{"id":57618,"date":"2024-02-27T17:52:50","date_gmt":"2024-02-27T17:52:50","guid":{"rendered":"https:\/\/medsname.com\/inmecin\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"inmecin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/inmecin\/","title":{"rendered":"Inmecin"},"content":{"rendered":"

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⚡ Quick Answer — What is Inmecin?<\/h3>\n

Inmecin<\/strong> je indomethacin capsule<\/strong> dostupn\u00fd v 25 mg and 50 mg<\/strong> strengths. Indomethacin is one of the most potent non-selective NSAIDs and is first-line for acute gout, pericarditis, ankylosing spondylitis, and Bartter syndrome<\/strong>. The usual adult dose is 25–50 mg two to three times daily with food<\/strong>. Indomethacin has a stronger CNS side-effect profile (headache, dizziness) than ibuprofen or diclofenac, and should be used at the lowest effective dose for the shortest reasonable time.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Inmecin<\/strong> is an immediate-release oral capsule containing indomethacin<\/strong>, a powerful non-selective NSAID developed in 1963. Indomethacin is on the WHO Essential Medicines List and remains the gold-standard oral NSAID for several specific indications where its unusually strong anti-inflammatory effect outweighs its relatively higher side-effect burden compared to newer NSAIDs.<\/p>\n

K dispozici jsou dv\u011b s\u00edly kapsl\u00ed:<\/p>\n

    \n
  • Inmecin 25 mg<\/strong> — starting and maintenance dose, especially in older patients<\/li>\n
  • Inmecin 50 mg<\/strong> — for more severe inflammatory pain; acute gout and pericarditis commonly need this strength<\/li>\n<\/ul>\n

    What Is Inmecin Used For?<\/h2>\n
      \n
    • Akutn\u00ed dna<\/strong> — gold-standard oral NSAID for a gout flare; higher-dose 50 mg TID for 2–3 days then taper<\/li>\n
    • Rheumatoid arthritis and osteoarthritis<\/strong> — when other NSAIDs are inadequate<\/li>\n
    • Ankylozuj\u00edc\u00ed spondylitida<\/strong> — first-line NSAID in many guidelines<\/li>\n
    • Pericarditis<\/strong> — a first-line oral NSAID, usually combined with colchicine<\/li>\n
    • Reactive arthritis, psoriatic arthritis<\/strong> — inflammatory spondyloarthritides<\/li>\n
    • Pseudogout (calcium pyrophosphate deposition)<\/strong> — acute flare<\/li>\n
    • Patent ductus arteriosus (PDA) closure in neonates<\/strong> — hospital setting only<\/li>\n
    • Bartter syndrome and Gitelman syndrome<\/strong> — to reduce renal prostaglandin overproduction<\/li>\n
    • Prim\u00e1rn\u00ed dysmenorea<\/strong> — second-line<\/li>\n<\/ul>\n

      How Does Indomethacin Work?<\/h2>\n

      Indomethacin is a neselektivn\u00ed NSAID<\/strong> \u2014 blokuje jak COX-1<\/strong> (kter\u00fd udr\u017euje \u017ealude\u010dn\u00ed sliznici, funkci krevn\u00edch desti\u010dek a prokrven\u00ed ledvin), tak COX-2<\/strong> (kter\u00fd je zv\u00fd\u0161en\u011b exprimov\u00e1n v m\u00edstech z\u00e1n\u011btu). Toto \u0161irok\u00e9 p\u016fsoben\u00ed vysv\u011btluje jak jeho siln\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek, tak jeho dob\u0159e zn\u00e1m\u00fd profil gastrointestin\u00e1ln\u00edch a ren\u00e1ln\u00edch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/p>\n

      Terapeutick\u00fd \u0159et\u011bzec ud\u00e1lost\u00ed je u v\u0161ech NSAID stejn\u00fd:<\/p>\n

