<\/p>\n
Dompewal<\/strong> je tableta s obsahem domperidonu 10 mg \u2014 perifern\u00ed antagonista receptoru D2 pou\u017e\u00edvan\u00fd kr\u00e1tkodob\u011b p\u0159i nevolnosti, zvracen\u00ed a gastroparezi<\/strong>. Zrychluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku, zvy\u0161uje tonus doln\u00edho j\u00edcnov\u00e9ho sv\u011bra\u010de a blokuje receptory D2 v oblasti spou\u0161t\u011b\u010de chemoreceptor\u016f. Na rozd\u00edl od metoklopramidu nep\u0159ekon\u00e1v\u00e1 v v\u00fdznamn\u00e9 m\u00ed\u0159e hematoencefalickou bari\u00e9ru, a nezp\u016fsobuje tedy extrapyramidov\u00e9 p\u0159\u00edznaky. Standardn\u00ed d\u00e1vka: 10 mg a\u017e t\u0159ikr\u00e1t denn\u011b, u\u017e\u00edvan\u00e9 15\u201330 minut p\u0159ed j\u00eddlem<\/strong>, maxim\u00e1ln\u011b po dobu 7 dn\u016f v maxim\u00e1ln\u00ed d\u00e1vce 30 mg\/den podle omezen\u00ed EMA z roku 2014. V\u00fdrobce certifikovan\u00fd WHO-GMP.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Dompewal je dod\u00e1v\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me bez dal\u0161\u00edch n\u00e1klad\u016f. Domperidon je \u0161iroce pou\u017e\u00edv\u00e1n pro kr\u00e1tkodobou \u00falevu od p\u0159\u00edznak\u016f a je u\u017eite\u010dnou alternativou k metoklopramidu u pacient\u016f, kte\u0159\u00ed na n\u011bj maj\u00ed extrapyramidov\u00e9 \u00fa\u010dinky.<\/p>\n Domperidon je deriv\u00e1t benzimidazolu, kter\u00fd selektivn\u011b blokuje dopaminov\u00e9 D2 receptory ve st\u011bn\u011b tr\u00e1vic\u00edho traktu (\u017ealude\u010dn\u00ed antrum a dvan\u00e1ctn\u00edk) a v chemorecep\u010dn\u00ed spou\u0161t\u011bc\u00ed z\u00f3n\u011b (CTZ) oblasti postremy, kter\u00e1 le\u017e\u00ed mimo hematoencefalickou bari\u00e9ru. Perifern\u00ed blok\u00e1da D2 receptor\u016f zvy\u0161uje uvol\u0148ov\u00e1n\u00ed acetylcholinu z cholinergn\u00edch neuron\u016f v myenterick\u00e9m plexu, \u010d\u00edm\u017e urychluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku a zvy\u0161uje tonus doln\u00edho j\u00edcnov\u00e9ho sv\u011bra\u010de. Blok\u00e1da CTZ m\u00e1 antiemetick\u00fd \u00fa\u010dinek. Proto\u017ee molekula \u0161patn\u011b pronik\u00e1 hematoencefalickou bari\u00e9rou, centr\u00e1ln\u00ed blok\u00e1da D2 receptor\u016f a s n\u00ed spojen\u00e9 extrapyramidov\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky jsou minim\u00e1ln\u00ed.<\/p>\n Dosp\u011bl\u00ed: 10 mg a\u017e t\u0159ikr\u00e1t denn\u011b, 15\u201330 minut p\u0159ed j\u00eddlem. Maxim\u00e1ln\u011b 30 mg\/den. Maxim\u00e1ln\u011b 7 dn\u00ed. D\u011bti > 12 let a > 35 kg: stejn\u011b jako dosp\u011bl\u00ed. D\u011bti < 35 kg: d\u00e1vkov\u00e1n\u00ed podle hmotnosti 250 mcg\/kg a\u017e 3kr\u00e1t denn\u011b, max. 750 mcg\/kg\/den. T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater: vyvarujte se. CrCl < 30: nen\u00ed kontraindikov\u00e1no, ale prodlu\u017ete interval.<\/p>\n 15\u201330 minut p\u0159ed j\u00eddlem nala\u010dno. J\u00eddlo zpomaluje vst\u0159eb\u00e1v\u00e1n\u00ed a oslabuje prokinetick\u00fd \u00fa\u010dinek.<\/p>\n Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed vy\u017eaduje dohled specialisty se z\u00e1kladn\u00edm a pravideln\u00fdm EKG. Pravidlo EMA pro kr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed plat\u00ed pro p\u0159edepisov\u00e1n\u00ed v b\u011b\u017en\u00e9 praxi; v\u00fdjimka pro specialisty je povolena, pokud p\u0159\u00ednosy p\u0159eva\u017euj\u00ed a je zaji\u0161t\u011bno monitorov\u00e1n\u00ed.<\/p>\n Oba jsou antagonisty D2 a prokinetika. Metoklopramid pronik\u00e1 hematoencefalickou bari\u00e9rou a m\u016f\u017ee zp\u016fsobit extrapyramidov\u00e9 p\u0159\u00edznaky (akutn\u00ed dystonie, tardivn\u00ed dyskineze \u2014 FDA black-box) a m\u00e1 vlastn\u00ed 12t\u00fddenn\u00ed limit. Domperidon m\u00e1 minim\u00e1ln\u00ed penetraci do CNS, ale jasn\u011bj\u0161\u00ed kardi\u00e1ln\u00ed (QT) sign\u00e1l a 7denn\u00ed pravidlo.