{"id":57068,"date":"2024-02-27T17:22:18","date_gmt":"2024-02-27T17:22:18","guid":{"rendered":"https:\/\/medsname.com\/fluconaz\/"},"modified":"2026-04-30T10:24:32","modified_gmt":"2026-04-30T10:24:32","slug":"fluconaz","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/fluconaz\/","title":{"rendered":"Fluconaz"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 20px;margin:18px 0;border-radius:6px;\">\n<h3 style=\"margin-top:0;\">\ud83d\udca1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\">Fluconaz je flukonazol 150 mg peror\u00e1ln\u00ed tableta \u2014 syst\u00e9mov\u00e9 triazolov\u00e9 antimykotikum. Jedin\u00e1 d\u00e1vka 150 mg pro vagin\u00e1ln\u00ed kandid\u00f3zu; 50\u2013400 mg\/den pro invazivn\u00ed kandid\u00f3zu, j\u00edcnovou mou\u010dnivku a profylaxi u imunokompromitovan\u00fdch pacient\u016f. Inhibuje fung\u00e1ln\u00ed CYP51 (lanosterol 14-\u03b1-demethyl\u00e1zu). Dlouh\u00fd polo\u010das (~30 h) umo\u017e\u0148uje pod\u00e1v\u00e1n\u00ed jednou denn\u011b nebo t\u00fddn\u011b. Hlavn\u00ed l\u00e9kov\u00e9 interakce prost\u0159ednictv\u00edm inhibice CYP3A4 \/ CYP2C9 \/ CYP2C19 \u2014 kontrolujte warfarin, statiny, sulfonylmo\u010doviny, fenytoin, peror\u00e1ln\u00ed antikoncepci.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f5f5;border:1px solid #e1e1e1;padding:18px 22px;margin:24px 0;border-radius:8px;display:flex;flex-wrap:wrap;justify-content:space-around;gap:16px;align-items:center;font-size:0.95em;\">\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udfed<br \/><strong>WHO-GMP<\/strong><br \/>certifikovan\u00fd v\u00fdrobce<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83d\udce6<br \/><strong>Diskr\u00e9tn\u00ed balen\u00ed<\/strong><br \/>oby\u010dejn\u00e1 ob\u00e1lka<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udf0d<br \/><strong>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/strong><br \/>do v\u011bt\u0161iny zem\u00ed<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\u2b50<br \/><strong>1 400+ z\u00e1kazn\u00edk\u016f<\/strong><br \/><a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a><\/div>\n<\/div>\n<h2>\ud83d\udd12 Pro\u010d objedn\u00e1vat Fluconaz z MedsBase<\/h2>\n<ul>\n<li><strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2014 dod\u00e1v\u00e1no z regulovan\u00e9ho za\u0159\u00edzen\u00ed, kompletn\u00ed balen\u00ed s \u010d\u00edslem \u0161ar\u017ee a datem expirace.<\/li>\n<li><strong>Diskr\u00e9tn\u00ed balen\u00ed<\/strong> \u2014 oby\u010dejn\u00e1 ob\u00e1lka, bez uveden\u00ed n\u00e1zvu l\u00e9ku na vn\u011bj\u0161\u00ed stran\u011b.<\/li>\n<li><strong>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/strong> do v\u011bt\u0161iny zem\u00ed s <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a>.<\/li>\n<li><strong>V\u011brnostn\u00ed body<\/strong> \u2014 1 bod za ka\u017ed\u00fd utracen\u00fd 1$ (neplat\u00ed pro peptidy\/dopravu); 100 bod\u016f = 5$ sleva na dal\u0161\u00ed objedn\u00e1vku.