{"id":57618,"date":"2024-02-27T17:52:50","date_gmt":"2024-02-27T17:52:50","guid":{"rendered":"https:\/\/medsname.com\/inmecin\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"inmecin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/inmecin\/","title":{"rendered":"Inmecin"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Inmecin?<\/h3>\n

Inmecin<\/strong> je indomethacin tobolka<\/strong> dostupn\u00fd v 25 mg a 50 mg<\/strong> siln\u00e9 protiz\u00e1n\u011btliv\u00e9 \u00fa\u010dinky. Indomethacin pat\u0159\u00ed mezi nejsiln\u011bj\u0161\u00ed neselektivn\u00ed NSAID a je l\u00e9k prvn\u00ed volby u akutn\u00ed dny, perikarditidy, ankylozuj\u00edc\u00ed spondylitidy a Bartterova syndromu<\/strong>. Obvykl\u00e1 d\u00e1vka pro dosp\u011bl\u00e9 je 25\u201350 mg dvakr\u00e1t a\u017e t\u0159ikr\u00e1t denn\u011b s j\u00eddlem<\/strong>. Indomethacin m\u00e1 v\u00fdrazn\u011bj\u0161\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky na CNS (bolesti hlavy, z\u00e1vrat\u011b) ve srovn\u00e1n\u00ed s ibuprofenem nebo diklofenakem a m\u011bl by b\u00fdt pod\u00e1v\u00e1n v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce po co nejkrat\u0161\u00ed dobu.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Inmecin<\/strong> je tobolka s okam\u017eit\u00fdm uvol\u0148ov\u00e1n\u00edm obsahuj\u00edc\u00ed indomethacin<\/strong>, siln\u00e9 neselektivn\u00ed NSAID vyvinut\u00e9 v roce 1963. Indomethacin je na Seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO a z\u016fst\u00e1v\u00e1 zlat\u00fdm standardem mezi peror\u00e1ln\u00edmi NSAID u n\u011bkolika specifick\u00fdch indikac\u00ed, kde jeho neobvykle siln\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek p\u0159eva\u017euje nad relativn\u011b vy\u0161\u0161\u00ed z\u00e1t\u011b\u017e\u00ed ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f ve srovn\u00e1n\u00ed s nov\u011bj\u0161\u00edmi NSAID.<\/p>\n

K dispozici jsou dv\u011b s\u00edly kapsl\u00ed:<\/p>\n

    \n
  • Inmecin 25 mg<\/strong> \u2014 po\u010d\u00e1te\u010dn\u00ed a udr\u017eovac\u00ed d\u00e1vka, zejm\u00e9na u star\u0161\u00edch pacient\u016f<\/li>\n
  • Inmecin 50 mg<\/strong> \u2014 pro siln\u011bj\u0161\u00ed z\u00e1n\u011btliv\u00e9 bolesti; akutn\u00ed dna a perikarditida obvykle vy\u017eaduj\u00ed tuto s\u00edlu<\/li>\n<\/ul>\n

    K \u010demu se Inmecin pou\u017e\u00edv\u00e1?<\/h2>\n
      \n
    • Akutn\u00ed dna<\/strong> \u2014 zlat\u00fd standard mezi peror\u00e1ln\u00edmi NSAID u dnav\u00e9ho z\u00e1chvatu; vy\u0161\u0161\u00ed d\u00e1vka 50 mg t\u0159ikr\u00e1t denn\u011b po dobu 2\u20133 dn\u016f, pot\u00e9 postupn\u011b sni\u017eovat<\/li>\n
    • Revmatoidn\u00ed artritida a osteoartritida<\/strong> \u2014 kdy\u017e jin\u00e1 NSAID nejsou dostate\u010dn\u011b \u00fa\u010dinn\u00e1<\/li>\n
    • Ankylozuj\u00edc\u00ed spondylitida<\/strong> \u2014 NSAID prvn\u00ed volby v mnoha doporu\u010den\u00edch<\/li>\n
    • Perikarditida<\/strong> \u2014 peror\u00e1ln\u00ed NSAID prvn\u00ed volby, obvykle v kombinaci s kolchicinem<\/li>\n
    • Reaktivn\u00ed artritida, psoriatick\u00e1 artritida<\/strong> \u2014 z\u00e1n\u011btliv\u00e9 spondyloartritidy<\/li>\n
    • Pseudodna (depozice kalcium pyrofosf\u00e1tu)<\/strong> \u2014 akutn\u00ed vzplanut\u00ed<\/li>\n
    • Uzav\u0159en\u00ed ductus arteriosus (PDA) u novorozenc\u016f<\/strong> \u2014 pouze v nemocni\u010dn\u00edm prost\u0159ed\u00ed<\/li>\n
    • Bartter\u016fv syndrom a Gitelman\u016fv syndrom<\/strong> \u2014 ke sn\u00ed\u017een\u00ed nadprodukce ren\u00e1ln\u00edch prostaglandin\u016f<\/li>\n
    • Prim\u00e1rn\u00ed dysmenorea<\/strong> \u2014 druh\u00e1 volba<\/li>\n<\/ul>\n

