{"id":56945,"date":"2024-02-27T17:15:28","date_gmt":"2024-02-27T17:15:28","guid":{"rendered":"https:\/\/medsname.com\/etova\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"etova","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/etova\/","title":{"rendered":"Etova"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Etova?<\/h3>\n

Etova<\/strong> je etodolac<\/strong> tablety dostupn\u00e9 v 200 mg a 400 mg<\/strong> s\u00edly. Etodolac je preferen\u010dn\u00ed COX-2 NSAID<\/strong> \u2014 v terapeutick\u00fdch d\u00e1vk\u00e1ch blokuje sp\u00ed\u0161e enzym COX-2 zp\u016fsobuj\u00edc\u00ed z\u00e1n\u011bt ne\u017e COX-1 chr\u00e1n\u00edc\u00ed \u017ealudek, co\u017e poskytuje m\u00edrn\u011b \u0161etrn\u011bj\u0161\u00ed gastrointestin\u00e1ln\u00ed profil ve srovn\u00e1n\u00ed s diklofenakem, ibuprofenem nebo naproxenem. Obvykl\u00e1 d\u00e1vka pro dosp\u011bl\u00e9 je 200\u2013400 mg dvakr\u00e1t denn\u011b s j\u00eddlem<\/strong>. Etova se b\u011b\u017en\u011b pou\u017e\u00edv\u00e1 p\u0159i osteoartr\u00f3ze, revmatoidn\u00ed artritid\u011b, akutn\u00ed muskuloskelet\u00e1ln\u00ed bolesti a poopera\u010dn\u00ed bolesti.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Etova<\/strong> je peror\u00e1ln\u00ed tableta obsahuj\u00edc\u00ed etodolac<\/strong>, NSAID druh\u00e9 generace uveden\u00e9 na trh spole\u010dnost\u00ed Ipca Laboratories. Etodolac pat\u0159\u00ed do t\u0159\u00eddy pyrankarboxylov\u00fdch kyselin a m\u00e1 prok\u00e1zanou 5\u201310n\u00e1sobnou preferenci pro COX-2 oproti COX-1<\/strong> v klinick\u00fdch d\u00e1vk\u00e1ch. To jej \u0159ad\u00ed mezi klasick\u00e1 neselektivn\u00ed NSAID (ibuprofen, diklofenak) a vysoce selektivn\u00ed inhibitory COX-2 (celecoxib), s obecn\u011b st\u0159edn\u00edm rizikov\u00fdm profilem.<\/p>\n

Polo\u010das etodolaku 7 hodin umo\u017e\u0148uje jednoduch\u00e9 d\u00e1vkov\u00e1n\u00ed dvakr\u00e1t denn\u011b a preferen\u010dn\u00ed aktivita COX-2 znamen\u00e1 m\u00e9n\u011b hl\u00e1\u0161en\u00fdch p\u0159\u00edpad\u016f za\u017e\u00edvac\u00edch pot\u00ed\u017e\u00ed, gastritidy a peptick\u00e9ho v\u0159edov\u00e9ho onemocn\u011bn\u00ed ve srovn\u00e1n\u00ed s neselektivn\u00edmi NSAID p\u0159i stejn\u00e9 protiz\u00e1n\u011btliv\u00e9 \u00fa\u010dinnosti.<\/p>\n

K \u010demu se Etova pou\u017e\u00edv\u00e1?<\/h2>\n
    \n
  • Osteoartritida<\/strong> \u2014 bolest kloub\u016f, ztuhlost, omezen\u00fd rozsah pohybu<\/li>\n
  • Revmatoidn\u00ed artritida<\/strong> \u2014 symptomatick\u00e1 \u00faleva p\u0159i z\u00e1n\u011btliv\u00fdch vzplanut\u00edch<\/li>\n
  • Akutn\u00ed bolest pohybov\u00e9ho apar\u00e1tu<\/strong> \u2014 v\u00fdrony, nata\u017een\u00ed, poran\u011bn\u00ed m\u011bkk\u00fdch tk\u00e1n\u00ed<\/li>\n
  • Poopera\u010dn\u00ed bolest<\/strong> \u2014 v\u010detn\u011b stomatologick\u00fdch, ortopedick\u00fdch a gynekologick\u00fdch z\u00e1krok\u016f<\/li>\n
  • Bolesti zad<\/strong><\/li>\n
  • Ankylozuj\u00edc\u00ed spondylitida<\/strong> \u2014 mo\u017enost druh\u00e9 volby, kdy\u017e nen\u00ed tolerov\u00e1n indomethacin<\/li>\n
  • Prim\u00e1rn\u00ed dysmenorea<\/strong><\/li>\n
  • Zubn\u00ed a orofaci\u00e1ln\u00ed bolest<\/strong><\/li>\n<\/ul>\n

