{"id":57573,"date":"2024-02-27T17:50:34","date_gmt":"2024-02-27T17:50:34","guid":{"rendered":"https:\/\/medsname.com\/hydrosar\/"},"modified":"2026-04-30T10:24:24","modified_gmt":"2026-04-30T10:24:24","slug":"hydrosar","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/hydrosar\/","title":{"rendered":"Hydrosar"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Hydrosar?<\/h3>\n<p style=\"margin:0;\"><strong>Hydrosar<\/strong> je peror\u00e1ln\u00ed tobolka od spole\u010dnosti Sarabhai Chemicals obsahuj\u00edc\u00ed <strong>hydroxyurea (hydroxykarbamid) 500 mg<\/strong> \u2014 inhibitor ribonukleotid redukt\u00e1zy pou\u017e\u00edvan\u00fd k <strong>chronick\u00e1 myeloidn\u00ed leuk\u00e9mie, polycytemia vera, esenci\u00e1ln\u00ed trombocyt\u00e9mie, srpkovit\u00e1 an\u00e9mie<\/strong>, a n\u011bkolik solidn\u00edch n\u00e1dor\u016f (hlava a krk, melanom). Standardn\u00ed d\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9 se li\u0161\u00ed podle indikace: obvykle <strong>15\u201330 mg\/kg\/den<\/strong> v hematologii; <strong>20\u201335 mg\/kg\/den<\/strong> u srpkovit\u00e9 an\u00e9mie. Povinn\u00e9 monitorov\u00e1n\u00ed: <strong>krevn\u00ed obraz ka\u017ed\u00e9 2 t\u00fddny zpo\u010d\u00e1tku, pot\u00e9 m\u011bs\u00ed\u010dn\u011b<\/strong> \u2014 titrujte na ANC &gt; 2 000\/\u00b5L a trombocyty &gt; 100 000\/\u00b5L. Kontraindikace v t\u011bhotenstv\u00ed; spolehliv\u00e1 antikoncepce u obou pohlav\u00ed po celou dobu l\u00e9\u010dby. Dlouhodob\u00e9 obavy: b\u00e9rcov\u00e9 v\u0159edy (chronick\u00e9, bolestiv\u00e9), spinocelul\u00e1rn\u00ed karcinomy k\u016f\u017ee, mo\u017en\u00e9 sekund\u00e1rn\u00ed leuk\u00e9mie (kontroverzn\u00ed, hlavn\u011b u dlouhodob\u00e9 polycytemia vera).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">Co je Hydrosar?<\/h2>\n<p>Hydrosar je peror\u00e1ln\u00ed tobolka od spole\u010dnosti Sarabhai Chemicals obsahuj\u00edc\u00ed <strong>hydroxyurea 500 mg<\/strong> (tak\u00e9 naz\u00fdvan\u00e1 hydroxykarbamid). Hydroxyurea inhibuje ribonukleotid redukt\u00e1zu, \u010d\u00edm\u017e blokuje synt\u00e9zu DNA. Je to jeden z nejpou\u017e\u00edvan\u011bj\u0161\u00edch a nejd\u00e9le pou\u017e\u00edvan\u00fdch cytoreduk\u010dn\u00edch prost\u0159edk\u016f s 60letou klinickou bezpe\u010dnostn\u00ed histori\u00ed u hematologick\u00fdch malignit, srpkovit\u00e9 an\u00e9mie a n\u011bkolika solidn\u00edch n\u00e1dor\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Chronick\u00e1 myeloidn\u00ed leuk\u00e9mie<\/strong> \u2014 cytoredukce p\u0159i diagn\u00f3ze nebo jako alternativa, kdy\u017e nelze pou\u017e\u00edt TKI (imatinib apod.)