{"id":56784,"date":"2024-02-27T17:07:36","date_gmt":"2024-02-27T17:07:36","guid":{"rendered":"https:\/\/medsname.com\/donemax\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"donemax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/donemax\/","title":{"rendered":"Donemax"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Donemax?<\/h3>\n<p style=\"margin:0;\"><strong>Donemax<\/strong> je peror\u00e1ln\u00ed tableta od Sun Pharma obsahuj\u00edc\u00ed <strong>donepezil<\/strong> \u2014 reverzibiln\u00ed <strong>inhibitor acetylcholinester\u00e1zy (AChE)<\/strong> pou\u017e\u00edvan\u00fd k symptomatick\u00e9 l\u00e9\u010db\u011b <strong>m\u00edrn\u00e9, st\u0159edn\u011b t\u011b\u017ek\u00e9 a t\u011b\u017ek\u00e9 Alzheimerovy choroby<\/strong>. K dispozici v <strong>10 mg<\/strong>. Standardn\u00ed udr\u017eovac\u00ed d\u00e1vka pro st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou Alzheimerovu chorobu. V\u017edy za\u010dn\u011bte s 5 mg\/den po dobu prvn\u00edch 4\u20136 t\u00fddn\u016f p\u0159ed zv\u00fd\u0161en\u00edm d\u00e1vky. Donepezil <strong>nezastavuje progresi onemocn\u011bn\u00ed<\/strong> \u2014 zlep\u0161uje kognitivn\u00ed p\u0159\u00edznaky (pam\u011b\u0165, pozornost, denn\u00ed fungov\u00e1n\u00ed) po dobu l\u00e9\u010dby. Nej\u010dast\u011bj\u0161\u00ed vedlej\u0161\u00ed \u00fa\u010dinky jsou gastrointestin\u00e1ln\u00ed (nevolnost, pr\u016fjem, anorexie), \u017eiv\u00e9 sny a bradykardie. <strong>Nikdy nevysazujte n\u00e1hle<\/strong> \u2014 vysazen\u00ed m\u016f\u017ee zp\u016fsobit rychl\u00fd kognitivn\u00ed \u00fapadek, kter\u00fd se po op\u011btovn\u00e9m nasazen\u00ed ne v\u017edy obnov\u00ed.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Co je Donemax?<\/h2>\n<p>Donemax je peror\u00e1ln\u00ed tableta od Sun Pharma obsahuj\u00edc\u00ed <strong>donepezil hydrochlorid<\/strong>. Donepezil je dlouhodob\u011b p\u016fsob\u00edc\u00ed, selektivn\u00ed, reverzibiln\u00ed inhibitor <strong>acetylcholinester\u00e1zy<\/strong> \u2014 enzymu, kter\u00fd odbour\u00e1v\u00e1 acetylcholin v mozku. Blokov\u00e1n\u00edm tohoto enzymu donepezil zvy\u0161uje hladinu synaptick\u00e9ho acetylcholinu a \u010d\u00e1ste\u010dn\u011b kompenzuje ztr\u00e1tu cholinergn\u00edch neuron\u016f, kter\u00e1 zp\u016fsobuje p\u0159\u00edznaky poruchy pam\u011bti a pozornosti u Alzheimerovy choroby.<\/p>\n<p>Donemax je cenov\u011b v\u00fdhodn\u00e1 tableta s 10 mg donepezilu od Sun Pharma \u2014 standardn\u00ed udr\u017eovac\u00ed d\u00e1vka pro st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou Alzheimerovu chorobu. L\u00e9\u010dba za\u010d\u00edn\u00e1 titra\u010dn\u00ed d\u00e1vkou 5 mg po dobu prvn\u00edch 4\u20136 t\u00fddn\u016f, pot\u00e9 se p\u0159ech\u00e1z\u00ed na Donemax 10 mg. Donepezil je celosv\u011btov\u011b nejp\u0159edepisovan\u011bj\u0161\u00edm l\u00e9kem na Alzheimerovu chorobu a jedin\u00fdm inhibitorem AChE schv\u00e1len\u00fdm pro v\u0161echny stupn\u011b z\u00e1va\u017enosti (m\u00edrn\u00e1, st\u0159edn\u011b t\u011b\u017ek\u00e1, t\u011b\u017ek\u00e1). <em>a<\/em> t\u011b\u017ek\u00e9 onemocn\u011bn\u00ed). Jedn\u00e1 se o symptomatickou terapii \u2014 nezpomaluje podkladovou neurodegeneraci, ale po dobu l\u00e9\u010dby p\u0159in\u00e1\u0161\u00ed m\u011b\u0159iteln\u00e9 zlep\u0161en\u00ed pam\u011bti, pozornosti, denn\u00edho fungov\u00e1n\u00ed a chov\u00e1n\u00ed, typicky z\u00edsk\u00e1v\u00e1 6\u201312 m\u011bs\u00edc\u016f kognitivn\u00ed funkce ve srovn\u00e1n\u00ed s nel\u00e9\u010den\u00edm.<\/p>\n<h2 class=\"wp-block-heading\">Donemax je<\/h2>\n<p>Alzheimerova choroba je charakterizov\u00e1na progresivn\u00ed ztr\u00e1tou cholinergn\u00edch neuron\u016f v baz\u00e1ln\u00edm p\u0159edn\u00edm mozku (nucleus basalis Meynert) \u2014 co\u017e zp\u016fsobuje v\u00fdrazn\u00fd deficit acetylcholinu v k\u016f\u0159e a hipokampu. Tento cholinergn\u00ed deficit vysv\u011btluje mnoho kognitivn\u00edch, pozornostn\u00edch a pam\u011b\u0165ov\u00fdch p\u0159\u00edznak\u016f.