{"id":57525,"date":"2024-02-27T17:48:32","date_gmt":"2024-02-27T17:48:32","guid":{"rendered":"https:\/\/medsname.com\/hydrocort-100-injection\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"hydrocort-100-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/hydrocort-100-injection\/","title":{"rendered":"Injekce Hydrocort 100"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Hydrocort 100 Injection?<\/h3>\n

Injekce Hydrocort 100<\/strong> je hydrocortisone sodium succinate 100 mg v jedn\u00e9 lahvi\u010dce<\/strong> steriln\u00ed pr\u00e1\u0161ek pro p\u0159\u00edpravu injek\u010dn\u00edho roztoku, ur\u010den\u00fd k intraven\u00f3zn\u00ed nebo intramuskul\u00e1rn\u00ed injekci<\/strong>. Je to standardn\u00ed parenter\u00e1ln\u00ed glukokortikoid pro akutn\u00ed alergick\u00e9 reakce, anafylaxi, adren\u00e1ln\u00ed krizi, t\u011b\u017ek\u00fd akutn\u00ed astma, z\u00e1va\u017en\u00e1 z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed, \u0161ok a jako kr\u00e1tkodob\u00e1 n\u00e1hrada p\u0159i adren\u00e1ln\u00ed insuficienci<\/strong>. Obvykl\u00e1 d\u00e1vka pro dosp\u011bl\u00e9 je 100 mg IV\/IM ka\u017ed\u00fdch 6 hodin<\/strong> v akutn\u00edch stavech, upraveno podle klinick\u00e9ho sc\u00e9n\u00e1\u0159e.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Injekce Hydrocort 100<\/strong> je steriln\u00ed pr\u00e1\u0161ek obsahuj\u00edc\u00ed hydrokortizon-natrium-sukcin\u00e1tu<\/strong>, ve vod\u011b rozpustn\u00fd ester hydrokortizonu, kter\u00fd lze p\u0159ipravit pro rychlou intraven\u00f3zn\u00ed nebo intramuskul\u00e1rn\u00ed aplikaci. Hydrokortizon je syntetick\u00e1 forma kortizolu<\/em>, p\u0159irozen\u00e9ho glukokortikoidu produkovan\u00e9ho k\u016frou nadledvin.<\/p>\n

Proto\u017ee parenter\u00e1ln\u00ed hydrokortizon p\u016fsob\u00ed b\u011bhem minut p\u0159i intraven\u00f3zn\u00edm pod\u00e1n\u00ed, je v\u00fdchoz\u00edm glukokortikoidem volby v nouzov\u00fdch situac\u00edch, kde je vy\u017eadov\u00e1n rychl\u00fd glukokortikoidn\u00ed \u00fa\u010dinek \u2014 anafylaxe, akutn\u00ed t\u011b\u017ek\u00e9 astma, \u0161ok p\u0159i adren\u00e1ln\u00ed insuficienci a t\u011b\u017ek\u00e9 z\u00e1n\u011btliv\u00e9 nebo alergick\u00e9 reakce. Nejpou\u017e\u00edvan\u011bj\u0161\u00ed s\u00edla v injek\u010dn\u00ed lahvi\u010dce je 100 mg u dosp\u011bl\u00fdch.<\/p>\n

