{"id":56879,"date":"2024-02-27T17:12:15","date_gmt":"2024-02-27T17:12:15","guid":{"rendered":"https:\/\/medsname.com\/duphaston\/"},"modified":"2026-04-30T10:17:17","modified_gmt":"2026-04-30T10:17:17","slug":"duphaston","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/duphaston\/","title":{"rendered":"Duphaston"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Rychl\u00e1 odpov\u011b\u010f<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Duphaston<\/strong> je <strong>dydrogesterone 10 mg<\/strong>, a retroprogesterone (stereoisomer of progesterone) with selective progestogenic activity \u2014 no androgenic, estrogenic, or glucocorticoid effects. Used for: <strong>Opozice progestinu v HRT<\/strong>, <strong>threatened and recurrent miscarriage<\/strong>, <strong>endometriosis<\/strong>, <strong>sekund\u00e1rn\u00ed amenorey<\/strong>, <strong>dysfunk\u010dn\u00ed d\u011blo\u017en\u00ed krv\u00e1cen\u00ed<\/strong>, a <strong>PMS<\/strong>. Favourable safety profile \u2014 no breast cancer signal in observational studies.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 Pro\u010d nakupovat na MedsBase:<\/strong> Ov\u011b\u0159en\u00e9 dod\u00e1vky p\u0159\u00edmo od v\u00fdrobce \u00b7 Diskr\u00e9tn\u00ed celosv\u011btov\u00e1 doprava \u00b7 Bezpe\u010dn\u00e9 platby (kreditn\u00ed karta, kryptom\u011bny) \u00b7 Hodnocen\u00ed 4.9\u2605 od 1 400+ z\u00e1kazn\u00edk\u016f\n<\/div>\n<h2><strong>What Is Duphaston?<\/strong><\/h2>\n<p>Duphaston is a branded generic of <strong>dydrogesterone<\/strong>, a stereoisomer of natural progesterone. Its molecular structure gives it <strong>highly selective progesterone receptor activity<\/strong> \u2014 without the androgenic, estrogenic, anti-mineralocorticoid, or glucocorticoid effects of other progestins. It is orally bioavailable (unlike micronized progesterone, which requires a special formulation) and has a 16\u201318 hour half-life. Manufactured by Abbott.<\/p>\n<h2><strong>Klinick\u00e9 pou\u017eit\u00ed<\/strong><\/h2>\n<ul>\n<li><strong>Progestinov\u00e1 opozice v HRT:<\/strong> 10 mg daily (continuous-combined) or 10 mg for 14 days\/cycle (sequential).<\/li>\n<li><strong>Threatened miscarriage:<\/strong> 40 mg loading then 10 mg twice daily until bleeding stops (PRISM trial subgroups).<\/li>\n<li><strong>Recurrent miscarriage:<\/strong> 10 mg twice daily from ovulation through week 12\u201320 (LOTUS I and II trials show improved pregnancy rates in IVF).<\/li>\n<li><strong>Sekund\u00e1rn\u00ed amenorea:<\/strong> 10 mg twice daily for 10 days with estradiol.<\/li>\n<li><strong>Dysfunk\u010dn\u00ed d\u011blo\u017en\u00ed krv\u00e1cen\u00ed:<\/strong> 10 mg twice daily for 5\u20137 days to stop bleeding, cyclic thereafter.<\/li>\n<li><strong>Endometri\u00f3za:<\/strong> 10 mg 2\u20133 times daily from day 5 to day 25 of cycle.<\/li>\n<li><strong>IVF luteal phase support:<\/strong> 10 mg three times daily starting at embryo transfer.<\/li>\n<li><strong>PMS \/ PMDD:<\/strong> 10 mg twice daily from day 12 to day 26 of cycle.<\/li>\n<\/ul>\n<h2><strong>Jak u\u017e\u00edvat<\/strong><\/h2>\n<ol>\n<li>Swallow tablet whole with water, with or without food.<\/li>\n<li>Dose and timing depend on indication \u2014 follow the prescribing clinician&#8217;s schedule carefully.<\/li>\n<li>For HRT, dydrogesterone is the oral progestin of choice for women who dislike the sedation of micronized progesterone.<\/li>\n<li>For pregnancy support, continue until week 12\u201320 per fertility specialist; do not stop abruptly during active use.<\/li>\n<\/ol>\n<h2><strong>Dydrogesterone vs Other Progestins<\/strong><\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Progestin<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Profile<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dydrogesterone<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Selective progesterone receptor; no androgenic, estrogenic, or glucocorticoid effects; no known breast cancer signal<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Micronized progesterone<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Bioidentical; sedative (via GABA-A metabolite); poor oral bioavailability unless micronized<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Medroxyprogesteron<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Mild androgenic, mild glucocorticoid; associated with modestly elevated breast cancer risk in WHI data<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Norethisteron<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Androgenic; effective in dysfunctional bleeding and endometriosis; cardiovascular considerations<\/td>\n<\/tr>\n<\/table>\n<h2><strong>Vedlej\u0161\u00ed \u00fa\u010dinky<\/strong><\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> headache, migraine, nausea, breast tenderness, breakthrough bleeding, spotting.<\/p>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong> depression, allergic skin reaction, weight change.<\/p>\n<p><strong>Vz\u00e1cn\u00e9:<\/strong> cholestasis, jaundice, VTE (much less than estrogens or combined OCPs).