{"id":57115,"date":"2024-02-27T17:24:43","date_gmt":"2024-02-27T17:24:43","guid":{"rendered":"https:\/\/medsname.com\/flonida-cream\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"flonida-cream","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/flonida-cream\/","title":{"rendered":"Flonida Cream"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Flonida kr\u00e9m?<\/h3>\n

Flonida Cream<\/strong> obsahuje fluorouracil (5-FU) 5% hm.\/hm.<\/strong> jako topick\u00fd kr\u00e9m od Yash Pharma \u2014 cytotoxick\u00e9 chemoterapeutikum<\/strong> pou\u017e\u00edvan\u00e9 lok\u00e1ln\u011b k l\u00e9\u010db\u011b aktinick\u00fdch (sol\u00e1rn\u00edch) kerat\u00f3z<\/strong>, povrchov\u00e9ho bazocelul\u00e1rn\u00edho karcinomu<\/strong>, a Bowenovy choroby (spinocelul\u00e1rn\u00ed karcinom in situ)<\/strong> kter\u00e9 byly potvrzeny l\u00e9ka\u0159em. 5-FU inhibuje thymidyl\u00e1t synt\u00e1zu a selektivn\u011b ni\u010d\u00ed rychle se d\u011bl\u00edc\u00ed dysplastick\u00e9 ko\u017en\u00ed bu\u0148ky. L\u00e9\u010dba vyvol\u00e1v\u00e1 z\u00e1m\u011brnou z\u00e1n\u011btlivou reakci<\/strong> (eryt\u00e9m \u2192 eroze \u2192 krusta \u2192 hojen\u00ed) b\u011bhem 2-6 t\u00fddn\u016f \u2014 to JE mechanismus \u00fa\u010dinku, nikoli ne\u017e\u00e1douc\u00ed reakce. Absolutn\u00ed kontraindikace:<\/strong> t\u011bhotenstv\u00ed (kategorie X), kojen\u00ed, zn\u00e1m\u00fd deficit DPD (dihydropyrimidin dehydrogen\u00e1zy), aplikace na sliznice, pou\u017eit\u00ed na nepotvrzen\u00e9 l\u00e9ze biopsi\u00ed. P\u0159\u00edsn\u00e9 vyh\u00fdb\u00e1n\u00ed se slunci<\/strong> b\u011bhem l\u00e9\u010dby a po dobu 1-2 m\u011bs\u00edc\u016f po jej\u00edm ukon\u010den\u00ed. Nen\u00ed n\u00e1hradou chirurgick\u00e9 excize<\/strong> nodul\u00e1rn\u00edch nebo invazivn\u00edch ko\u017en\u00edch n\u00e1dor\u016f \u2014 Flonida Cream je vhodn\u00e1 pouze pro povrchov\u00e9, biopsi\u00ed potvrzen\u00e9 l\u00e9ze pod odborn\u00fdm dermatologick\u00fdm dohledem.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Flonida Cream?<\/h2>\n

Flonida Cream je topick\u00fd fluorouracil (5-FU) 5% hm.\/hm.<\/strong> kr\u00e9m od spole\u010dnosti Yash Pharma, dod\u00e1van\u00fd v tub\u011b o obsahu 10 g. Fluorouracil je pyrimidinov\u00fd antimetabolit pou\u017e\u00edvan\u00fd v chemoterapii<\/strong> poprv\u00e9 syntetizovan\u00fd v roce 1957 a \u0161iroce pou\u017e\u00edvan\u00fd jako intraven\u00f3zn\u00ed cytostatikum u gastrointestin\u00e1ln\u00edch, prsn\u00edch a n\u00e1dor\u016f hlavy a krku. Topick\u00e1 forma byla zavedena v 60. letech pot\u00e9, co bylo pozorov\u00e1no, \u017ee intraven\u00f3zn\u00ed 5-FU odstra\u0148uje aktinick\u00e9 kerat\u00f3zy na k\u016f\u017ei vystaven\u00e9 slunci. Mezin\u00e1rodn\u011b je zn\u00e1m pod zna\u010dkami Efudix (UK, EU), Efudex (US), Adrucil (intraven\u00f3zn\u00ed forma), Carac, Tolak, Fluoroplex<\/strong>, a generiky. Z\u016fst\u00e1v\u00e1 nejpou\u017e\u00edvan\u011bj\u0161\u00ed topickou chemoterapi\u00ed pro pole-effect ko\u017en\u00edch n\u00e1dor\u016f a prekancer\u00f3z.<\/p>\n