<\/li>\n<\/ul>\n<h2 id=\"uses\">Pou\u017eit\u00ed a indikace<\/h2>\n<p>Fluconaz (fluconazol 150 mg, Eskag Pharma) je triazolov\u00e9 antimykotikum pou\u017e\u00edvan\u00e9 pro povrchov\u00e9 i syst\u00e9mov\u00e9 infekce zp\u016fsoben\u00e9 kvasinkami Candida a Cryptococcus. Na rozd\u00edl od lok\u00e1ln\u00edch p\u0159\u00edpravk\u016f peror\u00e1ln\u00ed fluconazol pronik\u00e1 do v\u0161ech t\u011blesn\u00fdch kompartment\u016f (v\u010detn\u011b mozkom\u00ed\u0161n\u00edho moku, ~80% plazmatick\u00e9 hladiny) \u2014 co\u017e z n\u011bj \u010din\u00ed z\u00e1kladn\u00ed l\u00e9k pro jakoukoli infekci, kter\u00e1 nen\u00ed striktn\u011b povrchov\u00e1.<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Indikace<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typick\u00e9 d\u00e1vkov\u00e1n\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Vagin\u00e1ln\u00ed kandid\u00f3za (nekomplikovan\u00e1)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Jednor\u00e1zov\u00e1 d\u00e1vka 150 mg peror\u00e1ln\u011b<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Recidivuj\u00edc\u00ed vulvovagin\u00e1ln\u00ed kandid\u00f3za<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">150 mg ka\u017ed\u00fdch 72 hodin \u00d7 3 d\u00e1vky, pot\u00e9 150 mg t\u00fddn\u011b \u00d7 6 m\u011bs\u00edc\u016f<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Orofarynge\u00e1ln\u00ed kandid\u00f3za<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg prvn\u00ed den, pot\u00e9 100 mg\/den \u00d7 7\u201314 dn\u00ed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Kandid\u00f3za j\u00edcnu<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200\u2013400 mg\/den \u00d7 14\u201321 dn\u00ed<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Invazivn\u00ed kandid\u00f3za<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">800 mg 1. den, pot\u00e9 400 mg\/den \u00d7 minim\u00e1ln\u011b 14 dn\u00ed (po prvn\u00edm negativn\u00edm hemokultu\u0159e)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Kryptokokov\u00e1 meningitida (konsolidace)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">400 mg\/den \u00d7 8 t\u00fddn\u016f, pot\u00e9 udr\u017eovac\u00ed d\u00e1vka 200 mg\/den<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Profylaxe v hematologii \/ po transplantaci<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200\u2013400 mg\/den<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"how-to-take\">Jak u\u017e\u00edvat<\/h2>\n<ul>\n<li>Tablety lze u\u017e\u00edvat s j\u00eddlem i bez j\u00eddla.<\/li>\n<li>P\u0159i jednor\u00e1zov\u00e9 l\u00e9\u010db\u011b vagin\u00e1ln\u00ed kandid\u00f3zy: u\u017eijte 1 tabletu 150 mg s vodou \u2014 p\u0159\u00edznaky obvykle ustoup\u00ed do 24\u201372 hodin.<\/li>\n<li>Pro t\u00fddenn\u00ed udr\u017eovac\u00ed l\u00e9\u010dbu: u\u017e\u00edvejte v\u017edy stejn\u00fd den v t\u00fddnu (nap\u0159. ka\u017edou ned\u011bli) \u2014 nastavte si p\u0159ipom\u00ednku, abyste nevynechali d\u00e1vku.<\/li>\n<li>Po vynechan\u00e9 d\u00e1vce neu\u017e\u00edvejte dvojn\u00e1sobnou d\u00e1vku \u2014 u\u017eijte vynechanou d\u00e1vku co nejd\u0159\u00edve, pokud nen\u00ed bl\u00edzko dal\u0161\u00ed d\u00e1vky.