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Amifru<\/strong> je 40\/5 mg fixed-dose tablet<\/strong> z furosemide (frusemide)<\/strong> — a loop diuretic — and amiloride<\/strong> — a potassium-sparing diuretic — from Sun Pharma. The combination is used when a loop diuretic is needed but hypokalaemia is a problem<\/strong> — amiloride blocks distal-tubule potassium loss driven by aldosterone activation, balancing the potassium depletion caused by furosemide’s upstream sodium load. Common uses: hypertension with oedema, chronic heart failure with tendency to hypokalaemia, hepatic ascites where adequate potassium-sparing is not provided by spironolactone alone. Typical dosing: one tablet once daily in the morning (some patients require twice-daily). Absolutely contraindicated in anuria, hyperkalaemia >5.5, severe CKD (eGFR <30), and Addison disease<\/strong>. Monitor potassium, sodium, and creatinine on initiation and regularly thereafter.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Amifru is an oral fixed-dose combination tablet supplying furosemide (frusemide)<\/strong> a amiloride<\/strong> in a single pill (typical ratio 40 mg furosemide + 5 mg amiloride per tablet). Made by Sun Pharma, supplied in 30-180 tablets.<\/p>\n Furosemide is the reference loop diuretic, introduced in 1964 as Lasix. Amiloride is a potassium-sparing diuretic acting at the epithelial sodium channel (ENaC) in the distal tubule — introduced by MSD in 1967 specifically to offset thiazide and loop diuretic potassium loss.<\/p>\n Loop diuretics deliver large sodium loads to the distal tubule. Aldosterone then drives distal sodium reabsorption in exchange for potassium excretion — the classical mechanism of loop-induced hypokalaemia. Two counter-strategies:<\/p>\n Amiloride is preferred over spironolactone when:<\/p>\n Amifru is particularly useful in hepatic ascites<\/strong> (where potassium losses are often severe), chronic HF patients with brittle potassium<\/strong>, a patients who need a quick loop-diuretic effect without dropping potassium<\/strong>.<\/p>\n Standardn\u00ed d\u00e1vka:<\/strong> one 40\/5 mg tablet once daily in the morning.<\/p>\n Titrace:<\/strong> <\/p>\n Monitorovac\u00ed pl\u00e1n:<\/strong><\/p>\n \u010cast\u00e9 (>1 %):<\/strong><\/p>\n Nep\u0159\u00edli\u0161 \u010dast\u00e9, ale klinicky v\u00fdznamn\u00e9:<\/strong><\/p>\n T\u011bhotenstv\u00ed:<\/strong> generally avoided. Loop diuretics cross the placenta; amiloride data in pregnancy are limited. Use only for compelling indications (pulmonary oedema) under specialist care.<\/p>\n Store Amifru below 25°C in the original blister pack. Keep out of reach of children.<\/p>\n Three situations. First, if you have developed hypokalaemia on furosemide alone and want a built-in potassium-sparing component<\/strong> without adding a separate spironolactone tablet. Second, if you have developed gynaecomastia or breast pain on spironolactone and need a non-steroidal alternative. Third, if rapid potassium-sparing effect<\/strong> is needed — amiloride acts within hours, whereas spironolactone takes 24-72 hours via its active metabolites.<\/p>\n Morning, with or without food. The diuretic effect peaks 1-2 hours after dosing and has mostly worn off by evening. Evening dosing causes nocturia and disrupts sleep.<\/p>\n Yes, with monitoring. The combination of amiloride + ACE inhibitor (or + ARB) raises potassium significantly and should be avoided in advanced CKD (eGFR <45) or if baseline potassium is >5.0. If combined, check potassium at 1 week, 1 month, and every 3 months. Many patients in this situation do better on a loop diuretic alone + ACEi\/ARB (without the amiloride), accepting a potassium supplement if needed.<\/p>\n No. Loop-diuretic combinations are reserved for specific indications — hypertension with oedema or advanced CKD, chronic heart failure, or cirrhotic ascites. For standard hypertension, start with an ARB or ACE inhibitor, add a calcium-channel blocker or thiazide, and step up to spironolactone (PATHWAY-2 trial) before a loop-diuretic combination.<\/p>\n The combination is designed to be potassium-neutral<\/strong> — furosemide loses potassium, amiloride saves it, and the net effect is usually a stable potassium. A small number of patients will drift one way or the other depending on diet, kidney function, and concurrent drugs (ACEi\/ARB raise potassium; corticosteroids lower it). Check potassium at baseline and 1-2 weeks to see which direction you drift.<\/p>\n With caution. The furosemide component can raise serum uric acid and precipitate gout flares. If gout is active, address the gout with urate-lowering therapy (allopurinol) rather than stopping Amifru outright — the underlying indication (HF, oedema, advanced CKD) usually cannot be managed without a loop diuretic.<\/p>\n Chronic NSAIDs are risky on any loop-diuretic combination — they reduce the diuretic effect AND substantially raise AKI risk when combined with an ACE inhibitor or ARB. Use paracetamol preferentially for chronic pain.<\/p>\n Take it as soon as you remember unless it is nearly time for the next dose — in that case skip the missed dose. Do not double up. A single missed dose in chronic HF can let fluid accumulate; monitor weight the next day.<\/p>\n Routinely avoided. Loop diuretics cross the placenta and amiloride data in pregnancy are limited. Use only for compelling indications (pulmonary oedema, resistant heart failure) under specialist care.<\/p>\n You can buy Amifru (40\/5 mg furosemide + amiloride, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n <\/p>\n Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n Amifru is Sun Pharma’s fixed-dose furosemide 40 mg + amiloride 5 mg tablets \u2014 combines a loop diuretic with a potassium-sparing agent acting on ENaC. Designed to prevent loop-induced hypokalaemia without adding spironolactone. Preferred when gynaecomastia contraindicates spironolactone or when rapid potassium-sparing effect is needed (hours, not days). Uses: heart failure with brittle potassium, hepatic ascites, oedema with CKD.<\/p>","protected":false},"featured_media":57156,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[4244,4245,4239],"class_list":{"0":"post-57155","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-amifru","11":"product_tag-amiloride","12":"product_tag-frusemide","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57155"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57156"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57155"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57155"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57155"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
What Is Amifru?<\/h2>\n
Why Combine Furosemide With Amiloride?<\/h2>\n
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D\u00e1vkov\u00e1n\u00ed & Titrace<\/h2>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Kontraindikace<\/h2>\n
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Interakce s l\u00e9\u010divy<\/h2>\n
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Skladov\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Why would I choose Amifru over plain furosemide?<\/h3>\n
When should I take Amifru?<\/h3>\n
Can I take Amifru with an ACE inhibitor or ARB?<\/h3>\n
Is Amifru a first-line blood-pressure drug?<\/h3>\n
Will I lose or gain potassium on Amifru?<\/h3>\n
I have gout — can I take Amifru?<\/h3>\n
Can I take ibuprofen with Amifru?<\/h3>\n
Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n
Can I take Amifru in pregnancy?<\/h3>\n
Where can I buy Amifru online?<\/h3>\n
Souvisej\u00edc\u00ed antihypertenziva a diuretika na MedsBase<\/h2>\n
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Souvisej\u00edc\u00ed alternativy<\/h3>\n
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