{"id":56585,"date":"2024-02-27T16:59:58","date_gmt":"2024-02-27T16:59:58","guid":{"rendered":"https:\/\/medsname.com\/dexona-tablet\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"dexona-tablet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/dexona-tablet\/","title":{"rendered":"Tableta Dexona"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je tableta Dexona?<\/h3>\n

Tableta Dexona<\/strong> je dexamethason 0,5 mg peror\u00e1ln\u00ed tableta<\/strong>, siln\u00fd dlouhodob\u011b p\u016fsob\u00edc\u00ed syntetick\u00fd kortikosteroid pou\u017e\u00edvan\u00fd u \u0161irok\u00e9ho spektra z\u00e1n\u011btliv\u00fdch, alergick\u00fdch, autoimunitn\u00edch a malign\u00edch stav\u016f. M\u00e1 25 a\u017e 30kr\u00e1t<\/strong> vy\u0161\u0161\u00ed protiz\u00e1n\u011btlivou \u00fa\u010dinnost ne\u017e hydrokortizon na miligram, \u017e\u00e1dnou mineralokortikoidn\u00ed (soli zadr\u017euj\u00edc\u00ed) aktivitu<\/strong>, a dlouh\u00fd biologick\u00fd polo\u010das (36\u201354 hodin) umo\u017e\u0148uj\u00edc\u00ed jednodenn\u00ed d\u00e1vkov\u00e1n\u00ed. Obvykl\u00e9 d\u00e1vky se pohybuj\u00ed od 0,75 mg do 9 mg denn\u011b<\/strong> v z\u00e1vislosti na indikaci. V\u017edy u\u017e\u00edvat s j\u00eddlem; po dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed nevysazovat n\u00e1hle.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Dexona 0,5 mg<\/strong> je peror\u00e1ln\u00ed tableta obsahuj\u00edc\u00ed dexamethason<\/strong>, syntetick\u00fd dlouhodob\u011b p\u016fsob\u00edc\u00ed glukokortikoid. Dexamethason je na Seznamu z\u00e1kladn\u00edch l\u00e9\u010div WHO a pat\u0159\u00ed mezi nejpou\u017e\u00edvan\u011bj\u0161\u00ed kortikosteroidy v klinick\u00e9 praxi s aplikacemi od mozkov\u00e9ho ed\u00e9mu a antiemetick\u00e9 ochrany b\u011bhem chemoterapie a\u017e po alergick\u00e9 reakce, autoimunitn\u00ed onemocn\u011bn\u00ed a (v\u00fdznamn\u011b od roku 2020) t\u011b\u017ek\u00fd pr\u016fb\u011bh COVID-19.<\/p>\n

Ve srovn\u00e1n\u00ed s hydrokortizonem a prednisolonem m\u00e1 dexamethason t\u0159i charakteristick\u00e9 farmakologick\u00e9 vlastnosti:<\/p>\n

    \n
  • Velmi vysok\u00e1 glukokortikoidn\u00ed \u00fa\u010dinnost<\/strong> \u2014 25\u201330\u00d7 vy\u0161\u0161\u00ed ne\u017e hydrokortizon<\/li>\n
  • \u017d\u00e1dn\u00e1 mineralokortikoidn\u00ed aktivita<\/strong> \u2014 nezp\u016fsobuje zadr\u017eov\u00e1n\u00ed tekutin, nepom\u00e1h\u00e1 p\u0159i adren\u00e1ln\u00ed krizi<\/li>\n
  • Dlouh\u00fd biologick\u00fd polo\u010das (36\u201354 hodin)<\/strong> \u2014 umo\u017e\u0148uje pod\u00e1v\u00e1n\u00ed jednou denn\u011b<\/li>\n<\/ul>\n

