{"id":56683,"date":"2024-02-27T17:03:35","date_gmt":"2024-02-27T17:03:35","guid":{"rendered":"https:\/\/medsname.com\/duvanta\/"},"modified":"2026-04-30T10:24:36","modified_gmt":"2026-04-30T10:24:36","slug":"duvanta","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/duvanta\/","title":{"rendered":"Duvanta"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Duvanta (Duloxetin 20\/30\/40\/60 mg) je inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed serotoninu a noradrenalinu pou\u017e\u00edvan\u00fd k l\u00e9\u010db\u011b velk\u00e9 deprese, generalizovan\u00e9 \u00fazkosti, diabetick\u00e9 perifern\u00ed neuropatie, fibromyalgie a chronick\u00e9 muskuloskelet\u00e1ln\u00ed bolesti. Zvl\u00e1\u0161t\u011b \u00fa\u010dinn\u00fd, kdy\u017e je deprese spojena s chronickou bolest\u00ed.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Duvanta na MedsBase je dod\u00e1v\u00e1na p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Duvanta a jak funguje<\/h2>\n

Duvanta je 20\/30\/40\/60 mg tobolka s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm duloxetinu dod\u00e1van\u00e1 spole\u010dnost\u00ed Intas. Duloxetin je vyv\u00e1\u017een\u00fd inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed serotoninu (5-HT) i noradrenalinu (NA) na jejich presynaptick\u00fdch transport\u00e9rech. Tento du\u00e1ln\u00ed mechanismus \u00fa\u010dinku je d\u016fvodem jeho efektivity jak na n\u00e1ladu, tak na bolest.<\/p>\n

Terapeutick\u00fd \u00fa\u010dinek na n\u00e1ladu a \u00fazkost se rozv\u00edj\u00ed b\u011bhem 4\u20136 t\u00fddn\u016f; analgetick\u00e9 \u00fa\u010dinky na neuropatickou a muskuloskelet\u00e1ln\u00ed bolest se \u010dasto objevuj\u00ed do 1\u20132 t\u00fddn\u016f p\u0159i stejn\u00e9 d\u00e1vce.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Hlavn\u00ed deprese<\/td>\n30 mg 1\u00d7 denn\u011b po dobu 1 t\u00fddne<\/td>\n60 mg 1\u00d7 denn\u011b<\/td>\n120 mg (rozd\u011bleno 2\u00d7 denn\u011b)<\/td>\n<\/tr>\n
Generalizovan\u00e1 \u00fazkost<\/td>\n30 mg 1\u00d7 denn\u011b po dobu 1 t\u00fddne<\/td>\n60 mg 1\u00d7 denn\u011b<\/td>\n120 mg<\/td>\n<\/tr>\n
Diabetick\u00e1 perifern\u00ed neuropatie<\/td>\n30 mg 1\u00d7 denn\u011b po dobu 1 t\u00fddne<\/td>\n60 mg 1\u00d7 denn\u011b<\/td>\n60 mg<\/td>\n<\/tr>\n
Fibromyalgie<\/td>\n30 mg 1\u00d7 denn\u011b po dobu 1 t\u00fddne<\/td>\n60 mg 1\u00d7 denn\u011b<\/td>\n60 mg<\/td>\n<\/tr>\n
Chronick\u00e1 muskuloskelet\u00e1ln\u00ed bolest<\/td>\n30 mg 1\u00d7 denn\u011b po dobu 1 t\u00fddne<\/td>\n60 mg 1\u00d7 denn\u011b<\/td>\n60 mg<\/td>\n<\/tr>\n
Stresov\u00e1 inkontinence mo\u010di (mimo schv\u00e1len\u00e9 indikace, EU)<\/td>\n20 mg 2\u00d7 denn\u011b<\/td>\n40 mg 2\u00d7 denn\u011b<\/td>\n40 mg 2\u00d7 denn\u011b<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nJatern\u00ed posti\u017een\u00ed \u2014 vyvarujte se u pacient\u016f s v\u00fdznamnou konzumac\u00ed alkoholu nebo jatern\u00ed nedostate\u010dnost\u00ed<\/strong><\/p>\n

Duloxetin m\u00e1 z\u00e1kladn\u00ed hepatotoxicitu, kter\u00e1 se st\u00e1v\u00e1 klinicky v\u00fdznamnou u pacient\u016f s v\u00fdznamn\u00fdm p\u0159\u00edjmem alkoholu (\u22653 drinky\/den) nebo chronick\u00fdm jatern\u00edm onemocn\u011bn\u00edm. Vyvarujte se pod\u00e1v\u00e1n\u00ed u jak\u00e9hokoli klinicky v\u00fdznamn\u00e9ho jatern\u00edho posti\u017een\u00ed.<\/strong> Zkontrolujte z\u00e1kladn\u00ed jatern\u00ed testy u star\u0161\u00edch dosp\u011bl\u00fdch a pacient\u016f u\u017e\u00edvaj\u00edc\u00edch v\u00edce hepat\u00e1ln\u011b metabolizovan\u00fdch l\u00e9k\u016f.<\/p>\n<\/div>\n

\nKrevn\u00ed tlak<\/strong><\/p>\n

Duloxetin zp\u016fsobuje m\u00edrn\u00fd, ale re\u00e1ln\u00fd vzestup krevn\u00edho tlaku \u2014 pr\u016fm\u011brn\u011b +2\u20133 mmHg systolick\u00e9ho tlaku p\u0159i terapeutick\u00fdch d\u00e1vk\u00e1ch. M\u00e9n\u011b ne\u017e venlafaxin, ale dostate\u010dn\u011b v\u00fdznamn\u00fd u \u0161patn\u011b kompenzovan\u00e9 hypertenze. Kontrolujte krevn\u00ed tlak na za\u010d\u00e1tku, po 2 t\u00fddnech a p\u0159i ka\u017ed\u00e9m zv\u00fd\u0161en\u00ed d\u00e1vky.<\/p>\n<\/div>\n

\nSyndrom z vysazen\u00ed<\/strong><\/p>\n

Duloxetin m\u00e1 kr\u00e1tk\u00fd elimina\u010dn\u00ed polo\u010das (12 hodin) \u2014 n\u00e1hl\u00e9 vysazen\u00ed m\u016f\u017ee do 24\u201372 hodin vyvolat z\u00e1vrat\u011b, parestezie (\u201celektrick\u00e9 \u0161oky\u201d), nevolnost, bolest hlavy a dysforii. V\u017edy sni\u017eujte d\u00e1vku postupn\u011b po dobu minim\u00e1ln\u011b 2\u20134 t\u00fddn\u016f. Nejni\u017e\u0161\u00ed dostupn\u00e1 s\u00edla kapsl\u00ed (20 mg nebo 30 mg, dle trhu) ur\u010duje spodn\u00ed hranici postupn\u00e9ho vysazen\u00ed \u2014 v klinick\u00e9 praxi se n\u011bkdy pro posledn\u00ed krok pou\u017e\u00edv\u00e1 vysyp\u00e1n\u00ed obsahu kapsl\u00ed.<\/p>\n<\/div>\n

\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u osob do 25 let)<\/strong><\/p>\n

V\u0161echna antidepresiva nesou \u010dern\u00e9 varov\u00e1n\u00ed FDA ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika sebevra\u017eedn\u00fdch my\u0161lenek u pacient\u016f mlad\u0161\u00edch 25 let.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n