<\/p>\n Domperidon zvy\u0161uje prolaktin blok\u00e1dou D2 v hypof\u00fdze. Toto je reverzibiln\u00ed po vysazen\u00ed. P\u0159etrv\u00e1vaj\u00edc\u00ed p\u0159\u00edznaky vy\u017eaduj\u00ed kontrolu s\u00e9rov\u00e9ho prolaktinu a p\u0159ehodnocen\u00ed.<\/p>\n Omezen\u00e9 \u00fadaje u lid\u00ed. Vyvarujte se, pokud l\u00e9ka\u0159 nerozhodne, \u017ee p\u0159\u00ednosy p\u0159eva\u017euj\u00ed. Kojen\u00ed: mal\u00e9 mno\u017estv\u00ed p\u0159ech\u00e1z\u00ed do mate\u0159sk\u00e9ho ml\u00e9ka; n\u011bkdy se pou\u017e\u00edv\u00e1 off-label ke zv\u00fd\u0161en\u00ed laktace, ale doporu\u010duje se konzultace se specialistou.<\/p>\n Informujte p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e o v\u0161ech l\u00e9c\u00edch, kter\u00e9 u\u017e\u00edv\u00e1te, zejm\u00e9na antibiotik\u00e1ch (azithro\/clari), antimykotik\u00e1ch (keto\/itra), antidepresivech (citalopram), antimalarik\u00e1ch (chloroquine) a methadonu. Prodlou\u017een\u00ed QT intervalu domperidonem se s\u010d\u00edt\u00e1 s t\u011bmito l\u00e9ky.<\/p>\n Farmakovigilan\u010dn\u00ed sign\u00e1l n\u00e1hl\u00e9ho srde\u010dn\u00edho \u00famrt\u00ed spojen\u00fd s vysok\u00fdmi d\u00e1vkami a dlouhodob\u00fdm u\u017e\u00edv\u00e1n\u00edm, zejm\u00e9na u star\u0161\u00edch dosp\u011bl\u00fdch. Sedmidenn\u00ed limit vyva\u017euje \u00falevu od p\u0159\u00edznak\u016f proti riziku arytmie.<\/p>\n Vyvarujte se. I perifern\u00ed blok\u00e1da D2 m\u016f\u017ee zhor\u0161it motorick\u00e9 p\u0159\u00edznaky u citliv\u00fdch pacient\u016f. Proberte alternativy s neurologem.<\/p>\n Pod 30 \u00b0C chra\u0148te p\u0159ed vlhkost\u00ed. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n U\u017e\u00edvejte p\u0159ed dal\u0161\u00edm j\u00eddlem, pot\u00e9 pokra\u010dujte podle pl\u00e1nu. Neduplikujte d\u00e1vky.<\/p>\n <\/p>\n Dompewal tableta (Domperidon 10 mg) \u2014 perifern\u00ed antagonista dopaminu D2 pro kr\u00e1tkodobou l\u00e9\u010dbu nevolnosti, zvracen\u00ed, regurgitace a gastropareze. Zrychluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku.<\/p>","protected":false},"featured_media":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342,3543],"product_tag":[3609,4137],"class_list":{"0":"post-56643","1":"product","2":"type-product","3":"status-publish","5":"product_cat-category-overview","6":"product_cat-gastro-health","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-domperidone","10":"product_tag-dompewal-tablet","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56643"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56643"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56643"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56643"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Mechanismus \u00fa\u010dinku<\/h2>\n
Indikace<\/h2>\n
\n
D\u00e1vka<\/h2>\n
Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
\n
Interakce l\u00e9k\u016f<\/h2>\n
\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Kdy m\u00e1m u\u017e\u00edvat Dompewal?<\/h3>\n
Mohu to u\u017e\u00edvat p\u0159i chronick\u00e9 gastroparezi?<\/h3>\n
Jak\u00fd je rozd\u00edl mezi domperidonem a metoklopramidem?<\/h3>\n
Pro\u010d m\u00e1m na tomto l\u00e9ku citlivost prsou?<\/h3>\n
Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n
Mohu to u\u017e\u00edvat se sv\u00fdmi l\u00e9ky na srdce?<\/h3>\n
Pro\u010d EMA omezuje u\u017e\u00edv\u00e1n\u00ed na 7 dn\u00ed?<\/h3>\n
Co kdy\u017e m\u00e1m Parkinsonovu chorobu?<\/h3>\n
Skladov\u00e1n\u00ed<\/h3>\n
Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n
Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n
\n