<\/p>\n<ul>\n<li><strong>Inhibice acetylcholinester\u00e1zy<\/strong> \u2014 donepezil reverzibiln\u011b blokuje enzym, kter\u00fd degraduje synaptick\u00fd acetylcholin, \u010d\u00edm\u017e zvy\u0161uje hladiny ACh na zb\u00fdvaj\u00edc\u00edch cholinergn\u00edch synaps\u00edch.<\/li>\n<li><strong>Selektivita pro kortex a hipokampus<\/strong> \u2014 donepezil se v\u00e1\u017ee preferen\u010dn\u011b na mozkovou AChE sp\u00ed\u0161e ne\u017e na perifern\u00ed cholinester\u00e1zu, co\u017e mu d\u00e1v\u00e1 \u010dist\u0161\u00ed profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f ne\u017e star\u0161\u00ed l\u00e1tky jako fyzostigmin.<\/li>\n<li><strong>Dlouh\u00fd polo\u010das (~70 hodin)<\/strong> \u2014 umo\u017e\u0148uje jednodenn\u00ed d\u00e1vkov\u00e1n\u00ed a poskytuje stabiln\u00ed zv\u00fd\u0161en\u00ed hladiny ACh v ust\u00e1len\u00e9m stavu, co\u017e je dob\u0159e tolerov\u00e1no.<\/li>\n<\/ul>\n<p>N\u00e1stup kognitivn\u00edho p\u0159\u00ednosu: viditeln\u00fd p\u0159i <strong>6\u201312 t\u00fddn\u016f<\/strong>; vrchol po 6 m\u011bs\u00edc\u00edch. P\u0159\u00ednos p\u0159etrv\u00e1v\u00e1 tak dlouho, jak je l\u00e9k u\u017e\u00edv\u00e1n \u2014 po vysazen\u00ed se kognitivn\u00ed funkce vrac\u00ed na (nebo pod) \u00farove\u0148, kter\u00e1 by byla bez l\u00e9\u010dby, \u010dasto b\u011bhem t\u00fddn\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>M\u00edrn\u00e1 demence u Alzheimerovy choroby<\/strong> \u2014 inhibitor cholinester\u00e1zy prvn\u00ed volby<\/li>\n<li><strong>St\u0159edn\u011b pokro\u010dil\u00e1 demence u Alzheimerovy choroby<\/strong> \u2014 prvn\u00ed volba, \u010dasto v kombinaci s memantinem<\/li>\n<li><strong>T\u011b\u017ek\u00e1 Alzheimerova demence<\/strong> \u2014 donepezil je jedn\u00edm z m\u00e1la inhibitor\u016f cholinester\u00e1zy schv\u00e1len\u00fdch v t\u00e9to f\u00e1zi; obvykle v kombinaci s memantinem<\/li>\n<li><strong>Demence s Lewyho t\u011bl\u00edsky<\/strong> \u2014 mimo schv\u00e1lenou indikaci, \u010dasto nejv\u00edce cholinergn\u011b reaguj\u00edc\u00ed z demenc\u00ed<\/li>\n<li><strong>Parkinsonova demence<\/strong> \u2014 mimo schv\u00e1lenou indikaci (rivastigmin m\u00e1 schv\u00e1lenou indikaci)<\/li>\n<li><strong>Vaskul\u00e1rn\u00ed demence (sm\u00ed\u0161en\u00fd typ)<\/strong> \u2014 mimor\u00e1mcov\u00fd m\u00edrn\u00fd p\u0159\u00ednos<\/li>\n<\/ul>\n<p>D\u00e1vkov\u00e1n\u00ed Donemaxu a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed <strong>ne<\/strong> je chorobu modifikuj\u00edc\u00ed terapie a nen\u00ed \u00fa\u010dinn\u00e1 pro: m\u00edrn\u00e9 kognitivn\u00ed posti\u017een\u00ed bez demence, frontotempor\u00e1ln\u00ed demenci (\u010dasto zhor\u0161uje behavior\u00e1ln\u00ed p\u0159\u00edznaky), norm\u00e1ln\u00ed v\u011bkem podm\u00edn\u011bn\u00e9 zapom\u00edn\u00e1n\u00ed nebo jako kognitivn\u00ed enhancer u zdrav\u00fdch dosp\u011bl\u00fdch.<\/p>\n<h2 class=\"wp-block-heading\">Donemax D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017eit\u00ed<\/h2>\n<p>Donemax je k dispozici <strong>10 mg<\/strong>. Standardn\u00ed d\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9:<\/p>\n<ul>\n<li><strong>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka:<\/strong> 5 mg jednou denn\u011b po dobu prvn\u00edch 4\u20136 t\u00fddn\u016f. Toto je povinn\u00e9 \u2014 za\u010d\u00e1tek s 10 mg zp\u016fsobuje u v\u011bt\u0161iny pacient\u016f nesnesiteln\u00e9 gastrointestin\u00e1ln\u00ed vedlej\u0161\u00ed \u00fa\u010dinky.<\/li>\n<li><strong>Udr\u017eovac\u00ed d\u00e1vka:<\/strong> 10 mg jednou denn\u011b po 4\u20136 t\u00fddnech, pokud je tolerov\u00e1no.<\/li>\n<li><strong>T\u011b\u017ek\u00e1 Alzheimerova choroba:<\/strong> 10 mg jednou denn\u011b; n\u011bkte\u0159\u00ed pacienti maj\u00ed prosp\u011bch z formulac\u00ed 23 mg\/den (nen\u00ed zde skladem \u2014 p\u0159edpis specialisty).