{"id":57098,"date":"2024-02-27T17:24:07","date_gmt":"2024-02-27T17:24:07","guid":{"rendered":"https:\/\/medsname.com\/sibelium\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"sibelium","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/sibelium\/","title":{"rendered":"Sibelium"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Sibelium?<\/h3>\n<p style=\"margin:0;\"><strong>Sibelium<\/strong> obsahuje <strong>flunarizin 5 mg \/ 10 mg<\/strong> tablety od Janssen Pharmaceuticals \u2014 <strong>selektivn\u00ed blok\u00e1tor kalciov\u00fdch kan\u00e1l\u016f s antihistaminickou a antidopaminergn\u00ed aktivitou<\/strong>, pou\u017e\u00edv\u00e1 se jako <strong>prvn\u00ed volba v prevenci epizodick\u00e9 a chronick\u00e9 migr\u00e9ny<\/strong> v Evrop\u011b, Asii a Ji\u017en\u00ed Americe (nen\u00ed schv\u00e1len FDA v USA). Standardn\u00ed d\u00e1vka: <strong>10 mg na noc pro dosp\u011bl\u00e9, 5 mg na noc pro pacienty 65 let<\/strong>. Pln\u00fd \u00fa\u010dinek nast\u00e1v\u00e1 za 6-8 t\u00fddn\u016f. U respondent\u016f sni\u017euje frekvenci migr\u00e9n o 50-70% \u2014 jeden z nej\u00fa\u010dinn\u011bj\u0161\u00edch peror\u00e1ln\u00edch profylaktik migr\u00e9ny ve srovn\u00e1vac\u00edch studi\u00edch, srovnateln\u00fd pouze s topiram\u00e1tem. Zvl\u00e1\u0161t\u011b u\u017eite\u010dn\u00fd pro: d\u011btskou a adolescentn\u00ed migr\u00e9nu (\u22655 let), vertigin\u00f3zn\u00ed\/vestibul\u00e1rn\u00ed migr\u00e9nu, hemiplegickou migr\u00e9nu a cyklick\u00e9 zvracen\u00ed. Hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky: <strong>p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze (u ~15% pacient\u016f)<\/strong>, sedace a \u2014 p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed \u2014 <strong>l\u00e9ky indukovan\u00fd parkinsonismus a deprese<\/strong> (dopaminergn\u00ed blok\u00e1da). Maxim\u00e1ln\u00ed doporu\u010den\u00e1 d\u00e9lka kontinu\u00e1ln\u00edho u\u017e\u00edv\u00e1n\u00ed <strong>6 m\u011bs\u00edc\u016f<\/strong>, s pl\u00e1novan\u00fdm vyplachovac\u00edm obdob\u00edm.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<h2 class=\"wp-block-heading\">Co je Sibelium?<\/h2>\n<p>Sibelium je peror\u00e1ln\u00ed tableta <strong>flunarizin 5 mg \/ 10 mg<\/strong> od Janssen Pharmaceuticals, dod\u00e1van\u00e1 v balen\u00edch po 30-180 tablet\u00e1ch. Flunarizin je selektivn\u00ed blok\u00e1tor kalciov\u00fdch kan\u00e1l\u016f odvozen\u00fd od piperazinu s dodate\u010dnou antihistaminovou (H<sub>1<\/sub>) a slabou antidopaminergn\u00ed (D<sub>2<\/sub>) aktivitou. \u0160iroce se pou\u017e\u00edv\u00e1 v Evrop\u011b od 80. let 20. stolet\u00ed jako <strong>Sibelium<\/strong> (origin\u00e1ln\u00ed zna\u010dka Janssen) k profylaxi migr\u00e9ny a vestibul\u00e1rn\u00edm poruch\u00e1m. Neschv\u00e1leno FDA v USA \u2014 proto mnoha americk\u00fdm l\u00e9ka\u0159\u016fm nezn\u00e1m\u00e9, p\u0159esto\u017ee je v evropsk\u00fdch, asijsk\u00fdch a latinskoamerick\u00fdch doporu\u010den\u00edch pro l\u00e9\u010dbu bolesti hlavy prvn\u00ed volbou.