{"id":57595,"date":"2024-02-27T17:52:15","date_gmt":"2024-02-27T17:52:15","guid":{"rendered":"https:\/\/medsname.com\/depsol\/"},"modified":"2026-04-30T10:24:24","modified_gmt":"2026-04-30T10:24:24","slug":"depsol","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/depsol\/","title":{"rendered":"Depsol"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\">Depsol (Imipramin 25 mg) je tricyklick\u00e9 antidepresivum. Pou\u017e\u00edv\u00e1 se u t\u011b\u017ek\u00fdch depres\u00ed, panick\u00e9 poruchy a (v\u00fdjime\u010dn\u011b) u d\u011btsk\u00e9 no\u010dn\u00ed enur\u00e9zy. Vy\u0161\u0161\u00ed z\u00e1t\u011b\u017e sn\u00e1\u0161enlivosti ne\u017e SSRI \u2014 druh\u00e1 volba pro v\u011bt\u0161inu pacient\u016f.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Depsol na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em <a href=\"https:\/\/medsbase.com\/cs\/loyalty-points\/\">v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n<h2>Co je Depsol a jak funguje<\/h2>\n<p>Depsol je tableta obsahuj\u00edc\u00ed Imipramin dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: <strong>25 mg<\/strong>.<\/p>\n<p>Imipramin bylo <strong>prvn\u00ed tricyklick\u00e9 antidepresivum<\/strong> (Geigy, 1957) a z\u016fst\u00e1v\u00e1 u\u017eite\u010dn\u00fdm prost\u0159edkem pro t\u011b\u017ek\u00e9 deprese, kde SSRI selhaly, panickou poruchu a \u2014 v\u00fdjime\u010dn\u011b \u2014 d\u011btskou no\u010dn\u00ed enur\u00e9zu (pomo\u010dov\u00e1n\u00ed), kde selhala behavior\u00e1ln\u00ed opat\u0159en\u00ed.<\/p>\n<p>Tricyklick\u00e1 antidepresiva blokuj\u00ed zp\u011btn\u00e9 vychyt\u00e1v\u00e1n\u00ed serotoninu a noradrenalinu na presynaptick\u00fdch transport\u00e9rech, podobn\u011b jako SSRI a SNRI. Jejich hor\u0161\u00ed sn\u00e1\u0161enlivost vych\u00e1z\u00ed z <strong>: muskarinov\u00fdch (anticholinergn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky), histaminergn\u00edch H1 (sedace, p\u0159\u00edr\u016fstek hmotnosti) a \u03b11-adrenergn\u00edch (ortostatick\u00e1 hypotenze). Tak\u00e9 blokuj\u00ed rychl\u00e9 sod\u00edkov\u00e9 kan\u00e1ly v srde\u010dn\u00ed tk\u00e1ni \u2013 co\u017e je z\u00e1klad jak pro jejich analgetick\u00fd \u00fa\u010dinek, tak pro jejich kardiotoxicitu p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed.<\/strong>: muskarinov\u00e9 (anticholinergn\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky), histaminergn\u00ed H1 (sedace, n\u00e1r\u016fst hmotnosti) a \u03b11-adrenergn\u00ed (ortostatick\u00e1 hypotenze). Blokuj\u00ed rovn\u011b\u017e rychl\u00e9 sod\u00edkov\u00e9 kan\u00e1ly v srde\u010dn\u00ed tk\u00e1ni \u2014 to je podkladem jak jejich analgetick\u00e9ho \u00fa\u010dinku, tak jejich kardi\u00e1ln\u00ed toxicity p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed.<\/p>\n<p>Imipramin m\u00e1 nejvyv\u00e1\u017een\u011bj\u0161\u00ed inhibici zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed serotoninu a noradrenalinu mezi TCA a je historickou referenc\u00ed pro nov\u011bj\u0161\u00ed l\u00e1tky.<\/p>\n<h2>Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indikace<\/th>\n<th>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\n<th>C\u00edlov\u00e1 d\u00e1vka<\/th>\n<th>Maxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Hlavn\u00ed deprese (dosp\u011bl\u00ed)<\/td>\n<td>25\u201350 mg p\u0159ed span\u00edm<\/td>\n<td>100\u2013200 mg\/den<\/td>\n<td>300 mg<\/td>\n<\/tr>\n<tr>\n<td>panick\u00e1 porucha<\/td>\n<td>10 mg 1\u00d7 denn\u011b po dobu 1 t\u00fddne<\/td>\n<td>50\u2013150 mg\/den<\/td>\n<td>200 mg<\/td>\n<\/tr>\n<tr>\n<td>D\u011btsk\u00e1 enur\u00e9za (\u22656 let)<\/td>\n<td>1,0\u20131,5 mg\/kg p\u0159ed span\u00edm<\/td>\n<td>1,5\u20132,5 mg\/kg HS<\/td>\n<td>2,5 mg\/kg nebo 75 mg, podle toho, co je ni\u017e\u0161\u00ed<\/td>\n<\/tr>\n<tr>\n<td>Star\u0161\u00ed dosp\u011bl\u00ed<\/td>\n<td>10 mg p\u0159ed span\u00edm<\/td>\n<td>30\u201350 mg\/den<\/td>\n<td>dle sn\u00e1\u0161enlivosti<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Riziko srde\u010dn\u00edch komplikac\u00ed a toxicita p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed<\/strong><\/p>\n<p style=\"margin-bottom:0;\">TCA prodlu\u017euj\u00ed QRS a QT interval a p\u0159ed\u00e1vkov\u00e1n\u00ed je <strong>\u017eivot ohro\u017euj\u00edc\u00ed<\/strong> \u2014 historicky nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dina \u00famrt\u00ed spojen\u00fdch s antidepresivy. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby u pacient\u016f se zn\u00e1m\u00fdm srde\u010dn\u00edm onemocn\u011bn\u00edm, l\u00e9\u010den\u00fdch l\u00e9ky prodlu\u017euj\u00edc\u00edmi QT interval nebo u star\u0161\u00edch dosp\u011bl\u00fdch je nutn\u00e9 prov\u00e9st v\u00fdchoz\u00ed EKG. Neza\u010d\u00ednejte l\u00e9\u010dbu u pacient\u016f s recentn\u00edm infarktem myokardu, poruchami veden\u00ed, dekompenzovan\u00fdm srde\u010dn\u00edm selh\u00e1n\u00edm nebo vrozen\u00fdm dlouh\u00fdm QT intervalem. U pacient\u016f s rizikem sebevra\u017edy omezte mno\u017estv\u00ed vyd\u00e1van\u00e9ho l\u00e9ku \u2014 terapeutick\u00fd index je \u00fazk\u00fd.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Anticholinergn\u00ed z\u00e1t\u011b\u017e<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Sucho v \u00fastech, z\u00e1cpa, rozmazan\u00e9 vid\u011bn\u00ed, obt\u00ed\u017ee s mo\u010den\u00edm, zpomalen\u00e9 kognitivn\u00ed funkce \u2014 tyto \u00fa\u010dinky se vyskytuj\u00ed u v\u0161ech pacient\u016f v terapeutick\u00fdch d\u00e1vk\u00e1ch. Vyvarujte se pod\u00e1v\u00e1n\u00ed u \u00fazk\u00e9ho \u00fahlu glaukomu, BPH s v\u00fdraznou retenc\u00ed mo\u010di a demence. Doporu\u010dte \u017ev\u00fdka\u010dky\/bezcukrov\u00e9 pastilky, vl\u00e1kninu + dostatek tekutin a zm\u011bk\u010dova\u010de stolice.