<\/p>\n
Lipikard<\/strong> obsahuje ezetimib<\/strong> (10 mg), inhibitor absorpce cholesterolu<\/strong> kter\u00fd blokuje transport\u00e9r NPC1L1 v tenk\u00e9m st\u0159ev\u011b. Je to prvn\u00ed volba jako dopl\u0148kov\u00e1 terapie, kdy\u017e samotn\u00fd statin nedos\u00e1hne c\u00edlov\u00e9 hladiny LDL<\/strong>. Samotn\u00fd ezetimib sni\u017euje LDL-C p\u0159ibli\u017en\u011b o 17\u201322%. V kombinaci se statinem poskytuje dal\u0161\u00ed sn\u00ed\u017een\u00ed LDL o ~20\u201325 %, co\u017e celkov\u011b p\u0159edstavuje pokles o 55\u201360 % \u2014 ekvivalentn\u00ed zdvojn\u00e1soben\u00ed d\u00e1vky statinu bez d\u00e1vkov\u011b z\u00e1visl\u00fdch svalov\u00fdch nebo jatern\u00edch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f. IMPROVE-IT<\/strong> Studie (18 144 pacient\u016f po akutn\u00edm koron\u00e1rn\u00edm syndromu) prok\u00e1zala, \u017ee p\u0159id\u00e1n\u00ed ezetimibu ke simvastatinu d\u00e1le sni\u017euje kardiovaskul\u00e1rn\u00ed p\u0159\u00edhody. D\u00e1vkov\u00e1n\u00ed: 10 mg jednou denn\u011b, kdykoli, s j\u00eddlem nebo bez j\u00eddla. Obecn\u011b velmi dob\u0159e sn\u00e1\u0161en \u2014 m\u00edrn\u00e9 gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee, ob\u010dasn\u00e9 myalgie, vz\u00e1cn\u00e9 zv\u00fd\u0161en\u00ed transamin\u00e1z. Vyvarujte se pod\u00e1v\u00e1n\u00ed p\u0159i t\u011b\u017ek\u00e9m po\u0161kozen\u00ed jater.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Ezedoc je peror\u00e1ln\u00ed hypolipidemikum obsahuj\u00edc\u00ed ezetimib<\/strong> (10 mg), vyr\u00e1b\u011bn\u00e9 v\u00fdrobcem certifikovan\u00fdm WHO-GMP. Dod\u00e1v\u00e1 se v balen\u00edch po 30, 60, 90 nebo 180 tablet\u00e1ch. Ezetimib je prvn\u00ed a jedin\u00fd l\u00e9k ze t\u0159\u00eddy inhibitor absorpce cholesterolu<\/strong> . Origin\u00e1ln\u00ed zna\u010dka: Zetia \/ Ezetrol<\/strong> (Merck, 2002).<\/p>\n Ezetimib je hlavn\u00edm pil\u00ed\u0159em druh\u00e9 linie l\u00e9\u010dby dyslipidemie \u2014 prvn\u00ed volbou, kdy\u017e pot\u0159ebujete v\u011bt\u0161\u00ed sn\u00ed\u017een\u00ed LDL, ne\u017e poskytuje tolerovan\u00e1 d\u00e1vka statinu, nebo kdy\u017e pacient nesnese vy\u0161\u0161\u00ed d\u00e1vky statin\u016f. Je tak\u00e9 nej\u010dast\u011bj\u0161\u00edm partnerem v pevn\u00fdch kombinac\u00edch (simvastatin\/ezetimib = Inegy\/Vytorin; rosuvastatin\/ezetimib = r\u016fzn\u00e9).<\/p>\n Ezetimib je slab\u00fd jako monoterapie (~17% sn\u00ed\u017een\u00ed LDL) ve srovn\u00e1n\u00ed se statinem (~30\u201360%); nej\u00fa\u010dinn\u011bj\u0161\u00ed je jako dopl\u0148kov\u00e1 l\u00e9\u010dba.<\/p>\n Ezetimib selektivn\u011b inhibuje transport\u00e9r Niemann-Pick C1-Like 1 (NPC1L1)<\/strong> na enterocytech v proxim\u00e1ln\u00edm tenk\u00e9m st\u0159ev\u011b. NPC1L1 je zodpov\u011bdn\u00fd za vst\u0159eb\u00e1v\u00e1n\u00ed cholesterolu z potravy a \u017elu\u010di ze st\u0159evn\u00edho lumen do enterocytu.