<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Donemax<\/h3>\n<ol>\n<li><strong>U\u017e\u00edvejte ve\u010der<\/strong>, ide\u00e1ln\u011b t\u011bsn\u011b p\u0159ed span\u00edm. 70hodinov\u00fd polo\u010das donepezilu znamen\u00e1, \u017ee na\u010dasov\u00e1n\u00ed m\u00e1 minim\u00e1ln\u00ed vliv na ust\u00e1len\u00e9 hladiny, ale ve\u010dern\u00ed pod\u00e1v\u00e1n\u00ed zp\u016fsob\u00ed, \u017ee vrchol cholinergn\u00edch vedlej\u0161\u00edch \u00fa\u010dink\u016f (m\u00edrn\u00e9 z\u00e1vrat\u011b, nevolnost) p\u0159ipadne na dobu sp\u00e1nku.<\/li>\n<li><strong>Pokud se objev\u00ed \u017eiv\u00e9 sny nebo nespavost<\/strong>, p\u0159ejd\u011bte na rann\u00ed pod\u00e1v\u00e1n\u00ed \u2013 to je zn\u00e1m\u00fd probl\u00e9m a zm\u011bna \u010dasu obvykle situaci vy\u0159e\u0161\u00ed do t\u00fddne.<\/li>\n<li><strong>S j\u00eddlem nebo bez j\u00eddla<\/strong> \u2013 j\u00eddlo neovliv\u0148uje vst\u0159eb\u00e1v\u00e1n\u00ed donepezilu.<\/li>\n<li><strong>Polykejte cel\u00e9 s vodou.<\/strong> Standardn\u00ed tablety lze rozd\u011blit, pokud jsou r\u00fdhovan\u00e9.<\/li>\n<li><strong>Jednou denn\u011b ve stejnou dobu<\/strong>. Pokud je d\u00e1vka vynech\u00e1na, ale vzpomenete si na ni je\u0161t\u011b ten den, vezm\u011bte ji. Pokud si vzpomenete a\u017e n\u00e1sleduj\u00edc\u00ed den, vynechejte a pokra\u010dujte obvykl\u00fdm zp\u016fsobem \u2013 ned\u00e1vejte dvojitou d\u00e1vku.<\/li>\n<li><strong>Nep\u0159est\u00e1vejte n\u00e1hle.<\/strong> N\u00e1hl\u00e9 vysazen\u00ed m\u016f\u017ee zp\u016fsobit rychl\u00e9 zhor\u0161en\u00ed kognitivn\u00edch funkc\u00ed, kter\u00e9 se po op\u011btovn\u00e9m nasazen\u00ed v\u017edy neobnov\u00ed. Pokud mus\u00ed b\u00fdt l\u00e9\u010dba ukon\u010dena, d\u011blejte tak postupn\u011b pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/li>\n<li><strong>Dohled pe\u010dovatele je kl\u00ed\u010dov\u00fd.<\/strong> Pacienti s Alzheimerovou chorobou \u010dasto zapom\u00ednaj\u00ed, zda si vzali d\u00e1vku \u2013 pou\u017e\u00edvejte t\u00fddenn\u00ed d\u00e1vkova\u010d napln\u011bn\u00fd \u010dlenem rodiny nebo pe\u010dovatelem.<\/li>\n<li><strong>Znovu vyhodno\u0165te po 6 m\u011bs\u00edc\u00edch.<\/strong> Kognitivn\u00ed testov\u00e1n\u00ed (MMSE nebo MoCA) by m\u011blo ur\u010dit, zda l\u00e9\u010dba pom\u00e1h\u00e1. Pokra\u010dujte, pokud je p\u0159\u00ednos; p\u0159ehodno\u0165te, pokud se kognice navzdory l\u00e9\u010db\u011b v\u00fdrazn\u011b zhor\u0161ila.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky Donemaxu<\/h2>\n<p><strong>B\u011b\u017en\u00e9 (nejhor\u0161\u00ed v prvn\u00edch 2\u20134 t\u00fddnech, obvykle ustoup\u00ed):<\/strong><\/p>\n<ul>\n<li>Nevolnost, pr\u016fjem, zvracen\u00ed<\/li>\n<li>Anorexie a \u00fabytek hmotnosti (u n\u011bkter\u00fdch pacient\u016f 5\u201310 % t\u011blesn\u00e9 hmotnosti)<\/li>\n<li>\u017div\u00e9 sny nebo no\u010dn\u00ed m\u016fry<\/li>\n<li>Nespavost (\u010dast\u011bj\u0161\u00ed p\u0159i ve\u010dern\u00edm pod\u00e1v\u00e1n\u00ed)<\/li>\n<li>Z\u00e1vrat\u011b, bolesti hlavy<\/li>\n<li>Svalov\u00e9 k\u0159e\u010de<\/li>\n<li>\u00danava<\/li>\n<\/ul>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9, ale d\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Bradykardie a synkopa<\/strong> \u2014 donepezil m\u00e1 vagotonick\u00fd \u00fa\u010dinek, kter\u00fd m\u016f\u017ee zpomalit srde\u010dn\u00ed frekvenci a zp\u016fsobit mdloby, zejm\u00e9na u pacient\u016f se syndromem nemocn\u00e9ho sinu nebo AV blok\u00e1dou<\/li>\n<li>Urin\u00e1rn\u00ed inkontinence (paradoxn\u00ed, v d\u016fsledku zv\u00fd\u0161en\u00e9ho cholinergn\u00edho tonu)<\/li>\n<li>Zhor\u0161en\u00ed astmatu nebo CHOPN<\/li>\n<li>Gastrointestin\u00e1ln\u00ed krv\u00e1cen\u00ed (zejm\u00e9na v kombinaci s NSAID nebo antikoagulancii)<\/li>\n<\/ul>\n<p><strong>Vz\u00e1cn\u00e9, ale vy\u017eaduje okam\u017eitou