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u osob do 25 let)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">V\u0161echna antidepresiva nesou varov\u00e1n\u00ed FDA v \u010dern\u00e9m r\u00e1me\u010dku o zv\u00fd\u0161en\u00e9m riziku sebevra\u017eedn\u00fdch my\u0161lenek u pacient\u016f mlad\u0161\u00edch 25 let \u2014 to je obzvl\u00e1\u0161t\u011b relevantn\u00ed pro klomipramin u adolescent\u016f s OCD.<\/p>\n<\/div>\n<h2>\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li><strong>Anticholinergn\u00ed \u00fa\u010dinky:<\/strong> sucho v \u00fastech, z\u00e1cpa, rozmazan\u00e9 vid\u011bn\u00ed, obt\u00ed\u017ee s mo\u010den\u00edm.<\/li>\n<li><strong>Sedace:<\/strong> zejm\u00e9na u doxepinu a klomipraminu; pod\u00e1v\u00e1n\u00ed p\u0159ed span\u00edm pom\u00e1h\u00e1.<\/li>\n<li><strong>Kardiovaskul\u00e1rn\u00ed:<\/strong> ortostatick\u00e1 hypotenze (\u03b11 blok\u00e1da), tachykardie, prodlou\u017een\u00ed p\u0159evodn\u00edch interval\u016f.<\/li>\n<li><strong>Metabolick\u00e9:<\/strong> p\u0159\u00edr\u016fstek hmotnosti (5\u201310 kg za 12 m\u011bs\u00edc\u016f u mnoha pacient\u016f), zv\u00fd\u0161en\u00e1 chu\u0165 k j\u00eddlu.<\/li>\n<li><strong>Sexu\u00e1ln\u00ed:<\/strong> sn\u00ed\u017een\u00e9 libido, opo\u017ed\u011bn\u00e1 ejakulace (n\u011bkdy se klinicky vyu\u017e\u00edv\u00e1 u p\u0159ed\u010dasn\u00e9 ejakulace), obt\u00ed\u017ee s erekc\u00ed.<\/li>\n<li><strong>Vysazen\u00ed:<\/strong> postupn\u00e9 sni\u017eov\u00e1n\u00ed d\u00e1vky po dobu 4 t\u00fddn\u016f; n\u00e1hl\u00e9 p\u0159eru\u0161en\u00ed m\u016f\u017ee zp\u016fsobit p\u0159\u00edznaky podobn\u00e9 ch\u0159ipce, gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee a poruchy sp\u00e1nku.<\/li>\n<\/ul>\n<h2>Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li><strong>MAOI<\/strong> \u2014 absolutn\u00ed kontraindikace. 14denn\u00ed vyplaven\u00ed p\u0159i p\u0159echodu ob\u011bma sm\u011bry.<\/li>\n<li><strong>SSRI \/ SNRI<\/strong> \u2014 aditivn\u00ed serotoninergn\u00ed riziko; inhibice CYP2D6 fluoxetinem a paroxetinem zvy\u0161uje hladiny TCA.<\/li>\n<li><strong>L\u00e9ky prodlu\u017euj\u00edc\u00ed QT interval<\/strong> (azoly, makrolidy, amiodaron, sotalol, metadon, ondansetron, antipsychotika) \u2014 aditivn\u00ed riziko.<\/li>\n<li><strong>Jin\u00e1 anticholinergika<\/strong> (oxybutynin, benztropin, antihistaminika, klozapin, olanzapin) \u2014 zv\u00fd\u0161en\u00e1 z\u00e1t\u011b\u017e u star\u0161\u00edch pacient\u016f.<\/li>\n<li><strong>CNS depresiva<\/strong> \u2014 aditivn\u00ed sedace.<\/li>\n<li><strong>Tramadol, bupropion, fluorochinolony<\/strong> \u2014 sni\u017euj\u00ed pr\u00e1h pro z\u00e1chvaty; aditivn\u00ed riziko vzniku z\u00e1chvat\u016f.