{"id":56569,"date":"2024-02-27T16:59:23","date_gmt":"2024-02-27T16:59:23","guid":{"rendered":"https:\/\/medsname.com\/desowen\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"desowen","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/desowen\/","title":{"rendered":"Desowen"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Desowen?<\/h3>\n

Desowen<\/strong> obsahuje desonid 0,05%<\/strong> jako lok\u00e1ln\u00ed loto od spole\u010dnosti Galderma \u2014 m\u00edrn\u00fd\/n\u00edzko\u00fa\u010dinn\u00fd topick\u00fd kortikosteroid (t\u0159\u00edda I v UK \/ t\u0159\u00edda VII-VI v USA). Proto\u017ee je m\u00edrn\u00fd, desonid pat\u0159\u00ed mezi<\/strong>. Proto\u017ee je m\u00edrn\u00fd, desonide je jedn\u00edm z nejbezpe\u010dn\u011bj\u0161\u00ed topick\u00e9 steroidy pro pou\u017eit\u00ed na obli\u010dej, o\u010dn\u00ed v\u00ed\u010dka (pod dermatologick\u00fdm dohledem), krk, intertrigin\u00f3zn\u00ed z\u00e1hyby a u pediatrick\u00fdch pacient\u016f (v\u010detn\u011b kojenc\u016f od 3 m\u011bs\u00edc\u016f)<\/strong>. Pou\u017e\u00edv\u00e1 se k atopick\u00e1 dermatitida (ekz\u00e9m), seboroick\u00e1 dermatitida, kontaktn\u00ed dermatitida, intertrigo, diskoidn\u00ed lupus<\/strong>, a dal\u0161\u00ed steroid-responsivn\u00ed z\u00e1n\u011btliv\u00e9 ko\u017en\u00ed stavy, kde posta\u010duje m\u00edrn\u00fd steroid nebo kde by siln\u00fd steroid zp\u016fsobil atrofii. Aplikujte tenkou vrstvu dvakr\u00e1t denn\u011b<\/strong> a\u017e po dobu 4 t\u00fddn\u016f na t\u011ble, 2 t\u00fddny na obli\u010deji, 1 t\u00fdden na v\u00ed\u010dk\u00e1ch nebo intertrigin\u00f3zn\u00edch oblastech. V\u00fdhodn\u00fd bezpe\u010dnostn\u00ed profil desonidu z n\u011bj \u010din\u00ed prvn\u00ed volbu v pediatrick\u00e9 dermatologii, ale m\u011bl by b\u00fdt pou\u017e\u00edv\u00e1n pod dohledem po nejkrat\u0161\u00ed nutnou dobu.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Desowen?<\/h2>\n

Desowen je topick\u00fd desonid 0,05%<\/strong> lotion od Galderma dod\u00e1van\u00fd v 30 mL balen\u00ed. Desonid je syntetick\u00fd nefluorovan\u00fd glukokortikoid klasifikovan\u00fd jako n\u00edzkopotentn\u00ed topick\u00fd kortikosteroid<\/strong> (UK t\u0159\u00edda I \/ US t\u0159\u00edda VI-VII, n\u011bkdy ozna\u010dovan\u00fd jako \u201cm\u00edrn\u00fd\u201d na evropsk\u00fdch stupnic\u00edch potency). Je molekulou volby, kdy\u017e aplikace na obli\u010dej, u d\u011bt\u00ed nebo v intertrigin\u00f3zn\u00edch oblastech vy\u017eaduje bezpe\u010dnostn\u00ed profil, kter\u00fd st\u0159edn\u011b siln\u00e9 a siln\u00e9 steroidy nemohou nab\u00eddnout.<\/p>\n

Mezin\u00e1rodn\u011b zna\u010dkov\u00e1n jako Desowen, DesoRx, Verdeso (p\u011bna), Tridesilon<\/strong> (US); Desowen je verze od Galderma dostupn\u00e1 p\u0159es MedsBase s celosv\u011btovou dopravou.<\/p>\n

