{"id":57335,"date":"2024-02-27T17:37:55","date_gmt":"2024-02-27T17:37:55","guid":{"rendered":"https:\/\/medsname.com\/ocivox\/"},"modified":"2026-04-30T10:24:28","modified_gmt":"2026-04-30T10:24:28","slug":"ocivox","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ocivox\/","title":{"rendered":"Ocivox"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Ocivox (Fluvoxamin male\u00e1t 50\/100 mg) je selektivn\u00ed inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed serotoninu pou\u017e\u00edvan\u00fd k l\u00e9\u010db\u011b deprese, \u00fazkosti a p\u0159\u00edbuzn\u00fdch poruch. N\u00e1stup antidepresivn\u00edho \u00fa\u010dinku je postupn\u00fd \u2014 pro objektivn\u00ed hodnocen\u00ed je pot\u0159eba 4\u20136 t\u00fddn\u016f.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Ocivox na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Jak Ocivox funguje<\/h2>\n

Ocivox<\/strong> je tableta obsahuj\u00edc\u00ed Fluvoxamin male\u00e1t od Sun Pharma. Dostupn\u00e9 s\u00edly: 50 \/ 100 mg<\/strong>. U\u017e\u00edvejte s j\u00eddlem nebo bez j\u00eddla, ve stejnou dobu ka\u017ed\u00fd den pro stabiln\u00ed hladinu v plazm\u011b.<\/p>\n

SSRI blokuj\u00ed zp\u011btn\u00e9 vychyt\u00e1v\u00e1n\u00ed serotoninu (5-HT) na presynaptick\u00e9m serotoninov\u00e9m transport\u00e9ru (SERT), \u010d\u00edm\u017e zvy\u0161uj\u00ed dostupnost synaptick\u00e9ho serotoninu. Terapeutick\u00fd \u00fa\u010dinek se objevuje se zpo\u017ed\u011bn\u00edm 2\u20136 t\u00fddn\u016f po blok\u00e1d\u011b transport\u00e9ru \u2014 toto zpo\u017ed\u011bn\u00ed odr\u00e1\u017e\u00ed n\u00e1sledn\u00e9 adaptace v citlivosti 5-HT autoreceptor\u016f, expresi BDNF a neurogenezi v hippocampu, nikoli p\u0159\u00edm\u00e9 \u00fa\u010dinky na receptory. Pacienti, kte\u0159\u00ed po 2 t\u00fddnech \u201cnec\u00edt\u00ed nic\u201d, by nem\u011bli l\u00e9\u010dbu p\u0159ed\u010dasn\u011b ukon\u010dovat; vyhodno\u0165te odpov\u011b\u010f po 4\u20136 t\u00fddnech adekv\u00e1tn\u00ed d\u00e1vky.<\/p>\n

Fluvoxamin je \u010dasto preferovan\u00e9 SSRI pro OCD<\/strong>, zejm\u00e9na v pediatrii (schv\u00e1leno FDA od 8 let). M\u00e1 minim\u00e1ln\u00ed sexu\u00e1ln\u00ed vedlej\u0161\u00ed \u00fa\u010dinky ve srovn\u00e1n\u00ed s jin\u00fdmi SSRI a m\u00e1 tendenci b\u00fdt sedativn\u00ed \u2014 pod\u00e1v\u00e1n\u00ed p\u0159ed span\u00edm pom\u00e1h\u00e1 jak s nespavost\u00ed, tak s toleranc\u00ed. Hypot\u00e9za \u201cfluvoxaminu pro COVID-19\u201d z let 2020\u201322 (protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek na sigma-1 receptor) z\u016fst\u00e1v\u00e1 neprok\u00e1zan\u00e1 a nem\u011bla by ovliv\u0148ovat rozhodov\u00e1n\u00ed o p\u0159edepisov\u00e1n\u00ed.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
25 mg HS \u00d7 1 t\u00fdden<\/td>\n50 mg p\u0159ed span\u00edm<\/td>\n100\u2013300 mg\/den<\/td>\n300 mg (rozd\u011blit >100)<\/td>\n<\/tr>\n
OCD (pediatrie \u22658 let)<\/td>\n25 mg p\u0159ed span\u00edm<\/td>\n50\u2013200 mg\/den<\/td>\n200 mg<\/td>\n<\/tr>\n
Soci\u00e1ln\u00ed \u00fazkost \/ GAD (mimo indikaci)<\/td>\n50 mg p\u0159ed span\u00edm<\/td>\n100\u2013200 mg\/den<\/td>\n300 mg<\/td>\n<\/tr>\n
Jatern\u00ed selh\u00e1n\u00ed \/ star\u0161\u00ed dosp\u011bl\u00ed<\/td>\n25 mg p\u0159ed span\u00edm<\/td>\n50\u2013100 mg\/den<\/td>\ndle sn\u00e1\u0161enlivosti<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nSiln\u00fd inhibitor CYP1A2 + CYP2C19 \u2014 mnoho interakc\u00ed<\/strong><\/p>\n

