{"id":57390,"date":"2024-02-27T17:40:16","date_gmt":"2024-02-27T17:40:16","guid":{"rendered":"https:\/\/medsname.com\/laregab-at\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"laregab-at","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/laregab-at\/","title":{"rendered":"Laregab AT (Gabapentin 300 mg + Amitriptylin 10 mg) \u2014 Refraktern\u00ed nervov\u00e1 bolest"},"content":{"rendered":"<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;\"><strong>\ud83d\udce6 US shipping note:<\/strong> We ship Laregab AT to the United States; however, due to gabapentin&#8217;s state-controlled-substance classification we cannot ship to <strong>Kentucky, Michigan, Tennessee, Virginia, or West Virginia<\/strong>. If you place an order with a delivery address in one of these restricted states, we will refund the relevant portion of your order or issue a coupon as compensation.<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;font-size:18px;color:#1a1a1a;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p><strong>Laregab AT<\/strong> je fixn\u00ed kombinace <strong>gabapentin 300 mg + amitriptyline 10 mg<\/strong>, used for refractory neuropathic pain that has not responded adequately to gabapentin or amitriptyline alone. The two molecules act on complementary pain pathways: gabapentin reduces excitatory neurotransmitter release at hyperexcitable nerve terminals, while amitriptyline boosts descending pain inhibition by raising synaptic noradrenaline and serotonin. Typical dose is one tablet at bedtime initially, increasing to twice daily. Both molecules cause drowsiness \u2014 start at night, drive cautiously, and taper slowly when stopping.<\/p>\n<\/div>\n<h2>What Is Laregab AT?<\/h2>\n<p>Laregab AT is an Indian-manufactured combination tablet containing two well-established neuropathic-pain agents:<\/p>\n<ul>\n<li><strong>Gabapentin 300 mg<\/strong> \u2014 alpha-2-delta calcium-channel ligand, anticonvulsant, neuropathic-pain analgesic<\/li>\n<li><strong>Amitriptyline 10 mg<\/strong> \u2014 tricyclic antidepressant, low-dose neuropathic-pain analgesic, sleep modulator<\/li>\n<\/ul>\n<p>The combination targets the multiple mechanisms underlying chronic nerve pain, often producing better symptom control than either drug alone \u2014 particularly when sleep disturbance and pain co-exist.<\/p>\n<h2>How the Two Molecules Complement Each Other<\/h2>\n<table>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Mechanismus \u00fa\u010dinku<\/th>\n<th>Gabapentin<\/th>\n<th>Amitriptylin<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Calcium-channel modulation<\/td>\n<td>Binds alpha-2-delta-1 subunit; reduces glutamate, substance P release<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Descending pain modulation<\/td>\n<td>\u2014<\/td>\n<td>Boosts noradrenaline and serotonin in descending inhibitory pathways<\/td>\n<\/tr>\n<tr>\n<td>\u00da\u010dinek na sp\u00e1nek<\/td>\n<td>Mild sedation<\/td>\n<td>Strong sleep-promoting effect at low dose (anticholinergic, antihistaminic)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Anxiety \/ mood lift<\/td>\n<td>Modest, off-label<\/td>\n<td>Modest at 10\u201325 mg; full antidepressant effect 75\u2013150 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Indikace<\/h2>\n<ul>\n<li><strong>Diabetick\u00e1 perifern\u00ed neuropatie<\/strong><\/li>\n<li><strong>Postherpetick\u00e1 neuralgie<\/strong> (shingles pain)<\/li>\n<li><strong>Post-traumatic and post-surgical neuropathic pain<\/strong><\/li>\n<li><strong>Chemotherapy-induced peripheral neuropathy<\/strong><\/li>\n<li><strong>Mixed nociceptive-neuropathic chronic low back pain with sciatica<\/strong><\/li>\n<li><strong>Fibromyalgie<\/strong> (off-label combination use)<\/li>\n<\/ul>\n<h2>D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n<table>\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Krok<\/th>\n<th>D\u00e1vka<\/th>\n<th>Na\u010dasov\u00e1n\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>T\u00fdden 1<\/td>\n<td>1 tablet at bedtime<\/td>\n<td>Night dose first \u2014 covers nocturnal pain and supports sleep<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Week 2 onward (if tolerated)<\/td>\n<td>1 tablet morning + 1 tablet bedtime<\/td>\n<td>Dvakr\u00e1t denn\u011b<\/td>\n<\/tr>\n<tr>\n<td>Selected patients<\/td>\n<td>1 tablet three times daily<\/td>\n<td>If pain control inadequate<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Star\u0161\u00ed pacienti<\/td>\n<td>1 tablet at bedtime, slow titration<\/td>\n<td>Anticholinergic risk higher in age 65+<\/td>\n<\/tr>\n<tr>\n<td>Porucha funkce ledvin<\/td>\n<td>Avoid or use with strict caution<\/td>\n<td>Gabapentin component is renally cleared; alternative regimen often safer<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Both components require slow tapering<\/strong> Stopping Laregab AT abruptly can cause withdrawal symptoms from both molecules \u2014 gabapentin withdrawal (anxiety, insomnia, sweating, rebound pain) and amitriptyline withdrawal (cholinergic rebound: nausea, dizziness, vivid dreams). Reduce by one tablet every 7\u201314 days if discontinuing.