{"id":57554,"date":"2024-02-27T17:49:59","date_gmt":"2024-02-27T17:49:59","guid":{"rendered":"https:\/\/medsname.com\/brufen\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"brufen","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/brufen\/","title":{"rendered":"Brufen"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Brufen?<\/h3>\n

Brufen<\/strong> je Ibuprofen<\/strong> tablety dostupn\u00e9 v 200, 400 a 600 mg<\/strong> s\u00edly. Je to neselektivn\u00ed nesteroidn\u00ed protiz\u00e1n\u011btliv\u00fd l\u00e9k (NSAID)<\/strong> \u0161iroce pou\u017e\u00edvan\u00fd na bolest, hore\u010dku a z\u00e1n\u011bt \u2014 v\u010detn\u011b bolesti hlavy, zubn\u00ed bolesti, menstrua\u010dn\u00edch k\u0159e\u010d\u00ed, poran\u011bn\u00ed pohybov\u00e9ho apar\u00e1tu, osteoartr\u00f3zy a revmatoidn\u00ed artritidy. Obvykl\u00e1 d\u00e1vka pro dosp\u011bl\u00e9 je 400 mg t\u0159ikr\u00e1t a\u017e \u010dty\u0159ikr\u00e1t denn\u011b<\/strong> s j\u00eddlem; nejbezpe\u010dn\u011bj\u0161\u00ed dlouhodob\u00e1 d\u00e1vka je 1 200 mg\/den nebo m\u00e9n\u011b.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Brufen 400 mg<\/strong> je jedn\u00edm z nej\u010dast\u011bji p\u0159edepisovan\u00fdch ibuprofenov\u00fdch p\u0159\u00edpravk\u016f na sv\u011bt\u011b, kter\u00fd uv\u00e1d\u00ed na trh spole\u010dnost Abbott a p\u016fvodn\u011b byl vyvinut spole\u010dnost\u00ed Boots v 60. letech 20. stolet\u00ed. Ibuprofen je na Seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO a m\u00e1 nejlep\u0161\u00ed bezpe\u010dnostn\u00ed profil ze v\u0161ech peror\u00e1ln\u00edch NSAID p\u0159i n\u00edzk\u00fdch a\u017e st\u0159edn\u00edch d\u00e1vk\u00e1ch. Je l\u00e9kem prvn\u00ed volby u v\u011bt\u0161iny bolest\u00ed a z\u00e1n\u011bt\u016f na komunitn\u00ed \u00farovni, proto\u017ee p\u016fsob\u00ed p\u0159edv\u00eddateln\u011b, je levn\u00fd a p\u0159i d\u00e1vce 1 200 mg\/den nebo m\u00e9n\u011b je relativn\u011b \u0161etrn\u00fd k \u017ealudku.<\/p>\n

Brufen je k dispozici ve t\u0159ech sil\u00e1ch tablet:<\/p>\n

    \n
  • Brufen 200 mg<\/strong> \u2014 voln\u011b prodejn\u00e1 s\u00edla, vhodn\u00e1 pro m\u00edrn\u00e9 bolesti, hore\u010dku a dysmenoreu<\/li>\n
  • Brufen 400 mg<\/strong> \u2014 standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 p\u0159i st\u0159edn\u011b siln\u00fdch bolestech, po zubn\u00edch z\u00e1kroc\u00edch, poran\u011bn\u00edch pohybov\u00e9ho apar\u00e1tu a z\u00e1n\u011btliv\u00fdch vzplanut\u00edch<\/li>\n
  • Brufen 600 mg<\/strong> \u2014 pou\u017e\u00edv\u00e1 se pod l\u00e9ka\u0159sk\u00fdm dohledem u revmatoidn\u00ed artritidy, osteoartr\u00f3zy, ankylozuj\u00edc\u00ed spondylitidy a akutn\u00ed dny<\/li>\n<\/ul>\n

    K \u010demu se Brufen pou\u017e\u00edv\u00e1?<\/h2>\n

    Brufen je indikov\u00e1n pro \u0161irok\u00e9 spektrum akutn\u00edch a chronick\u00fdch bolest\u00ed a z\u00e1n\u011btliv\u00fdch stav\u016f:<\/p>\n

