{"id":56583,"date":"2024-02-27T16:59:57","date_gmt":"2024-02-27T16:59:57","guid":{"rendered":"https:\/\/medsname.com\/dexona-injection\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"dexona-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/dexona-injection\/","title":{"rendered":"Injekce Dexona"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Dexona injekce?<\/h3>\n

Injekce Dexona<\/strong> je dexamethason-natriumfosf\u00e1t 4 mg\/ml roztok<\/strong> dod\u00e1v\u00e1no v 2 ml ampul\u00edch (celkem 8 mg)<\/strong>, for intramuskul\u00e1rn\u011b nebo intraven\u00f3zn\u011b<\/strong> pou\u017eit\u00ed. Jde o parenter\u00e1ln\u00ed dlouhodob\u011b p\u016fsob\u00edc\u00ed glukokortikoid volby p\u0159i pot\u0159eb\u011b IV nebo IM pod\u00e1n\u00ed a kdy nen\u00ed \u017e\u00e1douc\u00ed mineralokortikoidn\u00ed (soli zadr\u017euj\u00edc\u00ed) aktivita \u2014 mozkov\u00fd ed\u00e9m, antiemetick\u00e1 ochrana b\u011bhem chemoterapie, akutn\u00ed t\u011b\u017ek\u00e9 astma, akutn\u00ed alergick\u00e9 reakce a antenat\u00e1ln\u00ed zr\u00e1n\u00ed plicn\u00edch plic plodu. Typick\u00e1 d\u00e1vka pro dosp\u011bl\u00e9 je 4\u20138 mg IM\/IV<\/strong>, opakov\u00e1no podle klinick\u00e9 situace.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Dexona injekce 4 mg\/ml (2 ml ampule)<\/strong> je steriln\u00ed roztok dexamethasonu sodn\u00e9ho fosf\u00e1tu<\/strong>, ve vod\u011b rozpustn\u00e9 soli dexamethasonu, kter\u00e1 umo\u017e\u0148uje rychlou intraven\u00f3zn\u00ed nebo intramuskul\u00e1rn\u00ed aplikaci. Ka\u017ed\u00e1 2 ml ampule obsahuje 8 mg dexamethasonu \u2014 standardn\u00ed jednor\u00e1zovou d\u00e1vku pro dosp\u011bl\u00e9 u v\u011bt\u0161iny akutn\u00edch indikac\u00ed.<\/p>\n

Injekce je up\u0159ednost\u0148ov\u00e1na p\u0159ed peror\u00e1ln\u00edm dexamethasonem, kdy\u017e:<\/p>\n

    \n
  • Je vy\u017eadov\u00e1n rychl\u00fd syst\u00e9mov\u00fd \u00fa\u010dinek (akutn\u00ed alergick\u00e9 reakce, mozkov\u00fd ed\u00e9m, t\u011b\u017ek\u00e9 astma)<\/li>\n
  • Pacient nem\u016f\u017ee polykat (poopera\u010dn\u00ed stav, po c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b, zvracen\u00ed, porucha v\u011bdom\u00ed)<\/li>\n
  • Je nezbytn\u00e1 spolehliv\u00e1 biologick\u00e1 dostupnost (onemocn\u011bn\u00ed GIT, zvracen\u00ed, malabsorpce)<\/li>\n
  • Je \u017e\u00e1douc\u00ed depotn\u00ed IM \u00fa\u010dinek (prenat\u00e1ln\u00ed zr\u00e1n\u00ed plic)<\/li>\n<\/ul>\n