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Anticholinergn\u00ed z\u00e1t\u011b\u017e<\/strong> Amitriptyline contributes anticholinergic effects: dry mouth, constipation, urinary retention, blurred vision, and (in older adults) confusion. The 10 mg dose is small but the burden adds to other anticholinergic medicines. Avoid in patients with closed-angle glaucoma, prostatic hyperplasia with significant retention, or severe constipation.<\/div>\n<h2>B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Drowsiness, sedation (additive from both components)<\/li>\n<li>Z\u00e1vrat\u011b, to\u010den\u00ed hlavy p\u0159i postaven\u00ed<\/li>\n<li>Dry mouth (amitriptyline)<\/li>\n<li>Constipation (amitriptyline)<\/li>\n<li>Weight gain (both)<\/li>\n<li>Mild peripheral oedema (gabapentin)<\/li>\n<li>Blurred vision (amitriptyline)<\/li>\n<li>Vivid dreams<\/li>\n<\/ul>\n<h2>Serious Side Effects<\/h2>\n<ul>\n<li>Severe drowsiness or breathing difficulty (especially with opioids or alcohol)<\/li>\n<li>Cardiac conduction effects \u2014 prolonged QT, arrhythmia (amitriptyline)<\/li>\n<li>Suicidal ideation (anticonvulsant and tricyclic class warning)<\/li>\n<li>Zadr\u017eov\u00e1n\u00ed mo\u010di<\/li>\n<li>Z\u00e1va\u017en\u00e1 alergick\u00e1 reakce<\/li>\n<\/ul>\n<h2>Kontraindikace<\/h2>\n<ul>\n<li>Recent myocardial infarction, second- or third-degree heart block, arrhythmia<\/li>\n<li>Closed-angle glaucoma<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>U\u017e\u00edv\u00e1n\u00ed inhibitor\u016f MAO v p\u0159edchoz\u00edch 14 dnech<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na kteroukoli slo\u017eku<\/li>\n<\/ul>\n<h2>Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Opioids<\/strong> \u2014 additive CNS and respiratory depression; large mortality signal in real-world data<\/li>\n<li><strong>Jin\u00e1 CNS depresiva<\/strong> (benzodiazepines, alcohol, antihistamines) \u2014 additive sedation<\/li>\n<li><strong>SSRI \/ SNRI<\/strong> \u2014 risk of serotonin syndrome with amitriptyline component<\/li>\n<li><strong>Tramadol<\/strong> \u2014 additive serotonergic and seizure-threshold-lowering effect<\/li>\n<li><strong>Antiarrhythmics<\/strong> (Class IA, III) \u2014 additive QT prolongation<\/li>\n<li><strong>Antacids containing aluminium \/ magnesium<\/strong> \u2014 reduce gabapentin absorption; separate by at least 2 hours<\/li>\n<\/ul>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<p>Store below 25 \u00b0C in a dry place, away from direct sunlight. Keep in original blister packaging. Keep out of reach of children \u2014 amitriptyline overdose in children is potentially life-threatening.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>How is Laregab AT different from gabapentin alone?<\/h3>\n<p>Laregab AT pairs gabapentin 300 mg with amitriptyline 10 mg. Amitriptyline targets the descending pain-inhibitory pathway via noradrenaline and serotonin \u2014 a different mechanism from gabapentin&#8217;s calcium-channel binding. Combining the two often improves pain control when either alone has been insufficient, and the amitriptyline component also improves sleep.<\/p>\n<h3>Why is Laregab AT taken at night first?<\/h3>\n<p>Both components cause drowsiness, and the amitriptyline component has a strong sleep-promoting effect. Starting at bedtime avoids daytime sedation and lets the body adjust. Once tolerance to sedation develops, a morning dose can be added.<\/p>\n<h3>How long until Laregab AT works for nerve pain?<\/h3>\n<p>Gabapentin&#8217;s pain effect builds over 2\u20134 weeks. Amitriptyline&#8217;s analgesic effect (separate from its antidepressant effect) builds over 1\u20133 weeks. Most patients experience meaningful improvement by week 4 of regular dosing.<\/p>\n<h3>Can I drink alcohol with Laregab AT?<\/h3>\n<p>Avoid alcohol. The combination amplifies drowsiness, dizziness, and falls risk. Amitriptyline also lowers seizure threshold; combining with alcohol withdrawal can be dangerous.<\/p>\n<h3>Will Laregab AT make me gain weight?<\/h3>\n<p>Possibly \u2014 both molecules can promote weight gain. Average gain across the gabapentin + amitriptyline combination is 2\u20135 kg over 12 weeks. Watch portion sizes, prioritise protein, and stay active during titration.<\/p>\n<h3>Why can you not ship Laregab AT to certain US states?<\/h3>\n<p>Gabapentin is a controlled substance under state law in Kentucky, Michigan, Tennessee, Virginia, and West Virginia. We cannot ship to addresses in those states. Other US states are unaffected.