    K \u010demu se pou\u017e\u00edv\u00e1 tableta Dexona?<\/h2>\n
      \n
    • Mozkov\u00fd ed\u00e9m<\/strong> u prim\u00e1rn\u00edch nebo metastatick\u00fdch n\u00e1dor\u016f mozku<\/li>\n
    • Antiemetick\u00e1 ochrana<\/strong> b\u011bhem chemoterapie (vysoce \u00fa\u010dinn\u00e1, \u010dasto kombinovan\u00e1 s antagonisty 5-HT3)<\/li>\n
    • T\u011b\u017ek\u00fd pr\u016fb\u011bh COVID-19<\/strong> vy\u017eaduj\u00edc\u00ed kysl\u00edk (studie RECOVERY 2020; 6 mg denn\u011b po dobu a\u017e 10 dn\u00ed)<\/li>\n
    • T\u011b\u017ek\u00e9 akutn\u00ed alergick\u00e9 reakce<\/strong><\/li>\n
    • Autoimunitn\u00ed vzplanut\u00ed<\/strong> \u2014 SLE, revmatoidn\u00ed artritida, vaskulitida, z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed st\u0159ev<\/li>\n
    • Akutn\u00ed t\u011b\u017ek\u00e9 astma<\/strong> a t\u011b\u017ek\u00e9 exacerbace CHOPN (jedin\u00e1 d\u00e1vka 8\u201312 mg je \u00fa\u010dinn\u00e1 na pohotovosti)<\/li>\n
    • Laryngitida<\/strong> u d\u011bt\u00ed \u2014 jednor\u00e1zov\u00e1 peror\u00e1ln\u00ed d\u00e1vka 0,15\u20130,6 mg\/kg<\/li>\n
    • Prenat\u00e1ln\u00ed pou\u017eit\u00ed pro zr\u00e1n\u00ed plic plodu<\/strong> (specializovan\u00e9 porodnick\u00e9 pou\u017eit\u00ed p\u0159i riziku p\u0159ed\u010dasn\u00e9ho porodu)<\/li>\n
    • Hematologick\u00e9 malignity<\/strong> \u2014 sou\u010d\u00e1st chemoterapeutick\u00fdch protokol\u016f (ALL, mnoho\u010detn\u00fd myelom)<\/li>\n
    • Bakteri\u00e1ln\u00ed meningitida<\/strong> \u2014 adjuvantum ke sn\u00ed\u017een\u00ed neurologick\u00fdch n\u00e1sledk\u016f<\/li>\n
    • Dexamethasonov\u00fd supresn\u00ed test<\/strong> \u2014 diagnostick\u00e9 pou\u017eit\u00ed u Cushingova syndromu<\/li>\n<\/ul>\n

      Jak p\u016fsob\u00ed dexamethason?<\/h2>\n

      Dexamethason se vysoce afinitn\u011b v\u00e1\u017ee na intracelul\u00e1rn\u00ed glukokortikoidn\u00ed receptory. Aktivovan\u00fd receptor se translokuje do j\u00e1dra a moduluje transkripci gen\u016f, co\u017e vyvol\u00e1v\u00e1 \u0161irok\u00e9 protiz\u00e1n\u011btliv\u00e9, imunosupresivn\u00ed a metabolick\u00e9 \u00fa\u010dinky. V terapeutick\u00fdch d\u00e1vk\u00e1ch dexamethason potla\u010duje produkci cytokin\u016f, sni\u017euje migraci leukocyt\u016f do tk\u00e1n\u00ed, stabilizuje c\u00e9vn\u00ed permeabilitu a tlum\u00ed z\u00e1n\u011btlivou kask\u00e1du.<\/p>\n

      D\u00e1vkov\u00e1n\u00ed tablet Dexona<\/h2>\n
        \n
      • M\u00edrn\u00e9 z\u00e1n\u011btliv\u00e9 stavy:<\/strong> 0,75\u20133 mg\/den (1,5\u20136 tablet po 0,5 mg)<\/li>\n
      • St\u0159edn\u011b z\u00e1va\u017en\u00e9 stavy:<\/strong> 4\u20136 mg\/den<\/li>\n
      • Z\u00e1va\u017en\u00e9 stavy, mozkov\u00fd ed\u00e9m, antiemetikum p\u0159i chemoterapii:<\/strong> 4\u201316 mg\/den (tablety 4 mg a 8 mg \u2014 Decmax \u2014 jsou v t\u011bchto d\u00e1vk\u00e1ch prakti\u010dt\u011bj\u0161\u00ed)<\/li>\n
      • Laryngitida (d\u011bti):<\/strong> jednor\u00e1zov\u00e1 peror\u00e1ln\u00ed d\u00e1vka 0,15 mg\/kg (a\u017e 0,6 mg\/kg)<\/li>\n
      • U\u017e\u00edvejte s j\u00eddlem<\/strong> ke sn\u00ed\u017een\u00ed \u017ealude\u010dn\u00edho podr\u00e1\u017ed\u011bn\u00ed<\/li>\n
      • Rann\u00ed d\u00e1vka<\/strong> (p\u0159ed 9. hodinou rann\u00ed) napodobuje p\u0159irozen\u00fd kortizolov\u00fd rytmus a sni\u017euje supresi osy HPA<\/li>\n<\/ul>\n

