{"id":56836,"date":"2024-02-27T17:09:53","date_gmt":"2024-02-27T17:09:53","guid":{"rendered":"https:\/\/medsname.com\/draminate\/"},"modified":"2026-05-20T05:24:59","modified_gmt":"2026-05-20T05:24:59","slug":"draminate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/draminate\/","title":{"rendered":"Draminate"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Draminate?<\/h3>\n

Draminate<\/strong> je dimenhydrin\u00e1t 50 mg peror\u00e1ln\u00ed tableta<\/strong> pou\u017e\u00edv\u00e1 se k prevenci a l\u00e9\u010db\u011b kinet\u00f3zu<\/strong>, vertiga<\/strong> (v\u010detn\u011b Menierovy choroby a vestibul\u00e1rn\u00ed neuritidy) a nevolnosti a zvracen\u00ed<\/strong> vestibul\u00e1rn\u00edho p\u016fvodu. Dimenhydrin\u00e1t je antihistaminikum prvn\u00ed generace H1<\/strong> s anticholinergn\u00ed aktivitou \u2014 tato kombinace utlumuje vestibul\u00e1rn\u00ed sign\u00e1ly vnit\u0159n\u00edho ucha, kter\u00e9 spou\u0161t\u011bj\u00ed kinet\u00f3zu. N\u00e1stup \u00fa\u010dinku je Vrchol \u00fa\u010dinku:<\/strong> po peror\u00e1ln\u00edm pod\u00e1n\u00ed; doba trv\u00e1n\u00ed 4\u20136 hodin<\/strong>. U\u017e\u00edvejte 30\u201360 minut p\u0159ed cestou<\/strong> pro prevenci; opakujte ka\u017ed\u00e9 4\u20136 hodin, maxim\u00e1ln\u011b \u010dty\u0159i d\u00e1vky za 24 hodin. Nej\u010dast\u011bj\u0161\u00edm vedlej\u0161\u00edm \u00fa\u010dinkem je sedace<\/strong> \u2014 ne\u0159i\u010fte ani neobsluhujte stroje po dobu alespo\u0148 4 hodin. Nen\u00ed \u201cnesedativn\u00ed\u201d navzdory marketingov\u00fdm tvrzen\u00edm; antihistaminika druh\u00e9 generace (cetirizin, loratadin) ne\u00fa\u010dinkuj\u00ed proti kinet\u00f3ze \u2014 je pot\u0159eba sedativn\u00ed H1 a anticholinergn\u00ed efekt.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n
\n\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 \ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 \ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 \u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n

Co je Draminate?<\/h2>\n

Draminate je dimenhydrin\u00e1t 50 mg peror\u00e1ln\u00ed tableta<\/strong> pou\u017e\u00edv\u00e1n k prevenci a l\u00e9\u010db\u011b kinet\u00f3zy, vertiga a nevolnosti vestibul\u00e1rn\u00edho p\u016fvodu. Samotn\u00fd dimenhydrin\u00e1t je chloro-teofylin\u00e1tov\u00e1 s\u016fl difenhydraminu (Benadryl); v t\u011ble se disociuje za uvoln\u011bn\u00ed difenhydraminu, aktivn\u00edho antihistaminika, spolu s 8-chloroteofylinem (m\u00edrn\u00fdm stimulantem, kter\u00fd \u010d\u00e1ste\u010dn\u011b vyva\u017euje ospalost). Proto je dimenhydrin\u00e1t \u010dasto popisov\u00e1n jako \u201co n\u011bco m\u00e9n\u011b sedativn\u00ed\u201d ne\u017e samotn\u00fd difenhydramin \u2014 st\u00e1le v\u0161ak zp\u016fsobuje v\u00fdraznou ospalost a m\u011bl by b\u00fdt pova\u017eov\u00e1n za sedativn\u00ed l\u00e9k.<\/p>\n

Dimenhydrin\u00e1t se glob\u00e1ln\u011b prod\u00e1v\u00e1 jako Dramamine<\/strong> (US), Gravol<\/strong> (Kanada), Vomex A<\/strong> (N\u011bmecko), Travel Calm<\/strong> (r\u016fzn\u00e9) a mnoho generik. Draminate je indick\u00e1 generick\u00e1 zna\u010dka; d\u00e1vkov\u00e1n\u00ed a klinick\u00e9 indikace jsou u v\u0161ech zna\u010dek stejn\u00e9. Je na Seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO pro vertigo.<\/p>\n

L\u00e9k funguje nejl\u00e9pe pro p\u0159\u00edznaky vestibul\u00e1rn\u00edho p\u016fvodu<\/strong>: kinet\u00f3za, z\u00e1vrat\u011b z vnit\u0159n\u00edho ucha, labyrinthitida, z\u00e1chvaty Meni\u00e8rovy choroby a poopera\u010dn\u00ed nevolnost po u\u0161n\u00edch operac\u00edch. Je m\u00e9n\u011b \u00fa\u010dinn\u00fd<\/strong> pro nevolnost gastrointestin\u00e1ln\u00edho p\u016fvodu (gastroenteritida, chemoterapie, migr\u00e9na) \u2014 na ty obvykle l\u00e9pe zab\u00edr\u00e1 ondansetron nebo metoklopramid.<\/p>\n

