{"id":57554,"date":"2024-02-27T17:49:59","date_gmt":"2024-02-27T17:49:59","guid":{"rendered":"https:\/\/medsname.com\/brufen\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"brufen","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/brufen\/","title":{"rendered":"Brufen"},"content":{"rendered":"

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⚡ Quick Answer — What is Brufen?<\/h3>\n

Brufen<\/strong> je Ibuprofen<\/strong> tablety dostupn\u00e9 v 200, 400, and 600 mg<\/strong> strengths. It is a non-selective non-steroidal anti-inflammatory drug (NSAID)<\/strong> widely used for pain, fever, and inflammation — including headache, dental pain, menstrual cramps, musculoskeletal injury, osteoarthritis, and rheumatoid arthritis. Typical adult dose is 400 mg three to four times daily<\/strong> with food; the safest long-term dose is 1,200 mg\/day or less.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Brufen 400 mg<\/strong> is one of the most widely prescribed ibuprofen brands in the world, marketed by Abbott and originally developed by Boots in the 1960s. Ibuprofen is on the WHO Essential Medicines List and has the best overall safety profile of any oral NSAID at low to moderate doses. It is the first-line option for most community-level pain and inflammation because it works predictably, is cheap, and is comparatively gentle on the stomach at 1,200 mg\/day or less.<\/p>\n

Brufen is available in three tablet strengths:<\/p>\n

    \n
  • Brufen 200 mg<\/strong> — over-the-counter strength, useful for mild pain, fever, and dysmenorrhoea<\/li>\n
  • Brufen 400 mg<\/strong> — the standard adult dose for moderate pain, post-dental, musculoskeletal injury, and inflammatory flare-ups<\/li>\n
  • Brufen 600 mg<\/strong> — used under medical supervision for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gout<\/li>\n<\/ul>\n

    What Is Brufen Used For?<\/h2>\n

    Brufen is indicated for a broad range of acute and chronic pain and inflammatory conditions:<\/p>\n

      \n
    • Bolesti pohybov\u00e9ho apar\u00e1tu<\/strong> — sprains, strains, soft-tissue injuries, lower back pain<\/li>\n
    • Post-operative and post-dental pain<\/strong> — including after tooth extraction and minor surgery<\/li>\n
    • Prim\u00e1rn\u00ed dysmenorea<\/strong> (period pain) — first-line therapy; ibuprofen is more effective than paracetamol for period pain<\/li>\n
    • Headache and migraine<\/strong> — particularly tension-type headache; also useful in acute migraine with or without a triptan<\/li>\n
    • Hore\u010dka<\/strong> — including viral fever, post-vaccination fever, and fever in adult respiratory infections<\/li>\n
    • Osteoarthritis and rheumatoid arthritis<\/strong> — symptomatic relief of joint pain and stiffness<\/li>\n
    • Acute gout<\/strong> — high-dose (2,400 mg\/day) for 5–7 days, as an alternative to indomethacin or naproxen<\/li>\n
    • Juveniln\u00ed idiopatick\u00e1 artritida<\/strong> — weight-based dosing under paediatric supervision<\/li>\n<\/ul>\n

      Brufen is ne<\/em> a disease-modifying drug in rheumatoid arthritis — it relieves symptoms but does not slow joint damage. DMARDs such as methotrexate or biologics are needed for that.<\/p>\n

      How Does Ibuprofen Work?<\/h2>\n

      Ibuprofen is a non-selective NSAID<\/strong> — it blocks both COX-1<\/strong> (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2<\/strong> (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.<\/p>\n

      Terapeutick\u00fd \u0159et\u011bzec ud\u00e1lost\u00ed je u v\u0161ech NSAID stejn\u00fd:<\/p>\n

        \n
      1. Po\u0161kozen\u00ed tk\u00e1n\u011b nebo z\u00e1n\u011bt uvol\u0148uje fosfolipidy z bun\u011b\u010dn\u00fdch membr\u00e1n<\/li>\n
      2. Fosfolip\u00e1za A\u2082 je p\u0159em\u011b\u0148uje na kyselinu arachidonovou<\/li>\n
      3. Cyklooxygen\u00e1za (COX-1\/COX-2) p\u0159em\u011b\u0148uje kyselinu arachidonovou na prostaglandiny<\/strong> \u2014 molekuly zodpov\u011bdn\u00e9 za bolest, otok a hore\u010dku<\/li>\n
      4. Ibuprofen blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation<\/li>\n<\/ol>\n

        Proto\u017ee prostaglandiny tak\u00e9 chr\u00e1n\u00ed \u017ealude\u010dn\u00ed sliznici, reguluj\u00ed pr\u016ftok krve ledvinami a ovliv\u0148uj\u00ed funkci krevn\u00edch desti\u010dek, stejn\u00fd mechanismus, kter\u00fd zm\u00edr\u0148uje bolest, je tak\u00e9 zodpov\u011bdn\u00fd za hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky NSAID: podr\u00e1\u017ed\u011bn\u00ed \u017ealudku, zadr\u017eov\u00e1n\u00ed tekutin, vysok\u00fd krevn\u00ed tlak a (u n\u011bkter\u00fdch jedinc\u016f) z\u00e1t\u011b\u017e ledvin.<\/p>\n

