<\/p>\n
Inmecin-R<\/strong> je 75 mg sustained-release indomethacin capsule<\/strong>, a convenient once- or twice-daily form of one of the most potent non-selective NSAIDs in clinical use. It is used for chronic inflammatory arthritis<\/strong>, particularly rheumatoid arthritis, ankylosing spondylitis, and prolonged gout management. Typical adult dose is one 75 mg SR capsule once or twice daily with food<\/strong>. Indomethacin has a stronger CNS and GI profile than ibuprofen — use the lowest effective dose for the shortest reasonable time.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Inmecin-R 75 mg<\/strong> is a sustained-release (SR) oral capsule of indomethacin<\/strong>. The SR formulation spreads the release of the 75 mg dose over 8–12 hours, giving steadier blood levels and simpler once- or twice-daily dosing than the immediate-release 25\/50 mg capsule (Inmecin), which must be taken three times a day.<\/p>\n Inmecin-R is typically chosen when a patient needs chronic indomethacin therapy for an inflammatory spondyloarthropathy, chronic gout, or persistent inflammatory arthritis, and adherence to TDS dosing is difficult. The total daily dose of 75–150 mg is similar to that used with immediate-release indomethacin.<\/p>\n Indomethacin is a non-selective NSAID<\/strong> — it blocks both COX-1<\/strong> (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2<\/strong> (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.<\/p>\n The therapeutic chain of events is the same for every NSAID:<\/p>\n Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.<\/p>\n Swallow the SR capsule whole with water, with or after food. Do not open, crush, or chew<\/strong> — this destroys the sustained-release action and converts a 12-hour dose into an immediate burst, raising both GI and CNS risk.<\/p>\n Once-daily dosing is usually taken in the morning with breakfast. Twice-daily dosing should be spaced about 12 hours apart (e.g. 8 a.m. and 8 p.m., both with food).<\/p>\n GI safety — read this before the first dose.<\/strong> Every NSAID, including Inmecin-R, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Inmecin-R s j\u00eddlem<\/em>, use the lowest effective dose for the shortest reasonable time<\/em>, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.<\/p>\n<\/div>\n Indomethacin-specific cautions:<\/strong><\/p>\n All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.<\/p>\n NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors\/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.<\/p>\n The SR formulation does not eliminate indomethacin’s characteristic side effects — it smooths out plasma peaks but the total daily exposure is similar.<\/p>\n MedsBase nab\u00edz\u00ed celosv\u011btovou dopravu pro ka\u017edou objedn\u00e1vku. Objedn\u00e1vky jsou odes\u00edl\u00e1ny v diskr\u00e9tn\u00edch obalech a dod\u00e1v\u00e1ny v origin\u00e1ln\u00edch v\u00fdrobn\u00edch balen\u00edch. Pokud je po\u017eadovan\u00e1 s\u00edla nebo velikost balen\u00ed nedostupn\u00e1, kontaktujte z\u00e1kaznickou podporu pro odhad dodac\u00ed lh\u016fty.<\/p>\n Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. NSAIDs have well-documented gastrointestinal, cardiovascular, and renal risks — please talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, or are pregnant.<\/p>\n<\/div>\n Inmecin-R (indomethacin 75 mg SR) is used for chronic inflammatory conditions — rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis with significant inflammation, and chronic gout maintenance.<\/p>\n Same molecule (indomethacin), different formulation. Inmecin-R 75 mg is sustained release, dosed once or twice daily. Inmecin 25\/50 mg is immediate release, dosed three times a day. SR is more convenient for chronic therapy.<\/p>\n Indomethacin is first-line for acute gout, but the immediate-release<\/em> form (Inmecin 50 mg TDS) is usually preferred for rapid symptom control in the first 48–72 hours. Inmecin-R is more appropriate for chronic gout maintenance or when a patient is already on SR therapy.<\/p>\n No. The sustained-release pellets inside the capsule rely on an intact coating to release gradually. Opening, crushing, or chewing causes an immediate-release dump of 75 mg, which greatly increases side-effect risk.<\/p>\n Pain relief typically starts within 1–2 hours of the first dose; maximum anti-inflammatory benefit builds over 1–2 weeks of regular dosing.<\/p>\n Always take it with food or milk. Never on an empty stomach — gastric irritation is the most common reason patients drop out.<\/p>\n In ankylosing spondylitis, regular NSAID therapy (including indomethacin SR) may slow radiographic progression. Long-term use should be paired with a proton pump inhibitor for GI protection and regular monitoring of blood pressure, kidney function, and liver enzymes.<\/p>\n Avoid alcohol or limit to occasional light use. Alcohol increases GI bleed risk with any NSAID and can worsen dizziness and drowsiness.<\/p>\n No — contraindicated in the third trimester (risk of premature ductus arteriosus closure). Avoid in early pregnancy unless specifically supervised.<\/p>\n Lithium (levels rise), methotrexate (toxicity), ACE inhibitors + diuretics (kidney injury), anticoagulants and SSRIs (bleed risk), antihypertensives (blood-pressure effects blunted). Share your full medication list with your prescriber.<\/p>\n Test your own response first. Dizziness or drowsiness are common in the first few days; do not drive until you know how it affects you.<\/p>\n <\/p>\n Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n \u2705 Relieves Inflammation Inmecin-R contains Indomethacin.<\/p>","protected":false},"featured_media":57613,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3920,3555],"product_tag":[4335,4336],"class_list":{"0":"post-57612","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-gout-treatment","9":"product_cat-pain-relief-medication","10":"product_tag-indomethacin","11":"product_tag-inmecin-r","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57612"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57613"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57612"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57612"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57612"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
What Is Inmecin-R Used For?<\/h2>\n
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How Does Indomethacin Work?<\/h2>\n
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Inmecin-R Dosing<\/h2>\n
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Who Should Not Take Inmecin-R?<\/h2>\n
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Kardiovaskul\u00e1rn\u00ed riziko<\/h3>\n
Renal (kidney) safety<\/h3>\n
Side Effects of Inmecin-R<\/h2>\n
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Objedn\u00e1vky a dod\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
What is Inmecin-R used for?<\/h3>\n
How is Inmecin-R different from Inmecin?<\/h3>\n
Is Inmecin-R good for acute gout flares?<\/h3>\n
Can I open the Inmecin-R capsule?<\/h3>\n
How long does Inmecin-R take to work?<\/h3>\n
Can I take Inmecin-R with food?<\/h3>\n
Is Inmecin-R safe long-term?<\/h3>\n
Can I drink alcohol on Inmecin-R?<\/h3>\n
Is Inmecin-R safe in pregnancy?<\/h3>\n
What drug interactions should I know about?<\/h3>\n
Can I drive on Inmecin-R?<\/h3>\n
Souvisej\u00edc\u00ed alternativy<\/h3>\n
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\n\u2705 Eases Pain
\n\u2705 Reduces Swelling
\n\u2705 Treats Arthritis
\n\u2705 Manages Gout<\/p>\n