l\u00e9ka\u0159skou pomoc:<\/strong><\/p>\n<ul>\n<li>T\u011b\u017ek\u00e1 bradykardie, \u00fapln\u00e1 srde\u010dn\u00ed blok\u00e1da, synkopa<\/li>\n<li>K\u0159e\u010de (vz\u00e1cn\u00e9)<\/li>\n<li>T\u011b\u017ek\u00e9 zvracen\u00ed vedouc\u00ed k ruptu\u0159e j\u00edcnu (velmi vz\u00e1cn\u00e9)<\/li>\n<li>Stevens-Johnson\u016fv syndrom (kazuistiky)<\/li>\n<li>Neuroleptick\u00fd malign\u00ed syndrom (zejm\u00e9na v kombinaci s antipsychotiky)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Kardi\u00e1ln\u00ed:<\/strong> donepezil zpomaluje srde\u010dn\u00ed frekvenci. Opatrnost u pacient\u016f se syndromem nemocn\u00e9ho sinu, AV blok\u00e1dou druh\u00e9ho nebo t\u0159et\u00edho stupn\u011b nebo nevysv\u011btlitelnou synkopou. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby u pacient\u016f s kardiologickou anamn\u00e9zou prove\u010fte v\u00fdchoz\u00ed EKG.<\/li>\n<li><strong>Peptick\u00fd v\u0159ed a anamn\u00e9za gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed:<\/strong> donepezil zvy\u0161uje sekreci \u017ealude\u010dn\u00ed kyseliny. U vysoce rizikov\u00fdch pacient\u016f je rozumn\u00e9 p\u0159edepsat PPI.<\/li>\n<li><strong>Astma a CHOPN:<\/strong> zv\u00fd\u0161en\u00fd cholinergn\u00ed tonus m\u016f\u017ee zhor\u0161it bronchokonstrikci. Opatrnost u \u0161patn\u011b kompenzovan\u00e9ho onemocn\u011bn\u00ed.<\/li>\n<li><strong>Anestezie:<\/strong> informujte anesteziologa o u\u017e\u00edv\u00e1n\u00ed donepezilu p\u0159ed jak\u00fdmkoli chirurgick\u00fdm z\u00e1krokem. Donepezil prodlu\u017euje \u00fa\u010dinek sukcinylcholinu a dal\u0161\u00edch depolarizuj\u00edc\u00edch svalov\u00fdch relaxanci\u00ed.<\/li>\n<li><strong>Mo\u010dov\u00e1 obstrukce (BPH):<\/strong> zv\u00fd\u0161en\u00fd tonus detruzoru m\u016f\u017ee zp\u016fsobit urgentn\u00ed mo\u010den\u00ed nebo retenci.<\/li>\n<li><strong>Historie z\u00e1chvat\u016f:<\/strong> u\u017e\u00edvejte opatrn\u011b \u2014 cholinergn\u00ed aktivace teoreticky sni\u017euje pr\u00e1h pro z\u00e1chvaty.<\/li>\n<li><strong>Ren\u00e1ln\u00ed nebo jatern\u00ed porucha:<\/strong> nen\u00ed nutn\u00e1 \u00faprava d\u00e1vkov\u00e1n\u00ed u lehk\u00e9ho a\u017e st\u0159edn\u00edho posti\u017een\u00ed; opatrnost u t\u011b\u017ek\u00e9ho posti\u017een\u00ed.<\/li>\n<li><strong>Podpora pe\u010dovatele:<\/strong> pacienti s Alzheimerovou chorobou jen z\u0159\u00eddka bezpe\u010dn\u011b zvl\u00e1daj\u00ed vlastn\u00ed medikaci. Zapojen\u00ed pe\u010dovatele do p\u0159\u00edpravy d\u00e1vek, dohledu a dodr\u017eov\u00e1n\u00ed l\u00e9\u010debn\u00e9ho re\u017eimu je nezbytn\u00e9.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace \u2014 Kdo by NEM\u011aL u\u017e\u00edvat Donemax<\/h2>\n<ul>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na donepezil, piperidinov\u00e9 deriv\u00e1ty nebo jakoukoli pomocnou l\u00e1tku tablety<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C)<\/li>\n<li>Aktivn\u00ed peptick\u00fd v\u0159ed (do zahojen\u00ed)<\/li>\n<li>T\u011b\u017ek\u00e1 symptomatick\u00e1 bradykardie, syndrom nemocn\u00e9ho sinu, AV blok druh\u00e9ho nebo t\u0159et\u00edho stupn\u011b (bez kardiostimul\u00e1toru)<\/li>\n<li>T\u011b\u017ek\u00e1 nekontrolovan\u00e1 astma nebo CHOPN<\/li>\n<li>Ned\u00e1vn\u00e1 nevysv\u011btliteln\u00e1 synkopa<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Anticholinergika (oxybutynin, tolterodin, hyoscyamin, amitriptylin, difenhydramin, skopolamin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">P\u0159\u00edmo antagonizuj\u00ed mechanismus donepezilu \u2014 l\u00e9\u010dba selh\u00e1v\u00e1<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kombinaci se vyhn\u011bte. P\u0159epn\u011bte na mirabegron u l\u00e9\u010dby inkontinence; prov\u011b\u0159te v\u0161echna anticholinergika v l\u00e9\u010debn\u00e9m re\u017eimu.