<\/p>\n<h2 class=\"wp-block-heading\">Jak flunarizin p\u0159edch\u00e1z\u00ed migr\u00e9n\u011b<\/h2>\n<p>\u00da\u010dinnost flunarizinu proti migr\u00e9n\u011b je p\u0159ipisov\u00e1na \u010dty\u0159em mechanism\u016fm:<\/p>\n<ul>\n<li><strong>Selektivn\u00ed blok\u00e1da kalciov\u00fdch kan\u00e1l\u016f<\/strong> \u2014 sni\u017euje intracelul\u00e1rn\u00ed p\u0159et\u00ed\u017een\u00ed v\u00e1pn\u00edkem u citliv\u00fdch neuron\u016f; inhibuje kortik\u00e1ln\u00ed \u0161\u00ed\u0159\u00edc\u00ed depresi (patofyziologick\u00fd substr\u00e1t migr\u00e9nov\u00e9 aury)<\/li>\n<li><strong>Stabilizace vazomotoriky<\/strong> \u2014 sni\u017euje jak vazodilataci, tak vazospazmus krani\u00e1ln\u00edch tepen<\/li>\n<li><strong>Antihistaminov\u00fd \u00fa\u010dinek (H<sub>1<\/sub>)<\/strong> \u2014 vysv\u011btluje sedativn\u00ed a antivertigin\u00f3zn\u00ed \u00fa\u010dinek<\/li>\n<li><strong>Slab\u00fd D<sub>2<\/sub> antagonismus dopaminov\u00fdch receptor\u016f<\/strong> \u2014 vysv\u011btluje jak \u00fa\u010dinnost p\u0159i migr\u00e9n\u011b (kde je p\u0159\u00edtomna dysregulace dopaminu), tak dlouhodob\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky parkinsonismu\/deprese<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 a v\u011bdecky podlo\u017een\u00e9 indikace<\/h2>\n<ul>\n<li><strong>Profylaxe migr\u00e9ny u dosp\u011bl\u00fdch<\/strong> \u2014 sni\u017euje po\u010det migren\u00f3zn\u00edch dn\u016f m\u011bs\u00ed\u010dn\u011b o 50\u201370 % (n\u011bkolik randomizovan\u00fdch studi\u00ed; metaanal\u00fdza NNT ~3)<\/li>\n<li><strong>Profylaxe migr\u00e9ny u d\u011bt\u00ed<\/strong> (d\u011bti od 5 let, adolescenti) \u2014 obzvl\u00e1\u0161t\u011b \u00fa\u010dinn\u00e1; \u010dasto prvn\u00ed volba preventivn\u00ed l\u00e9\u010dby v evropsk\u00e9 d\u011btsk\u00e9 neurologii<\/li>\n<li><strong>Profylaxe hemiplegick\u00e9 migr\u00e9ny<\/strong> (famili\u00e1rn\u00ed a sporadick\u00e1)<\/li>\n<li><strong>Vestibul\u00e1rn\u00ed migr\u00e9na<\/strong> \u2014 u\u017eite\u010dn\u00e9 pro ob\u011b slo\u017eky migr\u00e9ny i vertiga<\/li>\n<li><strong>M\u00e9ni\u00e8rova choroba<\/strong> \u2014 sn\u00ed\u017een\u00ed vertiga<\/li>\n<li><strong>Syndrom cyklick\u00e9ho zvracen\u00ed<\/strong> u d\u011bt\u00ed<\/li>\n<li><strong>Perifern\u00ed vestibul\u00e1rn\u00ed vertigo<\/strong> (nemigren\u00f3zn\u00ed)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed Sibelium<\/h2>\n<ul>\n<li><strong>Dosp\u011bl\u00ed (40 kg):<\/strong> 10 mg peror\u00e1ln\u011b p\u0159ed span\u00edm<\/li>\n<li><strong>Dosp\u011bl\u00ed &gt;65 let nebo &lt;40 kg t\u011blesn\u00e9 hmotnosti:<\/strong> 5 mg p\u0159ed span\u00edm<\/li>\n<li><strong>D\u011bti 5+ (mimo schv\u00e1len\u00e9 indikace v n\u011bkter\u00fdch zem\u00edch):<\/strong> 5 mg p\u0159ed span\u00edm<\/li>\n<li>U\u017e\u00edvejte ve\u010der \u2014 flunarizin m\u00e1 sedativn\u00ed \u00fa\u010dinky, co\u017e usnad\u0148uje us\u00edn\u00e1n\u00ed a sni\u017euje denn\u00ed ospalost<\/li>\n<li>U\u017e\u00edvejte s j\u00eddlem nebo nala\u010dno<\/li>\n<li>Vyhodno\u0165te \u00fa\u010dinek po <strong>6-8 t\u00fddn\u016f<\/strong><\/li>\n<li><strong>Maxim\u00e1ln\u00ed d\u00e9lka nep\u0159eru\u0161ovan\u00e9ho u\u017e\u00edv\u00e1n\u00ed: 6 m\u011bs\u00edc\u016f<\/strong>, pot\u00e9 pl\u00e1novan\u00e1 p\u0159est\u00e1vka 1\u20133 m\u011bs\u00edce. L\u00e9\u010dbu obnovte, pokud se migr\u00e9ny vr\u00e1t\u00ed.<\/li>\n<\/ul>\n<p><strong>Pro\u010d je limit 6 m\u011bs\u00edc\u016f?<\/strong> Flunarizin m\u00e1 kumulativn\u00ed slab\u00fd dopaminergn\u00ed antagonismus. P\u0159i nep\u0159etr\u017eit\u00e9m u\u017e\u00edv\u00e1n\u00ed d\u00e9le ne\u017e 6 m\u011bs\u00edc\u016f roste riziko extrapyramidov\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f (parkinsonsk\u00fd t\u0159es, bradykineze, akatizie), zejm\u00e9na u star\u0161\u00edch pacient\u016f. Pl\u00e1novan\u00e9 p\u0159est\u00e1vky 1\u20133 m\u011bs\u00edce umo\u017e\u0148uj\u00ed obnovu dopaminergn\u00edch receptor\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>Velmi \u010dast\u00e9 (&gt;10 %):<\/strong><\/p>\n<ul>\n<li><strong>P\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze<\/strong> (~15 % u\u017eivatel\u016f; n\u00e1r\u016fst 5\u201310 kg za 6 m\u011bs\u00edc\u016f; mechanismus: zv\u00fd\u0161en\u00e1 chu\u0165 k j\u00eddlu p\u0159es H<sub>1<\/sub> )<\/li>\n<li>Ospalost, sedace (u\u017e\u00edvejte ve\u010der; \u010d\u00e1ste\u010dn\u00e1 adaptace b\u011bhem 2\u20134 t\u00fddn\u016f)<\/li>\n<li>Zv\u00fd\u0161en\u00e1 chu\u0165 k j\u00eddlu<\/li>\n<\/ul>\n<p><strong>B\u011b\u017en\u00e9 (1-10 %):<\/strong><\/p>\n<ul>\n<li>M\u00edrn\u00e1 deprese, skleslost (dopaminergn\u00ed efekt; \u010dast\u011bj\u0161\u00ed u pacient\u016f s depres\u00ed v anamn\u00e9ze)<\/li>\n<li>Letargie, astenie<\/li>\n<li>\u017dalude\u010dn\u00ed pot\u00ed\u017ee, sucho v \u00fastech<\/li>\n<li>Galaktorea, hyperprolaktinemie (dopaminergn\u00ed efekt)<\/li>\n<li>Menstrua\u010dn\u00ed nepravidelnosti u \u017een<\/li>\n<\/ul>\n<p><strong>D\u016fle\u017eit\u00e9 dlouhodob\u00e9 \u00fa\u010dinky (m\u011bs\u00edce a\u017e roky nep\u0159etr\u017eit\u00e9ho u\u017e\u00edv\u00e1n\u00ed):<\/strong><\/p>\n<ul>\n<li><strong>L\u00e9ky indukovan\u00fd parkinsonismus<\/strong> \u2014 t\u0159es, rigidita, bradykineze. Obvykle reverzibiln\u00ed b\u011bhem m\u011bs\u00edc\u016f po vysazen\u00ed. Riziko prudce stoup\u00e1 p\u0159i nep\u0159etr\u017eit\u00e9m u\u017e\u00edv\u00e1n\u00ed d\u00e9le ne\u017e 6 m\u011bs\u00edc\u016f, zejm\u00e9na u star\u0161\u00edch pacient\u016f. Proto existuje limit 6 m\u011bs\u00edc\u016f.<\/li>\n<li><strong>L\u00e9ky vyvolan\u00e1 deprese<\/strong> \u2014 m\u016f\u017ee b\u00fdt z\u00e1va\u017en\u00e1; mechanismus dopaminergn\u00ed. Nej\u010dast\u011bj\u0161\u00ed u pacient\u016f s p\u0159edchoz\u00ed depres\u00ed v anamn\u00e9ze.