      \n
    • Bolesti pohybov\u00e9ho apar\u00e1tu<\/strong> \u2014 v\u00fdrony, nata\u017een\u00ed, poran\u011bn\u00ed m\u011bkk\u00fdch tk\u00e1n\u00ed, bolesti zad<\/li>\n
    • Bolest po operaci a po zubn\u00edch z\u00e1kroc\u00edch<\/strong> \u2014 v\u010detn\u011b po extrakci zubu a men\u0161\u00edch chirurgick\u00fdch z\u00e1kroc\u00edch<\/li>\n
    • Prim\u00e1rn\u00ed dysmenorea<\/strong> (menstrua\u010dn\u00ed bolesti) \u2014 l\u00e9\u010dba prvn\u00ed volby; ibuprofen je \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e paracetamol p\u0159i menstrua\u010dn\u00edch bolestech<\/li>\n
    • Bolest hlavy a migr\u00e9na<\/strong> \u2014 zejm\u00e9na tenzn\u00ed bolest hlavy; tak\u00e9 \u00fa\u010dinn\u00fd p\u0159i akutn\u00ed migr\u00e9n\u011b s triptany nebo bez nich<\/li>\n
    • Hore\u010dka<\/strong> \u2014 v\u010detn\u011b virov\u00e9 hore\u010dky, hore\u010dky po o\u010dkov\u00e1n\u00ed a hore\u010dky u respira\u010dn\u00edch infekc\u00ed u dosp\u011bl\u00fdch<\/li>\n
    • Osteoartr\u00f3za a revmatoidn\u00ed artritida<\/strong> \u2014 symptomatick\u00e1 \u00faleva od bolesti kloub\u016f a ztuhlosti<\/li>\n
    • Akutn\u00ed dna<\/strong> \u2014 vysok\u00e1 d\u00e1vka (2 400 mg\/den) po dobu 5\u20137 dn\u00ed jako alternativa k indometacinu nebo naproxenu<\/li>\n
    • Juveniln\u00ed idiopatick\u00e1 artritida<\/strong> \u2014 d\u00e1vkov\u00e1n\u00ed podle hmotnosti pod dohledem pediatra<\/li>\n<\/ul>\n

      Brufen je ne<\/em> l\u00e9k modifikuj\u00edc\u00ed pr\u016fb\u011bh onemocn\u011bn\u00ed u revmatoidn\u00ed artritidy \u2014 zm\u00edr\u0148uje p\u0159\u00edznaky, ale nezpomaluje po\u0161kozen\u00ed kloub\u016f. K tomu jsou pot\u0159eba DMARDs, jako je methotrex\u00e1t nebo biologika.<\/p>\n

      Jak ibuprofen funguje?<\/h2>\n

      Ibuprofen je neselektivn\u00ed NSAID<\/strong> \u2014 blokuje jak COX-1<\/strong> (kter\u00fd udr\u017euje \u017ealude\u010dn\u00ed sliznici, funkci krevn\u00edch desti\u010dek a prokrven\u00ed ledvin), tak COX-2<\/strong> (kter\u00fd je zv\u00fd\u0161en\u011b exprimov\u00e1n v m\u00edstech z\u00e1n\u011btu). Toto \u0161irok\u00e9 p\u016fsoben\u00ed vysv\u011btluje jak jeho siln\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek, tak jeho dob\u0159e zn\u00e1m\u00fd profil gastrointestin\u00e1ln\u00edch a ren\u00e1ln\u00edch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/p>\n

      Terapeutick\u00fd \u0159et\u011bzec ud\u00e1lost\u00ed je u v\u0161ech NSAID stejn\u00fd:<\/p>\n

        \n
      1. Po\u0161kozen\u00ed tk\u00e1n\u011b nebo z\u00e1n\u011bt uvol\u0148uje fosfolipidy z bun\u011b\u010dn\u00fdch membr\u00e1n<\/li>\n
      2. Fosfolip\u00e1za A\u2082 je p\u0159em\u011b\u0148uje na kyselinu arachidonovou<\/li>\n
      3. Cyklooxygen\u00e1za (COX-1\/COX-2) p\u0159em\u011b\u0148uje kyselinu arachidonovou na prostaglandiny<\/strong> \u2014 molekuly zodpov\u011bdn\u00e9 za bolest, otok a hore\u010dku<\/li>\n
      4. Ibuprofen blokuje enzymy COX, \u010d\u00edm\u017e se sni\u017euje tvorba prostaglandin\u016f, co\u017e vede k men\u0161\u00ed bolesti a z\u00e1n\u011btu<\/li>\n<\/ol>\n