    K \u010demu se pou\u017e\u00edv\u00e1 injekce Dexona?<\/h2>\n
      \n
    • Mozkov\u00fd ed\u00e9m<\/strong> u mozkov\u00fdch n\u00e1dor\u016f \u2014 \u00favodn\u00ed IV d\u00e1vka, pot\u00e9 p\u0159echod na peror\u00e1ln\u00ed pod\u00e1n\u00ed<\/li>\n
    • Antiemetick\u00e1 ochrana p\u0159i chemoterapii<\/strong> \u2014 8\u201312 mg IV p\u0159ed vysoce emetogenn\u00edmi re\u017eimy<\/li>\n
    • Akutn\u00ed t\u011b\u017ek\u00e9 astma nebo exacerbace CHOPN<\/strong> \u2014 8 mg IV\/IM jednor\u00e1zov\u00e1 d\u00e1vka<\/li>\n
    • Akutn\u00ed alergick\u00e9 reakce, anafylaxe<\/strong> \u2014 dopln\u011bk k adrenalinu<\/li>\n
    • Prenat\u00e1ln\u00ed zr\u00e1n\u00ed plicn\u00edch tk\u00e1n\u00ed<\/strong> \u2014 6 mg IM ka\u017ed\u00fdch 12 hodin po dobu 4 d\u00e1vek (2 dny), mezi 24. a 34. t\u00fddnem t\u011bhotenstv\u00ed<\/li>\n
    • Bakteri\u00e1ln\u00ed meningitida<\/strong> \u2014 jako dopln\u011bk, 0,15 mg\/kg IV ka\u017ed\u00fdch 6 hodin po dobu 2\u20134 dn\u016f<\/li>\n
    • Z\u00e1d\u011brov\u00fd syndrom u d\u011bt\u00ed<\/strong> \u2014 jednor\u00e1zov\u00e1 IM d\u00e1vka 0,6 mg\/kg, pokud peror\u00e1ln\u00ed pod\u00e1n\u00ed nen\u00ed tolerov\u00e1no<\/li>\n
    • Akutn\u00ed exacerbace autoimunitn\u00edho onemocn\u011bn\u00ed<\/strong> \u2014 p\u0159echodn\u00e1 terapie p\u0159ed peror\u00e1ln\u00edmi steroidy<\/li>\n
    • Komprese m\u00edchy<\/strong> u malignit \u2014 vysok\u00e9 d\u00e1vky IV<\/li>\n
    • Hematologick\u00e9 malignity<\/strong> \u2014 slo\u017eky chemoterapie<\/li>\n<\/ul>\n

      D\u00e1vkov\u00e1n\u00ed Dexona injekce<\/h2>\n
        \n
      • Obecn\u00e1 akutn\u00ed d\u00e1vka pro dosp\u011bl\u00e9:<\/strong> 4\u20138 mg IV\/IM ka\u017ed\u00fdch 6\u201312 hodin, upraveno podle odpov\u011bdi<\/li>\n
      • Mozkov\u00fd ed\u00e9m:<\/strong> 10 mg IV \u00favodn\u00ed d\u00e1vka, pot\u00e9 4 mg ka\u017ed\u00fdch 6 hodin; p\u0159echod na peror\u00e1ln\u00ed pod\u00e1n\u00ed po 3\u20135 dnech<\/li>\n
      • Antiemetikum p\u0159i chemoterapii:<\/strong> 8\u201312 mg i.v. p\u0159ed l\u00e9\u010dbou, pokra\u010dovat peror\u00e1ln\u011b po dobu 2\u20134 dn\u016f<\/li>\n
      • Prenat\u00e1ln\u00ed zr\u00e1n\u00ed plic:<\/strong> 6 mg i.m. ka\u017ed\u00fdch 12 hodin po dobu 4 d\u00e1vek<\/li>\n
      • Laryngitida (i.m.):<\/strong> 0,6 mg\/kg jednor\u00e1zov\u00e1 d\u00e1vka<\/li>\n
      • Komprese m\u00edchy:<\/strong> 16 mg i.v. \u00favodn\u00ed d\u00e1vka, pot\u00e9 4 mg ka\u017ed\u00fdch 6 hodin s urgentn\u00edm pl\u00e1nov\u00e1n\u00edm radioterapie\/chirurgick\u00e9ho z\u00e1kroku<\/li>\n<\/ul>\n

        i.v. pod\u00e1n\u00ed: pomal\u00e1 injekce po dobu 1\u20132 minut pro d\u00e1vky do 8 mg; vy\u0161\u0161\u00ed d\u00e1vky na\u0159edit pro infuzi. i.m. pod\u00e1n\u00ed: hlubok\u00e1 intramuskul\u00e1rn\u00ed injekce, st\u0159\u00eddat m\u00edsta vpichu. Roztok lze tak\u00e9 sm\u00edchat s lidokainem pro kloubn\u00ed a m\u011bkkotk\u00e1\u0148ov\u00e9 injekce prov\u00e1d\u011bn\u00e9 specialisty.<\/p>\n

