{"id":56899,"date":"2024-02-27T17:13:01","date_gmt":"2024-02-27T17:13:01","guid":{"rendered":"https:\/\/medsname.com\/lexaheal\/"},"modified":"2026-04-30T10:24:33","modified_gmt":"2026-04-30T10:24:33","slug":"lexaheal","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/lexaheal\/","title":{"rendered":"Lexaheal"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Lexaheal (Escitalopram 5 \/ 10 \/ 20 mg) je selektivn\u00ed inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed serotoninu pou\u017e\u00edvan\u00fd k l\u00e9\u010db\u011b deprese, \u00fazkosti a souvisej\u00edc\u00edch poruch. N\u00e1stup antidepresivn\u00edho \u00fa\u010dinku je postupn\u00fd \u2014 pro spravedliv\u00e9 vyhodnocen\u00ed je pot\u0159eba 4\u20136 t\u00fddn\u016f.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Lexaheal u MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je kryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Jak Lexaheal funguje<\/h2>\n

Lexaheal<\/strong> je tableta obsahuj\u00edc\u00ed Escitalopram, SSRI, dod\u00e1van\u00e1 spole\u010dnost\u00ed Healing Pharma. Dostupn\u00e9 s\u00edly: 5 \/ 10 \/ 20 mg<\/strong>. U\u017e\u00edvejte s j\u00eddlem nebo bez j\u00eddla, ve stejnou dobu ka\u017ed\u00fd den pro stabiln\u00ed hladinu v plazm\u011b.<\/p>\n

SSRI blokuj\u00ed zp\u011btn\u00e9 vychyt\u00e1v\u00e1n\u00ed serotoninu (5-HT) na presynaptick\u00e9m serotoninov\u00e9m transport\u00e9ru (SERT), \u010d\u00edm\u017e zvy\u0161uj\u00ed dostupnost synaptick\u00e9ho serotoninu. Terapeutick\u00fd \u00fa\u010dinek se objevuje se zpo\u017ed\u011bn\u00edm 2\u20136 t\u00fddn\u016f po blok\u00e1d\u011b transport\u00e9ru \u2014 toto zpo\u017ed\u011bn\u00ed odr\u00e1\u017e\u00ed n\u00e1sledn\u00e9 adaptace v citlivosti 5-HT autoreceptor\u016f, expresi BDNF a neurogenezi v hippocampu, nikoli p\u0159\u00edm\u00e9 \u00fa\u010dinky na receptory. Pacienti, kte\u0159\u00ed po 2 t\u00fddnech \u201cnec\u00edt\u00ed nic\u201d, by nem\u011bli l\u00e9\u010dbu p\u0159ed\u010dasn\u011b ukon\u010dovat; vyhodno\u0165te odpov\u011b\u010f po 4\u20136 t\u00fddnech adekv\u00e1tn\u00ed d\u00e1vky.<\/p>\n

Escitalopram je S-enantiomer<\/strong> citalopramu. Podle hlavn\u00edch sm\u011brnic (NICE, APA, CANMAT) je pova\u017eov\u00e1n za jeden z nejl\u00e9pe sn\u00e1\u0161en\u00fdch a nej\u00fa\u010dinn\u011bj\u0161\u00edch SSRI, s nej\u010dist\u0161\u00edm farmakokinetick\u00fdm profilem (line\u00e1rn\u00ed, n\u00edzk\u00e1 vazba na proteiny, slab\u00e1 inhibice CYP).<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Hlavn\u00ed deprese<\/td>\n10 mg 1\u00d7 denn\u011b<\/td>\n10\u201320 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n
Generalizovan\u00e1 \u00fazkost<\/td>\n10 mg 1\u00d7 denn\u011b<\/td>\n10\u201320 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n
panick\u00e1 porucha<\/td>\n5 mg 1\u00d7 denn\u011b po dobu 1 t\u00fddne<\/td>\n10\u201320 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n
MDD\/GAD u dosp\u00edvaj\u00edc\u00edch (\u226512 let)<\/td>\n10 mg 1\u00d7 denn\u011b<\/td>\n10\u201320 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed \/ jatern\u00ed porucha<\/td>\n5 mg 1\u00d7 denn\u011b<\/td>\n10 mg 1\u00d7 denn\u011b<\/td>\n10 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nQT interval a d\u00e1vkovac\u00ed strop<\/strong><\/p>\n

20 mg\/den je maximum a vytv\u00e1\u0159\u00ed p\u0159ibli\u017en\u011b stejn\u00fd QT sign\u00e1l jako 40 mg racemick\u00e9ho citalopramu. Vyvarujte se u vrozen\u00e9ho dlouh\u00e9ho QT, hypokal\u00e9mie, hypomagnez\u00e9mie a sou\u010dasn\u00e9 terapie prodlu\u017euj\u00edc\u00ed QT interval. D\u00e1vka 10 mg m\u00e1 u v\u011bt\u0161iny pacient\u016f minim\u00e1ln\u00ed vliv na QT interval.<\/p>\n<\/div>\n

\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u osob do 25 let)<\/strong><\/p>\n

V\u0161echna SSRI nesou varov\u00e1n\u00ed FDA (\u010dern\u00fd r\u00e1me\u010dek) ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika sebevra\u017eedn\u00fdch my\u0161lenek u pacient\u016f mlad\u0161\u00edch 25 let, zejm\u00e9na v prvn\u00edch 4 t\u00fddnech a p\u0159i zm\u011bn\u00e1ch d\u00e1vkov\u00e1n\u00ed. To neznamen\u00e1, ne<\/em> \u017ee SSRI jsou pro mlad\u00e9 lidi celkov\u011b \u0161kodliv\u00e1 \u2014 metaanal\u00fdzy ukazuj\u00ed \u010dist\u00fd benefit \u2014 ale vy\u017eaduje to pe\u010dliv\u00e9 klinick\u00e9 sledov\u00e1n\u00ed b\u011bhem zah\u00e1jen\u00ed l\u00e9\u010dby a titrace u dosp\u00edvaj\u00edc\u00edch a mlad\u00fdch dosp\u011bl\u00fdch.<\/p>\n<\/div>\n

\nSerotoninov\u00fd syndrom<\/strong><\/p>\n

Kombinace Lexahealu s jin\u00fdmi serotonergn\u00edmi l\u00e1tkami m\u016f\u017ee zp\u016fsobit serotoninov\u00fd syndrom (t\u0159es, hyperreflexie, klonus, hypertermie, agitace). Vyvarujte se sou\u010dasn\u00e9ho u\u017e\u00edv\u00e1n\u00ed: MAOI (14denn\u00ed vynech\u00e1n\u00ed v obou sm\u011brech; fluoxetin vy\u017eaduje 5 t\u00fddn\u016f), tramadol, petidin, dextrometorfan, linezolid, methylenov\u00e1 mod\u0159, t\u0159ezalka te\u010dkovan\u00e1, MDMA. Triptan + SSRI je obecn\u011b tolerov\u00e1n u migr\u00e9ny \u2014 absolutn\u00ed riziko je n\u00edzk\u00e9.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n