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Intagesic MR<\/strong> je three-ingredient muscle-relaxant analgesic tablet<\/strong> \u2014 diclofenac 50 mg + paracetamol 325 mg + chlorzoxazone 250 mg<\/strong>. It is formulated for short-term treatment of moderate-to-severe musculoskeletal pain with muscle spasm<\/strong>: acute low back pain, neck pain, muscle strain, and post-traumatic soft-tissue injury. Usual adult dose is one tablet two to three times daily with food<\/strong>, for 3 to 7 days. The triple combination targets pain (paracetamol), inflammation (diclofenac), and muscle spasm (chlorzoxazone) simultaneously.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Intagesic MR<\/strong> is a fixed-dose combination tablet manufactured by Intas Pharmaceuticals. “MR” stands for Muscle Relaxant<\/em> — distinguishing it from the plain Intagesic (diclofenac + paracetamol) variant by the addition of chlorzoxazone<\/strong>, a centrally-acting skeletal muscle relaxant.<\/p>\n The rationale is that most acute non-radicular low back and neck pain involves three pathways: (1) local tissue inflammation, (2) nociceptive pain signalling, and (3) protective muscle spasm that amplifies and sustains the pain cycle. A three-drug tablet addresses all three in one dose:<\/p>\n The three ingredients act on complementary pathways:<\/p>\n Swallow with water after food. Do not lie down immediately after a dose. If you miss a dose, take it when you remember unless the next dose is due within 4 hours — then skip.<\/p>\n GI safety.<\/strong> Intagesic MR (or its NSAID component) carries real risk of gastritis, peptic ulcer, and upper-GI bleeding. Risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also on low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take with food, at the lowest effective dose for the shortest reasonable time, and ask your doctor about adding a proton pump inhibitor (omeprazole, pantoprazole) for courses over 2–4 weeks.<\/p>\n<\/div>\n Paracetamol and the liver.<\/strong> Paracetamol is extremely safe at recommended doses but is the single most common cause of acute liver failure worldwide at higher doses. Do not exceed 4 g (4,000 mg) per day from all sources combined.<\/strong> That is 8 tablets of 500 mg. Be careful not to double-dose by combining branded paracetamol (Calpol, Anacin, Panadol, Crocin, Tylenol) with cold\/flu preparations that often also contain paracetamol. Liver risk rises with regular alcohol use, chronic liver disease, and prolonged fasting — reduce the daily limit to 2 g in those cases.<\/p>\n<\/div>\n Chlorzoxazone hepatotoxicity.<\/strong> Chlorzoxazone has a small but recognised risk of idiosyncratic liver injury — usually in the first 2–4 weeks of therapy. This risk is part of why the muscle-relaxant component of Intagesic MR is a short-term drug. Stop the tablet and seek medical advice if you develop yellow skin\/eyes, dark urine, unexplained nausea, or right-upper-abdominal pain during or just after a course.<\/p>\n<\/div>\n MedsBase offers worldwide shipping on every order. Orders are dispatched in discreet packaging and arrive in branded manufacturer packs. If your preferred pack size is out of stock, contact customer support for an ETA.<\/p>\n Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. Talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, liver disease, or are pregnant.<\/p>\n<\/div>\n Intagesic MR is used for acute musculoskeletal pain with muscle spasm — low back pain, neck pain, torticollis, muscle strain, whiplash, and post-traumatic soft-tissue injury.<\/p>\n Acute musculoskeletal pain involves inflammation, pain signalling, and muscle spasm all at once. The three ingredients address each pathway: diclofenac (inflammation), paracetamol (pain perception), and chlorzoxazone (muscle spasm). One tablet covers what would otherwise be three separate medicines.<\/p>\n Yes — the chlorzoxazone component can cause drowsiness, dizziness, and slowed reaction time. Do not drive or operate machinery until you know how you respond.<\/p>\n Short courses of 3 to 7 days are typical. Do not use for longer than 2 weeks without medical review — both the NSAID and the muscle relaxant are short-term medications.<\/p>\n Only with care. Each tablet already contains 325 mg paracetamol. Combining Intagesic MR with Panadol, Crocin, Calpol, Anacin, or cold\/flu remedies can push your daily paracetamol dose above the 4 g safety ceiling. Check every label.<\/p>\n No. The diclofenac component already provides NSAID coverage. Adding another NSAID sharply increases GI bleed and kidney injury risk.<\/p>\n Avoid alcohol. It increases drowsiness (chlorzoxazone), raises liver risk (paracetamol and chlorzoxazone), and worsens GI bleed risk (diclofenac).<\/p>\n A metabolite of chlorzoxazone can give urine a harmless orange or red-tinged colour. This is not blood and resolves within a day or two of stopping the tablet.<\/p>\n No — the diclofenac component is avoided after 20 weeks and contraindicated in the third trimester. Chlorzoxazone data in pregnancy are limited. Paracetamol alone is the first-line pain medicine in pregnancy.<\/p>\n No — the triple combination is for adults. Paediatric dosing would need individual component titration, not a fixed-combination tablet.<\/p>\n Take it when you remember, unless the next dose is due within 4 hours — then skip. Never double up.<\/p>\n <\/p>\n Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n \u2705 Fast Pain Relief Intagesic MR contains Diclofenac, Paracetamol, and Chlorzoxazone.<\/p>","protected":false},"featured_media":56630,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3555],"product_tag":[4134,4128,4135,4136],"class_list":{"0":"post-56629","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-pain-relief-medication","9":"product_tag-chlorzoxazone","10":"product_tag-diclofenac","11":"product_tag-intagesic-mr","12":"product_tag-paracetamol","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56629"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56630"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56629"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56629"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56629"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
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What Is Intagesic MR Used For?<\/h2>\n
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How Does Intagesic MR Work?<\/h2>\n
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Intagesic MR Dosing<\/h2>\n
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Who Should Not Take Intagesic MR?<\/h2>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Objedn\u00e1vky a dod\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
What is Intagesic MR used for?<\/h3>\n
Why does Intagesic MR have three ingredients?<\/h3>\n
Does Intagesic MR cause drowsiness?<\/h3>\n
How long can I take Intagesic MR?<\/h3>\n
Can I take additional paracetamol with Intagesic MR?<\/h3>\n
Can I take Intagesic MR with ibuprofen or another NSAID?<\/h3>\n
Can I drink alcohol on Intagesic MR?<\/h3>\n
Why is my urine orange?<\/h3>\n
Is Intagesic MR safe in pregnancy?<\/h3>\n
Can children take Intagesic MR?<\/h3>\n
What if I miss a dose of Intagesic MR?<\/h3>\n
Souvisej\u00edc\u00ed alternativy<\/h3>\n
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\n\u2705 Muscle Relaxation
\n\u2705 Sni\u017euje z\u00e1n\u011bt
\n\u2705 Effective for Fever
\n\u2705 Triple Action Formula<\/p>\n