K \u010demu se pou\u017e\u00edv\u00e1 injekce Hydrocort 100?<\/h2>\n
    \n
  • Akutn\u00ed adren\u00e1ln\u00ed krize<\/strong> (Addisonova krize) \u2014 \u017eivot ohro\u017euj\u00edc\u00ed nedostatek kortizolu<\/li>\n
  • Anafylaxe<\/strong> \u2014 jako druh\u00e1 volba po adrenalinu; sni\u017euje pozdn\u00ed f\u00e1zi reakce<\/li>\n
  • Akutn\u00ed t\u011b\u017ek\u00e9 astma<\/strong> \u2014 pokud peror\u00e1ln\u00ed prednisolon nen\u00ed mo\u017en\u00fd (pacient p\u0159\u00edli\u0161 nemocn\u00fd, zvrac\u00ed)<\/li>\n
  • Akutn\u00ed exacerbace chronick\u00e9ho z\u00e1n\u011btliv\u00e9ho onemocn\u011bn\u00ed<\/strong> \u2014 z\u00e1n\u011btliv\u00e9 onemocn\u011bn\u00ed st\u0159ev, autoimunitn\u00ed revmatick\u00e9 onemocn\u011bn\u00ed<\/li>\n
  • T\u011b\u017ek\u00e9 alergick\u00e9 reakce<\/strong> \u2014 l\u00e9kov\u00e1 alergie, angioed\u00e9m, s\u00e9rov\u00e1 nemoc<\/li>\n
  • Septick\u00fd \u0161ok<\/strong> u podez\u0159en\u00ed na adren\u00e1ln\u00ed insuficienci (specializovan\u00e9 pou\u017eit\u00ed na JIP)<\/li>\n
  • Kryt\u00ed stresovou d\u00e1vkou<\/strong> pro pacienty na dlouhodob\u00e9 peror\u00e1ln\u00ed steroidn\u00ed terapii podstupuj\u00edc\u00ed chirurgick\u00fd z\u00e1krok nebo z\u00e1va\u017en\u00e9 onemocn\u011bn\u00ed<\/li>\n
  • Thyrotoxick\u00e1 krize<\/strong> \u2014 jako dopln\u011bk<\/li>\n
  • Mozkov\u00fd ed\u00e9m<\/strong> \u2014 a\u010dkoli je obvykle preferov\u00e1n dexamethason<\/li>\n
  • Transfuzn\u00ed reakce<\/strong>, z\u00e1va\u017en\u00e9 reakce na chemoterapii nebo kontrastn\u00ed l\u00e1tky<\/li>\n<\/ul>\n

    Jak funguje hydrokortizon?<\/h2>\n

    Hydrokortizon se v\u00e1\u017ee na intracelul\u00e1rn\u00ed glukokortikoidn\u00ed receptory, translokuje do j\u00e1dra a moduluje transkripci stovek gen\u016f. Celkov\u00fd efekt je \u0161irok\u00fd:<\/p>\n

      \n
    • Protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek<\/strong> \u2014 sni\u017euje produkci cytokin\u016f, migraci leukocyt\u016f a c\u00e9vn\u00ed permeabilitu<\/li>\n
    • Imunosupresivn\u00ed<\/strong> \u2014 potla\u010duje aktivaci T-lymfocyt\u016f, tvorbu protil\u00e1tek a funkci z\u00e1n\u011btliv\u00fdch bun\u011bk<\/li>\n
    • Metabolick\u00fd<\/strong> \u2014 zvy\u0161uje hladinu gluk\u00f3zy v krvi, podporuje katabolismus b\u00edlkovin, m\u011bn\u00ed distribuci tuk\u016f<\/li>\n
    • Mineralokortikoidn\u00ed aktivita<\/strong> \u2014 hydrokortizon m\u00e1 v\u00fdrazn\u00fd \u00fa\u010dinek na zadr\u017eov\u00e1n\u00ed sol\u00ed (na rozd\u00edl od dexamethasonu), co\u017e je u\u017eite\u010dn\u00e9 p\u0159i adren\u00e1ln\u00ed insuficienci, ale ve vysok\u00fdch d\u00e1vk\u00e1ch m\u016f\u017ee zp\u016fsobit zadr\u017eov\u00e1n\u00ed tekutin a hypertenzi<\/li>\n<\/ul>\n