<\/p>\n P\u0159i blok\u00e1d\u011b NPC1L1:<\/p>\n Proto\u017ee ezetimib a statiny p\u016fsob\u00ed na komplement\u00e1rn\u00ed dr\u00e1hy<\/strong> (absorpce vs. synt\u00e9za), jejich \u00fa\u010dinky jsou aditivn\u00ed. Statiny sni\u017euj\u00ed synt\u00e9zu LDL; ezetimib sni\u017euje absorpci\/vstup LDL. Spole\u010dn\u011b sni\u017euj\u00ed LDL v\u00edce ne\u017e ka\u017ed\u00fd zvl\u00e1\u0161\u0165, ani\u017e by zvy\u0161ovaly ne\u017e\u00e1douc\u00ed \u00fa\u010dinky druh\u00e9ho.<\/p>\n \u00dadaje o v\u00fdsledc\u00edch: studie IMPROVE-IT<\/strong> (2015) prok\u00e1zala, \u017ee p\u0159id\u00e1n\u00ed ezetimibu k simvastatinu u pacient\u016f po ACS sn\u00ed\u017eilo kombinovan\u00fd kardiovaskul\u00e1rn\u00ed endpoint o 6,4 % (NNT 50 za 7 let), co\u017e potvrdilo, \u017ee sn\u00ed\u017een\u00ed LDL se prom\u00edt\u00e1 do skute\u010dn\u00e9ho sn\u00ed\u017een\u00ed ud\u00e1lost\u00ed.<\/p>\n Standardn\u00ed d\u00e1vka:<\/strong> 10 mg jednou denn\u011b v kteroukoli denn\u00ed dobu, s j\u00eddlem nebo bez j\u00eddla.<\/p>\n Ezetimib je jedn\u00edm z nejl\u00e9pe sn\u00e1\u0161en\u00fdch l\u00e9k\u016f na sn\u00ed\u017een\u00ed lipid\u016f. Ne\u017e\u00e1douc\u00ed \u00fa\u010dinky jsou v studi\u00edch bl\u00edzk\u00e9 m\u00ed\u0159e placeba.<\/p>\n \u010cast\u00e9 (< 5 %):<\/strong><\/p>\n M\u00e9n\u011b \u010dast\u00e9:<\/strong><\/p>\n Skladujte p\u0159\u00edpravek Ezedoc p\u0159i teplot\u011b pod 25 \u00b0C na such\u00e9m m\u00edst\u011b, v p\u016fvodn\u00edm blistru. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n Obvykle ne. Jako monoterapie sni\u017euje ezetimib LDL pouze o ~17 % \u2013 mnohem m\u00e9n\u011b ne\u017e statin (30\u201360 %). Jako monoterapie je vhodn\u00fd pouze pro pacienty, kte\u0159\u00ed nesn\u00e1\u0161ej\u00ed \u017e\u00e1dn\u00fd statin v jak\u00e9koli d\u00e1vce. Pro v\u011bt\u0161inu lid\u00ed je nejlep\u0161\u00ed strategi\u00ed ke sn\u00ed\u017een\u00ed lipid\u016f nejprve statin, a pokud LDL z\u016fst\u00e1v\u00e1 nad c\u00edlovou hodnotou, p\u0159id\u00e1 se ezetimib.<\/p>\n Zdvojn\u00e1soben\u00ed d\u00e1vky statinu obvykle p\u0159id\u00e1 ~6 % sn\u00ed\u017een\u00ed LDL (tzv. \u201cpravidlo 6\u201d u statin\u016f). P\u0159id\u00e1n\u00ed ezetimibu p\u0159id\u00e1 ~20\u201325 % sn\u00ed\u017een\u00ed LDL. P\u0159id\u00e1n\u00ed ezetimibu je 3\u20134\u00d7 \u00fa\u010dinn\u011bj\u0161\u00ed<\/strong> ne\u017e zdvojn\u00e1soben\u00ed d\u00e1vky statinu, a to bez zv\u00fd\u0161en\u00ed svalov\u00fdch p\u0159\u00edznak\u016f souvisej\u00edc\u00edch s d\u00e1vkou. Proto modern\u00ed doporu\u010den\u00ed up\u0159ednost\u0148uj\u00ed kombinaci statinu a ezetimibu p\u0159ed zv\u00fd\u0161en\u00edm d\u00e1vky statinu na maximum.<\/p>\n Ano \u2013 studie IMPROVE-IT (18 144 pacient\u016f po ACS) uk\u00e1zala, \u017ee p\u0159id\u00e1n\u00ed ezetimibu k simvastatinu sn\u00ed\u017eilo kombinovan\u00fd endpoint kardiovaskul\u00e1rn\u00ed smrti, infarktu myokardu, nestabiln\u00ed anginy pectoris, revaskularizace nebo c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody o 6,4 % za 7 let. Toto je kl\u00ed\u010dov\u00fd d\u016fkaz, \u017ee sn\u00ed\u017een\u00ed LDL nad r\u00e1mec samotn\u00fdch statin\u016f st\u00e1le p\u0159in\u00e1\u0161\u00ed skute\u010dn\u00fd kardiovaskul\u00e1rn\u00ed prosp\u011bch.