      Jak funguje indometacin?<\/h2>\n

      Indometacin je neselektivn\u00ed NSAID<\/strong> \u2014 blokuje jak COX-1<\/strong> (kter\u00fd udr\u017euje \u017ealude\u010dn\u00ed sliznici, funkci krevn\u00edch desti\u010dek a prokrven\u00ed ledvin), tak COX-2<\/strong> (kter\u00fd je zv\u00fd\u0161en\u011b exprimov\u00e1n v m\u00edstech z\u00e1n\u011btu). Toto \u0161irok\u00e9 p\u016fsoben\u00ed vysv\u011btluje jak jeho siln\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek, tak jeho dob\u0159e zn\u00e1m\u00fd profil gastrointestin\u00e1ln\u00edch a ren\u00e1ln\u00edch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/p>\n

      Terapeutick\u00fd \u0159et\u011bzec ud\u00e1lost\u00ed je u v\u0161ech NSAID stejn\u00fd:<\/p>\n

        \n
      1. Po\u0161kozen\u00ed tk\u00e1n\u011b nebo z\u00e1n\u011bt uvol\u0148uje fosfolipidy z bun\u011b\u010dn\u00fdch membr\u00e1n<\/li>\n
      2. Fosfolip\u00e1za A\u2082 je p\u0159em\u011b\u0148uje na kyselinu arachidonovou<\/li>\n
      3. Cyklooxygen\u00e1za (COX-1\/COX-2) p\u0159em\u011b\u0148uje kyselinu arachidonovou na prostaglandiny<\/strong> \u2014 molekuly zodpov\u011bdn\u00e9 za bolest, otok a hore\u010dku<\/li>\n
      4. Indometacin blokuje COX enzymy, \u010d\u00edm\u017e se sni\u017euje tvorba prostaglandin\u016f, co\u017e vede k men\u0161\u00ed bolesti a z\u00e1n\u011btu<\/li>\n<\/ol>\n

        Proto\u017ee prostaglandiny tak\u00e9 chr\u00e1n\u00ed \u017ealude\u010dn\u00ed sliznici, reguluj\u00ed pr\u016ftok krve ledvinami a ovliv\u0148uj\u00ed funkci krevn\u00edch desti\u010dek, stejn\u00fd mechanismus, kter\u00fd zm\u00edr\u0148uje bolest, je tak\u00e9 zodpov\u011bdn\u00fd za hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky NSAID: podr\u00e1\u017ed\u011bn\u00ed \u017ealudku, zadr\u017eov\u00e1n\u00ed tekutin, vysok\u00fd krevn\u00ed tlak a (u n\u011bkter\u00fdch jedinc\u016f) z\u00e1t\u011b\u017e ledvin.<\/p>\n