<\/li>\n<\/ul>\n<h2>T\u011bhotenstv\u00ed, kojen\u00ed, pediatrie<\/h2>\n<p>TCA jsou v t\u011bhotenstv\u00ed klasifikov\u00e1ny FDA <strong>kategorie C<\/strong>. Expozice v pozdn\u00edm t\u011bhotenstv\u00ed m\u016f\u017ee zp\u016fsobit neonat\u00e1ln\u00ed anticholinergn\u00ed abstinen\u010dn\u00ed p\u0159\u00edznaky. Laktace: TCA p\u0159ech\u00e1zej\u00ed do mate\u0159sk\u00e9ho ml\u00e9ka v mal\u00e9m mno\u017estv\u00ed; nejl\u00e9pe prostudov\u00e1ny jsou nortriptylin a imipramin. Pediatrie: imipramin je schv\u00e1len od 6 let (enur\u00e9za) a klomipramin od 10 let (OCD); doxepin u dosp\u00edvaj\u00edc\u00edch pouze pod odborn\u00fdm dohledem.<\/p>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte p\u0159i teplot\u011b 15\u201330 \u00b0C, mimo p\u0159\u00edm\u00e9 slune\u010dn\u00ed sv\u011btlo, v p\u016fvodn\u00edm obalu. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed \u2014 po\u017eit\u00ed TCA d\u011btmi p\u0159edstavuje l\u00e9ka\u0159skou pohotovost.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Za jak dlouho za\u010dne Depsol \u00fa\u010dinkovat?<\/h3>\n<p>TCA obvykle vykazuj\u00ed \u00fa\u010dinek b\u011bhem 2\u20134 t\u00fddn\u016f. Zlep\u0161en\u00ed sp\u00e1nku a \u00fazkosti se \u010dasto objevuj\u00ed ji\u017e v 1. t\u00fddnu; antidepresivn\u00ed efekt se rozv\u00edj\u00ed b\u011bhem 4\u20136 t\u00fddn\u016f. <\/p>\n<h3>Pro\u010d d\u00e1vkov\u00e1n\u00ed p\u0159ed span\u00edm?<\/h3>\n<p>Doxepin, klomipramin a imipramin maj\u00ed sedativn\u00ed \u00fa\u010dinky. D\u00e1vkov\u00e1n\u00ed p\u0159ed span\u00edm vyu\u017e\u00edv\u00e1 tuto sedaci jako prosp\u011b\u0161n\u00fd vedlej\u0161\u00ed efekt (lep\u0161\u00ed sp\u00e1nek) nam\u00edsto ne\u017e\u00e1douc\u00edho \u00fa\u010dinku (denn\u00ed ospalost). Tak\u00e9 sni\u017euje ortostatickou hypotenzi t\u00edm, \u017ee pacient sp\u00ed b\u011bhem vrcholu \u00fa\u010dinku.<\/p>\n<h3>Je Depsol bezpe\u010dn\u00fd pro star\u0161\u00ed osoby?<\/h3>\n<p>TCAs jsou na seznamu Beers Criteria jako potenci\u00e1ln\u011b nevhodn\u00e9 l\u00e9ky pro seniory kv\u016fli anticholinergn\u00ed z\u00e1t\u011b\u017ei, ortostatick\u00e9 hypotenzi a srde\u010dn\u00edmu riziku. Nejsou absolutn\u011b kontraindikov\u00e1ny, ale obvykle jsou druhou volbou \u2014 SSRI\/SNRI jsou preferov\u00e1ny, pokud konkr\u00e9tn\u00ed benefit (nap\u0159. proti bolesti, na sp\u00e1nek) nep\u0159ev\u00e1\u017e\u00ed rizika.<\/p>\n<h3>Mohu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Depsolu?<\/h3>\n<p>Alkohol zesiluje sedativn\u00ed a ortostatick\u00e9 \u00fa\u010dinky TCA. Omezte konzumaci na p\u0159\u00edle\u017eitostn\u00e9 a st\u0159\u00eddm\u00e9 mno\u017estv\u00ed; \u00fapln\u011b se vyhn\u011bte n\u00e1razov\u00e9mu pit\u00ed. Kombinace obvykle nen\u00ed nebezpe\u010dn\u00e1 p\u0159i m\u00edrn\u00e9m u\u017e\u00edv\u00e1n\u00ed, ale subjektivn\u011b je h\u016f\u0159e sn\u00e1\u0161ena ne\u017e ka\u017ed\u00e1 l\u00e1tka samostatn\u011b.