<\/li>\n<li><strong>Polycytemia vera<\/strong> \u2014 prvn\u00ed linie cytoredukce u vysoce rizikov\u00e9ho onemocn\u011bn\u00ed<\/li>\n<li><strong>Esenci\u00e1ln\u00ed trombocyt\u00e9mie<\/strong> \u2014 prvn\u00ed linie cytoredukce u vysoce rizikov\u00e9ho onemocn\u011bn\u00ed<\/li>\n<li><strong>Myelofibr\u00f3za (ran\u00e9 st\u00e1dium)<\/strong> \u2014 kontrola symptom\u016f a krevn\u00edch hodnot<\/li>\n<li><strong>Srpkovit\u00e1 an\u00e9mie<\/strong> \u2014 sni\u017euje frekvenci vazookluzivn\u00edch kriz\u00ed a akutn\u00edho hrudn\u00edho syndromu; zvy\u0161uje HbF<\/li>\n<li><strong>Akutn\u00ed leuk\u00e9mie \u2014 urgentn\u00ed \u0159e\u0161en\u00ed leukocyt\u00f3zy<\/strong> redukce (rychl\u00e1 cytoredukce p\u0159ed definitivn\u00ed terapi\u00ed)<\/li>\n<li><strong>Spinocelul\u00e1rn\u00ed karcinom hlavy a krku<\/strong> \u2014 s konkomitantn\u00ed radioterapi\u00ed (star\u0161\u00ed re\u017eimy)<\/li>\n<li><strong>Melanom, ovari\u00e1ln\u00ed karcinom (omezen\u00e9 modern\u00ed pou\u017eit\u00ed)<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<p>D\u00e1vkov\u00e1n\u00ed se li\u0161\u00ed podle indikace. P\u0159\u00edklady pro dosp\u011bl\u00e9:<\/p>\n<ul>\n<li><strong>CML, ET, PV cytoredukce:<\/strong> za\u010d\u00edt s 15 mg\/kg\/den; titrovat na 15\u201330 mg\/kg\/den podle krevn\u00edch hodnot<\/li>\n<li><strong>Srpkovit\u00e1 an\u00e9mie:<\/strong> za\u010d\u00edt s 15 mg\/kg\/den; zvy\u0161ovat o 5 mg\/kg\/den ka\u017ed\u00fdch 8 t\u00fddn\u016f a\u017e na maximum 35 mg\/kg\/den nebo maxim\u00e1ln\u011b tolerovanou d\u00e1vku<\/li>\n<li><strong>Akutn\u00ed leuk\u00e9mie - urgentn\u00ed cytoredukce:<\/strong> 50\u2013100 mg\/kg\/den po dobu 1\u20132 dn\u016f (specializovan\u00e9 pod\u00e1n\u00ed)<\/li>\n<\/ul>\n<ol>\n<li>U\u017e\u00edvat 1\u00d7 a\u017e 2\u00d7 denn\u011b podle p\u0159edpisu, s j\u00eddlem nebo bez j\u00eddla.<\/li>\n<li>Polykejte tobolky vcelku. <strong>Nerozlamujte tobolky<\/strong> \u2014 pr\u00e1\u0161ek je cytotoxick\u00fd a p\u0159i kontaktu \u0161kodliv\u00fd. Pokud tobolku nelze spolknout, obsah lze rozpt\u00fdlit ve vod\u011b za pou\u017eit\u00ed ochrann\u00fdch rukavic a vyvarov\u00e1n\u00ed se kontaktu s poko\u017ekou\/o\u010dima.<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> Krevn\u00ed obraz ka\u017ed\u00e9 2 t\u00fddny zpo\u010d\u00e1tku (nebo t\u00fddn\u011b b\u011bhem titrace u srpkovit\u00e9 an\u00e9mie), pot\u00e9 m\u011bs\u00ed\u010dn\u011b. Elektrolyty + jatern\u00ed testy ka\u017ed\u00e9 1\u20133 m\u011bs\u00edce. Po\u010det retikulocyt\u016f, HbF (srpkovit\u00e1 an\u00e9mie). MCV se p\u0159i l\u00e9\u010db\u011b hydroxyureou zvy\u0161uje (u\u017eite\u010dn\u00fd marker adherence).<\/li>\n<li>\u00daprava d\u00e1vky podle krevn\u00edch hodnot: p\u0159eru\u0161it p\u0159i ANC &lt; 2 000\/\u00b5L, trombocytech &lt; 80 000\/\u00b5L nebo Hb &lt; 4,5 g\/dL. Po zotaven\u00ed pokra\u010dovat ni\u017e\u0161\u00ed d\u00e1vkou.<\/li>\n<li>Kyselina listov\u00e1 5 mg denn\u011b se \u010dasto p\u0159edepisuje sou\u010dasn\u011b (zejm\u00e9na u hemoglobinopati\u00ed).