    Jak Etodolac funguje?<\/h2>\n

    Etodolac m\u00e1 preferen\u010dn\u00ed aktivitu COX-2<\/strong> \u2014 v terapeutick\u00fdch d\u00e1vk\u00e1ch v\u00edce inhibuje z\u00e1n\u011btliv\u00fd enzym COX-2 ne\u017e \u017ealudek chr\u00e1n\u00edc\u00ed COX-1. To poskytuje m\u00edrn\u011b ni\u017e\u0161\u00ed riziko GI v\u0159ed\u016f ve srovn\u00e1n\u00ed s klasick\u00fdmi neselektivn\u00edmi NSAID, jako je diklofenak, ibuprofen a naproxen.<\/p>\n

    Terapeutick\u00fd \u0159et\u011bzec ud\u00e1lost\u00ed je u v\u0161ech NSAID stejn\u00fd:<\/p>\n

      \n
    1. Po\u0161kozen\u00ed tk\u00e1n\u011b nebo z\u00e1n\u011bt uvol\u0148uje fosfolipidy z bun\u011b\u010dn\u00fdch membr\u00e1n<\/li>\n
    2. Fosfolip\u00e1za A\u2082 je p\u0159em\u011b\u0148uje na kyselinu arachidonovou<\/li>\n
    3. Cyklooxygen\u00e1za (COX-1\/COX-2) p\u0159em\u011b\u0148uje kyselinu arachidonovou na prostaglandiny<\/strong> \u2014 molekuly zodpov\u011bdn\u00e9 za bolest, otok a hore\u010dku<\/li>\n
    4. Etodolac blokuje enzymy COX, tak\u017ee se produkuje m\u00e9n\u011b prostaglandin\u016f, a t\u00edm se sni\u017euje bolest a z\u00e1n\u011bt<\/li>\n<\/ol>\n

      Proto\u017ee prostaglandiny tak\u00e9 chr\u00e1n\u00ed \u017ealude\u010dn\u00ed sliznici, reguluj\u00ed pr\u016ftok krve ledvinami a ovliv\u0148uj\u00ed funkci krevn\u00edch desti\u010dek, stejn\u00fd mechanismus, kter\u00fd zm\u00edr\u0148uje bolest, je tak\u00e9 zodpov\u011bdn\u00fd za hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky NSAID: podr\u00e1\u017ed\u011bn\u00ed \u017ealudku, zadr\u017eov\u00e1n\u00ed tekutin, vysok\u00fd krevn\u00ed tlak a (u n\u011bkter\u00fdch jedinc\u016f) z\u00e1t\u011b\u017e ledvin.<\/p>\n

      D\u00e1vkov\u00e1n\u00ed Etovy<\/h2>\n
        \n
      • Osteoartr\u00f3za, revmatoidn\u00ed artritida:<\/strong> 200\u2013400 mg dvakr\u00e1t denn\u011b s j\u00eddlem. Maxim\u00e1ln\u011b 1 200 mg\/den (z\u0159\u00eddka pot\u0159ebn\u00e9).<\/li>\n
      • Akutn\u00ed bolest, poopera\u010dn\u00ed bolest:<\/strong> 200\u2013400 mg dvakr\u00e1t denn\u011b po dobu 3\u20137 dn\u00ed.<\/li>\n
      • Star\u0161\u00ed pacienti, n\u00edzk\u00e1 t\u011blesn\u00e1 hmotnost (< 60 kg), ren\u00e1ln\u00ed porucha:<\/strong> za\u010dn\u011bte s 200 mg dvakr\u00e1t denn\u011b a titrujte pouze v p\u0159\u00edpad\u011b pot\u0159eby.<\/li>\n<\/ul>\n

        U\u017e\u00edvejte s j\u00eddlem nebo ml\u00e9kem, abyste sn\u00ed\u017eili podr\u00e1\u017ed\u011bn\u00ed GI traktu. Tablety polykejte cel\u00e9 a zapijte vodou. D\u00e1vky by m\u011bly b\u00fdt rozlo\u017eeny p\u0159ibli\u017en\u011b 12 hodin od sebe (nap\u0159. v 8 hodin r\u00e1no a v 8 hodin ve\u010der). Pokud d\u00e1vku vynech\u00e1te: u\u017eijte ji, jakmile si vzpomenete, pokud nen\u00ed dal\u0161\u00ed d\u00e1vka napl\u00e1nov\u00e1na do 4 hodin \u2014 pak ji vynechejte.<\/p>\n

        \n

        GI bezpecnost \u2014 precist pred prvnim uzitim.<\/strong> Ka\u017ed\u00e9 NSAID, v\u010detn\u011b Etovy, nese skute\u010dn\u00e9 riziko gastritidy, peptick\u00e9ho v\u0159edu a krv\u00e1cen\u00ed v horn\u00ed \u010d\u00e1sti GI traktu. Riziko je nejvy\u0161\u0161\u00ed u pacient\u016f star\u0161\u00edch 65 let, u t\u011bch s p\u0159edchoz\u00edm v\u0159edov\u00fdm onemocn\u011bn\u00edm a u ka\u017ed\u00e9ho, kdo tak\u00e9 u\u017e\u00edv\u00e1 n\u00edzk\u00e9 d\u00e1vky aspirinu, kortikosteroid\u016f, SSRI nebo antikoagulanci\u00ed. U\u017e\u00edvejte Etovu s j\u00eddlem<\/em>, pouzijte nejnizsi ucinnou davku po nejkratsi rozumne dlouhou dobu<\/em>, a zeptejte se lekare na predpis inhibitoru protonove pumpy (omeprazol, pantoprazol), pokud ho potrebujete dele nez 2\u20134 tydny.<\/p>\n<\/div>\n

