{"id":56808,"date":"2024-02-27T17:08:42","date_gmt":"2024-02-27T17:08:42","guid":{"rendered":"https:\/\/medsname.com\/spectra\/"},"modified":"2026-04-30T10:24:34","modified_gmt":"2026-04-30T10:24:34","slug":"spectra","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/spectra\/","title":{"rendered":"Spectra"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Spectra (Doxepin 10\/25 mg) je tricyklick\u00e9 antidepresivum. Nej\u010dast\u011bji se v modern\u00ed praxi pou\u017e\u00edv\u00e1 v n\u00edzk\u00fdch d\u00e1vk\u00e1ch p\u0159i chronick\u00e9 nespavosti (3\u20136 mg) nebo v pln\u00fdch antidepresivn\u00edch d\u00e1vk\u00e1ch (75\u2013300 mg) pro sedativn\u00ed\/anxiolytick\u00e9 \u00fa\u010dinky u deprese.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Spectra na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Spectra a jak funguje<\/h2>\n

Spectra jsou tablety obsahuj\u00edc\u00ed Doxepin, dod\u00e1van\u00e9 spole\u010dnost\u00ed Cipla. Dostupn\u00e9 s\u00edly: 10 \/ 25 mg<\/strong>.<\/p>\n

Doxepin je mezi TCA neobvykl\u00fd t\u00edm, \u017ee jeho hlavn\u00ed modern\u00ed pou\u017eit\u00ed je v n\u00edzk\u00fdch d\u00e1vk\u00e1ch (3\u20136 mg) pro chronickou nespavost<\/strong> \u2014 jeho v\u00fdrazn\u00fd H1 antihistaminov\u00fd \u00fa\u010dinek je nejsiln\u011bj\u0161\u00ed ze v\u0161ech tricyklick\u00fdch antidepresiv a poskytuje \u00fa\u010dinek na udr\u017een\u00ed sp\u00e1nku bez n\u00e1vykov\u00e9ho profilu benzodiazepin\u016f nebo Z-l\u00e9k\u016f. V pln\u00fdch antidepresivn\u00edch d\u00e1vk\u00e1ch (75\u2013300 mg) funguje jako klasick\u00e9 sm\u00ed\u0161en\u00e9 serotonin-noradrenalinov\u00e9 TCA se sedativn\u00edmi, anxiolytick\u00fdmi a analgetick\u00fdmi vlastnostmi.<\/p>\n

Tricyklick\u00e1 antidepresiva blokuj\u00ed zp\u011btn\u00e9 vychyt\u00e1v\u00e1n\u00ed serotoninu a noradrenalinu na presynaptick\u00fdch transport\u00e9rech, podobn\u011b jako SSRI a SNRI. Jejich hor\u0161\u00ed sn\u00e1\u0161enlivost vych\u00e1z\u00ed z : muskarinov\u00fdch (anticholinergn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky), histaminergn\u00edch H1 (sedace, p\u0159\u00edr\u016fstek hmotnosti) a \u03b11-adrenergn\u00edch (ortostatick\u00e1 hypotenze). Tak\u00e9 blokuj\u00ed rychl\u00e9 sod\u00edkov\u00e9 kan\u00e1ly v srde\u010dn\u00ed tk\u00e1ni \u2013 co\u017e je z\u00e1klad jak pro jejich analgetick\u00fd \u00fa\u010dinek, tak pro jejich kardiotoxicitu p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed.<\/strong>: muskarinov\u00e9 (anticholinergn\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky), histaminergn\u00ed H1 (sedace, n\u00e1r\u016fst hmotnosti) a \u03b11-adrenergn\u00ed (ortostatick\u00e1 hypotenze). Blokuj\u00ed rovn\u011b\u017e rychl\u00e9 sod\u00edkov\u00e9 kan\u00e1ly v srde\u010dn\u00ed tk\u00e1ni \u2014 to je podkladem jak jejich analgetick\u00e9ho \u00fa\u010dinku, tak jejich kardi\u00e1ln\u00ed toxicity p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed.<\/p>\n