<\/li>\n<\/ul>\n<h2 id=\"mechanism\">Jak to funguje<\/h2>\n<p>Flukonazol selektivn\u011b inhibuje fung\u00e1ln\u00ed cytochrom P-450 enzym CYP51 (lanosterol 14-\u03b1-demethyl\u00e1za). T\u00edm blokuje p\u0159em\u011bnu lanosterolu na ergosterol \u2014 hlavn\u00ed sterol v bun\u011b\u010dn\u00fdch membr\u00e1n\u00e1ch hub. V\u00fdsledn\u00e1 membr\u00e1na chud\u00e1 na ergosterol se st\u00e1v\u00e1 propustnou a bu\u0148ka houby ztr\u00e1c\u00ed integritu. Selektivita pro fung\u00e1ln\u00ed vs. sav\u010d\u00ed CYP enzymy je d\u016fvodem, pro\u010d je flukonazol mnohem l\u00e9pe sn\u00e1\u0161en ne\u017e star\u0161\u00ed imidazolov\u00e1 antimykotika.<\/p>\n<h2 id=\"side-effects\">Ne\u017e\u00e1douc\u00ed \u00fa\u010dinky &amp; monitorov\u00e1n\u00ed<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Frekvence<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typick\u00e9 \u00fa\u010dinky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u010cast\u00e9 (\u22651\/100)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Bolest hlavy, nevolnost, bolest b\u0159icha, pr\u016fjem, p\u0159echodn\u00e9 zv\u00fd\u0161en\u00ed ALT\/AST, vyr\u00e1\u017eka<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">M\u00e9n\u011b \u010dast\u00e9<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Zvracen\u00ed, dyspepsie, poruchy chuti, z\u00e1vrat\u011b, m\u00edrn\u00e1 neutropenie<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hepatotoxicita (cholestatick\u00e1 nebo hepatocelul\u00e1rn\u00ed \u2014 p\u0159eru\u0161it l\u00e9\u010dbu, pokud AST\/ALT &gt;3\u00d7 ULN), Stevens-Johnson\u016fv syndrom\/TEN, prodlou\u017een\u00ed QT intervalu\/torsade de pointes, anafylaxe, alopecie (p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:20px 0;border-radius:6px;\"><strong>Funkce jater \u2014 kdy p\u0159eru\u0161it l\u00e9\u010dbu<\/strong><\/p>\n<div>M\u00edrn\u00e9 zv\u00fd\u0161en\u00ed ALT\/AST &lt; 3\u00d7 horn\u00ed hranice norm\u00e1lu je b\u011b\u017en\u00e9 a obvykle se uprav\u00ed p\u0159i pokra\u010duj\u00edc\u00ed l\u00e9\u010db\u011b. P\u0159eru\u0161te u\u017e\u00edv\u00e1n\u00ed flukonazolu a vyhledejte l\u00e9ka\u0159skou pomoc, pokud se objev\u00ed \u017eloutenka, sv\u011btl\u00e1 stolice, tmav\u00e1 mo\u010d, p\u0159etrv\u00e1vaj\u00edc\u00ed nevolnost, bolest v prav\u00e9m pod\u017eeb\u0159\u00ed nebo zmatenost \u2014 tyto p\u0159\u00edznaky mohou nazna\u010dovat symptomatickou hepatitidu. Pacienti na l\u00e9\u010db\u011b d\u00e9le ne\u017e 4 t\u00fddny by m\u011bli m\u00edt jatern\u00ed testy provedeny na za\u010d\u00e1tku a v pravideln\u00fdch intervalech.<\/div>\n<\/div>\n<h2 id=\"interactions\">L\u00e9kov\u00e9 interakce (ty v\u00fdznamn\u00e9)<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">T\u0159\u00edda l\u00e9ku \/ l\u00e9k<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u00da\u010dinek<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Praktick\u00fd postup<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Warfarin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">INR se zvy\u0161uje 2\u20134\u00d7 (inhibice CYP2C9)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Zkontrolujte INR b\u011bhem 3\u20135 dn\u016f; sni\u017ete d\u00e1vku warfarinu o 25\u201350 %<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Fenytoin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hladiny