Jak Flonida Cream funguje?<\/h2>\n
    \n
  • Metabolizuje se na 5-fluorodeoxyuridin monofosf\u00e1t (FdUMP)<\/strong>, kter\u00fd inhibuje thymidyl\u00e1t synt\u00e1zu (TS)<\/strong> \u2014 enzym, kter\u00fd p\u0159ev\u00e1d\u00ed dUMP na dTMP. Bez dTMP se synt\u00e9za DNA zastav\u00ed.<\/li>\n
  • Tak\u00e9 se za\u010dle\u0148uje do RNA jako FUTP a do DNA jako FdUTP<\/strong>, \u010d\u00edm\u017e naru\u0161uje transkripci a spou\u0161t\u00ed apopt\u00f3zu v rychle se d\u011bl\u00edc\u00edch bu\u0148k\u00e1ch.<\/li>\n
  • Selektivn\u011b ni\u010d\u00ed rychle proliferuj\u00edc\u00ed dysplastick\u00e9 a malign\u00ed keratinocyty<\/strong>, zat\u00edmco norm\u00e1ln\u00ed, pomalu se d\u011bl\u00edc\u00ed keratinocyty \u0161et\u0159\u00ed. Selektivita nen\u00ed dokonal\u00e1, proto doch\u00e1z\u00ed k z\u00e1n\u011btu i v norm\u00e1ln\u00ed k\u016f\u017ei v m\u00edst\u011b aplikace.<\/li>\n
  • Minim\u00e1ln\u00ed syst\u00e9mov\u00e1 absorpce<\/strong> p\u0159i topick\u00e9 aplikaci na intaktn\u00ed k\u016f\u017ei (<10% aplikovan\u00e9 d\u00e1vky), ale absorpce prudce stoup\u00e1 p\u0159i aplikaci na velk\u00e9 plochy, erodovanou nebo ulcerovanou k\u016f\u017ei nebo pod kryc\u00ed obvazy.<\/li>\n
  • Metabolismus<\/strong>: syst\u00e9mov\u00fd 5-FU je katabolizov\u00e1n dihydropyrimidin dehydrogen\u00e1zou (DPD)<\/strong>. Pacienti s \u00fapln\u00fdm nebo \u010d\u00e1ste\u010dn\u00fdm deficitem DPD (~3-5 % populace pro \u010d\u00e1ste\u010dn\u00fd deficit; ~0,2 % \u00fapln\u00fd) nedok\u00e1\u017eou odstranit 5-FU a trp\u00ed z\u00e1va\u017enou syst\u00e9movou toxicitou i po topick\u00e9 aplikaci \u2014 to je absolutn\u00ed kontraindikace.<\/li>\n<\/ul>\n

    O\u010dek\u00e1van\u00e1 sled viditeln\u00fdch reakc\u00ed<\/strong> v pr\u016fb\u011bhu 2-6 t\u00fddenn\u00ed l\u00e9\u010dby: m\u00edrn\u00e9 zarudnut\u00ed (1. t\u00fdden) \u2192 intenzivn\u00ed eryt\u00e9m a p\u00e1len\u00ed (2.-3. t\u00fdden) \u2192 eroze, krusty a mokv\u00e1n\u00ed (3.-4. t\u00fdden) \u2192 hojen\u00ed a reepitelizace (4.-6. t\u00fdden) \u2192 zbytkov\u00e9 zar\u016f\u017eov\u011bl\u00e9 zhojen\u00ed vybledne b\u011bhem 1-2 m\u011bs\u00edc\u016f. Tento sled reakc\u00ed p\u0159edstavuje mechanismus \u00fa\u010dinku a NEN\u00cd ne\u017e\u00e1douc\u00ed reakc\u00ed.<\/strong>. Pacienti \u010dasto reaguj\u00ed s obavami; p\u0159edchoz\u00ed edukace je nezbytn\u00e1. P\u0159ed\u010dasn\u00e9 ukon\u010den\u00ed l\u00e9\u010dby kv\u016fli tomu, \u017ee poko\u017eka \u201cvypad\u00e1 \u0161patn\u011b\u201d, je nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou ne\u00fasp\u011bchu l\u00e9\u010dby \u2014 viditeln\u00e1 reakce signalizuje, \u017ee l\u00e9k funguje.<\/p>\n

