{"id":57390,"date":"2024-02-27T17:40:16","date_gmt":"2024-02-27T17:40:16","guid":{"rendered":"https:\/\/medsname.com\/laregab-at\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"laregab-at","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/laregab-at\/","title":{"rendered":"Laregab AT (Gabapentin 300 mg + Amitriptylin 10 mg) \u2014 Refraktern\u00ed nervov\u00e1 bolest"},"content":{"rendered":"
\ud83d\udce6 Pozn\u00e1mka k doprav\u011b do USA:<\/strong> Laregab AT dopravujeme do Spojen\u00fdch st\u00e1t\u016f; av\u0161ak vzhledem k za\u0159azen\u00ed gabapentinu mezi l\u00e1tky kontrolovan\u00e9 jednotliv\u00fdmi st\u00e1ty nem\u016f\u017eeme dopravovat do Kentucky, Michigan, Tennessee, Virginie nebo Z\u00e1padn\u00ed Virginie<\/strong>. Pokud objedn\u00e1vku s dodac\u00ed adresou v jednom z t\u011bchto omezen\u00fdch st\u00e1t\u016f uskute\u010dn\u00edte, p\u0159\u00edslu\u0161nou \u010d\u00e1st objedn\u00e1vky v\u00e1m vr\u00e1t\u00edme nebo poskytneme kup\u00f3n jako kompenzaci.<\/div>\n
\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

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Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Laregab AT<\/strong> je fixn\u00ed kombinace gabapentin 300 mg + amitriptylin 10 mg<\/strong>, pou\u017e\u00edvan\u00e9 k l\u00e9\u010db\u011b refraktern\u00ed neuropatick\u00e9 bolesti, kter\u00e1 nereagovala dostate\u010dn\u011b na samotn\u00fd gabapentin nebo amitriptylin. Tyto dv\u011b molekuly p\u016fsob\u00ed na komplement\u00e1rn\u00ed dr\u00e1hy bolesti: gabapentin sni\u017euje uvol\u0148ov\u00e1n\u00ed excita\u010dn\u00edch neurotransmiter\u016f na hyperexcitabiln\u00edch nervov\u00fdch zakon\u010den\u00edch, zat\u00edmco amitriptylin posiluje sestupnou inhibici bolesti zv\u00fd\u0161en\u00edm synaptick\u00e9ho noradrenalinu a serotoninu. Obvykl\u00e1 d\u00e1vka je zpo\u010d\u00e1tku jedna tableta p\u0159ed span\u00edm, s mo\u017en\u00fdm zv\u00fd\u0161en\u00edm na dv\u011b denn\u011b. Ob\u011b molekuly zp\u016fsobuj\u00ed ospalost \u2014 za\u010dn\u011bte u\u017e\u00edv\u00e1n\u00ed ve\u010der, jezd\u011bte opatrn\u011b a p\u0159i vysazov\u00e1n\u00ed postupn\u011b sni\u017eujte d\u00e1vky.<\/p>\n<\/div>\n

Co je Laregab AT?<\/h2>\n

Laregab AT je kombinovan\u00e1 tableta vyr\u00e1b\u011bn\u00e1 v Indii, kter\u00e1 obsahuje dv\u011b osv\u011bd\u010den\u00e9 l\u00e1tky pro l\u00e9\u010dbu neuropatick\u00e9 bolesti:<\/p>\n

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  • Gabapentin 300 mg<\/strong> \u2014 ligand alfa-2-delta v\u00e1pn\u00edkov\u00e9ho kan\u00e1lu, antikonvulzivum, analgetikum pro neuropatickou bolest<\/li>\n
  • Amitriptylin 10 mg<\/strong> \u2014 tricyklick\u00e9 antidepresivum, analgetikum pro neuropatickou bolest v n\u00edzk\u00fdch d\u00e1vk\u00e1ch, modul\u00e1tor sp\u00e1nku<\/li>\n<\/ul>\n

    Kombinace c\u00edl\u00ed na v\u00edce mechanism\u016f pod\u00edlej\u00edc\u00edch se na chronick\u00e9 nervov\u00e9 bolesti, \u010dasto poskytuje lep\u0161\u00ed kontrolu p\u0159\u00edznak\u016f ne\u017e ka\u017ed\u00fd l\u00e9k samostatn\u011b \u2014 zejm\u00e9na p\u0159i sou\u010dasn\u00e9m v\u00fdskytu poruch sp\u00e1nku a bolesti.<\/p>\n

    Jak se ob\u011b molekuly vz\u00e1jemn\u011b dopl\u0148uj\u00ed<\/h2>\n\n\n\n\n\n\n\n\n
    Mechanismus \u00fa\u010dinku<\/th>\nGabapentin<\/th>\nAmitriptylin<\/th>\n<\/tr>\n<\/thead>\n
    Modulace v\u00e1pn\u00edkov\u00fdch kan\u00e1l\u016f<\/td>\nV\u00e1\u017ee se na podjednotku alfa-2-delta-1; sni\u017euje uvol\u0148ov\u00e1n\u00ed glutam\u00e1tu a substance P<\/td>\n\u2014<\/td>\n<\/tr>\n
    Modulace sestupn\u00e9 dr\u00e1hy bolesti<\/td>\n\u2014<\/td>\nZvy\u0161uje noradrenalin a serotonin v inhibi\u010dn\u00edch sestupn\u00fdch drah\u00e1ch<\/td>\n<\/tr>\n
    \u00da\u010dinek na sp\u00e1nek<\/td>\nM\u00edrn\u00e1 sedace<\/td>\nSiln\u00fd \u00fa\u010dinek na podporu sp\u00e1nku v n\u00edzk\u00fdch d\u00e1vk\u00e1ch (anticholinergn\u00ed, antihistaminov\u00fd \u00fa\u010dinek)<\/td>\n<\/tr>\n
    \u00daleva od \u00fazkosti \/ zlep\u0161en\u00ed n\u00e1lady<\/td>\nM\u00edrn\u00fd, off-label \u00fa\u010dinek<\/td>\nM\u00edrn\u00fd p\u0159i 10\u201325 mg; pln\u00fd antidepresivn\u00ed \u00fa\u010dinek p\u0159i 75\u2013150 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Indikace<\/h2>\n