      D\u00e1vkov\u00e1n\u00ed injekce Hydrocort 100<\/h2>\n
        \n
      • Dosp\u011bl\u00ed s akutn\u00edm z\u00e1n\u011btem\/anafylax\u00ed\/astmatem:<\/strong> 100\u2013200 mg intraven\u00f3zn\u011b\/ intramuskul\u00e1rn\u011b, opakovat v intervalech 2\u20136 hodin podle pot\u0159eby<\/li>\n
      • Akutn\u00ed adren\u00e1ln\u00ed krize:<\/strong> 100 mg intraven\u00f3zn\u011b v bolusu, pot\u00e9 100 mg ka\u017ed\u00fdch 6 hodin pomalou intraven\u00f3zn\u00ed infuz\u00ed a\u017e do tolerance peror\u00e1ln\u00ed terapie<\/li>\n
      • Perioperativn\u00ed stresov\u00e9 kryt\u00ed<\/strong> u pacient\u016f dlouhodob\u011b u\u017e\u00edvaj\u00edc\u00edch steroidy: 100 mg intraven\u00f3zn\u011b p\u0159ed indukc\u00ed, pot\u00e9 100 mg ka\u017ed\u00fdch 6 hodin po dobu prvn\u00edch 24\u201348 hodin<\/li>\n
      • D\u011bti:<\/strong> na z\u00e1klad\u011b hmotnosti a v\u011bku; obvykle 2\u20134 mg\/kg na d\u00e1vku intraven\u00f3zn\u011b\/intramuskul\u00e1rn\u011b, ka\u017ed\u00fdch 6 hodin (specializovan\u00e1 pediatrick\u00e1 p\u00e9\u010de)<\/li>\n<\/ul>\n

        P\u0159ed pou\u017eit\u00edm okam\u017eit\u011b rekonstituujte lahvi\u010dku 2 ml vody na injekci; p\u0159ed pod\u00e1n\u00edm zkontrolujte p\u0159\u00edtomnost \u010d\u00e1stic. Intraven\u00f3zn\u00ed bolus by m\u011bl b\u00fdt pod\u00e1v\u00e1n alespo\u0148 30 sekund pro d\u00e1vku 100 mg; vy\u0161\u0161\u00ed d\u00e1vky by m\u011bly b\u00fdt pod\u00e1v\u00e1ny po dobu 10 minut nebo na\u0159ed\u011bny k infuzi.<\/p>\n

