{"id":56581,"date":"2024-02-27T16:59:56","date_gmt":"2024-02-27T16:59:56","guid":{"rendered":"https:\/\/medsname.com\/decmax\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"decmax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/decmax\/","title":{"rendered":"Decmax"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Decmax?<\/h3>\n

Decmax<\/strong> je dexamethason 4 mg tablety k peror\u00e1ln\u00edmu u\u017eit\u00ed<\/strong> \u2014 standardn\u00ed vy\u0161\u0161\u00ed d\u00e1vka tohoto siln\u00e9ho dlouhodob\u011b p\u016fsob\u00edc\u00edho syntetick\u00e9ho kortikosteroidu pro dosp\u011bl\u00e9. Pou\u017e\u00edv\u00e1 se u st\u0159edn\u011b z\u00e1va\u017en\u00fdch a\u017e z\u00e1va\u017en\u00fdch z\u00e1n\u011btliv\u00fdch, autoimunitn\u00edch, alergick\u00fdch a malign\u00edch stav\u016f<\/strong>: mozkov\u00fd ed\u00e9m, prevence nevolnosti p\u0159i chemoterapii, t\u011b\u017ek\u00fd pr\u016fb\u011bh COVID-19, t\u011b\u017ek\u00e9 astmatick\u00e9 z\u00e1chvaty, vzplanut\u00ed autoimunitn\u00edch onemocn\u011bn\u00ed a paliativn\u00ed p\u00e9\u010de. Obvykl\u00e1 d\u00e1vka je 4 a\u017e 16 mg denn\u011b<\/strong> v z\u00e1vislosti na indikaci, u\u017e\u00edvan\u00e1 s j\u00eddlem, nejl\u00e9pe r\u00e1no.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Decmax 4 mg<\/strong> je peror\u00e1ln\u00ed tableta dexamethasonu vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Cadila\/Zydus. S\u00edla 4 mg je praktick\u00e1 pro v\u011bt\u0161inu indikac\u00ed u dosp\u011bl\u00fdch, kde je pot\u0159eba st\u0159edn\u00ed a\u017e vysok\u00e1 d\u00e1vka \u2014 4 mg je standardn\u00ed jednor\u00e1zov\u00e1 d\u00e1vka pro mozkov\u00fd ed\u00e9m, antiemetickou profylaxi p\u0159i chemoterapii a akutn\u00ed z\u00e1n\u011btliv\u00e9 stavy.<\/p>\n

K \u010demu se Decmax pou\u017e\u00edv\u00e1?<\/h2>\n
    \n
  • Mozkov\u00fd ed\u00e9m<\/strong> u mozkov\u00fdch n\u00e1dor\u016f (prim\u00e1rn\u00edch nebo metastatick\u00fdch) \u2014 obvykle 4 mg \u010dty\u0159ikr\u00e1t denn\u011b, s postupn\u00fdm sni\u017eov\u00e1n\u00edm po zlep\u0161en\u00ed p\u0159\u00edznak\u016f<\/li>\n
  • Antiemetick\u00e1 ochrana p\u0159i chemoterapii<\/strong> \u2014 8\u201312 mg p\u0159ed vysoce emetogenn\u00ed chemoterapi\u00ed, obvykle v kombinaci s antagonistou 5-HT3<\/li>\n
  • T\u011b\u017ek\u00fd pr\u016fb\u011bh COVID-19<\/strong> vy\u017eaduj\u00edc\u00ed dodate\u010dn\u00fd kysl\u00edk nebo mechanickou ventilaci \u2014 6 mg (1\u00bd tablety) denn\u011b po dobu a\u017e 10 dn\u016f (re\u017eim studie RECOVERY)<\/li>\n
  • Akutn\u00ed t\u011b\u017ek\u00e9 astma<\/strong> \u2014 jednor\u00e1zov\u00e1 d\u00e1vka 8\u201312 mg na pohotovosti<\/li>\n
  • T\u011b\u017ek\u00e1 exacerbace CHOPN<\/strong> \u2014 alternativa k peror\u00e1ln\u00edmu prednisolonu<\/li>\n
  • T\u011b\u017ek\u00e9 alergick\u00e9 reakce<\/strong><\/li>\n
  • Vzplanut\u00ed autoimunitn\u00edch onemocn\u011bn\u00ed<\/strong> \u2014 RA, SLE, vaskulitida, polymyalgia rheumatica, z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed st\u0159ev<\/li>\n
  • Bakteri\u00e1ln\u00ed meningitida<\/strong> \u2014 dopln\u011bk k antibiotick\u00e9 terapii<\/li>\n
  • Prenat\u00e1ln\u00ed zr\u00e1n\u00ed plicn\u00edch tk\u00e1n\u00ed<\/strong> \u2014 specializovan\u00e9 pou\u017eit\u00ed v porodnictv\u00ed<\/li>\n
  • Hematologick\u00e9 malignity<\/strong> \u2014 sou\u010d\u00e1st chemoterapeutick\u00fdch protokol\u016f (ALL, mnoho\u010detn\u00fd myelom)<\/li>\n
  • Paliativn\u00ed p\u00e9\u010de<\/strong> \u2014 stimulace chuti k j\u00eddlu, antiemetikum, protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek, zm\u00edrn\u011bn\u00ed n\u00e1dorov\u00fdch p\u0159\u00edznak\u016f<\/li>\n<\/ul>\n