Fluvoxamin m\u00e1 nej\u0161ir\u0161\u00ed a klinicky nejv\u00fdznamn\u011bj\u0161\u00ed profil inhibice CYP ze v\u0161ech SSRI<\/strong>. V\u00fdznamn\u011b zvy\u0161uje hladiny: teofylinu (toxicita i p\u0159i n\u00edzk\u00fdch d\u00e1vk\u00e1ch), tizanidinu (t\u011b\u017ek\u00e1 hypotenze \u2014 absolutn\u00ed kontraindikace), klozapinu (4\u201310\u00d7 zv\u00fd\u0161en\u00ed koncentrace; sn\u00ed\u017eit d\u00e1vku klozapinu na polovinu), olanzapinu, melatoninu, kofeinu (nespavost, palpitace), warfarinu, propranololu, metadonu, ramelteonu. P\u0159ed p\u0159id\u00e1n\u00edm fluvoxaminu k st\u00e1vaj\u00edc\u00edmu re\u017eimu v\u017edy zkontrolujte interakce.<\/p>\n<\/div>\n

\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u osob do 25 let)<\/strong><\/p>\n

V\u0161echna SSRI nesou varov\u00e1n\u00ed FDA (\u010dern\u00fd r\u00e1me\u010dek) ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika sebevra\u017eedn\u00fdch my\u0161lenek u pacient\u016f mlad\u0161\u00edch 25 let, zejm\u00e9na v prvn\u00edch 4 t\u00fddnech a p\u0159i zm\u011bn\u00e1ch d\u00e1vkov\u00e1n\u00ed. To neznamen\u00e1, ne<\/em> \u017ee SSRI jsou pro mlad\u00e9 lidi celkov\u011b \u0161kodliv\u00e1 \u2014 metaanal\u00fdzy ukazuj\u00ed \u010dist\u00fd benefit \u2014 ale vy\u017eaduje to pe\u010dliv\u00e9 klinick\u00e9 sledov\u00e1n\u00ed b\u011bhem zah\u00e1jen\u00ed l\u00e9\u010dby a titrace u dosp\u00edvaj\u00edc\u00edch a mlad\u00fdch dosp\u011bl\u00fdch.<\/p>\n<\/div>\n

\nSerotoninov\u00fd syndrom<\/strong><\/p>\n

Kombinace Ocivoxu s jin\u00fdmi serotonergn\u00edmi l\u00e1tkami m\u016f\u017ee zp\u016fsobit serotoninov\u00fd syndrom (t\u0159es, hyperreflexie, klonus, hypertermie, agitovanost). Vyhn\u011bte se sou\u010dasn\u00e9mu u\u017e\u00edv\u00e1n\u00ed: MAOI (14denn\u00ed vynech\u00e1n\u00ed v obou sm\u011brech; fluoxetin vy\u017eaduje 5 t\u00fddn\u016f), tramadolu, petidinu, dextromethorfanu, linezolidu, methylenov\u00e9 mod\u0159i, t\u0159ezalky te\u010dkovan\u00e9, MDMA. Kombinace triptanu a SSRI je obecn\u011b tolerov\u00e1na u migr\u00e9ny \u2014 absolutn\u00ed riziko je n\u00edzk\u00e9.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n