{"id":57421,"date":"2024-02-27T17:41:57","date_gmt":"2024-02-27T17:41:57","guid":{"rendered":"https:\/\/medsname.com\/cort-s-injection\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"cort-s-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/cort-s-injection\/","title":{"rendered":"Cort-S Injection"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je injekce Cort-S?<\/h3>\n

Cort-S Injection<\/strong> je hydrokortizon-natrium-sukcin\u00e1t 100 mg v injek\u010dn\u00ed lahvi\u010dce<\/strong> po dobu intraven\u00f3zn\u011b nebo intramuskul\u00e1rn\u011b<\/strong> pod\u00e1n\u00ed. Jedn\u00e1 se o kr\u00e1tkodob\u011b p\u016fsob\u00edc\u00ed glukokortikoid v injek\u010dn\u00ed form\u011b pou\u017e\u00edvan\u00fd v akutn\u00edch medic\u00ednsk\u00fdch situac\u00edch \u2014 anafylaxe, t\u011b\u017ek\u00fd akutn\u00ed astmatick\u00fd z\u00e1chvat, adren\u00e1ln\u00ed krize, t\u011b\u017ek\u00e9 alergick\u00e9 reakce a perioperativn\u00ed stresov\u00e9 kryt\u00ed u pacient\u016f dlouhodob\u011b u\u017e\u00edvaj\u00edc\u00edch steroidy. Klinicky ekvivalentn\u00ed v\u00edce zn\u00e1m\u00fdm zna\u010dk\u00e1m Hydrocort a Solu-Cortef. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 je 100 mg IV\/IM ka\u017ed\u00fdch 6 hodin<\/strong> v akutn\u00edch stavech.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Cort-S Injection<\/strong> je rekonstituovan\u00fd injek\u010dn\u00ed p\u0159\u00edpravek hydrokortizon-natrium-sukcin\u00e1tu<\/strong> \u2014 ve vod\u011b rozpustn\u00fd ester hydrokortizonu (kortizolu), kter\u00fd umo\u017e\u0148uje rychl\u00e9 IV nebo IM pod\u00e1n\u00ed. S\u00edla 100 mg v injek\u010dn\u00ed lahvi\u010dce je standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 v nouzov\u00fdch a l\u016f\u017ekov\u00fdch podm\u00ednk\u00e1ch.<\/p>\n

Hydrokortizon je parenter\u00e1ln\u00ed glukokortikoid volby, kdy\u017e je vy\u017eadov\u00e1n rychl\u00fd, kr\u00e1tkodob\u011b p\u016fsob\u00edc\u00ed syst\u00e9mov\u00fd kortikosteroidn\u00ed \u00fa\u010dinek. Je m\u00e9n\u011b potentn\u00ed ne\u017e dexamethason na miligram, ale m\u00e1 v\u00fdznamn\u00fd mineralokortikoidn\u00ed (s\u016fl-zadr\u017euj\u00edc\u00ed) \u00fa\u010dinek, kter\u00fd jej \u010din\u00ed zvl\u00e1\u0161t\u011b u\u017eite\u010dn\u00fdm p\u0159i adren\u00e1ln\u00ed krizi, kde jsou pot\u0159eba jak glukokortikoidn\u00ed a<\/em> tak mineralokortikoidn\u00ed \u00fa\u010dinky.<\/p>\n