        Potence a ekvivalence kortikosteroid\u016f<\/h2>\n

        R\u016fzn\u00e9 kortikosteroidy se li\u0161\u00ed p\u0159edev\u0161\u00edm v potenci, d\u00e9lce \u00fa\u010dinku a mineralokortikoidn\u00ed (soli zadr\u017euj\u00edc\u00ed) aktivit\u011b. N\u00ed\u017ee uveden\u00e1 tabulka uv\u00e1d\u00ed klinicky u\u017eite\u010dn\u00e9 ekvivalence \u2014 umo\u017e\u0148uje p\u0159ev\u00e9st d\u00e1vku jednoho steroidu na ekvivalentn\u00ed d\u00e1vku jin\u00e9ho.<\/p>\n\n\n\n\n\n\n\n\n\n
        Kortikosteroid<\/th>\nGlukokortikoidn\u00ed potence<\/th>\nEkvivalentn\u00ed d\u00e1vka<\/th>\nMineralokortikoid<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
        Hydrokortizon<\/td>\n1 (referen\u010dn\u00ed)<\/td>\n20 mg<\/td>\nV\u00fdznamn\u00e1<\/td>\n8\u201312 h<\/td>\n<\/tr>\n
        Prednisolon<\/td>\n4<\/td>\n5 mg<\/td>\nN\u00edzk\u00e1<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
        Methylprednisolon<\/td>\n5<\/td>\n4 mg<\/td>\nMinim\u00e1ln\u00ed<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
        Dexamethasone<\/strong><\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n
        Betamethason<\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        Kdo by nem\u011bl dost\u00e1vat injekci Dexona?<\/h2>\n
          \n
        • Syst\u00e9mov\u00e1 pl\u00eds\u0148ov\u00e1 infekce (krom\u011b substitu\u010dn\u00ed terapie p\u0159i adren\u00e1ln\u00ed insuficienci)<\/li>\n
        • \u017div\u00e9 vakc\u00edny b\u011bhem imunosupresivn\u00edch d\u00e1vek (p\u0159ed BCG, MMR, \u017elutou zimnic\u00ed, plan\u00fdmi ne\u0161tovicemi, peror\u00e1ln\u00edm tyfem konzultujte odborn\u00edka)<\/li>\n
        • Aktivn\u00ed nel\u00e9\u010den\u00e1 bakteri\u00e1ln\u00ed infekce (nejprve zahajte antibiotika)<\/li>\n
        • Aktivn\u00ed tuberkul\u00f3za bez kryt\u00ed anti-TB l\u00e9\u010dbou<\/li>\n
        • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na \u00fa\u010dinnou l\u00e1tku nebo jakoukoli pomocnou l\u00e1tku<\/li>\n
        • Pou\u017e\u00edvejte s opatrnost\u00ed u: diabetes mellitus, m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed, hypertenze, osteopor\u00f3zy, peptick\u00e9ho v\u0159edu, psychiatrick\u00fdch poruch, glaukomu, herpes simplex ophthalmicus<\/li>\n
        • T\u011bhotenstv\u00ed: u\u017e\u00edvejte pouze v p\u0159\u00edpad\u011b jasn\u00e9 pot\u0159eby \u2013 prednisolon a hydrokortison pronikaj\u00ed placentou m\u00e9n\u011b ne\u017e dexamethason\/betamethason, kter\u00e9 jsou preferov\u00e1ny, kdy\u017e je zam\u00fd\u0161len \u00fa\u010dinek na plod (nap\u0159. zr\u00e1n\u00ed plic)<\/li>\n<\/ul>\n

          Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f<\/h2>\n

          Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f z\u00e1vis\u00ed na d\u00e1vce a d\u00e9lce pod\u00e1v\u00e1n\u00ed. Kr\u00e1tk\u00e9 k\u00fary (< 2 t\u00fddny) p\u0159i st\u0159edn\u00edch d\u00e1vk\u00e1ch jsou obvykle dob\u0159e sn\u00e1\u0161eny. Del\u0161\u00ed nebo vy\u0161\u0161\u00ed d\u00e1vkov\u00e1n\u00ed vyvol\u00e1v\u00e1 klasick\u00fd \u201cCushingoidn\u00ed\u201d profil.<\/p>\n

          Kr\u00e1tkodob\u00e9 (prvn\u00edch 1\u20132 t\u00fddny):<\/strong><\/p>\n