<\/li>\n<li>Dostate\u010dn\u00fd p\u0159\u00edjem tekutin ke sn\u00ed\u017een\u00ed rizika hyperurik\u00e9mie a syndromu n\u00e1dorov\u00e9ho rozpadu.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> myelosuprese (\u017e\u00e1douc\u00ed \u00fa\u010dinek v terapeutick\u00e9 d\u00e1vce), nevolnost, anorexie, mukozitida, m\u00edrn\u00fd pr\u016fjem, hyperpigmentace k\u016f\u017ee, pigmentace neht\u016f, \u0159\u00eddnut\u00ed vlas\u016f.<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>V\u0159edy na nohou<\/strong> \u2014 chronick\u00e9, bolestiv\u00e9, \u0161patn\u011b se hoj\u00edc\u00ed; postihuj\u00ed ~5 % dlouhodob\u00fdch u\u017eivatel\u016f; m\u016f\u017ee vy\u017eadovat sn\u00ed\u017een\u00ed d\u00e1vky nebo ukon\u010den\u00ed l\u00e9\u010dby<\/li>\n<li><strong>Spinocelul\u00e1rn\u00ed karcinomy k\u016f\u017ee<\/strong> \u2014 dlouhodob\u00ed u\u017eivatel\u00e9, zejm\u00e9na sv\u011btlej\u0161\u00ed pleti; ka\u017edoro\u010dn\u00ed dermatologick\u00e9 vy\u0161et\u0159en\u00ed a d\u016fsledn\u00e9 pou\u017e\u00edv\u00e1n\u00ed SPF<\/li>\n<li>Makrocyt\u00f3za (zv\u00fd\u0161en\u00fd MCV) \u2014 o\u010dek\u00e1van\u00fd jev, ukazatel compliance, nen\u00ed probl\u00e9m<\/li>\n<li>Plicn\u00ed fibr\u00f3za (vz\u00e1cn\u011b)<\/li>\n<li>Hyperurik\u00e9mie, dna<\/li>\n<li>Mo\u017en\u00fd sekund\u00e1rn\u00ed leukemie u dlouhodob\u00e9 polycyt\u00e9mie vera (kontroverzn\u00ed)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> teratogenn\u00ed. Siln\u00e1 antikoncepce po celou dobu l\u00e9\u010dby A\u017d po dobu 6 m\u011bs\u00edc\u016f po posledn\u00ed d\u00e1vce, u OBOU pohlav\u00ed.<\/li>\n<li><strong>Kojen\u00ed:<\/strong> vylu\u010dov\u00e1no do mate\u0159sk\u00e9ho ml\u00e9ka \u2014 vyvarovat se.<\/li>\n<li><strong>Porucha funkce ledvin:<\/strong> sn\u00ed\u017eit d\u00e1vku p\u0159i eGFR &lt; 60 ml\/min.<\/li>\n<li><strong>T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater:<\/strong> opatrn\u011b.<\/li>\n<li><strong>Screening ko\u017en\u00edch n\u00e1dor\u016f:<\/strong> ka\u017edoro\u010dn\u00ed dermatologick\u00e9 vy\u0161et\u0159en\u00ed pro dlouhodob\u00e9 u\u017eivatele; d\u016fsledn\u00e9 denn\u00ed pou\u017e\u00edv\u00e1n\u00ed SPF.<\/li>\n<li><strong>O\u010dkov\u00e1n\u00ed:<\/strong> \u017eiv\u00e9 vakc\u00edny kontraindikov\u00e1ny; ne\u017eiv\u00e9 vakc\u00edny bezpe\u010dn\u00e9 a doporu\u010den\u00e9.<\/li>\n<li><strong>HIV koinfekce:<\/strong> kombinace hydroxyurea + didanosin zp\u016fsobila fat\u00e1ln\u00ed pankreatitidu \u2014 vyvarujte se.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Didanosin (antiretrovirotikum pro HIV)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hl\u00e1\u0161ena fat\u00e1ln\u00ed pankreatitida<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kombinaci se absolutn\u011b vyh\u00fdbejte.