<\/p>\n<h2><strong>Who Should Not Take Duphaston<\/strong><\/h2>\n<ul>\n<li>Known or suspected pregnancy (unless used as pregnancy support under clinical guidance)<\/li>\n<li>Nediagnostikovan\u00e9 vagin\u00e1ln\u00ed krv\u00e1cen\u00ed<\/li>\n<li>Anamn\u00e9za karcinomu prsu<\/li>\n<li>Aktivn\u00ed jatern\u00ed onemocn\u011bn\u00ed<\/li>\n<li>Active thromboembolic disorder<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost<\/li>\n<\/ul>\n<h2><strong>Skladov\u00e1n\u00ed<\/strong><\/h2>\n<p>Store at room temperature (below 30 \u00b0C). Keep in original blister. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">How does dydrogesterone differ from natural progesterone?<\/h3>\n<p>Dydrogesterone is a stereoisomer \u2014 the molecules have the same atoms but a flipped 3D shape. The flip gives selective progesterone-receptor binding (no androgenic\/estrogenic\/mineralocorticoid effects) and eliminates the sedative property of natural progesterone.<\/p>\n<h3 class=\"wp-block-heading\">Is duphaston safe in pregnancy?<\/h3>\n<p>Widely used for threatened miscarriage and IVF support. The LOTUS and PRISM trials support its safety and efficacy in these indications. Generally considered safe in pregnancy under clinician guidance.<\/p>\n<h3 class=\"wp-block-heading\">Can I use duphaston for PMS?<\/h3>\n<p>Yes \u2014 cyclic dydrogesterone (day 12\u201326) is traditionally used for luteal phase support in PMS. Modern evidence favours SSRIs for severe PMS\/PMDD, but dydrogesterone remains an option particularly when SSRIs are not tolerated.<\/p>\n<h3 class=\"wp-block-heading\">Will duphaston make me gain weight?<\/h3>\n<p>Small weight fluctuations reported; generally considered weight-neutral in trials.<\/p>\n<h3 class=\"wp-block-heading\">Is dydrogesterone safer than medroxyprogesterone?<\/h3>\n<p>Observational data (E3N cohort) suggest dydrogesterone and micronized progesterone have a more favourable breast-cancer profile than synthetic progestins like medroxyprogesterone when used for HRT.<\/p>\n<h3 class=\"wp-block-heading\">Can I take duphaston while breastfeeding?<\/h3>\n<p>Small amounts pass into breast milk. Generally considered compatible with breastfeeding for short courses; discuss with clinician.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Take as soon as you remember unless nearly time for the next dose. Do not double-dose.<\/p>\n<h3 class=\"wp-block-heading\">Can I use duphaston for endometriosis?<\/h3>\n<p>Yes \u2014 10 mg 2\u20133 times daily cyclically (day 5\u201325). Modern alternatives (combined OCPs, Mirena IUD, GnRH agonists) are often preferred, but dydrogesterone remains useful in specific cases.<\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed produkty pro zdrav\u00ed \u017een<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tamodex\/\">Tamodex (Tamoxifen 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tamilong\/\">Tamilong (Tamoxifen 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/letroheal\/\">Letroheal (Letrozol 2,5 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/etibo\/\">Etibo (Lapatinib 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/deviry\/\">Deviry (Medroxyprogesteron 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/naprosyn\/\">Naprosyn (Naproxen 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/candid-v-gel\/\">Candid-V Gel (Clotrimazol)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed:<\/strong> Informace maj\u00ed vzd\u011bl\u00e1vac\u00ed charakter a nenahrazuj\u00ed l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli l\u00e9ku, zejm\u00e9na p\u0159i l\u00e9\u010db\u011b rakoviny, hormon\u00e1ln\u00ed terapii a p\u0159edepsan\u00fdch p\u0159\u00edpravc\u00edch, se pora\u010fte s l\u00e9ka\u0159em.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Zdrav\u00ed \u017een<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/proluton-depot\/\">Proluton Depot<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/duoluton-l\/\">Duoluton L<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/danogen\/\">Danogen<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ovral-g\/\">Ovral G<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endogest\/\">Endogest<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Regulates Menstrual Cycle<br \/>\n\u2705 Treats Menstrual Disorders<br \/>\n\u2705 Supports Pregnancy<br \/>\n\u2705 Prevents Miscarriage<br \/>\n\u2705 Prescribed Hormonal Therapy<\/p>\n<p>Duphaston contains Dydrogesterone.<\/p>","protected":false},"featured_media":56880,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3521,3522,3502],"product_tag":[4191,4192],"class_list":{"0":"post-56879","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-fertility","8":"product_cat-fertility-supplements-for-women","9":"product_cat-womens-health","10":"product_tag-duphaston","11":"product_tag-dydrogesterone","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56879"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56880"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56879"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56879"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56879"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}