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Betablok\u00e1tory, blok\u00e1tory kalciov\u00fdch kan\u00e1l\u016f (verapamil, diltiazem), digoxin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed riziko bradykardie a AV bloku<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte srde\u010dn\u00ed frekvenci a EKG; zva\u017ete sn\u00ed\u017een\u00ed d\u00e1vky nebo alternativu.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sukcinylcholin a dal\u0161\u00ed depolarizuj\u00edc\u00ed neuromuskul\u00e1rn\u00ed blok\u00e1tory (anestezie)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">V\u00fdrazn\u011b prodlou\u017een\u00e1 paral\u00fdza<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Informujte anesteziologa o donepezilu. Zva\u017ete nedepolarizuj\u00edc\u00ed alternativu.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">NSAID (ibuprofen, naproxen, diklofenak)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sklon ke krv\u00e1cen\u00ed do tr\u00e1vic\u00edho traktu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Pokud mo\u017eno se vyhn\u011bte; pokud je nutn\u00e9, p\u0159edepi\u0161te sou\u010dasn\u011b PPI.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Siln\u00e9 inhibitory CYP3A4 (ketokonazol, ritonavir, klarithromycin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zv\u00fd\u0161en\u00ed hladiny donepezilu \u2014 v\u00edce vedlej\u0161\u00edch \u00fa\u010dink\u016f<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte nevolnost\/z\u00e1vrat\u011b; zva\u017ete sn\u00ed\u017een\u00ed d\u00e1vky.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Siln\u00ed induktory CYP3A4 (rifampicin, fenytoin, karbamazepin, t\u0159ezalka te\u010dkovan\u00e1)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sn\u00ed\u017een\u00ed hladiny donepezilu \u2014 selh\u00e1n\u00ed l\u00e9\u010dby<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte kognici; zva\u017ete zv\u00fd\u0161en\u00ed d\u00e1vky pod odborn\u00fdm veden\u00edm.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Antipsychotika (haloperidol, risperidon, olanzapin, kvetiapin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zv\u00fd\u0161en\u00e9 riziko neuroleptick\u00e9ho malign\u00edho syndromu a extrapyramidov\u00fdch \u00fa\u010dink\u016f<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Pou\u017e\u00edvejte nejni\u017e\u0161\u00ed mo\u017enou d\u00e1vku; vyvarujte se u demence s Lewyho t\u011bl\u00edsky.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Memantin (kombina\u010dn\u00ed terapie u st\u0159edn\u011b t\u011b\u017ek\u00e9 a\u017e t\u011b\u017ek\u00e9 Alzheimerovy choroby)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed kognitivn\u00ed benefit, \u017e\u00e1dn\u00e1 v\u00fdznamn\u00e1 farmakokinetick\u00e1 interakce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standardn\u00ed kombinace \u2014 viz <a href=\"https:\/\/medsbase.com\/cs\/admenta\/\">Admenta<\/a>.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i pokojov\u00e9 teplot\u011b, <strong>15\u201325\u00b0C<\/strong>. Chra\u0148te p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/li>\n<li>Tablety uchov\u00e1vejte v p\u016fvodn\u00edm blistru a\u017e do pou\u017eit\u00ed.<\/li>\n<li>Neskladujte v koupeln\u011b \u2013 vlhkost zkracuje trvanlivost.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed a pacient\u016f, kte\u0159\u00ed nemus\u00ed ch\u00e1pat, \u017ee se jedn\u00e1 o l\u00e9ky.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace uveden\u00e9ho na obalu.<\/li>\n<li>Nepou\u017eit\u00e9 tablety vra\u0165te do l\u00e9k\u00e1rny k likvidaci.