        D\u00e1vkov\u00e1n\u00ed Inmecinu<\/h2>\n
          \n
        • Revmatoidn\u00ed artritida, osteoartritida, ankylozuj\u00edc\u00ed spondylitida:<\/strong> 25 mg dvakr\u00e1t a\u017e t\u0159ikr\u00e1t denn\u011b; lze zv\u00fd\u0161it na 50 mg t\u0159ikr\u00e1t denn\u011b p\u0159i pot\u0159eb\u011b. Maxim\u00e1ln\u011b 200 mg\/den (v\u00fdjime\u010dn\u011b od\u016fvodn\u011bno).<\/li>\n
        • Akutn\u00ed dna:<\/strong> 50 mg t\u0159ikr\u00e1t denn\u011b po dobu 2 dn\u016f, pot\u00e9 25 mg t\u0159ikr\u00e1t denn\u011b dal\u0161\u00ed 2\u20133 dny, pot\u00e9 ukon\u010dit.<\/li>\n
        • Perikarditida:<\/strong> 25\u201350 mg t\u0159ikr\u00e1t denn\u011b po dobu 2 t\u00fddn\u016f, s postupn\u00fdm sni\u017eov\u00e1n\u00edm d\u00e1vky, sou\u010dasn\u011b s kolchicinem.<\/li>\n
        • Prim\u00e1rn\u00ed dysmenorea:<\/strong> 25 mg t\u0159ikr\u00e1t denn\u011b od n\u00e1stupu bolesti po dobu 2\u20133 dn\u016f.<\/li>\n<\/ul>\n

          V\u017edy u\u017e\u00edvejte s j\u00eddlem nebo antacidem ke sn\u00ed\u017een\u00ed \u017ealude\u010dn\u00edho podr\u00e1\u017ed\u011bn\u00ed. Polykejte tobolky cel\u00e9 se sklenic\u00ed vody. Nelehejte si minim\u00e1ln\u011b 15 minut po u\u017eit\u00ed (sni\u017euje podr\u00e1\u017ed\u011bn\u00ed j\u00edcnu).<\/p>\n

          Proto\u017ee indometacin m\u00e1 polo\u010das 4 hodiny, standardn\u00ed je d\u00e1vkov\u00e1n\u00ed t\u0159ikr\u00e1t denn\u011b. Pro jednodu\u0161\u0161\u00ed jednou nebo dvakr\u00e1t denn\u011b je k dispozici forma s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm, jako je Inmecin-R 75 mg<\/strong> k dispozici.<\/p>\n

          \n

          GI bezpecnost \u2014 precist pred prvnim uzitim.<\/strong> Ka\u017ed\u00e9 NSAID, v\u010detn\u011b Inmecinu, nese re\u00e1ln\u00e9 riziko gastritidy, peptick\u00e9ho v\u0159edu a krv\u00e1cen\u00ed do horn\u00ed \u010d\u00e1sti tr\u00e1vic\u00edho traktu. Riziko je nejvy\u0161\u0161\u00ed u pacient\u016f nad 65 let, u t\u011bch s p\u0159edchoz\u00edm v\u0159edov\u00fdm onemocn\u011bn\u00edm a u v\u0161ech, kte\u0159\u00ed u\u017e\u00edvaj\u00ed n\u00edzk\u00e9 d\u00e1vky aspirinu, kortikosteroidy, SSRI nebo antikoagulancia. U\u017e\u00edvejte Inmecin s j\u00eddlem<\/em>, pouzijte nejnizsi ucinnou davku po nejkratsi rozumne dlouhou dobu<\/em>, a zeptejte se lekare na predpis inhibitoru protonove pumpy (omeprazol, pantoprazol), pokud ho potrebujete dele nez 2\u20134 tydny.<\/p>\n<\/div>\n