K \u010demu se pou\u017e\u00edv\u00e1 injekce Cort-S?<\/h2>\n
    \n
  • Akutn\u00ed adren\u00e1ln\u00ed insuficience (Addisonova krize)<\/strong> \u2014 \u017eivot ohro\u017euj\u00edc\u00ed stav<\/li>\n
  • Anafylaxe<\/strong> \u2014 jako dopln\u011bk k intramuskul\u00e1rn\u00edmu adrenalinu<\/li>\n
  • Akutn\u00ed t\u011b\u017ek\u00e9 astma<\/strong> \u2014 pokud peror\u00e1ln\u00ed prednisolon nen\u00ed tolerov\u00e1n<\/li>\n
  • Z\u00e1va\u017en\u00e9 alergick\u00e9 reakce na l\u00e9ky, reakce na transfuzi<\/strong><\/li>\n
  • Autoimunitn\u00ed vzplanut\u00ed<\/strong> \u2014 SLE, vaskulitida, z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed st\u0159ev<\/li>\n
  • Septick\u00fd \u0161ok<\/strong> p\u0159i podez\u0159en\u00ed na relativn\u00ed adren\u00e1ln\u00ed insuficienci<\/li>\n
  • Thyrotoxick\u00e1 krize<\/strong> \u2014 dopl\u0148kov\u00e1 terapie<\/li>\n
  • Perioperativn\u00ed \u201ckryt\u00ed stresem\u201d<\/strong> u pacient\u016f na chronick\u00e9 peror\u00e1ln\u00ed glukokortikoidech<\/li>\n
  • Z\u00e1va\u017en\u00e9 reakce na kontrastn\u00ed l\u00e1tky nebo chemoterapii<\/strong><\/li>\n<\/ul>\n

    Jak funguje Cort-S?<\/h2>\n

    Injekce Cort-S dod\u00e1v\u00e1 hydrokortizon do syst\u00e9mov\u00e9ho ob\u011bhu, kde se v\u00e1\u017ee na intracelul\u00e1rn\u00ed glukokortikoidn\u00ed receptory. Aktivovan\u00fd receptor vstupuje do j\u00e1dra a moduluje transkripci z\u00e1n\u011btliv\u00fdch, imunitn\u00edch a metabolick\u00fdch gen\u016f. Klinick\u00e9 \u00fa\u010dinky zahrnuj\u00ed potla\u010den\u00ed migrace leukocyt\u016f, sn\u00ed\u017een\u00ed produkce cytokin\u016f, stabilizaci vaskul\u00e1rn\u00ed permeability a obnoven\u00ed fyziologick\u00e9 aktivity kortizolu p\u0159i adren\u00e1ln\u00ed insuficienci.<\/p>\n

    D\u00e1vkov\u00e1n\u00ed injekce Cort-S<\/h2>\n
      \n
    • Akutn\u00ed z\u00e1n\u011btliv\u00e9 nebo alergick\u00e9 stavy u dosp\u011bl\u00fdch:<\/strong> 100\u2013200 mg IV\/IM, opakovat ka\u017ed\u00e9 2\u20136 hodin<\/li>\n
    • Adren\u00e1ln\u00ed krize:<\/strong> 100 mg IV bolus, pot\u00e9 100 mg ka\u017ed\u00fdch 6 hodin do stabilizace<\/li>\n
    • Kryt\u00ed stresu:<\/strong> 100 mg IV p\u0159ed operac\u00ed, pot\u00e9 ka\u017ed\u00fdch 6 hodin po dobu 24\u201348 hodin<\/li>\n
    • Pediatrie:<\/strong> 2\u20134 mg\/kg na d\u00e1vku IV\/IM (pod odborn\u00fdm dohledem)<\/li>\n<\/ul>\n

      P\u0159ipravte t\u011bsn\u011b p\u0159ed pou\u017eit\u00edm. IV pod\u00e1n\u00ed 100 mg by m\u011blo trvat alespo\u0148 30 sekund; vy\u0161\u0161\u00ed d\u00e1vky b\u011bhem n\u011bkolika minut nebo jako infuze.<\/p>\n