<\/p>\n Jakoukoli denn\u00ed dobu. Na rozd\u00edl od simvastatinu (preferovan\u00fd ve\u010der) na\u010dasov\u00e1n\u00ed ezetimibu nez\u00e1vis\u00ed na d\u00e1vce \u2014 vyberte si \u010das, kter\u00fd si budete d\u016fsledn\u011b pamatovat. Mnoho pacient\u016f jej u\u017e\u00edv\u00e1 sou\u010dasn\u011b se statinem.<\/p>\n Z\u0159\u00eddka. Monoterapie ezetimibem vykazuje vedlej\u0161\u00ed \u00fa\u010dinky na \u00farovni placeba. V kombinaci se statinem v\u00fdznamn\u011b nezvy\u0161uje statinem vyvolan\u00e9 svalov\u00e9 p\u0159\u00edznaky ve srovn\u00e1n\u00ed se samotn\u00fdm statinem.<\/p>\n Ezedoc (10 mg) si m\u016f\u017eete objednat na MedsBase v balen\u00edch po 30, 60, 90 nebo 180 tablet\u00e1ch. Dod\u00e1v\u00e1me po cel\u00e9m sv\u011bt\u011b s diskr\u00e9tn\u00edm balen\u00edm a z\u00e1sobami od certifikovan\u00e9ho v\u00fdrobce WHO-GMP.<\/p>\n Ezedoc je dod\u00e1v\u00e1n certifikovan\u00fdm v\u00fdrobcem WHO-GMP s \u00faplnou dokumentac\u00ed COA. Dod\u00e1v\u00e1me po cel\u00e9m sv\u011bt\u011b v prost\u00e9m, diskr\u00e9tn\u00edm balen\u00ed a ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. V\u00e1\u0161 popis transakce p\u0159i platb\u011b kartou zobrazuje regulovan\u00e9ho zpracovatele plateb (regulovan\u00e9ho zpracovatele plateb kartou), nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku.<\/p>\n <\/p>\n Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n \u2705 Sni\u017euje hladinu cholesterolu Ezedoc obsahuje ezetimib.<\/p>","protected":false},"featured_media":56973,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3953],"product_tag":[4210,4211],"class_list":{"0":"post-56972","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-high-cholesterol-treatments","9":"product_tag-ezedoc","10":"product_tag-ezetimibe","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56972"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56973"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56972"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56972"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56972"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Co je Ezedoc?<\/h2>\n
K \u010demu se Ezedoc pou\u017e\u00edv\u00e1?<\/h2>\n
\n
Jak funguje Ezedoc?<\/h2>\n
\n
D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n
\n
Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
\n
\n
Interakce s l\u00e9\u010divy<\/h2>\n
\n
Kdo by nem\u011bl u\u017e\u00edvat Ezedoc?<\/h2>\n
\n
Skladov\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Mohu u\u017e\u00edvat Ezedoc m\u00edsto statinu?<\/h3>\n
Jak se Ezedoc srovn\u00e1v\u00e1 se zdvojn\u00e1soben\u00edm d\u00e1vky statinu?<\/h3>\n
Sni\u017euje Ezedoc riziko infarktu a mrtvice?<\/h3>\n
Kdy bych m\u011bl u\u017e\u00edvat Ezedoc?<\/h3>\n
Zp\u016fsobuje Ezedoc bolesti sval\u016f jako statiny?<\/h3>\n
Kde lze koupit Ezedoc online?<\/h3>\n
Souvisej\u00edc\u00ed l\u00e9ky na cholesterol<\/h2>\n
\n
Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Souvisej\u00edc\u00ed alternativy<\/h3>\n
\n
\n\u2705 Sni\u017euje riziko srde\u010dn\u00edch onemocn\u011bn\u00ed
\n\u2705 P\u0159edch\u00e1z\u00ed ateroskler\u00f3ze
\n\u2705 P\u0159edepisov\u00e1no l\u00e9ka\u0159i
\n\u2705 Mo\u017enost peror\u00e1ln\u00ed medikace<\/p>\n