{"id":56978,"date":"2024-02-27T17:16:44","date_gmt":"2024-02-27T17:16:44","guid":{"rendered":"https:\/\/medsname.com\/penvir\/"},"modified":"2026-04-30T10:17:16","modified_gmt":"2026-04-30T10:17:16","slug":"penvir","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/penvir\/","title":{"rendered":"Penvir"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Rychl\u00e1 odpov\u011b\u010f<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Penvir<\/strong> je <strong>famciclovir<\/strong>, a prescription antiviral prodrug of penciclovir for genital herpes (HSV-2), cold sores (HSV-1), and shingles (VZV). Penciclovir has an extended intracellular half-life (~10 hours) \u2014 so famciclovir dosing is more forgiving than aciclovir. Typical outpatient dosing is once or twice daily.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f6f7fb;border:1px solid #e3e5ee;border-radius:8px;padding:14px 18px;margin:18px 0;font-size:14px;line-height:1.55;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 <a href=\"\/cs\/reviews\/\" rel=\"noopener\">1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Objedn\u00e1v\u00e1n\u00ed z MedsBase v\u00e1m zaji\u0161\u0165uje dod\u00e1vky od v\u00fdrobce certifikovan\u00e9ho WHO-GMP, diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce, celosv\u011btovou dopravu a hodnocen\u00ed 4,9\u2605 od v\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch z\u00e1kazn\u00edk\u016f. Platby kartou jsou sm\u011brov\u00e1ny p\u0159es regulovan\u00fd krypto-on-ramp \u2014 popis na v\u00fdpisu z va\u0161eho bankovn\u00edho \u00fa\u010dtu bude obsahovat jm\u00e9no procesoru (regulovan\u00e9ho procesoru plateb kartou), nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku. Ka\u017ed\u00e1 z\u00e1silka je pokryta na\u0161\u00edm <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\" rel=\"noopener\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>.<\/p>\n<h2><strong>What Is Penvir?<\/strong><\/h2>\n<p>Penvir is a branded generic of <strong>famciclovir<\/strong>, an oral prodrug of penciclovir. Famciclovir has ~77% oral bioavailability (vs ~5% for oral penciclovir directly, and ~15\u201320% for oral aciclovir). Inside herpes-virus-infected cells, penciclovir triphosphate blocks viral DNA polymerase \u2014 the same final mechanism as aciclovir.<\/p>\n<p>The clinical edge famciclovir offers is <strong>intracellular persistence<\/strong>: penciclovir triphosphate has a half-life of 10+ hours inside infected cells, vs ~1 hour for aciclovir triphosphate. This lets famciclovir use less-frequent dosing. Available in strengths of <strong>250 mg, 500 mg<\/strong>.<\/p>\n<h2><strong>Klinick\u00e9 pou\u017eit\u00ed<\/strong><\/h2>\n<ul>\n<li><strong>Genit\u00e1ln\u00ed herpes (prvn\u00ed epizoda):<\/strong> 250 mg three times daily for 7\u201310 days<\/li>\n<li><strong>Genit\u00e1ln\u00ed herpes (opakovan\u00e9 epizody):<\/strong> 1000 mg twice daily for one day, OR 125 mg twice daily for 5 days<\/li>\n<li><strong>Genit\u00e1ln\u00ed herpes (supresivn\u00ed l\u00e9\u010dba):<\/strong> 250 mg twice daily<\/li>\n<li><strong>Opary (herpes labialis):<\/strong> 1500 mg as a single dose, within 1 hour of prodrome<\/li>\n<li><strong>P\u00e1sov\u00fd opar (herpes zoster):<\/strong> 500 mg three times daily for 7 days \u2014 start within 72 hours of rash onset<\/li>\n<li><strong>Recurrent HSV in HIV-positive patients:<\/strong> 500 mg twice daily for 7 days<\/li>\n<\/ul>\n<h2><strong>Jak u\u017e\u00edvat<\/strong><\/h2>\n<ol>\n<li>Swallow the tablet whole with a glass of water, with or without food.<\/li>\n<li>Start at the first sign of an outbreak (tingling, burning, itching) \u2014 the single-dose cold-sore regimen only works if given within 1 hour of prodrome.<\/li>\n<li>Stay well hydrated; famciclovir is renally cleared.<\/li>\n<li>Complete the full course, even if symptoms resolve.<\/li>\n<\/ol>\n<h2><strong>Vedlej\u0161\u00ed \u00fa\u010dinky<\/strong><\/h2>\n<p><strong>\u010cast\u00e9 (\u22651 %):<\/strong> headache, nausea, diarrhoea, fatigue. Generally mild.<\/p>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong> rash, dizziness.<\/p>\n<p><strong>Vz\u00e1cn\u00e9 z\u00e1va\u017en\u00e9:<\/strong> transient elevations in liver enzymes, low platelets, acute kidney injury at very high doses in dehydrated patients.<\/p>\n<h2><strong>Who Should Not Take Penvir<\/strong><\/h2>\n<ul>\n<li>Known hypersensitivity to famciclovir or penciclovir<\/li>\n<li>Dose reduction required for creatinine clearance &lt;60 mL\/min<\/li>\n<li>Caution in pregnancy \u2014 less safety data than aciclovir; discuss with clinician<\/li>\n<li>Hereditary galactose intolerance (some formulations contain lactose)<\/li>\n<\/ul>\n<h2><strong>Interakce s l\u00e9\u010divy<\/strong><\/h2>\n<ul>\n<li><strong>Probenecid, cimetidin:<\/strong> may increase penciclovir levels.<\/li>\n<li><strong>Aldehyde oxidase inhibitors<\/strong> (e.g. raloxifene): may reduce famciclovir conversion.<\/li>\n<li>No significant interactions with hormonal contraceptives or antiretrovirals at standard doses.<\/li>\n<\/ul>\n<h2><strong>Skladov\u00e1n\u00ed<\/strong><\/h2>\n<p>Store at room temperature (15\u201330 \u00b0C \/ 59\u201386 \u00b0F), away from moisture and light. Keep in original blister. Keep out of reach of children.