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed l\u00e9ky na Alzheimerovu chorobu a demenci skladem na MedsBase:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/aricep\/\"><strong>Aricep (donepezil 5 \/ 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/donect\/\"><strong>Donect (donepezil 10 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/admenta\/\"><strong>Admenta (memantin 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/galamer\/\"><strong>Galamer (galantamine 4 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rivamer-2\/\"><strong>Rivamer (rivastigmin 1,5 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p>U\u017eite\u010dn\u00e9 \u010dten\u00ed: <a href=\"https:\/\/medsbase.com\/cs\/everything-you-need-to-know-about-alzheimers-disease\/\">V\u0161e, co pot\u0159ebujete v\u011bd\u011bt o Alzheimerov\u011b chorob\u011b<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/cs\/everything-to-know-about-dementia\/\">V\u0161e, co pot\u0159ebujete v\u011bd\u011bt o demenci<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/cs\/7-ways-to-protect-your-brain-health-as-you-age\/\">7 zp\u016fsob\u016f, jak chr\u00e1nit zdrav\u00ed sv\u00e9ho mozku s p\u0159ib\u00fdvaj\u00edc\u00edm v\u011bkem<\/a> \u00b7 <a href=\"https:\/\/medsbase.com\/cs\/best-foods-for-a-healthy-brain-and-improved-memory\/\">Nejlep\u0161\u00ed potraviny pro zdrav\u00fd mozek a lep\u0161\u00ed pam\u011b\u0165<\/a>.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Kdy uvid\u00edm j\u00e1 nebo \u010dlen m\u00e9 rodiny v\u00fdsledky u\u017e\u00edv\u00e1n\u00ed Donemaxu?<\/h3>\n<p>Viditeln\u00e9 zlep\u0161en\u00ed kognitivn\u00edch funkc\u00ed se objevuje <strong>6\u201312 t\u00fddn\u016f<\/strong> pravideln\u00e9ho d\u00e1vkov\u00e1n\u00ed; maxim\u00e1ln\u00ed \u00fa\u010dinek nast\u00e1v\u00e1 za 6 m\u011bs\u00edc\u016f. Mezi v\u00fdhody pat\u0159\u00ed lep\u0161\u00ed pozornost, pam\u011b\u0165, schopnost sledovat konverzaci a ka\u017edodenn\u00ed fungov\u00e1n\u00ed. Donepezil <strong>ne<\/strong> nezvr\u00e1t\u00ed po\u0161kozen\u00ed zp\u016fsoben\u00e9 Alzheimerovou chorobou \u2013 stabilizuje funkce po dobu obvykle 6\u201318 m\u011bs\u00edc\u016f. Po 6 m\u011bs\u00edc\u00edch prove\u010fte p\u0159ehodnocen\u00ed form\u00e1ln\u00edm kognitivn\u00edm testov\u00e1n\u00edm (MMSE nebo MoCA).<\/p>\n<h3 class=\"wp-block-heading\">Zastavuje nebo zpomaluje Donemax progresi Alzheimerovy choroby?<\/h3>\n<p><strong>Ne.<\/strong> Donepezil je symptomatick\u00e1 terapie, nikoli l\u00e9\u010dba modifikuj\u00edc\u00ed onemocn\u011bn\u00ed. Podkladov\u00e1 neurodegenerace pokra\u010duje stejnou rychlost\u00ed. Donepezil zp\u016fsobuje m\u011b\u0159iteln\u00fd posun kognitivn\u00edch funkc\u00ed po dobu l\u00e9\u010dby; po vysazen\u00ed se kognice vrac\u00ed k (nebo pod) nel\u00e9\u010denou trajektorii. Nov\u011bj\u0161\u00ed l\u00e9ky modifikuj\u00edc\u00ed onemocn\u011bn\u00ed (protil\u00e1tky proti amyloidu jako lekanemab) c\u00edl\u00ed na podkladovou patologii, ale nejsou zde skladem a vy\u017eaduj\u00ed specializovanou infuzn\u00ed terapii.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d mus\u00edm za\u010d\u00edt s d\u00e1vkou 5 mg p\u0159ed p\u0159echodem na 10 mg?<\/h3>\n<p>Titra\u010dn\u00ed obdob\u00ed 4\u20136 t\u00fddn\u016f je z\u00e1sadn\u00ed. Za\u010d\u00e1tek s 10 mg zp\u016fsobuje u v\u011bt\u0161iny pacient\u016f t\u011b\u017ekou nevolnost, pr\u016fjem a anorexii \u2013 natolik z\u00e1va\u017en\u00e9, \u017ee l\u00e9\u010dbu ukon\u010d\u00ed. Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka 5 mg umo\u017en\u00ed adaptaci tr\u00e1vic\u00edho traktu p\u0159ed plnou d\u00e1vkou. Vynech\u00e1n\u00ed titrace je nej\u010dast\u011bj\u0161\u00edm d\u016fvodem, pro\u010d pacienti \u201cnesnesou\u201d donepezil.<\/p>\n<h3 class=\"wp-block-heading\">Kdy m\u00e1m u\u017e\u00edvat Donemax \u2014 r\u00e1no nebo ve\u010der?<\/h3>\n<p>Standardn\u00ed doporu\u010den\u00ed je <strong>ve\u010der p\u0159ed span\u00edm<\/strong> \u2013 to um\u00edst\u00ed vrchol cholinergn\u00edch vedlej\u0161\u00edch \u00fa\u010dink\u016f (m\u00edrn\u00e9 z\u00e1vrat\u011b, nevolnost) do doby sp\u00e1nku. Pokud se objev\u00ed \u017eiv\u00e9 sny nebo nespavost (zn\u00e1m\u00fd vedlej\u0161\u00ed \u00fa\u010dinek p\u0159i ve\u010dern\u00edm d\u00e1vkov\u00e1n\u00ed), p\u0159ejd\u011bte na rann\u00ed u\u017e\u00edv\u00e1n\u00ed. Ob\u011b \u010dasov\u00e1n\u00ed poskytuj\u00ed stejn\u00fd kognitivn\u00ed benefit d\u00edky 70hodinov\u00e9mu polo\u010dasu donepezilu.