fenytoinu stoupaj\u00ed o 75 % (inhibice CYP2C9)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitorujte hladiny; sni\u017ete d\u00e1vku fenytoinu<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Sulfonylmo\u010doviny (glipizid\/glibenklamid)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Riziko hypoglyk\u00e9mie<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Pe\u010dliv\u011b monitorujte hladinu gluk\u00f3zy<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Simvastatin \/ atorvastatin \/ lovastatin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hladiny statin\u016f stoupaj\u00ed (CYP3A4) \u2192 myopatie \/ rhabdomyol\u00fdza<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">P\u0159epn\u011bte na pravastatin \/ rosuvastatin nebo p\u0159eru\u0161te u\u017e\u00edv\u00e1n\u00ed statinu b\u011bhem l\u00e9\u010dby<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tacrolimus \/ cyklosporin \/ sirolimus<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hladiny stoupaj\u00ed \u2014 nefrotoxicita, neurotoxicita<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Sni\u017ete d\u00e1vku; monitorujte spodn\u00ed hladinu<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Or\u00e1ln\u00ed antikoncepce<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">M\u00edrn\u00e9 zv\u00fd\u0161en\u00ed hladiny ethinylestradiolu \/ levonorgestrelu<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Pokra\u010dujte jako obvykle \u2014 \u00fa\u010dinnost nen\u00ed sn\u00ed\u017eena<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Amiodaron, sotalol, citalopram, methadon, ondansetron<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Prodlou\u017een\u00ed QT intervalu<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Pokud mo\u017eno se vyhn\u011bte kombinac\u00edm &gt; 200 mg\/den; EKG p\u0159i p\u0159\u00edznac\u00edch<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Rifampicin\/rifabutin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hladiny flukonazolu klesaj\u00ed (indukce)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Zv\u00fd\u0161it d\u00e1vku flukonazolu nebo p\u0159ej\u00edt na vorikonazol<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\">Kdo by nem\u011bl u\u017e\u00edvat flukonazol<\/h2>\n<ul>\n<li>Prok\u00e1zan\u00e1 p\u0159ecitliv\u011blost na flukonazol nebo jin\u00e9 azoly.<\/li>\n<li>Spole\u010dn\u00e9 pod\u00e1v\u00e1n\u00ed s terfenadinem, astemizolem, cisapridem, pimozidem, chinidinem nebo erytromycinem (prodlou\u017een\u00ed QT intervalu).<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed simvastatinu, atorvastatinu nebo lovastatinu v pln\u00e9 d\u00e1vce.<\/li>\n<li>Opatrnost u aktivn\u00edho jatern\u00edho onemocn\u011bn\u00ed, vrozen\u00e9ho syndromu dlouh\u00e9ho QT intervalu a t\u011b\u017ek\u00e9ho ren\u00e1ln\u00edho posti\u017een\u00ed (\u00faprava d\u00e1vkov\u00e1n\u00ed n\u00ed\u017ee).