\u017deb\u0159\u00ed\u010dek potency topick\u00fdch steroid\u016f \u2014 kde se nach\u00e1z\u00ed desonid<\/h2>\n\n\n\n\n\n\n\n\n
Britsk\u00e1 t\u0159\u00edda<\/th>\nAmerick\u00e1 t\u0159\u00edda<\/th>\nP\u0159\u00edklady<\/th>\n<\/tr>\n<\/thead>\n
I (m\u00edrn\u00fd)<\/td>\nVII-VI<\/td>\nHydrokortizon 0,5-1 %, desonid 0,05 % (Desowen)<\/strong><\/td>\n<\/tr>\n
II (st\u0159edn\u011b siln\u00fd)<\/td>\nV<\/td>\nKlobetason butyr\u00e1t, betamethason valer\u00e1t 0,025%<\/td>\n<\/tr>\n
III (siln\u00fd)<\/td>\nIII\u2013II<\/td>\nBetamethasonvaler\u00e1t 0,1 % (Betnovate<\/strong>), mometason 0,1 % (Elocon<\/a>, Momin<\/a>), flutikason (Flutivate<\/a>)<\/td>\n<\/tr>\n
IV (velmi siln\u00fd)<\/td>\nI<\/td>\nKlobetasolpropion\u00e1t 0,05 % (Tenovate<\/a>), halobetasolpropion\u00e1t 0,05 % (Halox<\/a>)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Desonid se nach\u00e1z\u00ed v nejm\u00edrn\u011bj\u0161\u00ed \u00farovni spolu s hydrokortizonem 0,5-1%. Kl\u00ed\u010dovou v\u00fdhodou oproti hydrokortizonu je, \u017ee desonid je nehalogenovan\u00fd<\/strong> \u2014 co\u017e znamen\u00e1, \u017ee m\u00e1 jedno z nejni\u017e\u0161\u00edch rizik ko\u017en\u00ed atrofie a teleangiekt\u00e1zi\u00ed ze v\u0161ech topick\u00fdch steroid\u016f, co\u017e jej \u010din\u00ed vhodn\u00fdm pro oblasti s tenkou k\u016f\u017e\u00ed (obli\u010dej, v\u00ed\u010dka, pediatrie), kde jsou siln\u00e9 steroidy kontraindikov\u00e1ny.<\/p>\n

Jak Desowen p\u016fsob\u00ed<\/h2>\n

Desonid se v\u00e1\u017ee na intracelul\u00e1rn\u00ed glukokortikoidn\u00ed receptory v keratinocytech a z\u00e1n\u011btliv\u00fdch bu\u0148k\u00e1ch. Aktivovan\u00fd receptorov\u00fd komplex vstupuje do j\u00e1dra a potla\u010duje transkripci proz\u00e1n\u011btliv\u00fdch cytokin\u016f (IL-1, IL-2, IL-6, TNF-\u03b1), inhibuje fosfolip\u00e1zu A2<\/sub> (sn\u00ed\u017een\u00edm synt\u00e9zy prostaglandin\u016f\/leukotrien\u016f) a spou\u0161t\u00ed apopt\u00f3zu aktivovan\u00fdch T-lymfocyt\u016f \u2014 \u010d\u00edm\u017e p\u0159eru\u0161uje cyklus sv\u011bd\u011bn\u00ed-z\u010derven\u00e1n\u00ed-z\u00e1n\u011bt u ekz\u00e9m\u016f a p\u0159\u00edbuzn\u00fdch dermat\u00f3z.<\/p>\n

N\u00e1stup \u00fa\u010dinku: sv\u011bd\u011bn\u00ed a zarudnut\u00ed se za\u010d\u00ednaj\u00ed zm\u00edr\u0148ovat za 24-48 hodin; pln\u00fd efekt nastupuje b\u011bhem 1-2 t\u00fddn\u016f.<\/p>\n

Schv\u00e1len\u00e9 a v\u011bdecky podlo\u017een\u00e9 indikace<\/h2>\n