{"id":57245,"date":"2024-02-27T17:31:51","date_gmt":"2024-02-27T17:31:51","guid":{"rendered":"https:\/\/medsname.com\/maxiliv-injection\/"},"modified":"2026-04-30T10:24:30","modified_gmt":"2026-04-30T10:24:30","slug":"maxiliv-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/maxiliv-injection\/","title":{"rendered":"Maxiliv injekce"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Maxiliv Injection?<\/h3>\n<p style=\"margin:0;\"><strong>Maxiliv injekce<\/strong> je <strong>reduced glutathione (GSH) 600 mg per vial for IV use<\/strong> &mdash; a tripeptide antioxidant (glutamate-cysteine-glycine) used clinically for <strong>oxidative liver stress, cisplatin- or oxaliplatin-induced peripheral neuropathy, and adjunct therapy in chemotherapy<\/strong>. It is administered intravenously by a healthcare professional. Glutathione is the body&#8217;s principal intracellular antioxidant, neutralising reactive oxygen species and conjugating reactive electrophiles for renal\/biliary excretion.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; NOT a skin-whitening or anti-ageing drug.<\/strong> Glutathione has been marketed for skin-lightening at non-clinical doses and frequencies. There is no FDA approval for cosmetic skin-lightening, no quality evidence, and the FDA has issued specific warnings against IV glutathione for cosmetic use due to risks of Stevens-Johnson syndrome, TEN, thyroid dysfunction, kidney impairment, and air embolism from unsupervised injections. Maxiliv Injection is a hospital-administered antioxidant for documented clinical indications, not a cosmetic product. Cosmetic claims are not endorsed by MedsBase.<\/div>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#128161; Hospital-only administration.<\/strong> IV glutathione must be given by a healthcare professional in a clinical setting with monitoring. It is not for self-injection. The vial provides the active compound; the prescribing clinician determines dose, frequency, and infusion protocol.<\/div>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Maxiliv Injection is supplied from a <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. IV glutathione is used as supportive therapy in oncology and hepatology &mdash; not as a cosmetic intervention. Clinical doses, frequencies, and administration protocols are determined by the treating physician.<\/p>\n<h2 class=\"wp-block-heading\">Mechanismus \u00fa\u010dinku<\/h2>\n<p>Glutathione is a thiol tripeptide that exists in reduced (GSH) and oxidised (GSSG) forms; the reduced form donates electrons to neutralise hydrogen peroxide and lipid peroxides via glutathione peroxidase, and conjugates reactive electrophiles via glutathione-S-transferase. Cellular glutathione is depleted by oxidative stress, paracetamol overdose, alcohol, ageing, and several disease states. IV glutathione transiently raises circulating levels; cellular uptake of intact GSH is limited, but the molecule is hydrolysed and the constituent amino acids (especially cysteine, the rate-limiting precursor) support intracellular re-synthesis.<\/p>\n<h2 class=\"wp-block-heading\">Clinical indications<\/h2>\n<ul>\n<li>Cisplatin- and oxaliplatin-induced peripheral neuropathy (Schmitt 2009 trial &mdash; preserved sensory nerve function on serial nerve-conduction studies)<\/li>\n<li>Oxidative liver stress in chronic hepatitis, fatty liver, post-anaesthetic, post-chemotherapy<\/li>\n<li>Acute paracetamol toxicity (N-acetylcysteine is the standard antidote that replenishes intracellular GSH; IV GSH is supplementary)<\/li>\n<li>Some Parkinson&#8217;s disease research protocols (off-label, low evidence)<\/li>\n<li>Idiopathic pulmonary fibrosis adjunct (low evidence)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Doses (clinician-determined)<\/h2>\n<p>Cisplatin-induced neuropathy: 1.5&ndash;2.4 g IV before each chemotherapy cycle. Hepatic support: 600 mg&ndash;1.2 g once daily or every other day. Always slow IV push or short infusion in compatible diluent (typically 5 percent dextrose or normal saline; check compatibility per local protocol).<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Injection-site reactions, mild venous irritation<\/li>\n<li>Sulphurous taste \/ smell during infusion<\/li>\n<li>Hypersensitivity (rare; thiol allergy, asthma triggers)<\/li>\n<li>Stevens-Johnson syndrome \/ TEN (rare but reported, particularly with frequent unsupervised cosmetic dosing)<\/li>\n<li>Thyroid dysfunction with chronic high-dose use (FDA cosmetic-use warning)<\/li>\n<li>Renal impairment (rare)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Cautions<\/h2>\n<ul>\n<li>Severe asthma (sulphite\/thiol exacerbation risk)<\/li>\n<li>Active malignancy &mdash; specialist oncology decision (concern that antioxidant therapy could blunt chemo cytotoxicity offset by neuroprotection benefit)<\/li>\n<li>Pregnancy and breastfeeding &mdash; insufficient data, avoid unless clinical benefit is clear<\/li>\n<li>Renal impairment &mdash; reduce dose<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Can I have IV glutathione for skin-whitening?