<\/p>\n
Dompewal<\/strong> is an oral domperidone 10 mg tablet — a peripheral dopamine D2 receptor antagonist used short-term for nausea, vomiting, and gastroparesis<\/strong>. It accelerates gastric emptying, increases lower-oesophageal sphincter tone, and antagonises D2 receptors in the chemoreceptor trigger zone. Unlike metoclopramide it does not cross the blood-brain barrier in significant amounts and so does not produce extrapyramidal symptoms. Standard dose: 10 mg up to three times daily, taken 15–30 minutes before meals<\/strong>, for a maximum of 7 days at a maximum of 30 mg\/day per EMA 2014 restriction. WHO-GMP certified manufacturer.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Dompewal is supplied from a v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> — if it does not arrive within 20 business days, we reship at no cost. Domperidone is widely used for short-term symptom relief and is a useful alternative to metoclopramide in patients who experience extrapyramidal effects on the latter.<\/p>\n Domperidone is a benzimidazole derivative that selectively blocks dopamine D2 receptors in the gut wall (gastric antrum and duodenum) and in the chemoreceptor trigger zone (CTZ) of the area postrema, which lies outside the blood-brain barrier. Peripheral D2 blockade increases acetylcholine release from cholinergic neurons in the myenteric plexus, accelerating gastric emptying and tightening LES tone. CTZ blockade produces antiemetic effect. Because the molecule has poor BBB penetration, central D2 blockade and the resulting extrapyramidal side effects are minimal.<\/p>\n Adults: 10 mg up to three times daily, 15–30 minutes before meals. Maximum 30 mg\/day. Maximum 7 days. Children > 12 years and > 35 kg: same as adult. Children < 35 kg: weight-based 250 mcg\/kg up to 3 times daily, max 750 mcg\/kg\/day. Severe hepatic impairment: avoid. CrCl < 30: not contraindicated but extend interval.<\/p>\n 15–30 minutes before meals on an empty stomach. Food delays absorption and weakens the prokinetic effect.<\/p>\n Long-term use needs specialist supervision with baseline and periodic ECG. The EMA short-course rule applies to general practice prescribing; specialist exemption is allowed when benefits outweigh and monitoring is in place.<\/p>\n Both are D2 antagonists and prokinetics. Metoclopramide crosses the BBB and can cause extrapyramidal symptoms (acute dystonia, tardive dyskinesia — FDA black-box) and has its own 12-week limit. Domperidone has minimal CNS penetration but a clearer cardiac (QT) signal and a 7-day rule.<\/p>\n Domperidone raises prolactin via pituitary D2 blockade. This is reversible on discontinuation. Persistent symptoms warrant a serum prolactin check and review.<\/p>\n Limited human data. Avoid unless the prescriber decides benefits outweigh. Breastfeeding: small amounts in breast milk; sometimes used off-label to enhance lactation but specialist input is recommended.<\/p>\n Tell the prescriber about every drug you take, especially antibiotics (azithro\/clari), antifungals (keto\/itra), antidepressants (citalopram), antimalarials (chloroquine), and methadone. Domperidone QT-prolongation stacks with these.<\/p>\n Pharmacovigilance signal of sudden cardiac death linked to high doses and long courses, particularly in older adults. The 7-day cap balances symptom relief against arrhythmia risk.<\/p>\n Avoid. Even peripheral D2 blockade can worsen motor symptoms in vulnerable patients. Discuss alternatives with neurology.<\/p>\n Pod 30 \u00b0C chra\u0148te p\u0159ed vlhkost\u00ed. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n Take it before the next meal, then continue the schedule. Do not double up.<\/p>\n <\/p>\n Dompewal Tablet (Domperidone 10 mg) \u2014 peripheral dopamine D2 antagonist for short-term nausea, vomiting, regurgitation, and gastroparesis. Speeds gastric emptying.<\/p>","protected":false},"featured_media":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342,3543],"product_tag":[3609,4137],"class_list":{"0":"post-56643","1":"product","2":"type-product","3":"status-publish","5":"product_cat-category-overview","6":"product_cat-gastro-health","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-domperidone","10":"product_tag-dompewal-tablet","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56643"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56643"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56643"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56643"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Mechanismus \u00fa\u010dinku<\/h2>\n
Indikace<\/h2>\n
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D\u00e1vka<\/h2>\n
Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce l\u00e9k\u016f<\/h2>\n
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\u010casto kladen\u00e9 dotazy<\/h2>\n
When should I take Dompewal?<\/h3>\n
Can I take it for chronic gastroparesis?<\/h3>\n
What is the difference between domperidone and metoclopramide?<\/h3>\n
Why do I have breast tenderness on this drug?<\/h3>\n
Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n
Can I take it with my heart medication?<\/h3>\n
Why does the EMA limit it to 7 days?<\/h3>\n
What if I have Parkinson’s?<\/h3>\n
Skladov\u00e1n\u00ed<\/h3>\n
Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n
Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n
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