    Kdy se pou\u017e\u00edv\u00e1 Flonida Cream<\/h2>\n

    Schv\u00e1len\u00e9 indikace (pod dermatologick\u00fdm dohledem a po bioptick\u00e9m potvrzen\u00ed, je-li to vhodn\u00e9):<\/strong><\/p>\n

      \n
    • Aktinick\u00e9 kerat\u00f3zy (sol\u00e1rn\u00ed kerat\u00f3zy)<\/strong> \u2014 sluncem vyvolan\u00e9 p\u0159edn\u00e1dorov\u00e9 l\u00e9ze na obli\u010deji, poko\u017ece hlavy, u\u0161\u00edch, h\u0159betu rukou a p\u0159edlokt\u00ed. Topick\u00fd 5-FU je l\u00e9kem prvn\u00ed volby pro l\u00e9\u010dbu rozs\u00e1hl\u00fdch lo\u017eisek (mnoho\u010detn\u00e9 l\u00e9ze na v\u011bt\u0161\u00ed plo\u0161e).<\/li>\n
    • Povrchov\u00fd bazocelul\u00e1rn\u00ed karcinom (sBCC)<\/strong> \u2014 biopticky potvrzen\u00fd, lokalizovan\u00fd na trupu nebo kon\u010detin\u00e1ch (ne na hlav\u011b\/krku, pokud nen\u00ed v\u00fdslovn\u011b ur\u010deno), kde je chirurgick\u00e1 excize nepraktick\u00e1 nebo kosmeticky ne\u017e\u00e1douc\u00ed.<\/li>\n
    • Bowenovy choroby (spinocelul\u00e1rn\u00ed karcinom in situ)<\/strong> \u2014 biopticky potvrzen\u00fd, dob\u0159e ohrani\u010den\u00fd, na trupu nebo kon\u010detin\u00e1ch.<\/li>\n
    • Keratoakantom<\/strong> (speci\u00e1ln\u00ed pou\u017eit\u00ed, pouze u specifick\u00fdch podtyp\u016f)<\/li>\n<\/ul>\n

      Flonida Cream je ur\u010den pro NEN\u00cd<\/strong> za:<\/p>\n

        \n
      • Nodul\u00e1rn\u00ed nebo invazivn\u00ed bazocelul\u00e1rn\u00ed karcinom<\/strong> \u2014 vy\u017eaduje chirurgick\u00e9 odstran\u011bn\u00ed, Mohsovu chirurgii nebo radioterapii<\/li>\n
      • Invazivn\u00ed spinocelul\u00e1rn\u00ed karcinom<\/strong> \u2014 vy\u017eaduje chirurgick\u00e9 odstran\u011bn\u00ed<\/li>\n
      • Melanom nebo l\u00e9ze podez\u0159el\u00e9 z melanomu<\/strong><\/li>\n
      • L\u00e9ze bez histologick\u00e9 diagn\u00f3zy<\/strong> \u2014 nejprve mus\u00ed biopsie potvrdit typ ko\u017en\u00edho n\u00e1doru; topick\u00fd 5-FU m\u016f\u017ee zplo\u0161tit a \u010d\u00e1ste\u010dn\u011b l\u00e9\u010dit invazivn\u00ed n\u00e1dor natolik, \u017ee odd\u00e1l\u00ed chirurgickou diagn\u00f3zu, zat\u00edmco hlub\u0161\u00ed onemocn\u011bn\u00ed postupuje<\/li>\n
      • B\u011b\u017en\u00e9 vr\u00e1sky, po\u0161kozen\u00ed sluncem nebo pigmentace<\/strong> (kosmetick\u00e9 pou\u017eit\u00ed) \u2014 jedn\u00e1 se o chemoterapeutikum, nikoli o kosmetick\u00fd p\u0159\u00edpravek<\/li>\n
      • Intertrigin\u00f3zn\u00ed nebo slizni\u010dn\u00ed oblasti<\/strong><\/li>\n<\/ul>\n