<\/h3>\n<p>No &mdash; this is not a recognised medical indication. The FDA has issued specific warnings against unsupervised IV glutathione for cosmetic use due to serious adverse-event reports.<\/p>\n<h3 class=\"wp-block-heading\">Does it really protect against chemo-induced neuropathy?<\/h3>\n<p>Schmitt 2009 (Italian Multicentre Cooperative Group) showed reduced sensory neuropathy on cisplatin in colorectal cancer patients pre-treated with IV glutathione. Several subsequent trials have shown variable effects. It remains an option in oncology supportive care but is not universally adopted.<\/p>\n<h3 class=\"wp-block-heading\">How is it administered?<\/h3>\n<p>By a healthcare professional, intravenously, after reconstitution with a compatible diluent. Self-administration is unsafe and not endorsed.<\/p>\n<h3 class=\"wp-block-heading\">Are there oral alternatives?<\/h3>\n<p>Liposomal oral glutathione has modest absorption. N-acetylcysteine (NAC) 600&ndash;1200 mg\/day is a more bioavailable cysteine precursor and is the standard oral approach to raising intracellular glutathione.<\/p>\n<h3 class=\"wp-block-heading\">Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p>Insufficient data &mdash; avoid unless the clinical situation strongly justifies it. NAC has a longer pregnancy safety record.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with chemotherapy?<\/h3>\n<p>Only under oncology supervision. The interaction between antioxidant supplementation and chemotherapy efficacy is debated; clinical decisions need to be made within the multidisciplinary team.<\/p>\n<h3 class=\"wp-block-heading\">Why does it smell of sulphur?<\/h3>\n<p>Glutathione contains a sulfhydryl (-SH) group. The smell during infusion is harmless and dissipates within minutes.<\/p>\n<h3 class=\"wp-block-heading\">How often should I have it?<\/h3>\n<p>Determined by the treating clinician. Frequent dosing (more than once weekly) is not supported by clinical evidence and increases risk of adverse reactions.<\/p>\n<h3 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h3>\n<p>Below 25&deg;C, protect from light. Discard reconstituted solution if not used within the local protocol&#8217;s stability window (typically 2&ndash;4 hours).<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Discuss with the treating clinician. Do not self-administer or arrange unsupervised infusions.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/udimax-300\/\">Udimax 300 &mdash; UDCA (cholestatic liver)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/liv-52-ds\/\">Liv 52 DS \u2014 \u00c1jurv\u00e9dsk\u00fd hepatoprotektivn\u00ed p\u0159\u00edpravek<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mucinac\/\">Mucinac &mdash; N-acetylcysteine (oral cysteine precursor)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/folvite\/\">Folvite \u2014 Kyselina listov\u00e1<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/gasex\/\">Gasex \u2014 \u00c1jurv\u00e9dsk\u00fd tr\u00e1vic\u00ed prost\u0159edek<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/gastro-health\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. IV glutathione is hospital-administered. Cosmetic skin-whitening claims are not endorsed and not supported by clinical evidence. The FDA has issued specific warnings against unsupervised cosmetic IV glutathione use.<\/div>","protected":false},"excerpt":{"rendered":"<p>Maxiliv Injection (Glutathione 600 mg per IV vial) \u2014 antioxidant tripeptide for chemotherapy-induced peripheral neuropathy and oxidative liver stress. Hospital-administered. Not for cosmetic skin-whitening (FDA-warned). WHO-GMP certified manufacturer.<\/p>","protected":false},"featured_media":57246,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[3667,4265],"class_list":{"0":"post-57245","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-glutathione","10":"product_tag-maxiliv-injection","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57245"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57246"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57245"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57245"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57245"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}