<\/p>\n<h3>Jak\u00e9 je riziko p\u0159ed\u00e1vkov\u00e1n\u00ed?<\/h3>\n<p>TCAs pat\u0159\u00ed mezi nejnebezpe\u010dn\u011bj\u0161\u00ed t\u0159\u00eddy l\u00e9k\u016f p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed \u2014 <strong>kolaps srde\u010dn\u00edho p\u0159evodu, z\u00e1chvaty a k\u00f3ma<\/strong> mohou nastat p\u0159i relativn\u011b n\u00edzk\u00fdch n\u00e1sobc\u00edch terapeutick\u00e9 d\u00e1vky. Omezte mno\u017estv\u00ed vyd\u00e1van\u00fdch d\u00e1vek u pacient\u016f s jak\u00fdmkoli rizikem sebevra\u017edy. P\u0159i podez\u0159en\u00ed na p\u0159ed\u00e1vkov\u00e1n\u00ed okam\u017eit\u011b vyhledejte pohotovost \u2014 hydrogenuhli\u010ditan sodn\u00fd je antidotem pro srde\u010dn\u00ed toxicitu, ale na\u010dasov\u00e1n\u00ed je kl\u00ed\u010dov\u00e9.<\/p>\n<h3>Ovlivn\u00ed Depsol m\u00e9 \u0159\u00edzen\u00ed vozidla?<\/h3>\n<p>Sedace a zpomalen\u00ed reak\u010dn\u00edho \u010dasu jsou b\u011b\u017en\u00e9 v prvn\u00edch 1\u20132 t\u00fddnech. Vyhn\u011bte se \u0159\u00edzen\u00ed, dokud nen\u00ed zn\u00e1ma tolerance v ust\u00e1len\u00e9m stavu. N\u011bkte\u0159\u00ed pacienti sn\u00e1\u0161ej\u00ed pln\u00e9 d\u00e1vky trvale bez ovlivn\u011bn\u00ed \u0159\u00edzen\u00ed; jin\u00ed z\u016fst\u00e1vaj\u00ed p\u0159\u00edli\u0161 sedovan\u00ed i p\u0159i n\u00edzk\u00fdch d\u00e1vk\u00e1ch.<\/p>\n<h3>Lze Depsol kombinovat s SSRI?<\/h3>\n<p>Obecn\u011b ne \u2014 kombinace zvy\u0161uje riziko serotoninov\u00e9ho syndromu a hladiny TCA v s\u00e9ru (zejm\u00e9na s fluoxetinem a paroxetinem). Kombinace se n\u011bkdy pou\u017e\u00edv\u00e1 u rezistentn\u00ed OCD nebo deprese pod odborn\u00fdm dohledem s TDM, nikdy empiricky.<\/p>\n<h3>Jak postupovat p\u0159i vysazov\u00e1n\u00ed Depsolu?<\/h3>\n<p>Sni\u017eujte d\u00e1vku p\u0159ibli\u017en\u011b o 25\u201350 % ka\u017ed\u00e9 2 t\u00fddny. Abstinen\u010dn\u00ed p\u0159\u00edznaky (n\u011bkdy naz\u00fdvan\u00e9 \u201cTCA ch\u0159ipka\u201d) zahrnuj\u00ed mal\u00e1tnost, gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee a poruchy sp\u00e1nku \u2014 lze zvl\u00e1dnout pomalej\u0161\u00edm sni\u017eov\u00e1n\u00edm d\u00e1vek. P\u0159ed \u00fapln\u00fdm vysazen\u00edm se pora\u010fte s p\u0159edepisuj\u00edc\u00edm l\u00e9ka\u0159em.<\/p>\n<h3>Zp\u016fsobuje Depsol p\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze?<\/h3>\n<p>Ano \u2014 v\u011bt\u0161ina TCA zp\u016fsobuje v\u00fdznamn\u00e9 p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze b\u011bhem 6\u201312 m\u011bs\u00edc\u016f, \u010dasto o 5\u201310 kg. Doxepin a amitriptylin jsou nejhor\u0161\u00ed; nortriptylin m\u00e9n\u011b. Pokud je to hlavn\u00ed obava, proberte to p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby \u2014 SSRI\/SNRI m\u016f\u017ee b\u00fdt vhodn\u011bj\u0161\u00ed volbou.