<\/li>\n<\/ul>\n<h2 id=\"renal\">\u00daprava d\u00e1vkov\u00e1n\u00ed p\u0159i ren\u00e1ln\u00ed insuficienci<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">ClCr (mL\/min)<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u00daprava<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">&gt; 50<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Beze zm\u011bny<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u2264 50 (bez dial\u00fdzy)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Podat standardn\u00ed nasycovac\u00ed d\u00e1vku, pot\u00e9 50% udr\u017eovac\u00ed d\u00e1vky<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Hemodial\u00fdza<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Podat 100% d\u00e1vku po ka\u017ed\u00e9 dial\u00fdze<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"pregnancy\">T\u011bhotenstv\u00ed a kojen\u00ed<\/h2>\n<p>Jednor\u00e1zov\u00e1 d\u00e1vka 150 mg pro vagin\u00e1ln\u00ed kandid\u00f3zu je obecn\u011b pova\u017eov\u00e1na za n\u00edzkorizikovou v t\u011bhotenstv\u00ed po prvn\u00edm trimestru, ale topick\u00fd klotrimazol je preferov\u00e1n, pokud je to mo\u017en\u00e9. <strong>Vysok\u00e9 d\u00e1vky flukonazolu (\u2265 400 mg\/den) v prvn\u00edm trimestru<\/strong> byly spojeny s rozpoznateln\u00fdm vzorem vrozen\u00fdch abnormalit (srde\u010dn\u00edch, kraniofaci\u00e1ln\u00edch, skelet\u00e1ln\u00edch) a m\u011bly by b\u00fdt vynech\u00e1ny. Flukonazol je vylu\u010dov\u00e1n do mate\u0159sk\u00e9ho ml\u00e9ka v koncentrac\u00edch bl\u00edzk\u00fdch mate\u0159sk\u00e9 plazm\u011b \u2014 jednor\u00e1zov\u00e1 d\u00e1vka 150 mg je slu\u010diteln\u00e1 s kojen\u00edm; kontinu\u00e1ln\u00ed vysok\u00e9 d\u00e1vky nikoli.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Za jak dlouho se budu c\u00edtit l\u00e9pe?<\/h3>\n<p>Vagin\u00e1ln\u00ed kandid\u00f3za: sv\u011bd\u011bn\u00ed a v\u00fdtok obvykle ustoup\u00ed do 24\u201372 hodin po jednor\u00e1zov\u00e9 d\u00e1vce 150 mg. Or\u00e1ln\u00ed kandid\u00f3za: znateln\u00e9 zlep\u0161en\u00ed za 3\u20135 dn\u00ed. Invazivn\u00ed kandid\u00e9mie: klinick\u00e1 odpov\u011b\u010f se posuzuje za 5\u20137 dn\u00ed.<\/p>\n<h3>M\u016f\u017eu p\u00edt alkohol s flukonazolem?<\/h3>\n<p>Neexistuje specifick\u00e1 disulfiramov\u00e1 reakce, ale alkohol i flukonazol jsou metabolizov\u00e1ny j\u00e1try. T\u011b\u017ek\u00e1 nebo chronick\u00e1 konzumace alkoholu zvy\u0161uje riziko hepatotoxicity \u2014 omezte p\u0159\u00edjem, ide\u00e1ln\u011b se alkoholu b\u011bhem l\u00e9\u010dby vyhn\u011bte, zejm\u00e9na p\u0159i l\u00e9\u010db\u011b del\u0161\u00ed ne\u017e 7 dn\u00ed.<\/p>\n<h3>Pro\u010d sta\u010d\u00ed jedna d\u00e1vka 150 mg na kandid\u00f3zu?<\/h3>\n<p>Fluconazol m\u00e1 dlouh\u00fd elimina\u010dn\u00ed polo\u010das (~30 hodin) a dob\u0159e se koncentruje v po\u0161evn\u00edm sekretu. Po jedn\u00e9 d\u00e1vce 150 mg p\u0159etrv\u00e1vaj\u00ed fungicidn\u00ed hladiny po dobu 72 hodin nebo d\u00e9le \u2014 dostate\u010dn\u011b dlouho k vyl\u00e9\u010den\u00ed nekomplikovan\u00e9 infekce zp\u016fsoben\u00e9 Candida albicans.<\/p>\n<h3>Je fluconazol tot\u00e9\u017e co Diflucan?<\/h3>\n<p>Ano \u2014 Diflucan je p\u016fvodn\u00ed zna\u010dka fluconazolu od Pfizeru. Fluconaz obsahuje stejnou \u00fa\u010dinnou l\u00e1tku, vyr\u00e1b\u011bnou spole\u010dnost\u00ed Eskag Pharma v souladu s WHO-GMP. Jde o bioekvivalentn\u00ed generikum.