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dal\u0161\u00ed myelosupresivn\u00ed l\u00e9ky (chemoterapie, imunosupresiva)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed \u00fatlum kostn\u00ed d\u0159en\u011b<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Odborn\u00fd dohled; pe\u010dliv\u00e9 sledov\u00e1n\u00ed krevn\u00edho obrazu.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u017div\u00e9 vakc\u00edny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Riziko diseminovan\u00e9 infekce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindikov\u00e1no.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Allopurinol nebo febuxostat<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">U\u017eite\u010dn\u00e9 p\u0159i hyperurik\u00e9mii\/dn\u011b z bun\u011b\u010dn\u00e9ho obratu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u010casto p\u0159edepisov\u00e1no v kombinaci.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Pokojov\u00e1 teplota, 15\u201330\u00b0C, p\u016fvodn\u00ed blistr.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed, \u017een v plodn\u00e9m v\u011bku, dom\u00e1c\u00edch zv\u00ed\u0159at.<\/li>\n<li>O\u0161et\u0159uj\u00edc\u00ed osoby manipuluj\u00edc\u00ed s po\u0161kozen\u00fdmi kapslemi by m\u011bly pou\u017e\u00edvat rukavice \u2013 pr\u00e1\u0161ek je cytotoxick\u00fd.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ondrea\/\"><strong>Ondrea (hydroxyurea 500 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/riborea\/\"><strong>Riborea (hydroxyurea 500 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Jak pom\u00e1h\u00e1 Hydrosar p\u0159i srpkovit\u00e9 an\u00e9mii?<\/h3>\n<p>Hydroxyurea je nejv\u00fdznamn\u011bj\u0161\u00edm chorobu modifikuj\u00edc\u00edm l\u00e9kem pro srpkovitou an\u00e9mii. Zvy\u0161uje hladinu fet\u00e1ln\u00edho hemoglobinu (HbF), kter\u00fd zabra\u0148uje srpkovitosti \u010derven\u00fdch krvinek. \u00da\u010dinky: <strong>~50% sn\u00ed\u017een\u00ed vazookluzivn\u00edch kriz\u00ed, m\u00e9n\u011b hospitalizac\u00ed, m\u00e9n\u011b p\u0159\u00edpad\u016f akutn\u00edho hrudn\u00edho syndromu, ni\u017e\u0161\u00ed pot\u0159eba krevn\u00edch transfuz\u00ed, zlep\u0161en\u00e9 p\u0159e\u017eit\u00ed<\/strong>. V\u011bt\u0161ina pacient\u016f pozoruje klinick\u00fd benefit po 8\u201312 t\u00fddnech titrace d\u00e1vky; pln\u00fd benefit za 6\u201312 m\u011bs\u00edc\u016f. Celosv\u011btov\u011b nedostate\u010dn\u011b vyu\u017e\u00edv\u00e1na navzdory siln\u00e9 d\u016fkazov\u00e9 z\u00e1kladn\u011b \u2013 pora\u010fte se se sv\u00fdm hematologem, pokud m\u00e1te srpkovitou an\u00e9mii a nebyla v\u00e1m nab\u00eddnuta hydroxyurea.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 krevn\u00ed testy pot\u0159ebuji p\u0159i u\u017e\u00edv\u00e1n\u00ed Hydrosaru?