Jak funguje Draminate?<\/h2>\n

Kinet\u00f3za nast\u00e1v\u00e1, kdy\u017e vestibul\u00e1rn\u00ed syst\u00e9m<\/strong> (rovnov\u00e1\u017en\u00e9 org\u00e1ny vnit\u0159n\u00edho ucha) a zrakov\u00fd syst\u00e9m<\/strong> (o\u010di) vys\u00edlaj\u00ed do mozku protich\u016fdn\u00e9 sign\u00e1ly \u2014 nap\u0159\u00edklad kdy\u017e \u010dtete v jedouc\u00edm aut\u011b, va\u0161e o\u010di \u0159\u00edkaj\u00ed \u201cv klidu\u201d, ale va\u0161e vnit\u0159n\u00ed ucho \u0159\u00edk\u00e1 \u201czat\u00e1\u010d\u00edme v zat\u00e1\u010dce\u201d. Tento nesoulad aktivuje zvracen\u00ed<\/strong> v prodlou\u017een\u00e9 m\u00ed\u0161e prost\u0159ednictv\u00edm histaminov\u00fdch (H1) a muskarinov\u00fdch (M1) receptorov\u00fdch drah, co\u017e vyvol\u00e1v\u00e1 nevolnost, bledost, studen\u00fd pot a zvracen\u00ed.<\/p>\n

Dimenhydrin\u00e1t blokuje ob\u011b dr\u00e1hy:<\/p>\n

    \n
  • \u00da\u010dinek H1 antihistaminika<\/strong> utlumuje histaminovou signalizaci ve vestibul\u00e1rn\u00edch j\u00e1drech a v chemorecep\u010dn\u00ed spou\u0161t\u011bc\u00ed z\u00f3n\u011b<\/li>\n
  • Anticholinergn\u00ed (antimuskarinov\u00fd) \u00fa\u010dinek<\/strong> blokuje M1 receptory ve stejn\u00fdch drah\u00e1ch \u2013 to je kl\u00ed\u010dov\u00fd mechanismus pro kinet\u00f3zu, proto nesedativn\u00ed antihistaminika druh\u00e9 generace (cetirizin, loratadin, fexofenadin) ne<\/em> ne\u00fa\u010dinkuj\u00ed p\u0159i kinet\u00f3ze, p\u0159esto\u017ee maj\u00ed siln\u011bj\u0161\u00ed H1 \u00fa\u010dinek; postr\u00e1daj\u00ed anticholinergn\u00ed aktivitu<\/li>\n<\/ul>\n

    N\u00e1stup \u00fa\u010dinku po pln\u00e9 peror\u00e1ln\u00ed d\u00e1vce je Vrchol \u00fa\u010dinku:<\/strong>, a maxim\u00e1ln\u00ed hladiny v krvi dosahuje za 1\u20132 hodiny<\/strong>, a klinick\u00e9 trv\u00e1n\u00ed 4\u20136 hodin<\/strong>. Elimina\u010dn\u00ed polo\u010das je p\u0159ibli\u017en\u011b 8 hodin; sedace m\u016f\u017ee p\u0159etrv\u00e1vat d\u00e9le.<\/p>\n

    Pou\u017eit\u00ed a indikace<\/h2>\n
      \n
    • Cestovn\u00ed nevolnost<\/strong> \u2014 auto, lo\u010f, letadlo, vlak (prevence a l\u00e9\u010dba)<\/li>\n
    • Perifern\u00ed vertigo<\/strong> \u2014 Menierova choroba, labyrinthitida, vestibul\u00e1rn\u00ed neuritida, benign\u00ed paroxyzm\u00e1ln\u00ed polohov\u00e9 vertigo (akutn\u00ed symptomatick\u00e1 \u00faleva; ne<\/em> pro dlouhodobou kontrolu)<\/li>\n
    • Poopera\u010dn\u00ed nevolnost a zvracen\u00ed<\/strong> po operac\u00edch ucha, nosu, krku nebo o\u010d\u00ed<\/li>\n
    • Rann\u00ed nevolnost v t\u011bhotenstv\u00ed<\/strong> (mimo indikaci v n\u011bkter\u00fdch regionech; obvykle preferov\u00e1na prvn\u00ed volba doxylamin nebo ondansetron)<\/li>\n
    • Radia\u010dn\u011b indukovan\u00e1 nevolnost<\/strong> \u2014 adjuvantn\u00ed l\u00e9\u010dba<\/li>\n<\/ul>\n