<\/p>\n<h3>Lze Depsol pou\u017e\u00edt p\u0159i chronick\u00e9 bolesti?<\/h3>\n<p>Ano \u2014 TCA (zejm\u00e9na amitriptylin, nortriptylin a imipramin) v n\u00edzk\u00fdch d\u00e1vk\u00e1ch (10\u201375 mg) jsou prvn\u00ed volbou u diabetick\u00e9 perifern\u00ed neuropatie, postherpetick\u00e9 neuralgie a tenzn\u00edho typu chronick\u00e9 bolesti hlavy. Blok\u00e1da sod\u00edkov\u00fdch kan\u00e1l\u016f je dominantn\u00edm mechanismem. Analgetick\u00fd \u00fa\u010dinek je nez\u00e1visl\u00fd na antidepresivn\u00edm \u00fa\u010dinku a objevuje se d\u0159\u00edve (1\u20132 t\u00fddny).<\/p>\n<h2>Dal\u0161\u00ed l\u00e9ky na du\u0161evn\u00ed zdrav\u00ed<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/spectra\/\">Spectra (Doxepin TCA)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/doxin\/\">Doxin (Doxepin TCA)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/antidep\/\">Antidep (Imipramin TCA)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/flunil\/\">Flunil (Fluoxetine SSRI)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/duvanta\/\">Duvanta (Duloxetine SNRI)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> Tato str\u00e1nka m\u00e1 vzd\u011bl\u00e1vac\u00ed charakter a nenahrazuje individu\u00e1ln\u00ed l\u00e9ka\u0159skou radu. Farmakoterapie du\u0161evn\u00edho zdrav\u00ed by m\u011bla b\u00fdt zah\u00e1jena, monitorov\u00e1na a upravov\u00e1na pod dohledem kvalifikovan\u00e9ho l\u00e9ka\u0159e. Pokud vy nebo n\u011bkdo, koho zn\u00e1te, pro\u017e\u00edv\u00e1 sebevra\u017eednou krizi, okam\u017eit\u011b kontaktujte m\u00edstn\u00ed z\u00e1chrann\u00e9 slu\u017eby nebo volejte linku prevence sebevra\u017ed ve va\u0161\u00ed zemi (USA\/Kanada: 988; UK: Samaritans 116 123; mezin\u00e1rodn\u00ed seznam: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Depsol (Imipramin 25 mg) \u2014 prvn\u00ed generace TCA pro depresi, paniku, enur\u00e9zu, neuropatickou bolest. Analgetick\u00fd \u00fa\u010dinek v n\u00edzk\u00fdch d\u00e1vk\u00e1ch od 1\u20132 t\u00fddn\u016f.<\/p>","protected":false},"featured_media":57596,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4332,4333],"class_list":{"0":"post-57595","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-depsol","10":"product_tag-imipramine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57595"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57596"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57595"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57595"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57595"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}