<\/li>\n<li><strong>Tardivn\u00ed dyskineze<\/strong> \u2014 vz\u00e1cn\u00e9; mimovoln\u00ed pohyby obli\u010deje, jazyka nebo kon\u010detin; m\u016f\u017ee b\u00fdt nevratn\u00e9 i po vysazen\u00ed. Neobvykl\u00e9 p\u0159i 6m\u011bs\u00ed\u010dn\u00edm u\u017e\u00edv\u00e1n\u00ed.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Aktu\u00e1ln\u00ed nebo anamn\u00e9za deprese<\/li>\n<li>Parkinsonova choroba nebo jin\u00e9 extrapyramidov\u00e9 poruchy<\/li>\n<li>P\u0159ecitliv\u011blost na flunarizin nebo piperaziny<\/li>\n<li>T\u011bhotenstv\u00ed a kojen\u00ed (nedostate\u010dn\u00e9 bezpe\u010dnostn\u00ed \u00fadaje; dopaminergn\u00ed l\u00e9ky se nedoporu\u010duj\u00ed)<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Alkohol, benzodiazepiny, opioidy, sedativn\u00ed antihistaminika<\/strong> \u2014 kumulativn\u00ed \u00fatlum CNS<\/li>\n<li><strong>Antipsychotika<\/strong> \u2014 aditivn\u00ed dopaminergn\u00ed blok\u00e1da; vyvarujte se kombinace (riziko extrapyramidov\u00fdch p\u0159\u00edznak\u016f)<\/li>\n<li><strong>Metoklopramid, prochlorperazin<\/strong> \u2014 dopaminergn\u00ed; vyvarujte se dlouhodob\u00e9ho spole\u010dn\u00e9ho u\u017e\u00edv\u00e1n\u00ed<\/li>\n<li><strong>Beta-blok\u00e1tory<\/strong> \u2014 obecn\u011b dob\u0159e sn\u00e1\u0161en; lze kombinovat s <a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">propranolol<\/a> pro migreniky vy\u017eaduj\u00edc\u00ed kombinovanou prevenci<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte p\u0159i teplot\u011b do 25\u00b0C. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Jak dlouho trv\u00e1, ne\u017e Sibelium za\u010dne \u00fa\u010dinkovat?<\/h3>\n<p>6-8 t\u00fddn\u016f v c\u00edlov\u00e9 d\u00e1vce. U respondent\u016f je typick\u00e9 sn\u00ed\u017een\u00ed po\u010dtu migren\u00f3zn\u00edch dn\u016f o 50-70 % m\u011bs\u00ed\u010dn\u011b. Pokud nedojde k odpov\u011bdi po 8 t\u00fddnech u d\u00e1vky 10 mg, p\u0159ejd\u011bte na jin\u00fd p\u0159\u00edpravek (<a href=\"https:\/\/medsbase.com\/cs\/topicon\/\">topiram\u00e1t<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">propranolol<\/a>, amitriptylin).<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d pouze 6 m\u011bs\u00edc\u016f nep\u0159etr\u017eit\u00e9ho u\u017e\u00edv\u00e1n\u00ed?<\/h3>\n<p>Flunarizin slab\u011b blokuje dopaminov\u00e9 receptory. P\u0159i nep\u0159etr\u017eit\u00e9m u\u017e\u00edv\u00e1n\u00ed d\u00e9le ne\u017e 6 m\u011bs\u00edc\u016f stoup\u00e1 riziko l\u00e9ky indukovan\u00e9 parkinsonovy choroby (t\u0159es, ztuhlost, zpomalenost) a deprese. Pl\u00e1novan\u00e1 p\u0159est\u00e1vka 1-3 m\u011bs\u00edce ka\u017ed\u00fdch 6 m\u011bs\u00edc\u016f umo\u017e\u0148uje obnovu dopaminergn\u00ed aktivity. Pokud migr\u00e9ny z\u016fstanou pod kontrolou po p\u0159est\u00e1vce, nemus\u00edte l\u00e9\u010dbu obnovovat; pokud se vr\u00e1t\u00ed, za\u010dn\u011bte nov\u00fd 6m\u011bs\u00ed\u010dn\u00ed cyklus.