        Proto\u017ee prostaglandiny tak\u00e9 chr\u00e1n\u00ed \u017ealude\u010dn\u00ed sliznici, reguluj\u00ed pr\u016ftok krve ledvinami a ovliv\u0148uj\u00ed funkci krevn\u00edch desti\u010dek, stejn\u00fd mechanismus, kter\u00fd zm\u00edr\u0148uje bolest, je tak\u00e9 zodpov\u011bdn\u00fd za hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky NSAID: podr\u00e1\u017ed\u011bn\u00ed \u017ealudku, zadr\u017eov\u00e1n\u00ed tekutin, vysok\u00fd krevn\u00ed tlak a (u n\u011bkter\u00fdch jedinc\u016f) z\u00e1t\u011b\u017e ledvin.<\/p>\n

        D\u00e1vkov\u00e1n\u00ed Brufenu<\/h2>\n

        Dosp\u011bl\u00ed:<\/strong><\/p>\n

          \n
        • M\u00edrn\u00e1 a\u017e st\u0159edn\u00ed bolest \/ hore\u010dka \/ dysmenorea:<\/strong> 200\u2013400 mg ka\u017ed\u00fdch 4\u20136 hodin podle pot\u0159eby, maxim\u00e1ln\u011b 1 200 mg\/den<\/li>\n
        • Revmatoidn\u00ed artritida, osteoartritida, ankylozuj\u00edc\u00ed spondylitida:<\/strong> 400\u2013800 mg t\u0159ikr\u00e1t a\u017e \u010dty\u0159ikr\u00e1t denn\u011b pod l\u00e9ka\u0159sk\u00fdm dohledem; maximum 3 200 mg\/den (z\u0159\u00eddka pou\u017e\u00edv\u00e1no)<\/li>\n
        • Akutn\u00ed dna:<\/strong> 800 mg t\u0159ikr\u00e1t denn\u011b po dobu 2\u20133 dn\u016f, pot\u00e9 postupn\u011b sni\u017eovat<\/li>\n<\/ul>\n

          D\u011bti (> 6 m\u011bs\u00edc\u016f, dle hmotnosti):<\/strong> 5\u201310 mg\/kg ka\u017ed\u00fdch 6\u20138 hodin, max 40 mg\/kg\/den, pod pediatrick\u00fdm dohledem.<\/p>\n

          U\u017e\u00edvejte Brufen s j\u00eddlem nebo sklenic\u00ed ml\u00e9ka<\/strong>. Tablety polykejte vcelku; nedr\u0165te, nel\u00e1mejte a ne\u017ev\u00fdkejte tabletu 600 mg. Pokud d\u00e1vku zapomenete, u\u017eijte ji, jakmile si vzpomenete, pokud nen\u00ed dal\u0161\u00ed d\u00e1vka due do 2 hodin \u2014 v tom p\u0159\u00edpad\u011b vynechejte. Nikdy nezdvojujte d\u00e1vku.<\/p>\n

          \n

          GI bezpecnost \u2014 precist pred prvnim uzitim.<\/strong> Ka\u017ed\u00e9 NSAID, v\u010detn\u011b Brufenu, nese re\u00e1ln\u00e9 riziko gastritidy, peptick\u00e9ho v\u0159edu a krv\u00e1cen\u00ed do horn\u00ed \u010d\u00e1sti tr\u00e1vic\u00edho traktu. Riziko je nejvy\u0161\u0161\u00ed u pacient\u016f nad 65 let, u t\u011bch s p\u0159edchoz\u00edm v\u0159edov\u00fdm onemocn\u011bn\u00edm a u ka\u017ed\u00e9ho, kdo u\u017e\u00edv\u00e1 n\u00edzkod\u00e1vkov\u00fd aspirin, kortikosteroidy, SSRI nebo antikoagulancia. U\u017e\u00edvejte Brufen s j\u00eddlem<\/em>, pouzijte nejnizsi ucinnou davku po nejkratsi rozumne dlouhou dobu<\/em>, a zeptejte se lekare na predpis inhibitoru protonove pumpy (omeprazol, pantoprazol), pokud ho potrebujete dele nez 2\u20134 tydny.<\/p>\n<\/div>\n

          Kdo by nem\u011bl u\u017e\u00edvat Brufen?<\/h2>\n
            \n
          • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na ibuprofen nebo jak\u00e9koli NSAID<\/li>\n
          • Aktivn\u00ed nebo opakuj\u00edc\u00ed se peptick\u00fd v\u0159ed, krv\u00e1cen\u00ed nebo perforace tr\u00e1vic\u00edho traktu<\/li>\n
          • Astma, kop\u0159ivka nebo rinitida vyvolan\u00e1 aspirinem nebo jin\u00fdm NSAID (\u201caspirinem exacerbovan\u00e9 respira\u010dn\u00ed onemocn\u011bn\u00ed\u201d)<\/li>\n
          • T\u011b\u017ek\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed (NYHA t\u0159\u00edda IV)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater (Child\u2013Pugh C)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed ledvin (CrCl < 30 ml\/min)<\/li>\n
          • T\u0159et\u00ed trimestr t\u011bhotenstv\u00ed (riziko p\u0159ed\u010dasn\u00e9ho uzav\u0159en\u00ed ductus arteriosus a oligohydramnionu)<\/li>\n
          • Ned\u00e1vn\u00e1 operace koron\u00e1rn\u00edho bypassu (CABG) \u2014 absolutn\u00ed kontraindikace pro v\u0161echna NSAID<\/li>\n<\/ul>\n