        Potence a ekvivalence kortikosteroid\u016f<\/h2>\n

        R\u016fzn\u00e9 kortikosteroidy se li\u0161\u00ed p\u0159edev\u0161\u00edm v potenci, d\u00e9lce \u00fa\u010dinku a mineralokortikoidn\u00ed (soli zadr\u017euj\u00edc\u00ed) aktivit\u011b. N\u00ed\u017ee uveden\u00e1 tabulka uv\u00e1d\u00ed klinicky u\u017eite\u010dn\u00e9 ekvivalence \u2014 umo\u017e\u0148uje p\u0159ev\u00e9st d\u00e1vku jednoho steroidu na ekvivalentn\u00ed d\u00e1vku jin\u00e9ho.<\/p>\n\n\n\n\n\n\n\n\n\n
        Kortikosteroid<\/th>\nGlukokortikoidn\u00ed potence<\/th>\nEkvivalentn\u00ed d\u00e1vka<\/th>\nMineralokortikoid<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
        Hydrokortizon<\/td>\n1 (referen\u010dn\u00ed)<\/td>\n20 mg<\/td>\nV\u00fdznamn\u00e1<\/td>\n8\u201312 h<\/td>\n<\/tr>\n
        Prednisolon<\/td>\n4<\/td>\n5 mg<\/td>\nN\u00edzk\u00e1<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
        Methylprednisolon<\/td>\n5<\/td>\n4 mg<\/td>\nMinim\u00e1ln\u00ed<\/td>\n12\u201336 h<\/td>\n<\/tr>\n
        Dexamethasone<\/strong><\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n
        Betamethason<\/td>\n25\u201330<\/td>\n0,75 mg<\/td>\n\u017d\u00e1dn\u00e9<\/td>\n36\u201354 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        Kdo by nem\u011bl u\u017e\u00edvat injekci Hydrocort 100?<\/h2>\n
          \n
        • Syst\u00e9mov\u00e1 pl\u00eds\u0148ov\u00e1 infekce (krom\u011b substitu\u010dn\u00ed terapie p\u0159i adren\u00e1ln\u00ed insuficienci)<\/li>\n
        • \u017div\u00e9 vakc\u00edny b\u011bhem imunosupresivn\u00edch d\u00e1vek (p\u0159ed BCG, MMR, \u017elutou zimnic\u00ed, plan\u00fdmi ne\u0161tovicemi, peror\u00e1ln\u00edm tyfem konzultujte odborn\u00edka)<\/li>\n
        • Aktivn\u00ed nel\u00e9\u010den\u00e1 bakteri\u00e1ln\u00ed infekce (nejprve zahajte antibiotika)<\/li>\n
        • Aktivn\u00ed tuberkul\u00f3za bez kryt\u00ed anti-TB l\u00e9\u010dbou<\/li>\n
        • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na \u00fa\u010dinnou l\u00e1tku nebo jakoukoli pomocnou l\u00e1tku<\/li>\n
        • Pou\u017e\u00edvejte s opatrnost\u00ed u: diabetes mellitus, m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed, hypertenze, osteopor\u00f3zy, peptick\u00e9ho v\u0159edu, psychiatrick\u00fdch poruch, glaukomu, herpes simplex ophthalmicus<\/li>\n
        • T\u011bhotenstv\u00ed: u\u017e\u00edvejte pouze v p\u0159\u00edpad\u011b jasn\u00e9 pot\u0159eby \u2013 prednisolon a hydrokortison pronikaj\u00ed placentou m\u00e9n\u011b ne\u017e dexamethason\/betamethason, kter\u00e9 jsou preferov\u00e1ny, kdy\u017e je zam\u00fd\u0161len \u00fa\u010dinek na plod (nap\u0159. zr\u00e1n\u00ed plic)<\/li>\n<\/ul>\n

          Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f<\/h2>\n

          Vedlej\u0161\u00ed \u00fa\u010dinky kortikosteroid\u016f z\u00e1vis\u00ed na d\u00e1vce a d\u00e9lce pod\u00e1v\u00e1n\u00ed. Kr\u00e1tk\u00e9 k\u00fary (< 2 t\u00fddny) p\u0159i st\u0159edn\u00edch d\u00e1vk\u00e1ch jsou obvykle dob\u0159e sn\u00e1\u0161eny. Del\u0161\u00ed nebo vy\u0161\u0161\u00ed d\u00e1vkov\u00e1n\u00ed vyvol\u00e1v\u00e1 klasick\u00fd \u201cCushingoidn\u00ed\u201d profil.<\/p>\n

          Kr\u00e1tkodob\u00e9 (prvn\u00edch 1\u20132 t\u00fddny):<\/strong><\/p>\n

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          • Nespavost, \u00fazkost, euforie, podr\u00e1\u017ed\u011bnost \u2014 zejm\u00e9na p\u0159i d\u00e1vk\u00e1ch > 20 mg ekvivalentu prednisolonu<\/li>\n
          • Zv\u00fd\u0161en\u00e1 chu\u0165 k j\u00eddlu, p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze<\/li>\n
          • Zv\u00fd\u0161en\u00e1 hladina gluk\u00f3zy v krvi (zvl\u00e1\u0161t\u011b u diabetik\u016f)<\/li>\n
          • Zadr\u017eov\u00e1n\u00ed tekutin, m\u00edrn\u00e9 otoky kotn\u00edk\u016f<\/li>\n
          • P\u00e1len\u00ed \u017e\u00e1hy, dyspepsie<\/li>\n
          • Hypertenze \u2014 zejm\u00e9na u kortikoid\u016f s vy\u0161\u0161\u00ed mineralokortikoidn\u00ed aktivitou (hydrokortizon, fludrokortizon)<\/li>\n<\/ul>\n

            Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed (t\u00fddny a\u017e m\u011bs\u00edce):<\/strong><\/p>\n