-age patients. Cyclophosphamide is gonadotoxic &mdash; sperm banking, oocyte \/ embryo cryopreservation, or GnRH-agonist ovarian protection should be offered.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> nausea, vomiting (preventable with antiemetics), alopecia, anorexia, mucositis, fatigue.<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Myelosuprese<\/strong> &mdash; nadir at 7&ndash;10 days; full recovery by day 21<\/li>\n<li><strong>Haemorrhagic cystitis<\/strong> &mdash; from acrolein bladder toxicity; prevent with high fluid intake (3 L\/day) and frequent bladder emptying; mesna for high-dose regimens<\/li>\n<li><strong>Permanent infertility<\/strong> &mdash; gonadotoxic; sperm banking and oocyte preservation should be offered before starting in reproductive-age patients<\/li>\n<li>Bladder cancer (long-term, dose-related)<\/li>\n<li>Secondary leukaemia \/ myelodysplastic syndrome<\/li>\n<li>Cardiotoxicity (mostly high-dose IV regimens)<\/li>\n<li>Pulmonary fibrosis (rare)<\/li>\n<li>SIADH and water intoxication (high-dose IV)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> teratogenic and abortifacient. Strict contraception throughout treatment + 12 months after for women, 6 months for men.<\/li>\n<li><strong>Kojen\u00ed:<\/strong> kontraindikov\u00e1no.<\/li>\n<li><strong>T\u011b\u017ek\u00e9 jatern\u00ed nebo ren\u00e1ln\u00ed posti\u017een\u00ed:<\/strong> reduce dose, specialist guidance.<\/li>\n<li><strong>\u017div\u00e9 vakc\u00edny:<\/strong> kontraindikov\u00e1no.<\/li>\n<li><strong>Active urinary tract infection:<\/strong> treat before starting.<\/li>\n<li><strong>Caregivers:<\/strong> wear gloves when handling tablets or contaminated body fluids; wash exposed skin immediately.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Allopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Raises cyclophosphamide marrow toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor FBC closely.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">INR variability<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR weekly.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u017div\u00e9 vakc\u00edny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diseminovan\u00e1 infekce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindikov\u00e1no.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other immunosuppressants<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive infection risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dohled specialisty.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">CYP3A4 inhibitors \/ inducers<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Modify activation of cyclophosphamide prodrug<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Konzultace specialistou.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>P\u0159i pokojov\u00e9 teplot\u011b, 15\u201325\u00b0C, v p\u016fvodn\u00edm blistru.<\/li>\n<li>Mimo dosah d\u011bt\u00ed, \u017een v reproduk\u010dn\u00edm v\u011bku, dom\u00e1c\u00edch zv\u00ed\u0159at.<\/li>\n<li>Caregivers wear gloves when handling.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temotero\/\"><strong>Temotero (temozolomid 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\"><strong>Lomoother (lomustin 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Why do I need so much fluid on Endoxan?<\/h3>\n<p>Cyclophosphamide produces a toxic metabolite called <strong>acrolein<\/strong> that concentrates in the bladder and causes <strong>haemorrhagic cystitis<\/strong> &mdash; bleeding from the bladder wall. Aggressive hydration (at least 3 L of fluid per day during active dosing) flushes acrolein out before it damages the bladder. Empty your bladder frequently and avoid holding urine overnight if possible. For higher-dose regimens, mesna (a thiol drug that neutralises acrolein) is prescribed.<\/p>\n<h3 class=\"wp-block-heading\">Will Endoxan make me infertile?<\/h3>\n<p>Yes &mdash; cyclophosphamide is gonadotoxic and may cause <strong>permanent infertility<\/strong>, especially with cumulative doses &gt; 5&ndash;7 g\/m&sup2; and in older reproductive-age patients. <strong>Fertility preservation should be offered before starting<\/strong> in any reproductive-age patient: sperm banking (men), oocyte or embryo cryopreservation (women), or GnRH-agonist ovarian protection during treatment. Discuss with the oncologist before the first dose.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 krevn\u00ed testy pot\u0159ebuji?<\/h3>\n<p>Mandatory: FBC every 1&ndash;2 weeks (nadir at days 7&ndash;10, recovery by day 21); urinalysis monthly (haematuria detection); LFTs monthly; baseline + ongoing renal function. Inform your specialist of any blood in urine, fever, mouth ulcers, or unusual bleeding.<\/p>\n<h3 class=\"wp-block-heading\">Why is bladder cancer a long-term risk?<\/h3>\n<p>Long-term cyclophosphamide exposure increases bladder cancer risk, dose-related and cumulative-dose-related. After a course of cyclophosphamide, regular urinalysis (at least annually) for haematuria is reasonable; cystoscopy if persistent haematuria. Stop smoking &mdash; smoking compounds the bladder cancer risk dramatically.<\/p>\n<h3 class=\"wp-block-heading\">Can I get pregnant on Endoxan?<\/h3>\n<p>No &mdash; cyclophosphamide is teratogenic and abortifacient. Reliable contraception throughout treatment AND for at least 12 months after the last dose (women) or 6 months (men). Discuss family planning with your specialist; consider fertility preservation before starting.<\/p>\n<h3 class=\"wp-block-heading\">Mohu dostat \u017eiv\u00e9 vakc\u00edny?<\/h3>\n<p>No &mdash; live vaccines (MMR, yellow fever, BCG, oral polio, varicella) contraindicated during cyclophosphamide and for 3&ndash;6 months after stopping. Inactivated vaccines (annual flu, pneumococcal, COVID-19) are not only safe but recommended.<\/p>\n<h3 class=\"wp-block-heading\">What infections should I watch for?<\/h3>\n<p>Cyclophosphamide-induced lymphopenia raises risk of opportunistic infections. Seek same-day care for any fever &gt; 38&deg;C, persistent cough, breathlessness, severe diarrhoea, or new rash. PCP prophylaxis (co-trimoxazole) may be prescribed at higher doses or in transplant settings.<\/p>\n<h3 class=\"wp-block-heading\">Caregivers handling Endoxan &mdash; any precautions?<\/h3>\n<p>Yes &mdash; cyclophosphamide tablets and patient body fluids (urine, vomit) for the first 48 hours after a dose contain cytotoxic compounds. Caregivers should wear gloves when handling tablets, contaminated linen, or body fluids; wash hands afterwards; double-flush the toilet. Pregnant caregivers should avoid handling cyclophosphamide entirely.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\">Celkeran (chlorambucil 2 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\">Lomoother (lomustin 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/folitrax\/\">Folitrax (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imutrex\/\">Imutrex (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Treats various cancers<br \/>\n\u2705 Suppresses immune system<br \/>\n\u2705 Controls autoimmune diseases<br \/>\n\u2705 Sni\u017euje z\u00e1n\u011bt<br \/>\n\u2705 Manages nephrotic syndrome<\/p>\n<p>Endoxan contains Cyclophosphamide.<\/p>","protected":false},"featured_media":56304,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4095,4096],"class_list":{"0":"post-56303","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-cyclophosphamide","10":"product_tag-endoxan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56303"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56304"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56303"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56303"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56303"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}