        D\u00e1vkov\u00e1n\u00ed a l\u00e9\u010debn\u00e9 protokoly Flonida Cream<\/h2>\n

        Standardn\u00ed protokol pro aktinickou kerat\u00f3zu (obli\u010dej, poko\u017eka hlavy)<\/h3>\n
          \n
        1. O\u0161et\u0159ovanou oblast umyjte jemn\u00fdm m\u00fddlem a vla\u017enou vodou; jemn\u011b osu\u0161te.<\/li>\n
        2. Naneste tenkou vrstvu Flonida Cream<\/strong> p\u0159\u00edmo na posti\u017eenou oblast a kr\u00e1tk\u00fd okraj (1-2 cm) okoln\u00ed k\u016f\u017ee; jemn\u011b vet\u0159ete prstem v rukavici nebo vatovou ty\u010dinkou.<\/li>\n
        3. Po aplikaci si d\u016fkladn\u011b umyjte ruce. NEDOT\u00ddKEJTE se o\u010d\u00ed, rt\u016f, vnit\u0159ku nosn\u00edch d\u00edrek ani sliznic<\/strong> rukama pot\u0159\u00edsn\u011bn\u00fdmi kr\u00e9mem.<\/li>\n
        4. Aplikujte dvakr\u00e1t denn\u011b po dobu 2\u20134 t\u00fddn\u016f<\/strong> na obli\u010dej a poko\u017eku hlavy. D\u00e9lka l\u00e9\u010dby se upravuje podle klinick\u00e9 reakce \u2014 jakmile je dosa\u017eeno dobr\u00e9 z\u00e1n\u011btliv\u00e9\/erozn\u00ed reakce, byl c\u00edl dosa\u017een a l\u00e9\u010dbu lze ukon\u010dit.<\/li>\n
        5. \u017d\u00e1dn\u00e9 okluzivn\u00ed obvazy.<\/strong> Kr\u00e9m se nech\u00e1v\u00e1 voln\u011b bez kryt\u00ed \u2014 okluze zvy\u0161uje absorpci a z\u00e1va\u017enost reakce nad zam\u00fd\u0161lenou m\u00edru.<\/li>\n
        6. Po ukon\u010den\u00ed l\u00e9\u010dby poko\u017eka pokra\u010duje v hojen\u00ed po dobu 2\u20136 t\u00fddn\u016f. B\u011bhem f\u00e1ze hojen\u00ed aplikujte nedr\u00e1\u017ediv\u00e9 emoliencium (vazel\u00ednu, paraf\u00ednov\u00fd hydrata\u010dn\u00ed p\u0159\u00edpravek). \u017d\u00c1DN\u00c1 kosmetika, \u017d\u00c1DN\u00c9 vystaven\u00ed slunci.<\/strong><\/li>\n<\/ol>\n

          Protokol pro povrchov\u00fd BCC\/Bowenovu chorobu<\/h3>\n
            \n
          1. Nejprve mus\u00ed b\u00fdt diagn\u00f3za potvrzena biopsi\u00ed.<\/strong> Povrchov\u00fd BCC na trupu\/kon\u010detin\u00e1ch nebo Bowenova choroba pouze \u2014 pod odborn\u00fdm dermatologick\u00fdm veden\u00edm.<\/li>\n
          2. Aplikujte dvakr\u00e1t denn\u011b po dobu 3-6 t\u00fddn\u016f<\/strong>.<\/li>\n
          3. L\u00e9\u010dba \u010dasto vypad\u00e1 h\u016f\u0159e a trv\u00e1 d\u00e9le ne\u017e l\u00e9\u010dba AK \u2014 o\u010dek\u00e1vejte intenzivn\u00ed z\u00e1n\u011bt, erozi a mokv\u00e1n\u00ed po dobu 2-3 t\u00fddn\u016f, n\u00e1sledovan\u00e9 pomalou f\u00e1z\u00ed hojen\u00ed.<\/li>\n
          4. Kontroln\u00ed biopsie za 8-12 t\u00fddn\u016f<\/strong> je \u010dasto doporu\u010dov\u00e1na k potvrzen\u00ed vyl\u00e9\u010den\u00ed. M\u00edra recidivy za 5 let je 10-30% \u2014 standardem je ka\u017edoro\u010dn\u00ed dermatologick\u00e9 sledov\u00e1n\u00ed po dobu 5 let.<\/li>\n<\/ol>\n