<\/p>\n<h2><strong>Famciclovir vs Valacyclovir vs Aciclovir<\/strong><\/h2>\n<p>All three are first-line HSV\/VZV antivirals with comparable efficacy when dosed correctly. Famciclovir&#8217;s unique advantage is its long intracellular half-life, allowing single-dose cold sore treatment. Valacyclovir leads on convenience for daily suppression. Aciclovir remains the cost-leader. Choice usually comes down to dosing schedule, pricing, and clinician preference.<\/p>\n<p>See the full comparison: <a href=\"https:\/\/medsbase.com\/cs\/herpes-antivirals-daily-vs-episodic-treatment\/\"><strong>Denn\u00ed vs. epizodick\u00e1 l\u00e9\u010dba oparu<\/strong><\/a>.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Does Penvir cure herpes?<\/h3>\n<p>No. Penvir suppresses viral replication and shortens outbreaks but cannot eliminate the virus. Herpes remains latent in nerve ganglia for life.<\/p>\n<h3 class=\"wp-block-heading\">Is the single-dose cold sore regimen really effective?<\/h3>\n<p>Yes, but timing is critical. 1500 mg as a single dose, taken within 1 hour of the prodromal tingle, reduces lesion duration and pain comparably to the 5-day aciclovir regimen. Miss that window and the benefit drops.<\/p>\n<h3 class=\"wp-block-heading\">How does famciclovir differ from valacyclovir?<\/h3>\n<p>Both are prodrugs. Famciclovir converts to penciclovir; valacyclovir converts to aciclovir. The key practical difference is penciclovir&#8217;s longer intracellular half-life (~10 h) vs aciclovir&#8217;s (~1 h). Famciclovir thus supports less-frequent dosing and the single-dose cold sore regimen, which aciclovir\/valacyclovir cannot match.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Penvir during pregnancy?<\/h3>\n<p>Less safety data than aciclovir or valacyclovir. Most clinicians prefer aciclovir\/valacyclovir for pregnancy. Discuss with your obstetrician.<\/p>\n<h3 class=\"wp-block-heading\">How quickly does Penvir work?<\/h3>\n<p>For episodic treatment, most patients feel improvement within 24\u201348 hours. Lesion healing is accelerated by 1\u20132 days vs untreated.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Take it as soon as you remember unless it is nearly time for the next dose. Never double-dose.<\/p>\n<h3 class=\"wp-block-heading\">Can famciclovir be used for shingles?<\/h3>\n<p>Yes \u2014 500 mg three times daily for 7 days. Start within 72 hours of rash onset for best outcome, especially to reduce post-herpetic neuralgia risk.<\/p>\n<h3 class=\"wp-block-heading\">Any interactions with hormonal contraception?<\/h3>\n<p>No clinically significant interaction. Hormonal contraceptives remain effective.<\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed produkty a pr\u016fvodci<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valacyclovir-vs-acyclovir\/\">Pr\u016fvodce: Valaciklovir vs. Aciklovir<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/herpes-antivirals-daily-vs-episodic-treatment\/\">Denn\u00ed vs. epizodick\u00e1 l\u00e9\u010dba oparu<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valclovir\/\">Valclovir (Valacyclovir)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valovera\/\">Valovera (Valacyclovir)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valcosign\/\">Valcosign (Valacyclovir)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/acivir-200-dt\/\">Acivir 200 DT (Aciclovir)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed:<\/strong> Informace na t\u00e9to str\u00e1nce slou\u017e\u00ed pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nenahrazuj\u00ed l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli l\u00e9ku se v\u017edy pora\u010fte s kvalifikovan\u00fdm l\u00e9ka\u0159em. L\u00e9ky na p\u0159edpis by m\u011bly b\u00fdt u\u017e\u00edv\u00e1ny pouze pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Sexu\u00e1ln\u00ed zdrav\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valovera\/\">Valovera<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/acivir-200-dt\/\">Acivir 200 DT<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imiquad-cream\/\">Imiquad kr\u00e9m<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/neckcin-100-dt\/\">Neckcin 100 DT<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valclovir\/\">Valclovir<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Treats Viral Infections<br \/>\n\u2705 Reduces Cold Sore Duration<br \/>\n\u2705 Alleviates Shingles Symptoms<br \/>\n\u2705 Prescribed Antiviral Medication<br \/>\n\u2705 Oral Medication Option<\/p>\n<p>Penvir contains Famciclovir.<\/p>","protected":false},"featured_media":56979,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3832,3337],"product_tag":[4212,4213],"class_list":{"0":"post-56978","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-genital-herpes-treatment","8":"product_cat-sexual-health","9":"product_tag-famciclovir","10":"product_tag-penvir","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/56978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=56978"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/56979"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=56978"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=56978"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=56978"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=56978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}