<\/p>\n<h3>Mohu u\u017e\u00edvat fluconazol p\u0159i onemocn\u011bn\u00ed jater?<\/h3>\n<p>Opatrn\u011b. P\u0159i m\u00edrn\u00e9m kompenzovan\u00e9m onemocn\u011bn\u00ed jater jsou obvykle mo\u017en\u00e9 kr\u00e1tk\u00e9 k\u00fary s monitorov\u00e1n\u00edm jatern\u00edch test\u016f. U dekompenzovan\u00e9 cirh\u00f3zy nebo aktivn\u00ed hepatitidy \u2014 konzultujte s l\u00e9ka\u0159em; mohou b\u00fdt vhodn\u011bj\u0161\u00ed alternativn\u00ed l\u00e9\u010diva.<\/p>\n<h3>M\u00e1m opakovan\u00e9 kvasinkov\u00e9 infekce \u2014 jak\u00fd je udr\u017eovac\u00ed re\u017eim?<\/h3>\n<p>Po \u00favodn\u00ed f\u00e1zi 3 d\u00e1vek (150 mg ka\u017ed\u00fdch 72 hodin \u00d7 3) n\u00e1sleduje udr\u017eovac\u00ed l\u00e9\u010dba 150 mg jednou t\u00fddn\u011b po dobu 6 m\u011bs\u00edc\u016f. Tento re\u017eim sni\u017euje recidivy p\u0159ibli\u017en\u011b o 80 % ve srovn\u00e1n\u00ed s placebem (Sobel 2004 NEJM).<\/p>\n<h3>Co kdy\u017e m\u00e1 m\u016fj partner kvasinkovou infekci?<\/h3>\n<p>Vulvovagin\u00e1ln\u00ed kandid\u00f3za nen\u00ed pohlavn\u011b p\u0159enosn\u00e1 infekce. Rutinn\u00ed l\u00e9\u010dba partnera se nedoporu\u010duje, pokud mu\u017esk\u00fd partner nem\u00e1 symptomatickou balanitidu (l\u00e9\u010denou topick\u00fdm klotrimazolem).<\/p>\n<h3>Ovlivn\u00ed fluconazol \u00fa\u010dinnost m\u00e9 antikoncep\u010dn\u00ed pilulky?<\/h3>\n<p>Ne \u2014 fluconazol m\u00edrn\u011b zvy\u0161uje hladiny ethinylestradiolu a levonorgestrelu, ale antikoncep\u010dn\u00ed \u00fa\u010dinnost je zachov\u00e1na. Pokra\u010dujte v b\u011b\u017en\u00e9m u\u017e\u00edv\u00e1n\u00ed pilulek.<\/p>\n<h3>Co kdy\u017e se m\u00e9 p\u0159\u00edznaky vr\u00e1t\u00ed po jedn\u00e9 d\u00e1vce?<\/h3>\n<p>Pokud p\u0159\u00edznaky p\u0159etrv\u00e1vaj\u00ed d\u00e9le ne\u017e 7 dn\u00ed nebo se vr\u00e1t\u00ed do 4 t\u00fddn\u016f, m\u016f\u017ee b\u00fdt diagn\u00f3za nespr\u00e1vn\u00e1 (bakteri\u00e1ln\u00ed vagin\u00f3za, trichomoni\u00e1za, dermatitida), nebo m\u016f\u017ee j\u00edt o azol-rezistentn\u00ed kmeny Candida glabrata \u010di Candida krusei \u2014 vyhledejte l\u00e9ka\u0159e pro st\u011br a kultivaci.<\/p>\n<h3>Mohu u\u017e\u00edvat fluconazol a klotrimazolov\u00e9 \u010d\u00edpky sou\u010dasn\u011b?<\/h3>\n<p>Ano \u2014 kombinace peror\u00e1ln\u00edho fluconazolu s topick\u00fdm klotrimazolem je bezpe\u010dn\u00e1 a n\u011bkdy se pou\u017e\u00edv\u00e1 u t\u011b\u017ek\u00fdch nebo recidivuj\u00edc\u00edch vagin\u00e1ln\u00edch kandid\u00f3z. Mezi t\u011bmito dv\u011bma l\u00e9ky nehroz\u00ed interakce.<\/p>\n<h2 id=\"storage\">Skladov\u00e1n\u00ed<\/h2>\n<p>Tablety skladujte p\u0159i pokojov\u00e9 teplot\u011b (pod 25 \u00b0C \/ 77 \u00b0F) v p\u016fvodn\u00edm blistru, mimo dosah p\u0159\u00edm\u00e9ho slune\u010dn\u00edho z\u00e1\u0159en\u00ed, tepla a vlhkosti. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed. Nepou\u017e\u00edvejte po uplynut\u00ed data exspirace uveden\u00e9ho na obalu.