      Draminate nen\u00ed vhodn\u00e1 volba<\/strong> pro: chemoterapi\u00ed indukovanou nevolnost (pou\u017eijte antagonisty 5-HT3 jako ondansetron), nevolnost p\u0159i gastroenteritid\u011b, zvracen\u00ed spojen\u00e9 s migr\u00e9nou (metoklopramid + triptan) nebo nevolnost zp\u016fsobenou opioidy (ondansetron nebo cyklizin).<\/p>\n

      D\u00e1vkov\u00e1n\u00ed p\u0159\u00edpravku Draminate<\/h2>\n\n\n\n\n\n\n\n\n\n
      V\u011bk<\/th>\nD\u00e1vka<\/th>\nFrekvence<\/th>\nMaxim\u00e1ln\u00ed denn\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
      Dosp\u011bl\u00ed a d\u011bti \u226512 let<\/td>\n50\u2013100 mg<\/strong><\/td>\nKa\u017ed\u00fdch 4\u20136 hodin<\/td>\n400 mg \/ 24 hodin<\/td>\n<\/tr>\n
      D\u011bti 6\u201311 let<\/td>\n25\u201350 mg<\/strong> (p\u016fl a\u017e jedna tableta)<\/td>\nKa\u017ed\u00fdch 6\u20138 hodin<\/td>\n150 mg \/ 24 hodin<\/td>\n<\/tr>\n
      D\u011bti 2\u20135 let<\/td>\n12,5\u201325 mg<\/strong> (\u010dtvrt a\u017e p\u016fl tablety)<\/td>\nKa\u017ed\u00fdch 6\u20138 hodin<\/td>\n75 mg \/ 24 hodin<\/td>\n<\/tr>\n
      D\u011bti do 2 let<\/td>\nNedoporu\u010duje se<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n
      Senio\u0159i (\u226565)<\/td>\nZa\u010dn\u011bte s 25 mg; opatrn\u011b zvy\u0161ujte d\u00e1vku<\/td>\nKa\u017ed\u00fdch 6\u20138 hodin<\/td>\n150 mg \/ 24 h; zva\u017ete alternativy<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      Jak spr\u00e1vn\u011b u\u017e\u00edvat Draminate<\/h3>\n
        \n
      1. U\u017e\u00edvejte 30\u201360 minut p\u0159ed cestou<\/strong> pro prevenci kinet\u00f3zy \u2014 \u010dek\u00e1n\u00ed a\u017e na za\u010d\u00e1tek nevolnosti sni\u017euje \u00fa\u010dinnost a zvy\u0161uje riziko zvracen\u00ed.<\/li>\n
      2. Zapijte vodou.<\/strong> Potrava v\u00fdznamn\u011b neovliv\u0148uje vst\u0159eb\u00e1v\u00e1n\u00ed, ale lehk\u00e9 j\u00eddlo sni\u017euje \u017ealude\u010dn\u00ed pot\u00ed\u017ee.<\/li>\n
      3. Vyhn\u011bte se alkoholu<\/strong> a dal\u0161\u00ed sedativa po dobu alespo\u0148 6 hodin po d\u00e1vce \u2014 riziko zv\u00fd\u0161en\u00e9 sedace a respira\u010dn\u00ed deprese.<\/li>\n
      4. Nerid\u011bte ani neobsluhujte stroje.<\/strong> po dobu alespo\u0148 4\u20136 hodin po pod\u00e1n\u00ed d\u00e1vky.<\/li>\n
      5. Opakujte d\u00e1vku ka\u017ed\u00fdch 4\u20136 hodin<\/strong> p\u0159i dlouh\u00e9 cest\u011b (maxim\u00e1ln\u011b 4 d\u00e1vky za 24 hodin u dosp\u011bl\u00fdch).<\/li>\n
      6. P\u0159i z\u00e1chvatech vertiga \u2014 u\u017eijte okam\u017eit\u011b p\u0159i prvn\u00edch p\u0159\u00edznac\u00edch; um\u00edst\u011bte se na bezpe\u010dn\u00e9 m\u00edsto (lehn\u011bte si do tich\u00e9, tmav\u00e9 m\u00edstnosti), nepokou\u0161ejte se chodit.<\/li>\n
      7. Pijte dostatek vody \u2014 anticholinergn\u00ed \u00fa\u010dinek zp\u016fsobuje sucho v \u00fastech a m\u00edrnou dehydrataci.<\/li>\n
      8. Pokud l\u00e9k u\u017e\u00edv\u00e1te p\u0159i chronick\u00e9m vertigu, zkonzultujte se sv\u00fdm l\u00e9ka\u0159em po 48\u201372 hodin\u00e1ch \u2014 dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed m\u016f\u017ee maskovat z\u00e1kladn\u00ed diagn\u00f3zu a zp\u016fsobit l\u00e9ky vyvolan\u00e9 zhor\u0161en\u00ed kognitivn\u00edch funkc\u00ed.<\/li>\n<\/ol>\n

        Vedlej\u0161\u00ed \u00fa\u010dinky p\u0159\u00edpravku Draminate<\/h2>\n

        \u010cast\u00e9:<\/strong><\/p>\n