<\/p>\n<h3>Is Laregab AT a controlled substance?<\/h3>\n<p>In most jurisdictions, gabapentin is not a federally controlled substance \u2014 but several US states (KY, MI, TN, VA, WV) have scheduled it. Amitriptyline is not controlled. Check local regulations before ordering.<\/p>\n<h3>Can I drive on Laregab AT?<\/h3>\n<p>Caution is essential, especially in the first 2\u20134 weeks. The combination causes more sedation than either drug alone. Do not drive until you know how the medication affects you, and avoid driving after the bedtime dose.<\/p>\n<h3>Is Laregab AT safe in pregnancy?<\/h3>\n<p>Both components have pregnancy concerns. Gabapentin has limited human data; amitriptyline has been linked with respiratory and feeding problems in newborns when used in late pregnancy. Discuss alternatives with your obstetrician.<\/p>\n<h3>How do I stop taking Laregab AT?<\/h3>\n<p>Always taper. Reduce by one tablet every 1\u20132 weeks. Sudden cessation can cause withdrawal from either molecule \u2014 anxiety, insomnia, rebound pain, vivid dreams, and (rarely) cholinergic rebound symptoms.<\/p>\n<h3>Does Laregab AT help with my mood?<\/h3>\n<p>The amitriptyline 10 mg dose is below the typical antidepressant range (75\u2013150 mg). It will not provide a full antidepressant effect, although better sleep and reduced pain often improve mood indirectly. If depression is a primary concern, a dedicated antidepressant at therapeutic dose is more appropriate.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka m\u00e1 pouze informativn\u00ed charakter a nenahrazuje odborn\u00e9 l\u00e9ka\u0159sk\u00e9 poradenstv\u00ed. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli l\u00e9ku se v\u017edy pora\u010fte s kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem, zejm\u00e9na pokud m\u00e1te jin\u00e9 zdravotn\u00ed pot\u00ed\u017ee, u\u017e\u00edv\u00e1te jin\u00e9 l\u00e9ky, jste t\u011bhotn\u00e1 nebo koj\u00edte, nebo je v\u00e1m v\u00edce ne\u017e 65 let.<\/div>\n<p class=\"medsbase-link-boost-2026-04-30\" data-marker=\"mb-link-boost-gabasign\">Patients responding to the gabapentin component of Laregab AT but tolerating amitriptyline poorly can switch to <a href='\/cs\/gabasign\/'>Gabasign (gabapentin monotherapy)<\/a> at the same gabapentin dose without the anticholinergic burden of the TCA combination.<\/p>\n<p data-mb-link-target=\"gabasign\" style=\"margin-top:1em;font-size:0.95em;color:#444;border-left:3px solid #2c7cb0;padding:0.5em 0.75em;background:#f4f8fb;\"><strong>Viz tak\u00e9:<\/strong> <a href=\"https:\/\/medsbase.com\/cs\/gabasign\/\"><strong>Gabasign 300 \/ 600 mg<\/strong><\/a> \u2014 generikum gabapentinu od spole\u010dnosti Cipla \u2014 stejn\u00e1 molekula schv\u00e1len\u00e1 FDA, pln\u00e9 d\u00e1vkov\u00e1n\u00ed od po\u010d\u00e1te\u010dn\u00ed d\u00e1vky 300 mg po udr\u017eovac\u00ed d\u00e1vku 600 mg.<\/p>\n<p data-mb-link-target=\"synaptol\" style=\"margin-top:1em;font-size:0.95em;color:#444;border-left:3px solid #2c7cb0;padding:0.5em 0.75em;background:#f4f8fb;\"><strong>Viz tak\u00e9:<\/strong> <a href=\"https:\/\/medsbase.com\/cs\/synaptol\/\"><strong>Synaptol 150 mg<\/strong><\/a> \u2014 alternativa tolperisonu, pokud je sedace cyklobenzaprinem nep\u0159ijateln\u00e1 \u2014 centr\u00e1ln\u011b p\u016fsob\u00edc\u00ed bez ospalosti zp\u016fsoben\u00e9 H1 antihistaminiky.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cozartan-h\/\">Cozartan-H<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/pivasta\/\">Rosu-HDL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sertima\/\">Sertima<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/proclid\/\">Proclid<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/folitrax\/\">Folitrax<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Ulevuje od nervov\u00e9 bolesti<br \/>\n\u2705 Combats depression<br \/>\n\u2705 Manages neuropathy<br \/>\n\u2705 Improves sleep quality<br \/>\n\u2705 Reduces anxiety<\/p>\n<p>Laregab AT contains Gabapentin and Amitriptyline.<\/p>","protected":false},"featured_media":57391,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3985],"product_tag":[4293,4250,4294],"class_list":{"0":"post-57390","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neuropathic-pain-medication","9":"product_tag-amitriptyline","10":"product_tag-gabapentin","11":"product_tag-laregab-at","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57390"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57391"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57390"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57390"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57390"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}