<\/p>\n<h3 class=\"wp-block-heading\">Zp\u016fsob\u00ed Sibelium p\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze?<\/h3>\n<p>Ano, u p\u0159ibli\u017en\u011b 15 % u\u017eivatel\u016f \u2013 a\u017e 5-10 kg za 6 m\u011bs\u00edc\u016f. Mechanismus: antihistaminikum zvy\u0161uje chu\u0165 k j\u00eddlu. Pokud je p\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze probl\u00e9m, <a href=\"https:\/\/medsbase.com\/cs\/topicon\/\">topiram\u00e1t<\/a> (zp\u016fsobuje \u00fabytek hmotnosti) nebo <a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">propranolol<\/a> (neutr\u00e1ln\u00ed v\u016f\u010di v\u00e1ze) jsou alternativy.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Sibelium v t\u011bhotenstv\u00ed?<\/h3>\n<p>Ne \u2013 nedostate\u010dn\u00e9 bezpe\u010dnostn\u00ed \u00fadaje a dopaminergn\u00ed l\u00e9ky se v t\u011bhotenstv\u00ed obecn\u011b nedoporu\u010duj\u00ed. Pro t\u011bhotn\u00e9 migreniky je, <a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">propranolol<\/a> preferovanou prevenc\u00ed; amitriptylin je druhou mo\u017enost\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Je Sibelium bezpe\u010dn\u00e9 pro d\u011bti?<\/h3>\n<p>Ano \u2013 flunarizin je jedn\u00edm z preferovan\u00fdch preventivn\u00edch p\u0159\u00edpravk\u016f proti migr\u00e9n\u011b v evropsk\u00e9 pediatrick\u00e9 neurologii (v\u011bk 5+), obvykle 5 mg p\u0159ed span\u00edm. Pediatrick\u00e9 studie prok\u00e1zaly podobnou \u00fa\u010dinnost jako u dosp\u011bl\u00fdch. Plat\u00ed stejn\u00e9 omezen\u00ed na 6m\u011bs\u00ed\u010dn\u00ed cyklus.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017ee Sibelium l\u00e9\u010dit z\u00e1vrat\u011b?<\/h3>\n<p>Ano \u2014 flunarizin je schv\u00e1len pro vestibul\u00e1rn\u00ed z\u00e1vrat\u011b (M\u00e9ni\u00e8r\u016fv syndrom, perifern\u00ed z\u00e1vrat\u011b, vestibul\u00e1rn\u00ed migr\u00e9na). Antihistaminov\u00fd a blokuj\u00edc\u00ed \u00fa\u010dinek na v\u00e1pn\u00edkov\u00e9 kan\u00e1ly sni\u017euje vestibul\u00e1rn\u00ed dr\u00e1\u017edivost. D\u00e1vkov\u00e1n\u00ed je stejn\u00e9 jako u migr\u00e9ny.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d nen\u00ed Sibelium dostupn\u00fd v USA?<\/h3>\n<p>Spole\u010dnost Janssen nikdy nepo\u017e\u00e1dala o schv\u00e1len\u00ed FDA. Je \u0161iroce dostupn\u00fd v Evrop\u011b, Asii, Latinsk\u00e9 Americe a Kanad\u011b jako l\u00e9k prvn\u00ed volby pro prevenci migr\u00e9ny. Pacienti v USA si ho n\u011bkdy obstar\u00e1vaj\u00ed prost\u0159ednictv\u00edm mezin\u00e1rodn\u00edch l\u00e9k\u00e1ren.<\/p>\n<h3 class=\"wp-block-heading\">Kde lze koupit Sibelium online?<\/h3>\n<p>Sibelium (flunarizin 5 mg \/ 10 mg, balen\u00ed po 30-180 tablet\u00e1ch) m\u016f\u017eete zakoupit na MedsBase s diskr\u00e9tn\u00edm balen\u00edm a celosv\u011btovou dopravou.