<\/h3>\n<p><strong>Povinn\u00e9:<\/strong> Kompletn\u00ed krevn\u00ed obraz (FBC) ka\u017ed\u00e9 2 t\u00fddny zpo\u010d\u00e1tku (t\u00fddn\u011b b\u011bhem titrace u srpkovit\u00e9 an\u00e9mie), pot\u00e9 m\u011bs\u00ed\u010dn\u011b po stabilizaci. U&amp;E + LFT ka\u017ed\u00e9 1\u20133 m\u011bs\u00edce. Pacienti se srpkovitou an\u00e9mi\u00ed tak\u00e9: m\u011b\u0159en\u00ed HbF, po\u010det retikulocyt\u016f. P\u0159eru\u0161te nebo sni\u017ete d\u00e1vku p\u0159i ANC &lt; 2 000\/\u00b5L, trombocytech &lt; 80 000\/\u00b5L nebo Hb &lt; 4,5 g\/dL.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d je Hydrosar spojov\u00e1n s v\u0159edy na nohou?<\/h3>\n<p>Chronick\u00e9, bolestiv\u00e9 b\u00e9rcov\u00e9 v\u0159edy postihuj\u00ed ~5 % dlouhodob\u00fdch u\u017eivatel\u016f hydroxyurey, v\u011bt\u0161inou v oblasti kotn\u00edku. Mechanismus nen\u00ed jasn\u00fd (pravd\u011bpodobn\u011b mikrovaskul\u00e1rn\u00ed). Hoj\u00ed se pomalu a mohou vy\u017eadovat sn\u00ed\u017een\u00ed d\u00e1vky nebo vysazen\u00ed hydroxyurey. Okam\u017eit\u011b informujte sv\u00e9ho l\u00e9ka\u0159e, pokud se u v\u00e1s b\u011bhem u\u017e\u00edv\u00e1n\u00ed hydroxyurey objev\u00ed b\u00e9rcov\u00fd v\u0159ed \u2013 neodkl\u00e1dejte to.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017ee Hydrosar zp\u016fsobit rakovinu?<\/h3>\n<p>Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed hydroxyurey m\u00edrn\u011b zvy\u0161uje riziko <strong>spinocelul\u00e1rn\u00edch karcinom\u016f k\u016f\u017ee<\/strong>, zejm\u00e9na u pacient\u016f se sv\u011btlou plet\u00ed. Ro\u010dn\u00ed dermatologick\u00e9 vy\u0161et\u0159en\u00ed cel\u00e9ho t\u011bla, denn\u00ed pou\u017e\u00edv\u00e1n\u00ed \u0161irokospektr\u00e1ln\u00edho SPF kr\u00e9mu, vyh\u00fdb\u00e1n\u00ed se slunci. Historick\u00e1 obava ohledn\u011b <strong>sekund\u00e1rn\u00ed leuk\u00e9mie u polycyt\u00e9mie vera<\/strong> p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed hydroxyurey je p\u0159edm\u011btem diskuse \u2014 rozs\u00e1hl\u00e9 modern\u00ed \u00fadaje nazna\u010duj\u00ed, \u017ee riziko je n\u00edzk\u00e9 a \u017ee samotn\u00e1 PV nese inherentn\u00ed riziko leukemick\u00e9 transformace.<\/p>\n<h3 class=\"wp-block-heading\">Mohu ot\u011bhotn\u011bt p\u0159i u\u017e\u00edv\u00e1n\u00ed Hydrosaru?<\/h3>\n<p>Hydroxyurea je teratogenn\u00ed. Spolehliv\u00e1 antikoncepce je povinn\u00e1 po celou dobu l\u00e9\u010dby A alespo\u0148 <strong>6 m\u011bs\u00edc\u016f po posledn\u00ed d\u00e1vce, u pacient\u016f obou pohlav\u00ed<\/strong>. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby proberte pl\u00e1nov\u00e1n\u00ed rodiny se sv\u00fdm hematologem. U srpkovit\u00e9 an\u00e9mie se hydroxyurea n\u011bkdy vysazuje b\u011bhem pl\u00e1novan\u00e9ho t\u011bhotenstv\u00ed s pe\u010dliv\u00fdm monitorov\u00e1n\u00edm.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d se mi p\u0159i u\u017e\u00edv\u00e1n\u00ed Hydrosaru zvy\u0161uje MCV?