            Kardiovaskul\u00e1rn\u00ed riziko<\/h3>\n

            V\u0161echna NSAID (krom\u011b n\u00edzk\u00fdch d\u00e1vek aspirinu) nesou ur\u010dit\u00e9 zv\u00fd\u0161en\u00ed rizika infarktu a mrtvice a mohou zhor\u0161it srde\u010dn\u00ed selh\u00e1n\u00ed. Riziko je z\u00e1visl\u00e9 na d\u00e1vce a d\u00e9lce u\u017e\u00edv\u00e1n\u00ed a je obecn\u011b nejvy\u0161\u0161\u00ed u COX-2 selektivn\u00edch l\u00e1tek a u diklofenaku. Pacienti s prok\u00e1zan\u00fdm ischemick\u00fdm onemocn\u011bn\u00edm srdce, perifern\u00edm arteri\u00e1ln\u00edm onemocn\u011bn\u00edm, mrtvic\u00ed nebo nekontrolovanou hypertenz\u00ed by m\u011bli pou\u017e\u00edvat neselektivn\u00ed NSAID (ibuprofen nebo naproxen) v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce, nebo pokud mo\u017eno m\u00edsto nich paracetamol.<\/p>\n

            Ren\u00e1ln\u00ed (ledvinov\u00e1) bezpe\u010dnost<\/h3>\n

            NSAID sni\u017euj\u00ed produkci ren\u00e1ln\u00edch prostaglandin\u016f, co\u017e m\u016f\u017ee zp\u016fsobit zadr\u017eov\u00e1n\u00ed sol\u00ed a vody, zv\u00fd\u0161en\u00ed krevn\u00edho tlaku a \u2013 u zraniteln\u00fdch pacient\u016f \u2013 akutn\u00ed po\u0161kozen\u00ed ledvin. Mezi vysoce rizikov\u00e9 skupiny pat\u0159\u00ed star\u0161\u00ed pacienti, pacienti u\u017e\u00edvaj\u00edc\u00ed ACE inhibitory\/ARB spolu s diuretiky (tzv. \u201ctrojit\u00fd z\u00e1sah\u201d), dehydratovan\u00ed jedinci (zvracen\u00ed, pr\u016fjem, horko, intenzivn\u00ed cvi\u010den\u00ed) a pacienti s ji\u017e existuj\u00edc\u00edm CKD. P\u0159esta\u0148te u\u017e\u00edvat NSAID a vyhledejte l\u00e9ka\u0159skou kontrolu, pokud se u v\u00e1s objev\u00ed sn\u00ed\u017een\u00fd v\u00fddej mo\u010di, otoky nebo nevysv\u011btlen\u00fd p\u0159\u00edr\u016fstek hmotnosti.<\/p>\n

            B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky p\u0159\u00edpravku Brufen<\/h2>\n

            V\u011bt\u0161ina u\u017eivatel\u016f kr\u00e1tkodob\u00e9 l\u00e9\u010dby sn\u00e1\u0161\u00ed Brufen dob\u0159e. Hl\u00e1\u0161en\u00e9 \u00fa\u010dinky zahrnuj\u00ed:<\/p>\n

            B\u011b\u017en\u00e9 (1\u201310 %):<\/strong><\/p>\n

              \n
            • Za\u017e\u00edvac\u00ed pot\u00ed\u017ee, p\u00e1len\u00ed \u017e\u00e1hy, nevolnost, nepohodl\u00ed v b\u0159i\u0161e<\/li>\n
            • Bolest hlavy, z\u00e1vrat\u011b<\/li>\n
            • Zadr\u017eov\u00e1n\u00ed tekutin, m\u00edrn\u00e9 otoky kotn\u00edk\u016f<\/li>\n
            • Vyr\u00e1\u017eka, sv\u011bd\u011bn\u00ed<\/li>\n<\/ul>\n

              M\u00e9n\u011b \u010dast\u00e9, ale d\u016fle\u017eit\u00e9:<\/strong><\/p>\n