    Jak p\u016fsob\u00ed dexamethason?<\/h2>\n

    Dexamethason se s vysokou afinitou v\u00e1\u017ee na intracelul\u00e1rn\u00ed glukokortikoidn\u00ed receptory. Aktivovan\u00fd receptor se translokuje do j\u00e1dra a moduluje transkripci stovek gen\u016f zapojen\u00fdch do z\u00e1n\u011btu, imunitn\u00ed funkce a metabolismu. \u010cist\u00fd klinick\u00fd efekt: \u0161irok\u00e9 protiz\u00e1n\u011btliv\u00e9 a imunosupresivn\u00ed p\u016fsoben\u00ed, sn\u00ed\u017een\u00ed vaskul\u00e1rn\u00ed permeability (u\u017eite\u010dn\u00e9 u mozkov\u00e9ho ed\u00e9mu), potla\u010den\u00ed emetick\u00fdch sign\u00e1l\u016f v oblasti postremy (u\u017eite\u010dn\u00e9 u chemoterapi\u00ed vyvolan\u00e9 nevolnosti) a modulace cytokinov\u00e9 bou\u0159e pozorovan\u00e9 u t\u011b\u017ek\u00e9ho pr\u016fb\u011bhu COVID-19.<\/p>\n

    D\u00e1vkov\u00e1n\u00ed Decmax<\/h2>\n
      \n
    • Mozkov\u00fd ed\u00e9m:<\/strong> 16 mg\/den ve 4 rozd\u011blen\u00fdch d\u00e1vk\u00e1ch (4 mg QDS), s postupn\u00fdm sni\u017eov\u00e1n\u00edm po 3\u20135 dnech<\/li>\n
    • Antiemetikum p\u0159i chemoterapii:<\/strong> 8\u201312 mg (2\u20133 tablety) jednou p\u0159ed chemoterapi\u00ed; pokra\u010dovat po dobu 2\u20134 dn\u016f<\/li>\n
    • T\u011b\u017ek\u00fd pr\u016fb\u011bh COVID-19:<\/strong> 6 mg jednou denn\u011b po dobu a\u017e 10 dn\u016f<\/li>\n
    • T\u011b\u017ek\u00e9 zhor\u0161en\u00ed astmatu:<\/strong> 8\u201312 mg jako jednor\u00e1zov\u00e1 nebo dvoud\u00e1vkov\u00e1 l\u00e9\u010dba<\/li>\n
    • Autoimunitn\u00ed zhor\u0161en\u00ed:<\/strong> 4\u201316 mg\/den v rozd\u011blen\u00fdch d\u00e1vk\u00e1ch, pot\u00e9 postupn\u011b sni\u017eovat<\/li>\n
    • U\u017e\u00edvejte s j\u00eddlem<\/strong>, nejl\u00e9pe r\u00e1no<\/li>\n<\/ul>\n