<\/h3>\n<p>Makrocyt\u00f3za (zv\u00fd\u0161en\u00e9 MCV) je o\u010dek\u00e1van\u00fd a u\u017eite\u010dn\u00fd \u00fa\u010dinek \u2014 nazna\u010duje, \u017ee l\u00e9k u\u017e\u00edv\u00e1te pravideln\u011b. L\u00e9ka\u0159i pou\u017e\u00edvaj\u00ed MCV jako ukazatel compliance u srpkovit\u00e9 an\u00e9mie. Toto zv\u00fd\u0161en\u00ed je benign\u00ed a nen\u00ed spojeno s \u017e\u00e1dn\u00fdm klinick\u00fdm probl\u00e9mem.<\/p>\n<h3 class=\"wp-block-heading\">Mohu otev\u0159\u00edt tobolku, pokud ji nemohu spolknout?<\/h3>\n<p>Je lep\u0161\u00ed se tomu vyhnout \u2014 pr\u00e1\u0161ek je cytotoxick\u00fd a \u0161kodliv\u00fd p\u0159i kontaktu s k\u016f\u017e\u00ed, o\u010dima a d\u00fdchac\u00edmi cestami. Pokud je to nezbytn\u00e9, pe\u010dovatel mus\u00ed nosit rukavice, pracovat v v\u011btran\u00e9m prostoru a obsah rozpt\u00fdlit v mal\u00e9m mno\u017estv\u00ed vody, aby pacient mohl tekutinu okam\u017eit\u011b vyp\u00edt. Pot\u00e9 si umyjte ruce a povrchy. Specializovan\u00fd l\u00e9k\u00e1rn\u00edk m\u016f\u017ee p\u0159ipravit tekutou suspenzi jako alternativu.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Hydrosar s HIV antiretrovirov\u00fdmi l\u00e9ky?<\/h3>\n<p>V\u011bt\u0161ina ART je kompatibiln\u00ed. Nebezpe\u010dn\u00e1 kombinace je <strong>hydroxyurea + didanosin<\/strong>, kter\u00e1 zp\u016fsobila fat\u00e1ln\u00ed pankreatitidu. Informujte ka\u017ed\u00e9ho p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e o obou l\u00e9c\u00edch a ujist\u011bte se, \u017ee ve va\u0161em re\u017eimu nen\u00ed \u017e\u00e1dn\u00fd didanosin.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ondrea\/\">Ondrea (hydroxyurea 500 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endoxan\/\">Endoxan (cyklofosfamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imatib\/\">Imatib (imatinib 100\/400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/veenat\/\">Veenat (imatinib 100\/400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/folitrax\/\">Folitrax (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 L\u00e9\u010d\u00ed srpkovitou an\u00e9mii<br \/>\n\u2705 Sni\u017euje \u010detnost bolestiv\u00fdch kriz\u00ed<br \/>\n\u2705 Reguluje tvorbu krevn\u00edch bun\u011bk<br \/>\n\u2705 Zabr\u00e1n\u00ed tvorb\u011b krevn\u00edch sra\u017eenin<br \/>\n\u2705 Sni\u017euje riziko mrtvice<\/p>\n<p>Hydrosar obsahuje hydroxyureu.<\/p>","protected":false},"featured_media":57574,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4331,4315],"class_list":{"0":"post-57573","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-hydrosar","10":"product_tag-hydroxyurea","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57573"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57574"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57573"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57573"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57573"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}