        \n
      1. Po\u0161kozen\u00ed tk\u00e1n\u011b nebo z\u00e1n\u011bt uvol\u0148uje fosfolipidy z bun\u011b\u010dn\u00fdch membr\u00e1n<\/li>\n
      2. Fosfolip\u00e1za A\u2082 je p\u0159em\u011b\u0148uje na kyselinu arachidonovou<\/li>\n
      3. Cyklooxygen\u00e1za (COX-1\/COX-2) p\u0159em\u011b\u0148uje kyselinu arachidonovou na prostaglandiny<\/strong> \u2014 molekuly zodpov\u011bdn\u00e9 za bolest, otok a hore\u010dku<\/li>\n
      4. Indomethacin blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation<\/li>\n<\/ol>\n

        Proto\u017ee prostaglandiny tak\u00e9 chr\u00e1n\u00ed \u017ealude\u010dn\u00ed sliznici, reguluj\u00ed pr\u016ftok krve ledvinami a ovliv\u0148uj\u00ed funkci krevn\u00edch desti\u010dek, stejn\u00fd mechanismus, kter\u00fd zm\u00edr\u0148uje bolest, je tak\u00e9 zodpov\u011bdn\u00fd za hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky NSAID: podr\u00e1\u017ed\u011bn\u00ed \u017ealudku, zadr\u017eov\u00e1n\u00ed tekutin, vysok\u00fd krevn\u00ed tlak a (u n\u011bkter\u00fdch jedinc\u016f) z\u00e1t\u011b\u017e ledvin.<\/p>\n

        Inmecin Dosing<\/h2>\n
          \n
        • Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis:<\/strong> 25 mg two or three times daily; may increase to 50 mg TID if needed. Maximum 200 mg\/day (rarely justified).<\/li>\n
        • Akutn\u00ed dna:<\/strong> 50 mg three times daily for 2 days, then 25 mg TID for a further 2–3 days, then stop.<\/li>\n
        • Pericarditis:<\/strong> 25–50 mg three times daily for 2 weeks, tapering thereafter, alongside colchicine.<\/li>\n
        • Primary dysmenorrhoea:<\/strong> 25 mg three times daily from onset of pain for 2–3 days.<\/li>\n<\/ul>\n

          Always take with food or an antacid to reduce gastric irritation. Swallow capsules whole with a full glass of water. Do not lie down for at least 15 minutes after a dose (reduces oesophageal irritation).<\/p>\n

          Because indomethacin has a 4-hour half-life, three-times-daily dosing is standard. For a simpler once-daily or twice-daily schedule, a sustained-release formulation such as Inmecin-R 75 mg<\/strong> is available.<\/p>\n

          \n

          GI bezpecnost \u2014 precist pred prvnim uzitim.<\/strong> Every NSAID, including Inmecin, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Inmecin s j\u00eddlem<\/em>, pouzijte nejnizsi ucinnou davku po nejkratsi rozumne dlouhou dobu<\/em>, a zeptejte se lekare na predpis inhibitoru protonove pumpy (omeprazol, pantoprazol), pokud ho potrebujete dele nez 2\u20134 tydny.<\/p>\n<\/div>\n

          Who Should Not Take Inmecin?<\/h2>\n
            \n
          • Known hypersensitivity to Indomethacin or any NSAID<\/li>\n
          • Aktivn\u00ed nebo opakuj\u00edc\u00ed se peptick\u00fd v\u0159ed, krv\u00e1cen\u00ed nebo perforace tr\u00e1vic\u00edho traktu<\/li>\n
          • Astma, kop\u0159ivka nebo rinitida vyvolan\u00e1 aspirinem nebo jin\u00fdm NSAID (\u201caspirinem exacerbovan\u00e9 respira\u010dn\u00ed onemocn\u011bn\u00ed\u201d)<\/li>\n
          • T\u011b\u017ek\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed (NYHA t\u0159\u00edda IV)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater (Child\u2013Pugh C)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed ledvin (CrCl < 30 ml\/min)<\/li>\n
          • T\u0159et\u00ed trimestr t\u011bhotenstv\u00ed (riziko p\u0159ed\u010dasn\u00e9ho uzav\u0159en\u00ed ductus arteriosus a oligohydramnionu)<\/li>\n
          • Ned\u00e1vn\u00e1 operace koron\u00e1rn\u00edho bypassu (CABG) \u2014 absolutn\u00ed kontraindikace pro v\u0161echna NSAID<\/li>\n<\/ul>\n