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed l\u00e9\u010dba migr\u00e9ny na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zolmist-nasal-spray\/\">Zolmist nosn\u00ed sprej \u2014 Zolmitriptan 5 mg (rychlej\u0161\u00ed n\u00e1stup \u00fa\u010dinku)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zolitas-ods\/\">Zolitas ODS \u2014 Zolmitriptan 2,5\/5 mg orodispergovateln\u00e9 tablety<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/maxtan\/\">Maxtan \u2014 Rizatriptan 5\/10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rizatop\/\">Rizatop \u2014 Rizatriptan 10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rizact\/\">Rizact \u2014 Rizatriptan (Cipla)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sumitop\/\">Sumitop \u2014 Sumatriptan 25\/50\/100 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/anti-migraine\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky proti migr\u00e9n\u011b<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, zm\u011bnou nebo ukon\u010den\u00edm jak\u00e9hokoli l\u00e9\u010den\u00ed migr\u00e9ny se v\u017edy pora\u010fte se sv\u00fdm l\u00e9ka\u0159em.<\/div>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/placentrex-injection\/\">Placentrex Injekce<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/methycobal-injection\/\">Methycobal Injekce<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/frusenex\/\">Frusenex<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/syndopa\/\">Syndopa<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/losatec-h\/\">Losatec H<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Sibelium jsou flunarizinov\u00e9 tablety 5 mg\/10 mg od Janssenu \u2014 selektivn\u00ed blok\u00e1tor kalciov\u00fdch kan\u00e1l\u016f s antihistaminick\u00fdm a antidopaminergn\u00edm \u00fa\u010dinkem. Prvn\u00ed volba v prevenci migr\u00e9ny podle evropsk\u00fdch, asijsk\u00fdch a latinskoamerick\u00fdch doporu\u010den\u00ed (nen\u00ed schv\u00e1len FDA v USA). Standardn\u00ed d\u00e1vka je 10 mg na noc pro dosp\u011bl\u00e9 do 65 let; 5 mg pro seniory nebo d\u011bti. Zvl\u00e1\u0161t\u011b \u00fa\u010dinn\u00fd pro d\u011btskou migr\u00e9nu, vestibul\u00e1rn\u00ed migr\u00e9nu a hemiplegickou migr\u00e9nu. Maxim\u00e1ln\u00ed d\u00e9lka nep\u0159etr\u017eit\u00e9 l\u00e9\u010dby je 6 m\u011bs\u00edc\u016f.<\/p>","protected":false},"featured_media":57099,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3553,3141,3223,3342,3554],"product_tag":[4231,4232],"class_list":{"0":"post-57098","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-migraine","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-migraine-treatment","11":"product_tag-flunarizine-dihydrochloride","12":"product_tag-sibelium","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57098"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57099"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57098"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57098"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57098"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}