      Potence a ekvivalence kortikosteroid\u016f<\/h2>\n

      R\u016fzn\u00e9 kortikosteroidy se li\u0161\u00ed p\u0159edev\u0161\u00edm v potenci, d\u00e9lce \u00fa\u010dinku a mineralokortikoidn\u00ed (soli zadr\u017euj\u00edc\u00ed) aktivit\u011b. N\u00ed\u017ee uveden\u00e1 tabulka uv\u00e1d\u00ed klinicky u\u017eite\u010dn\u00e9 ekvivalence \u2014 umo\u017e\u0148uje p\u0159ev\u00e9st d\u00e1vku jednoho steroidu na ekvivalentn\u00ed d\u00e1vku jin\u00e9ho.<\/p>\n\n\n\n\n\n\n\n\n\n
      Kortikosteroid<\/th>\nGlukokortikoidn\u00ed potence<\/th>\nEkvivalentn\u00ed d\u00e1vka<\/th>\nMineralokortikoid<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
      Hydrokortizon<\/td>\n1 (referen\u010dn\u00ed)<\/td>\n20 mg<\/td>\nV\u00fdznamn\u00e1<\/td>\n8\u201312 h<\/td>\n<\/tr>\n
      Prednisolon<\/td>\n4<\/td>\n5 mg<\/td>\nN\u00edzk\u00e1<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
      Methylprednisolon<\/td>\n5<\/td>\n4 mg<\/td>\nMinim\u00e1ln\u00ed<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
      Dexamethasone<\/strong><\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n
      Betamethason<\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      Kdo by nem\u011bl u\u017e\u00edvat injekci Cort-S?<\/h2>\n
        \n
      • Syst\u00e9mov\u00e1 pl\u00eds\u0148ov\u00e1 infekce (krom\u011b substitu\u010dn\u00ed terapie p\u0159i adren\u00e1ln\u00ed insuficienci)<\/li>\n
      • \u017div\u00e9 vakc\u00edny b\u011bhem imunosupresivn\u00edch d\u00e1vek (p\u0159ed BCG, MMR, \u017elutou zimnic\u00ed, plan\u00fdmi ne\u0161tovicemi, peror\u00e1ln\u00edm tyfem konzultujte odborn\u00edka)<\/li>\n
      • Aktivn\u00ed nel\u00e9\u010den\u00e1 bakteri\u00e1ln\u00ed infekce (nejprve zahajte antibiotika)<\/li>\n
      • Aktivn\u00ed tuberkul\u00f3za bez kryt\u00ed anti-TB l\u00e9\u010dbou<\/li>\n
      • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na \u00fa\u010dinnou l\u00e1tku nebo jakoukoli pomocnou l\u00e1tku<\/li>\n
      • Pou\u017e\u00edvejte s opatrnost\u00ed u: diabetes mellitus, m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed, hypertenze, osteopor\u00f3zy, peptick\u00e9ho v\u0159edu, psychiatrick\u00fdch poruch, glaukomu, herpes simplex ophthalmicus<\/li>\n
      • T\u011bhotenstv\u00ed: u\u017e\u00edvejte pouze v p\u0159\u00edpad\u011b jasn\u00e9 pot\u0159eby \u2013 prednisolon a hydrokortison pronikaj\u00ed placentou m\u00e9n\u011b ne\u017e dexamethason\/betamethason, kter\u00e9 jsou preferov\u00e1ny, kdy\u017e je zam\u00fd\u0161len \u00fa\u010dinek na plod (nap\u0159. zr\u00e1n\u00ed plic)<\/li>\n<\/ul>\n

        Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f<\/h2>\n

        Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f z\u00e1vis\u00ed na d\u00e1vce a d\u00e9lce pod\u00e1v\u00e1n\u00ed. Kr\u00e1tk\u00e9 k\u00fary (< 2 t\u00fddny) p\u0159i st\u0159edn\u00edch d\u00e1vk\u00e1ch jsou obvykle dob\u0159e sn\u00e1\u0161eny. Del\u0161\u00ed nebo vy\u0161\u0161\u00ed d\u00e1vkov\u00e1n\u00ed vyvol\u00e1v\u00e1 klasick\u00fd \u201cCushingoidn\u00ed\u201d profil.<\/p>\n

        Kr\u00e1tkodob\u00e9 (prvn\u00edch 1\u20132 t\u00fddny):<\/strong><\/p>\n