Indikace nespavosti v d\u00e1vce 3\u20136 mg je jedin\u00fdm rozsahem d\u00e1vek TCA, kter\u00fd nevy\u017eaduje EKG a poradenstv\u00ed t\u00fdkaj\u00edc\u00ed se anticholinergn\u00edch \u00fa\u010dink\u016f t\u0159\u00eddy TCA \u2014 p\u0159i t\u011bchto d\u00e1vk\u00e1ch je syst\u00e9mov\u00e1 expozice zanedbateln\u00e1.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Hlavn\u00ed deprese \/ \u00fazkost<\/td>\n25\u201375 mg HS<\/td>\n75\u2013300 mg\/den<\/td>\n300 mg<\/td>\n<\/tr>\n
Chronick\u00e1 nespavost (n\u00edzk\u00e1 d\u00e1vka)<\/td>\n3 mg p\u0159ed span\u00edm<\/td>\n3\u20136 mg p\u0159ed span\u00edm<\/td>\n6 mg<\/td>\n<\/tr>\n
Chronick\u00e1 kop\u0159ivka\/sv\u011bd\u011bn\u00ed<\/td>\n10 mg 3\u00d7 denn\u011b<\/td>\n10\u201325 mg 3\u00d7 denn\u011b<\/td>\ndle sn\u00e1\u0161enlivosti<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed<\/td>\n10 mg p\u0159ed span\u00edm<\/td>\n30\u201375 mg\/den<\/td>\n150 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nRiziko srde\u010dn\u00edch komplikac\u00ed a toxicita p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed<\/strong><\/p>\n

TCA prodlu\u017euj\u00ed QRS a QT interval a p\u0159ed\u00e1vkov\u00e1n\u00ed je \u017eivot ohro\u017euj\u00edc\u00ed<\/strong> \u2014 historicky nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dina \u00famrt\u00ed spojen\u00fdch s antidepresivy. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby u pacient\u016f se zn\u00e1m\u00fdm srde\u010dn\u00edm onemocn\u011bn\u00edm, l\u00e9\u010den\u00fdch l\u00e9ky prodlu\u017euj\u00edc\u00edmi QT interval nebo u star\u0161\u00edch dosp\u011bl\u00fdch je nutn\u00e9 prov\u00e9st v\u00fdchoz\u00ed EKG. Neza\u010d\u00ednejte l\u00e9\u010dbu u pacient\u016f s recentn\u00edm infarktem myokardu, poruchami veden\u00ed, dekompenzovan\u00fdm srde\u010dn\u00edm selh\u00e1n\u00edm nebo vrozen\u00fdm dlouh\u00fdm QT intervalem. U pacient\u016f s rizikem sebevra\u017edy omezte mno\u017estv\u00ed vyd\u00e1van\u00e9ho l\u00e9ku \u2014 terapeutick\u00fd index je \u00fazk\u00fd.<\/p>\n<\/div>\n

\nAnticholinergn\u00ed z\u00e1t\u011b\u017e<\/strong><\/p>\n

Sucho v \u00fastech, z\u00e1cpa, rozmazan\u00e9 vid\u011bn\u00ed, obt\u00ed\u017ee s mo\u010den\u00edm, zpomalen\u00e9 kognitivn\u00ed funkce \u2014 tyto \u00fa\u010dinky se vyskytuj\u00ed u v\u0161ech pacient\u016f v terapeutick\u00fdch d\u00e1vk\u00e1ch. Vyvarujte se pod\u00e1v\u00e1n\u00ed u \u00fazk\u00e9ho \u00fahlu glaukomu, BPH s v\u00fdraznou retenc\u00ed mo\u010di a demence. Doporu\u010dte \u017ev\u00fdka\u010dky\/bezcukrov\u00e9 pastilky, vl\u00e1kninu + dostatek tekutin a zm\u011bk\u010dova\u010de stolice.<\/p>\n<\/div>\n

\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u osob do 25 let)<\/strong><\/p>\n

V\u0161echna antidepresiva nesou varov\u00e1n\u00ed FDA v \u010dern\u00e9m r\u00e1me\u010dku o zv\u00fd\u0161en\u00e9m riziku sebevra\u017eedn\u00fdch my\u0161lenek u pacient\u016f mlad\u0161\u00edch 25 let \u2014 to je obzvl\u00e1\u0161t\u011b relevantn\u00ed pro klomipramin u adolescent\u016f s OCD.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n