        Kdo by nem\u011bl u\u017e\u00edvat Etovu?<\/h2>\n
          \n
        • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na etodolak nebo jak\u00e9koli NSAID<\/li>\n
        • Aktivn\u00ed nebo opakuj\u00edc\u00ed se peptick\u00fd v\u0159ed, krv\u00e1cen\u00ed nebo perforace tr\u00e1vic\u00edho traktu<\/li>\n
        • Astma, kop\u0159ivka nebo rinitida vyvolan\u00e1 aspirinem nebo jin\u00fdm NSAID (\u201caspirinem exacerbovan\u00e9 respira\u010dn\u00ed onemocn\u011bn\u00ed\u201d)<\/li>\n
        • T\u011b\u017ek\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed (NYHA t\u0159\u00edda IV)<\/li>\n
        • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater (Child\u2013Pugh C)<\/li>\n
        • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed ledvin (CrCl < 30 ml\/min)<\/li>\n
        • T\u0159et\u00ed trimestr t\u011bhotenstv\u00ed (riziko p\u0159ed\u010dasn\u00e9ho uzav\u0159en\u00ed ductus arteriosus a oligohydramnionu)<\/li>\n
        • Ned\u00e1vn\u00e1 operace koron\u00e1rn\u00edho bypassu (CABG) \u2014 absolutn\u00ed kontraindikace pro v\u0161echna NSAID<\/li>\n<\/ul>\n

          Kardiovaskul\u00e1rn\u00ed riziko<\/h3>\n

          V\u0161echna NSAID (krom\u011b n\u00edzk\u00fdch d\u00e1vek aspirinu) nesou ur\u010dit\u00e9 zv\u00fd\u0161en\u00ed rizika infarktu a mrtvice a mohou zhor\u0161it srde\u010dn\u00ed selh\u00e1n\u00ed. Riziko je z\u00e1visl\u00e9 na d\u00e1vce a d\u00e9lce u\u017e\u00edv\u00e1n\u00ed a je obecn\u011b nejvy\u0161\u0161\u00ed u COX-2 selektivn\u00edch l\u00e1tek a u diklofenaku. Pacienti s prok\u00e1zan\u00fdm ischemick\u00fdm onemocn\u011bn\u00edm srdce, perifern\u00edm arteri\u00e1ln\u00edm onemocn\u011bn\u00edm, mrtvic\u00ed nebo nekontrolovanou hypertenz\u00ed by m\u011bli pou\u017e\u00edvat neselektivn\u00ed NSAID (ibuprofen nebo naproxen) v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce, nebo pokud mo\u017eno m\u00edsto nich paracetamol.<\/p>\n

          Ren\u00e1ln\u00ed (ledvinov\u00e1) bezpe\u010dnost<\/h3>\n

          NSAID sni\u017euj\u00ed produkci ren\u00e1ln\u00edch prostaglandin\u016f, co\u017e m\u016f\u017ee zp\u016fsobit zadr\u017eov\u00e1n\u00ed sol\u00ed a vody, zv\u00fd\u0161en\u00ed krevn\u00edho tlaku a \u2013 u zraniteln\u00fdch pacient\u016f \u2013 akutn\u00ed po\u0161kozen\u00ed ledvin. Mezi vysoce rizikov\u00e9 skupiny pat\u0159\u00ed star\u0161\u00ed pacienti, pacienti u\u017e\u00edvaj\u00edc\u00ed ACE inhibitory\/ARB spolu s diuretiky (tzv. \u201ctrojit\u00fd z\u00e1sah\u201d), dehydratovan\u00ed jedinci (zvracen\u00ed, pr\u016fjem, horko, intenzivn\u00ed cvi\u010den\u00ed) a pacienti s ji\u017e existuj\u00edc\u00edm CKD. P\u0159esta\u0148te u\u017e\u00edvat NSAID a vyhledejte l\u00e9ka\u0159skou kontrolu, pokud se u v\u00e1s objev\u00ed sn\u00ed\u017een\u00fd v\u00fddej mo\u010di, otoky nebo nevysv\u011btlen\u00fd p\u0159\u00edr\u016fstek hmotnosti.<\/p>\n

          Vedlej\u0161\u00ed \u00fa\u010dinky Etovy<\/h2>\n

          Etova je obecn\u011b dob\u0159e sn\u00e1\u0161ena p\u0159i standardn\u00edch d\u00e1vk\u00e1ch.<\/p>\n