      Potence a ekvivalence kortikosteroid\u016f<\/h2>\n

      R\u016fzn\u00e9 kortikosteroidy se li\u0161\u00ed p\u0159edev\u0161\u00edm v potenci, d\u00e9lce \u00fa\u010dinku a mineralokortikoidn\u00ed (soli zadr\u017euj\u00edc\u00ed) aktivit\u011b. N\u00ed\u017ee uveden\u00e1 tabulka uv\u00e1d\u00ed klinicky u\u017eite\u010dn\u00e9 ekvivalence \u2014 umo\u017e\u0148uje p\u0159ev\u00e9st d\u00e1vku jednoho steroidu na ekvivalentn\u00ed d\u00e1vku jin\u00e9ho.<\/p>\n\n\n\n\n\n\n\n\n\n
      Kortikosteroid<\/th>\nGlukokortikoidn\u00ed potence<\/th>\nEkvivalentn\u00ed d\u00e1vka<\/th>\nMineralokortikoid<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
      Hydrokortizon<\/td>\n1 (referen\u010dn\u00ed)<\/td>\n20 mg<\/td>\nV\u00fdznamn\u00e1<\/td>\n8\u201312 h<\/td>\n<\/tr>\n
      Prednisolon<\/td>\n4<\/td>\n5 mg<\/td>\nN\u00edzk\u00e1<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
      Methylprednisolon<\/td>\n5<\/td>\n4 mg<\/td>\nMinim\u00e1ln\u00ed<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
      Dexamethasone<\/strong><\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n
      Betamethason<\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      Kdo by nem\u011bl u\u017e\u00edvat Decmax?<\/h2>\n
        \n
      • Syst\u00e9mov\u00e1 pl\u00eds\u0148ov\u00e1 infekce (krom\u011b substitu\u010dn\u00ed terapie p\u0159i adren\u00e1ln\u00ed insuficienci)<\/li>\n
      • \u017div\u00e9 vakc\u00edny b\u011bhem imunosupresivn\u00edch d\u00e1vek (p\u0159ed BCG, MMR, \u017elutou zimnic\u00ed, plan\u00fdmi ne\u0161tovicemi, peror\u00e1ln\u00edm tyfem konzultujte odborn\u00edka)<\/li>\n
      • Aktivn\u00ed nel\u00e9\u010den\u00e1 bakteri\u00e1ln\u00ed infekce (nejprve zahajte antibiotika)<\/li>\n
      • Aktivn\u00ed tuberkul\u00f3za bez kryt\u00ed anti-TB l\u00e9\u010dbou<\/li>\n
      • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na \u00fa\u010dinnou l\u00e1tku nebo jakoukoli pomocnou l\u00e1tku<\/li>\n
      • Pou\u017e\u00edvejte s opatrnost\u00ed u: diabetes mellitus, m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed, hypertenze, osteopor\u00f3zy, peptick\u00e9ho v\u0159edu, psychiatrick\u00fdch poruch, glaukomu, herpes simplex ophthalmicus<\/li>\n
      • T\u011bhotenstv\u00ed: u\u017e\u00edvejte pouze v p\u0159\u00edpad\u011b jasn\u00e9 pot\u0159eby \u2013 prednisolon a hydrokortison pronikaj\u00ed placentou m\u00e9n\u011b ne\u017e dexamethason\/betamethason, kter\u00e9 jsou preferov\u00e1ny, kdy\u017e je zam\u00fd\u0161len \u00fa\u010dinek na plod (nap\u0159. zr\u00e1n\u00ed plic)<\/li>\n<\/ul>\n

        Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f<\/h2>\n

        Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f z\u00e1vis\u00ed na d\u00e1vce a d\u00e9lce pod\u00e1v\u00e1n\u00ed. Kr\u00e1tk\u00e9 k\u00fary (< 2 t\u00fddny) p\u0159i st\u0159edn\u00edch d\u00e1vk\u00e1ch jsou obvykle dob\u0159e sn\u00e1\u0161eny. Del\u0161\u00ed nebo vy\u0161\u0161\u00ed d\u00e1vkov\u00e1n\u00ed vyvol\u00e1v\u00e1 klasick\u00fd \u201cCushingoidn\u00ed\u201d profil.<\/p>\n

        Kr\u00e1tkodob\u00e9 (prvn\u00edch 1\u20132 t\u00fddny):<\/strong><\/p>\n

          \n
        • Nespavost, \u00fazkost, euforie, podr\u00e1\u017ed\u011bnost \u2014 zejm\u00e9na p\u0159i d\u00e1vk\u00e1ch > 20 mg ekvivalentu prednisolonu<\/li>\n
        • Zv\u00fd\u0161en\u00e1 chu\u0165 k j\u00eddlu, p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze<\/li>\n
        • Zv\u00fd\u0161en\u00e1 hladina gluk\u00f3zy v krvi (zvl\u00e1\u0161t\u011b u diabetik\u016f)<\/li>\n
        • Zadr\u017eov\u00e1n\u00ed tekutin, m\u00edrn\u00e9 otoky kotn\u00edk\u016f<\/li>\n
        • P\u00e1len\u00ed \u017e\u00e1hy, dyspepsie<\/li>\n
        • Hypertenze \u2014 zejm\u00e9na u kortikoid\u016f s vy\u0161\u0161\u00ed mineralokortikoidn\u00ed aktivitou (hydrokortizon, fludrokortizon)<\/li>\n<\/ul>\n

          Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed (t\u00fddny a\u017e m\u011bs\u00edce):<\/strong><\/p>\n