        Potence a ekvivalence kortikosteroid\u016f<\/h2>\n

        R\u016fzn\u00e9 kortikosteroidy se li\u0161\u00ed p\u0159edev\u0161\u00edm v potenci, d\u00e9lce \u00fa\u010dinku a mineralokortikoidn\u00ed (soli zadr\u017euj\u00edc\u00ed) aktivit\u011b. N\u00ed\u017ee uveden\u00e1 tabulka uv\u00e1d\u00ed klinicky u\u017eite\u010dn\u00e9 ekvivalence \u2014 umo\u017e\u0148uje p\u0159ev\u00e9st d\u00e1vku jednoho steroidu na ekvivalentn\u00ed d\u00e1vku jin\u00e9ho.<\/p>\n\n\n\n\n\n\n\n\n\n
        Kortikosteroid<\/th>\nGlukokortikoidn\u00ed potence<\/th>\nEkvivalentn\u00ed d\u00e1vka<\/th>\nMineralokortikoid<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
        Hydrokortizon<\/td>\n1 (referen\u010dn\u00ed)<\/td>\n20 mg<\/td>\nV\u00fdznamn\u00e1<\/td>\n8\u201312 h<\/td>\n<\/tr>\n
        Prednisolon<\/td>\n4<\/td>\n5 mg<\/td>\nN\u00edzk\u00e1<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
        Methylprednisolon<\/td>\n5<\/td>\n4 mg<\/td>\nMinim\u00e1ln\u00ed<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
        Dexamethasone<\/strong><\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n
        Betamethason<\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        Kdo by nem\u011bl u\u017e\u00edvat Dexonu?<\/h2>\n
          \n
        • Syst\u00e9mov\u00e1 pl\u00eds\u0148ov\u00e1 infekce (krom\u011b substitu\u010dn\u00ed terapie p\u0159i adren\u00e1ln\u00ed insuficienci)<\/li>\n
        • \u017div\u00e9 vakc\u00edny b\u011bhem imunosupresivn\u00edch d\u00e1vek (p\u0159ed BCG, MMR, \u017elutou zimnic\u00ed, plan\u00fdmi ne\u0161tovicemi, peror\u00e1ln\u00edm tyfem konzultujte odborn\u00edka)<\/li>\n
        • Aktivn\u00ed nel\u00e9\u010den\u00e1 bakteri\u00e1ln\u00ed infekce (nejprve zahajte antibiotika)<\/li>\n
        • Aktivn\u00ed tuberkul\u00f3za bez kryt\u00ed anti-TB l\u00e9\u010dbou<\/li>\n
        • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na \u00fa\u010dinnou l\u00e1tku nebo jakoukoli pomocnou l\u00e1tku<\/li>\n
        • Pou\u017e\u00edvejte s opatrnost\u00ed u: diabetes mellitus, m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed, hypertenze, osteopor\u00f3zy, peptick\u00e9ho v\u0159edu, psychiatrick\u00fdch poruch, glaukomu, herpes simplex ophthalmicus<\/li>\n
        • T\u011bhotenstv\u00ed: u\u017e\u00edvejte pouze v p\u0159\u00edpad\u011b jasn\u00e9 pot\u0159eby \u2013 prednisolon a hydrokortison pronikaj\u00ed placentou m\u00e9n\u011b ne\u017e dexamethason\/betamethason, kter\u00e9 jsou preferov\u00e1ny, kdy\u017e je zam\u00fd\u0161len \u00fa\u010dinek na plod (nap\u0159. zr\u00e1n\u00ed plic)<\/li>\n<\/ul>\n

          Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f<\/h2>\n

          Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f z\u00e1vis\u00ed na d\u00e1vce a d\u00e9lce pod\u00e1v\u00e1n\u00ed. Kr\u00e1tk\u00e9 k\u00fary (< 2 t\u00fddny) p\u0159i st\u0159edn\u00edch d\u00e1vk\u00e1ch jsou obvykle dob\u0159e sn\u00e1\u0161eny. Del\u0161\u00ed nebo vy\u0161\u0161\u00ed d\u00e1vkov\u00e1n\u00ed vyvol\u00e1v\u00e1 klasick\u00fd \u201cCushingoidn\u00ed\u201d profil.<\/p>\n

          Kr\u00e1tkodob\u00e9 (prvn\u00edch 1\u20132 t\u00fddny):<\/strong><\/p>\n