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u0159estat u\u017e\u00edvat Donemax, pokud nepom\u00e1h\u00e1?<\/h3>\n<p>Nejd\u0159\u00edve se pora\u010fte s p\u0159edepisuj\u00edc\u00edm l\u00e9ka\u0159em. Pokud form\u00e1ln\u00ed kognitivn\u00ed testov\u00e1n\u00ed po 6 m\u011bs\u00edc\u00edch neprok\u00e1\u017ee benefit a pacient jasn\u011b progredoval, lze donepezil vysadit \u2013 ale v\u017edy <strong>postupn\u011b sni\u017eujte d\u00e1vku<\/strong>, nikoli n\u00e1hle. N\u00e1hl\u00e9 vysazen\u00ed m\u016f\u017ee zp\u016fsobit rychl\u00e9 zhor\u0161en\u00ed kognitivn\u00edch funkc\u00ed (tzv. \u201cwashout\u201d efekt), kter\u00e9 se po op\u011btovn\u00e9m nasazen\u00ed nemus\u00ed v\u017edy pln\u011b obnovit. Typick\u00e9 postupn\u00e9 vysazov\u00e1n\u00ed: sn\u00ed\u017eit d\u00e1vku na 5 mg na 2\u20134 t\u00fddny, pot\u00e9 \u00fapln\u011b vysadit.<\/p>\n<h3 class=\"wp-block-heading\">Lze Donemax kombinovat s memantinem?<\/h3>\n<p>Ano \u2014 toto je standardn\u00ed kombinace pro <strong>st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou Alzheimerovu chorobu<\/strong>. Donepezil a memantin p\u016fsob\u00ed na r\u016fzn\u00fdch drah\u00e1ch (cholinergn\u00ed + glutam\u00e1tergn\u00ed) a poskytuj\u00ed aditivn\u00ed kognitivn\u00ed benefit bez v\u00fdznamn\u00e9 interakce. <a href=\"https:\/\/medsbase.com\/cs\/admenta\/\">Admenta<\/a> je zde dostupn\u00e1 zna\u010dka memantinu.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d jsou gastrointestin\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky tak \u010dast\u00e9?<\/h3>\n<p>Donepezil zvy\u0161uje hladinu acetylcholinu v cel\u00e9m t\u011ble, nejen v mozku. Zv\u00fd\u0161en\u00fd cholinergn\u00ed tonus ve st\u0159evech urychluje motilitu (pr\u016fjem), zvy\u0161uje sekreci (nevolnost) a sni\u017euje chu\u0165 k j\u00eddlu (anorexie). V\u011bt\u0161ina GI ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f ustoup\u00ed do 2\u20134 t\u00fddn\u016f. P\u0159etrv\u00e1vaj\u00edc\u00ed nevolnost lze \u0159e\u0161it u\u017eit\u00edm d\u00e1vky s j\u00eddlem, p\u0159echodem na ve\u010dern\u00ed d\u00e1vkov\u00e1n\u00ed nebo do\u010dasn\u00fdm sn\u00ed\u017een\u00edm d\u00e1vky na 5 mg.<\/p>\n<h3 class=\"wp-block-heading\">Co l\u00e9ky s anticholinergn\u00edm \u00fa\u010dinkem, kter\u00e9 ji\u017e u\u017e\u00edv\u00e1m?<\/h3>\n<p>Toto je jeden z nej\u010dast\u011bj\u0161\u00edch d\u016fvod\u016f, pro\u010d donepezil \u201cnefunguje\u201d. Mezi b\u011b\u017en\u00e9 anticholinergika, kter\u00e1 <strong>p\u0159\u00edmo ru\u0161\u00ed<\/strong> donepezil pat\u0159\u00ed: oxybutynin a tolterodin (hyperaktivn\u00ed mo\u010dov\u00fd m\u011bch\u00fd\u0159), amitriptylin a nortriptylin (star\u0161\u00ed antidepresiva), difenhydramin (Benadryl, prost\u0159edky na span\u00ed) a hyoscyamin. Po\u017e\u00e1dejte sv\u00e9ho l\u00e9ka\u0159e o revizi v\u0161ech l\u00e9k\u016f a mo\u017enou n\u00e1hradu \u2014 pro p\u0159\u00edznaky mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e je mirabegron neanticholinergn\u00ed alternativou.<\/p>\n<h3 class=\"wp-block-heading\">Je Donemax bezpe\u010dn\u00fd s dal\u0161\u00edmi l\u00e9ky na demenci, kter\u00e9 m\u016fj rodi\u010d u\u017e\u00edv\u00e1?<\/h3>\n<p>Donepezil + memantin je standardn\u00ed kombinace pro st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou Alzheimerovu chorobu. Donepezil + galantamin nebo donepezil + rivastigmin <strong>nedoporu\u010duje se<\/strong> \u2014 kombinace dvou inhibitor\u016f cholinester\u00e1zy zvy\u0161uje gastrointestin\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky bez dal\u0161\u00edho p\u0159\u00ednosu. Informujte ka\u017ed\u00e9ho l\u00e9ka\u0159e, \u017ee pacient u\u017e\u00edv\u00e1 donepezil; zejm\u00e9na anesteziologov\u00e9 pot\u0159ebuj\u00ed tuto informaci p\u0159ed jak\u00fdmkoli chirurgick\u00fdm z\u00e1krokem.