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed antifung\u00e1ln\u00ed l\u00e9ky, kter\u00e9 by v\u00e1s mohly zaj\u00edmat<\/h2>\n<p>Pokud nen\u00ed Fluconaz dostupn\u00fd nebo pot\u0159ebujete jinou formu, zde jsou alternativy \u2013 stejn\u00e1 molekula od jin\u00e9ho v\u00fdrobce nebo jin\u00e1 t\u0159\u00edda l\u00e9k\u016f pro indikace, kde fluconazol nen\u00ed prvn\u00ed volbou.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zocon\/\"><strong>Zocon (fluconazol 150 mg)<\/strong><\/a> \u2014 Jednor\u00e1zov\u00e1 peror\u00e1ln\u00ed standardn\u00ed l\u00e9\u010dba vagin\u00e1ln\u00ed kandid\u00f3zy.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/forcan\/\"><strong>Forcan (fluconazol 150 mg)<\/strong><\/a> \u2014 Stejn\u00e1 molekula, jin\u00fd v\u00fdrobce.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/fluka\/\"><strong>Fluka (fluconazol 150 mg)<\/strong><\/a> \u2014 Zna\u010dka Cipla; bioekvivalentn\u00ed.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/clocip\/\"><strong>Clocip (clotrimazol 1% kr\u00e9m)<\/strong><\/a> \u2014 Lok\u00e1ln\u00ed \u00faleva p\u0159i sv\u011bd\u011bn\u00ed zp\u016fsoben\u00e9m vulv\u00e1ln\u00ed\/ko\u017en\u00ed kandid\u00f3zou.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sporanox-capsule\/\"><strong>Sporanox (itraconazol)<\/strong><\/a> \u2014 Alternativn\u00ed peror\u00e1ln\u00ed azol pro infekce rezistentn\u00ed na fluconazol.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 18px;margin:24px 0;font-size:0.95em;\"><strong>Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> Tato str\u00e1nka obsahuje informace o produktu pro dosp\u011bl\u00e9, kte\u0159\u00ed si objedn\u00e1vaj\u00ed antifung\u00e1ln\u00ed l\u00e9ky pro osobn\u00ed pot\u0159ebu. Nenahrazuje individu\u00e1ln\u00ed l\u00e9ka\u0159skou radu. Proberte vhodn\u00e9 antifung\u00e1ln\u00ed l\u00e9\u010divo, d\u00e1vkov\u00e1n\u00ed a d\u00e9lku l\u00e9\u010dby s kvalifikovan\u00fdm l\u00e9ka\u0159em \u2013 zejm\u00e9na pokud m\u00e1te onemocn\u011bn\u00ed jater, jste t\u011bhotn\u00e1 nebo koj\u00edte, u\u017e\u00edv\u00e1te warfarin, statiny, imunosupresiva nebo m\u00e1te pl\u00eds\u0148ovou infekci neht\u016f, kter\u00e1 m\u016f\u017ee b\u00fdt jinou diagn\u00f3zou (psori\u00e1za, lichen planus, trauma).<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 L\u00e9\u010dba pl\u00eds\u0148ov\u00fdch infekc\u00ed<br \/>\n\u2705 Pro or\u00e1ln\u00ed i m\u00edstn\u00ed pou\u017eit\u00ed<br \/>\n\u2705 \u0160irokospektr\u00e9 antimykotikum<br \/>\n\u2705 Jednod\u00e1vkov\u00e9 pod\u00e1n\u00ed<br \/>\n\u2705 \u00da\u010dinn\u00e9 proti kvasink\u00e1m<\/p>\n<p>Fluconaz obsahuje Fluconazole.<\/p>","protected":false},"featured_media":57069,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[4227,3619],"class_list":{"0":"post-57068","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-fluconaz","11":"product_tag-fluconazole","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57068","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57068"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57069"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57068"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57068"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57068"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}