            Alternativn\u00ed re\u017eimy<\/h3>\n

            V\u00e1\u0161 dermatolog m\u016f\u017ee doporu\u010dit pulzn\u00ed re\u017eim<\/strong> (nap\u0159. 2 t\u00fddny l\u00e9\u010dby, 2 t\u00fddny pauza, opakovat; nebo pouze o v\u00edkendech po del\u0161\u00ed obdob\u00ed) ke sn\u00ed\u017een\u00ed z\u00e1va\u017enosti z\u00e1n\u011btliv\u00e9 reakce u pacient\u016f, kte\u0159\u00ed nesnesou standardn\u00ed 4t\u00fddenn\u00ed l\u00e9\u010dbu. Kombinace s kalcipotriolem<\/strong> (4denn\u00ed re\u017eim) nebo sekven\u010dn\u00ed aplikac\u00ed imiquimodu<\/strong> se pou\u017e\u00edv\u00e1 u t\u011b\u017ek\u00e9ho posti\u017een\u00ed rozs\u00e1hl\u00fdch ploch. Tyto protokoly pat\u0159\u00ed do odborn\u00e9 dermatologie \u2014 neexperimentujte sami.<\/p>\n

            O\u010dek\u00e1van\u00fd \u010dasov\u00fd pr\u016fb\u011bh reakce \u2014 Co o\u010dek\u00e1vat<\/h2>\n\n\n\n\n\n\n\n\n\n
            F\u00e1ze<\/th>\nCo uvid\u00edte<\/th>\n<\/tr>\n<\/thead>\n
            Dny 1-7 (po\u010d\u00e1te\u010dn\u00ed f\u00e1ze)<\/strong><\/td>\nM\u00edrn\u00e9 zarudnut\u00ed a lehk\u00e9 brn\u011bn\u00ed. D\u0159\u00edve neviditeln\u00e9 l\u00e9ze se mohou st\u00e1t viditeln\u00fdmi, jak reaguj\u00ed na l\u00e9\u010dbu.<\/td>\n<\/tr>\n
            Dny 7-14 (reak\u010dn\u00ed f\u00e1ze)<\/strong><\/td>\nIntenzivn\u00ed eryt\u00e9m, p\u00e1len\u00ed, citlivost, \u0161t\u00edp\u00e1n\u00ed. K\u016f\u017ee je hork\u00e1 na dotek. L\u00e9ze tmavnou a st\u00e1vaj\u00ed se v\u00fdrazn\u011bj\u0161\u00edmi.<\/td>\n<\/tr>\n
            Dny 14-28 (erozn\u00ed f\u00e1ze)<\/strong><\/td>\nEroze, mokv\u00e1n\u00ed, tvorba stroupk\u016f. K\u016f\u017ee vypad\u00e1 v\u00fdrazn\u011b podr\u00e1\u017ed\u011bn\u011b. To je zn\u00e1mka toho, \u017ee l\u00e9k p\u016fsob\u00ed na c\u00edlov\u00e9 bu\u0148ky.<\/td>\n<\/tr>\n
            Dny 28-42 (hojen\u00ed)<\/strong><\/td>\nZa\u010d\u00edn\u00e1 reepitelizace. Pouze jemn\u00fd emolien\u010dn\u00ed p\u0159\u00edpravek; \u017e\u00e1dn\u00e1 kosmetika, \u017e\u00e1dn\u00e9 slunce. R\u016f\u017eov\u00e1 nov\u00e1 k\u016f\u017ee nahrazuje erozi.<\/td>\n<\/tr>\n
            T\u00fddny 6-12 (zhojen\u00ed)<\/strong><\/td>\nR\u016f\u017eov\u00e1 k\u016f\u017ee postupn\u011b p\u0159ech\u00e1z\u00ed do norm\u00e1ln\u00ed barvy. Zbytkov\u00e9 zarudnut\u00ed m\u016f\u017ee p\u0159etrv\u00e1vat n\u011bkolik m\u011bs\u00edc\u016f. M\u016f\u017ee se objevit hyper- nebo hypo-pigmentace, kter\u00e1 je obvykle trval\u00e1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

            Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n