<\/p>\n<h3 class=\"wp-block-heading\">Donemax vs galantamin vs rivastigmin \u2014 kter\u00fd je vhodn\u00fd?<\/h3>\n<p>V\u0161echny t\u0159i jsou inhibitory AChE s podobn\u00fdm p\u0159\u00ednosem pro kognitivn\u00ed funkce, ale li\u0161\u00ed se profilem ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f. <strong>Donepezil:<\/strong> jednou denn\u011b, nejlep\u0161\u00ed gastrointestin\u00e1ln\u00ed sn\u00e1\u0161enlivost, jedin\u00fd schv\u00e1len\u00fd pro t\u011b\u017ekou Alzheimerovu chorobu. <strong><a href=\"https:\/\/medsbase.com\/cs\/galamer\/\">Galantamin<\/a>:<\/strong> dvakr\u00e1t denn\u011b, tak\u00e9 modul\u00e1tor nikotinov\u00fdch ACh receptor\u016f, m\u00edrn\u011b vy\u0161\u0161\u00ed gastrointestin\u00e1ln\u00ed z\u00e1t\u011b\u017e. <strong><a href=\"https:\/\/medsbase.com\/cs\/rivamer-2\/\">Rivastigmin<\/a>:<\/strong> dvakr\u00e1t denn\u011b peror\u00e1ln\u011b nebo transderm\u00e1ln\u00ed n\u00e1plast, jedin\u00fd inhibitor AChE schv\u00e1len\u00fd pro demenci u Parkinsonovy choroby, nejvy\u0161\u0161\u00ed gastrointestin\u00e1ln\u00ed z\u00e1t\u011b\u017e v peror\u00e1ln\u00ed form\u011b (n\u00e1plast ji sni\u017euje). Donepezil je standardn\u00ed prvn\u00ed volbou, pokud pacient nem\u00e1 demenci u Parkinsonovy choroby.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/beclate-inhaler\/\">Beclate Inhaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/wysolone\/\">Wysolone<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/triohale-rotacaps\/\">Triohale Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amantrel\/\">Amantrel<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sumitop\/\">Sumitop<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p><span class=\"x1xsqp64 xiy17q3 x1o6pynw x19co3pv xdj266r xcwd3tp xat24cr x39eecv x2b8uid\" data-testid=\"emoji\"><span class=\"xexx8yu xn5pp95 x18d9i69 x2fxd7x x1yqt14a x1bhl96m\">\u2705<\/span><\/span> Zlep\u0161uje pam\u011b\u0165ov\u00e9 funkce<br \/>\n<span class=\"x1xsqp64 xiy17q3 x1o6pynw x19co3pv xdj266r xcwd3tp xat24cr x39eecv x2b8uid\" data-testid=\"emoji\"><span class=\"xexx8yu xn5pp95 x18d9i69 x2fxd7x x1yqt14a x1bhl96m\">\u2705<\/span><\/span> L\u00e9\u010d\u00ed p\u0159\u00edznaky Alzheimerovy choroby<br \/>\n<span class=\"x1xsqp64 xiy17q3 x1o6pynw x19co3pv xdj266r xcwd3tp xat24cr x39eecv x2b8uid\" data-testid=\"emoji\"><span class=\"xexx8yu xn5pp95 x18d9i69 x2fxd7x x1yqt14a x1bhl96m\">\u2705<\/span><\/span> Kognitivn\u00ed zlep\u0161en\u00ed<br \/>\n<span class=\"x1xsqp64 xiy17q3 x1o6pynw x19co3pv xdj266r xcwd3tp xat24cr x39eecv x2b8uid\" data-testid=\"emoji\"><span class=\"xexx8yu xn5pp95 x18d9i69 x2fxd7x x1yqt14a x1bhl96m\">\u2705<\/span><\/span> Jednor\u00e1zov\u00e1 denn\u00ed d\u00e1vka<br \/>\n<span class=\"x1xsqp64 xiy17q3 x1o6pynw x19co3pv xdj266r xcwd3tp xat24cr x39eecv x2b8uid\" data-testid=\"emoji\"><span class=\"xexx8yu xn5pp95 x18d9i69 x2fxd7x x1yqt14a x1bhl96m\">\u2705<\/span><\/span> P\u0159edepisov\u00e1no neurology<\/p>\n<p>Donemax obsahuje Donepezil.<\/p>","protected":false},"featured_media":56785,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3772,3141,3223],"product_tag":[4172,3849],"class_list":{"0":"post-56784","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alzheimers-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-donemax","10":"product_tag-donepezil","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56784"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56785"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56784"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56784"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56784"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}