        Brufen Dosing<\/h2>\n

        Dosp\u011bl\u00ed:<\/strong><\/p>\n

          \n
        • Mild to moderate pain \/ fever \/ dysmenorrhoea:<\/strong> 200–400 mg every 4–6 hours as needed, up to 1,200 mg\/day<\/li>\n
        • Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis:<\/strong> 400–800 mg three to four times daily under medical review; maximum 3,200 mg\/day (rarely used)<\/li>\n
        • Acute gout:<\/strong> 800 mg three times daily for 2–3 days, then taper<\/li>\n<\/ul>\n

          Children (> 6 months, weight-based):<\/strong> 5–10 mg\/kg every 6–8 hours, max 40 mg\/kg\/day, under paediatric supervision.<\/p>\n

          Take Brufen with food or a glass of milk<\/strong>. Swallow tablets whole; do not crush, break, or chew a 600 mg tablet. If you forget a dose, take it when you remember unless your next dose is due within 2 hours — then skip the missed dose. Never double up.<\/p>\n

          \n

          GI bezpecnost \u2014 precist pred prvnim uzitim.<\/strong> Every NSAID, including Brufen, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Brufen s j\u00eddlem<\/em>, pouzijte nejnizsi ucinnou davku po nejkratsi rozumne dlouhou dobu<\/em>, a zeptejte se lekare na predpis inhibitoru protonove pumpy (omeprazol, pantoprazol), pokud ho potrebujete dele nez 2\u20134 tydny.<\/p>\n<\/div>\n

          Who Should Not Take Brufen?<\/h2>\n
            \n
          • Known hypersensitivity to Ibuprofen or any NSAID<\/li>\n
          • Active or recurrent peptic ulcer, GI bleed, or GI perforation<\/li>\n
          • Asthma, urticaria, or rhinitis precipitated by aspirin or another NSAID (“aspirin-exacerbated respiratory disease”)<\/li>\n
          • Severe heart failure (NYHA class IV)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater (Child\u2013Pugh C)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed ledvin (CrCl < 30 ml\/min)<\/li>\n
          • Third trimester of pregnancy (risk of premature ductus arteriosus closure and oligohydramnios)<\/li>\n
          • Recent coronary artery bypass graft surgery (CABG) — absolute contraindication for all NSAIDs<\/li>\n<\/ul>\n

            Kardiovaskul\u00e1rn\u00ed riziko<\/h3>\n

            V\u0161echna NSAID (krom\u011b n\u00edzk\u00fdch d\u00e1vek aspirinu) nesou ur\u010dit\u00e9 zv\u00fd\u0161en\u00ed rizika infarktu a mrtvice a mohou zhor\u0161it srde\u010dn\u00ed selh\u00e1n\u00ed. Riziko je z\u00e1visl\u00e9 na d\u00e1vce a d\u00e9lce u\u017e\u00edv\u00e1n\u00ed a je obecn\u011b nejvy\u0161\u0161\u00ed u COX-2 selektivn\u00edch l\u00e1tek a u diklofenaku. Pacienti s prok\u00e1zan\u00fdm ischemick\u00fdm onemocn\u011bn\u00edm srdce, perifern\u00edm arteri\u00e1ln\u00edm onemocn\u011bn\u00edm, mrtvic\u00ed nebo nekontrolovanou hypertenz\u00ed by m\u011bli pou\u017e\u00edvat neselektivn\u00ed NSAID (ibuprofen nebo naproxen) v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce, nebo pokud mo\u017eno m\u00edsto nich paracetamol.<\/p>\n

            Ren\u00e1ln\u00ed (ledvinov\u00e1) bezpe\u010dnost<\/h3>\n

            NSAID sni\u017euj\u00ed produkci ren\u00e1ln\u00edch prostaglandin\u016f, co\u017e m\u016f\u017ee zp\u016fsobit zadr\u017eov\u00e1n\u00ed sol\u00ed a vody, zv\u00fd\u0161en\u00ed krevn\u00edho tlaku a \u2013 u zraniteln\u00fdch pacient\u016f \u2013 akutn\u00ed po\u0161kozen\u00ed ledvin. Mezi vysoce rizikov\u00e9 skupiny pat\u0159\u00ed star\u0161\u00ed pacienti, pacienti u\u017e\u00edvaj\u00edc\u00ed ACE inhibitory\/ARB spolu s diuretiky (tzv. \u201ctrojit\u00fd z\u00e1sah\u201d), dehydratovan\u00ed jedinci (zvracen\u00ed, pr\u016fjem, horko, intenzivn\u00ed cvi\u010den\u00ed) a pacienti s ji\u017e existuj\u00edc\u00edm CKD. P\u0159esta\u0148te u\u017e\u00edvat NSAID a vyhledejte l\u00e9ka\u0159skou kontrolu, pokud se u v\u00e1s objev\u00ed sn\u00ed\u017een\u00fd v\u00fddej mo\u010di, otoky nebo nevysv\u011btlen\u00fd p\u0159\u00edr\u016fstek hmotnosti.<\/p>\n

            Common Side Effects of Brufen<\/h2>\n

            Most short-course users tolerate Brufen well. Reported effects include:<\/p>\n

            B\u011b\u017en\u00e9 (1\u201310 %):<\/strong><\/p>\n