            Indomethacin-specific cautions:<\/strong><\/p>\n

              \n
            • History of seizures or epilepsy — indomethacin can lower seizure threshold<\/li>\n
            • Psychiatric disorders — can cause confusion, depression, hallucinations (more than other NSAIDs)<\/li>\n
            • Parkinson’s disease — may worsen symptoms<\/li>\n
            • Elderly patients — higher risk of CNS side effects; consider a lower dose or alternative NSAID<\/li>\n<\/ul>\n

              Kardiovaskul\u00e1rn\u00ed riziko<\/h3>\n

              V\u0161echna NSAID (krom\u011b n\u00edzk\u00fdch d\u00e1vek aspirinu) nesou ur\u010dit\u00e9 zv\u00fd\u0161en\u00ed rizika infarktu a mrtvice a mohou zhor\u0161it srde\u010dn\u00ed selh\u00e1n\u00ed. Riziko je z\u00e1visl\u00e9 na d\u00e1vce a d\u00e9lce u\u017e\u00edv\u00e1n\u00ed a je obecn\u011b nejvy\u0161\u0161\u00ed u COX-2 selektivn\u00edch l\u00e1tek a u diklofenaku. Pacienti s prok\u00e1zan\u00fdm ischemick\u00fdm onemocn\u011bn\u00edm srdce, perifern\u00edm arteri\u00e1ln\u00edm onemocn\u011bn\u00edm, mrtvic\u00ed nebo nekontrolovanou hypertenz\u00ed by m\u011bli pou\u017e\u00edvat neselektivn\u00ed NSAID (ibuprofen nebo naproxen) v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce, nebo pokud mo\u017eno m\u00edsto nich paracetamol.<\/p>\n

              Ren\u00e1ln\u00ed (ledvinov\u00e1) bezpe\u010dnost<\/h3>\n

              NSAID sni\u017euj\u00ed produkci ren\u00e1ln\u00edch prostaglandin\u016f, co\u017e m\u016f\u017ee zp\u016fsobit zadr\u017eov\u00e1n\u00ed sol\u00ed a vody, zv\u00fd\u0161en\u00ed krevn\u00edho tlaku a \u2013 u zraniteln\u00fdch pacient\u016f \u2013 akutn\u00ed po\u0161kozen\u00ed ledvin. Mezi vysoce rizikov\u00e9 skupiny pat\u0159\u00ed star\u0161\u00ed pacienti, pacienti u\u017e\u00edvaj\u00edc\u00ed ACE inhibitory\/ARB spolu s diuretiky (tzv. \u201ctrojit\u00fd z\u00e1sah\u201d), dehydratovan\u00ed jedinci (zvracen\u00ed, pr\u016fjem, horko, intenzivn\u00ed cvi\u010den\u00ed) a pacienti s ji\u017e existuj\u00edc\u00edm CKD. P\u0159esta\u0148te u\u017e\u00edvat NSAID a vyhledejte l\u00e9ka\u0159skou kontrolu, pokud se u v\u00e1s objev\u00ed sn\u00ed\u017een\u00fd v\u00fddej mo\u010di, otoky nebo nevysv\u011btlen\u00fd p\u0159\u00edr\u016fstek hmotnosti.<\/p>\n

              Common Side Effects of Inmecin<\/h2>\n

              Indomethacin has a stronger side-effect profile than ibuprofen or diclofenac, particularly in the central nervous system.<\/p>\n

              Velmi \u010dast\u00e9 (>10 %):<\/strong><\/p>\n