          Kdo by nem\u011bl u\u017e\u00edvat Inmecin?<\/h2>\n
            \n
          • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na indometacin nebo jak\u00e9koli NSAID<\/li>\n
          • Aktivn\u00ed nebo opakuj\u00edc\u00ed se peptick\u00fd v\u0159ed, krv\u00e1cen\u00ed nebo perforace tr\u00e1vic\u00edho traktu<\/li>\n
          • Astma, kop\u0159ivka nebo rinitida vyvolan\u00e1 aspirinem nebo jin\u00fdm NSAID (\u201caspirinem exacerbovan\u00e9 respira\u010dn\u00ed onemocn\u011bn\u00ed\u201d)<\/li>\n
          • T\u011b\u017ek\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed (NYHA t\u0159\u00edda IV)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater (Child\u2013Pugh C)<\/li>\n
          • T\u011b\u017ek\u00e9 po\u0161kozen\u00ed ledvin (CrCl < 30 ml\/min)<\/li>\n
          • T\u0159et\u00ed trimestr t\u011bhotenstv\u00ed (riziko p\u0159ed\u010dasn\u00e9ho uzav\u0159en\u00ed ductus arteriosus a oligohydramnionu)<\/li>\n
          • Ned\u00e1vn\u00e1 operace koron\u00e1rn\u00edho bypassu (CABG) \u2014 absolutn\u00ed kontraindikace pro v\u0161echna NSAID<\/li>\n<\/ul>\n

            Specifick\u00e1 upozorn\u011bn\u00ed pro indometacin:<\/strong><\/p>\n

              \n
            • Historie z\u00e1chvat\u016f nebo epilepsie \u2014 indometacin m\u016f\u017ee sn\u00ed\u017eit pr\u00e1h z\u00e1chvat\u016f<\/li>\n
            • Psychiatrick\u00e9 poruchy \u2014 m\u016f\u017ee zp\u016fsobit zmatenost, deprese, halucinace (\u010dast\u011bji ne\u017e jin\u00e1 NSAID)<\/li>\n
            • Parkinsonova choroba \u2014 m\u016f\u017ee zhor\u0161it p\u0159\u00edznaky<\/li>\n
            • Star\u0161\u00ed pacienti \u2014 vy\u0161\u0161\u00ed riziko ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f na CNS; zva\u017ete ni\u017e\u0161\u00ed d\u00e1vku nebo alternativn\u00ed NSAID<\/li>\n<\/ul>\n

              Kardiovaskul\u00e1rn\u00ed riziko<\/h3>\n

              V\u0161echna NSAID (krom\u011b n\u00edzk\u00fdch d\u00e1vek aspirinu) nesou ur\u010dit\u00e9 zv\u00fd\u0161en\u00ed rizika infarktu a mrtvice a mohou zhor\u0161it srde\u010dn\u00ed selh\u00e1n\u00ed. Riziko je z\u00e1visl\u00e9 na d\u00e1vce a d\u00e9lce u\u017e\u00edv\u00e1n\u00ed a je obecn\u011b nejvy\u0161\u0161\u00ed u COX-2 selektivn\u00edch l\u00e1tek a u diklofenaku. Pacienti s prok\u00e1zan\u00fdm ischemick\u00fdm onemocn\u011bn\u00edm srdce, perifern\u00edm arteri\u00e1ln\u00edm onemocn\u011bn\u00edm, mrtvic\u00ed nebo nekontrolovanou hypertenz\u00ed by m\u011bli pou\u017e\u00edvat neselektivn\u00ed NSAID (ibuprofen nebo naproxen) v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce, nebo pokud mo\u017eno m\u00edsto nich paracetamol.<\/p>\n

              Ren\u00e1ln\u00ed (ledvinov\u00e1) bezpe\u010dnost<\/h3>\n

              NSAID sni\u017euj\u00ed produkci ren\u00e1ln\u00edch prostaglandin\u016f, co\u017e m\u016f\u017ee zp\u016fsobit zadr\u017eov\u00e1n\u00ed sol\u00ed a vody, zv\u00fd\u0161en\u00ed krevn\u00edho tlaku a \u2013 u zraniteln\u00fdch pacient\u016f \u2013 akutn\u00ed po\u0161kozen\u00ed ledvin. Mezi vysoce rizikov\u00e9 skupiny pat\u0159\u00ed star\u0161\u00ed pacienti, pacienti u\u017e\u00edvaj\u00edc\u00ed ACE inhibitory\/ARB spolu s diuretiky (tzv. \u201ctrojit\u00fd z\u00e1sah\u201d), dehydratovan\u00ed jedinci (zvracen\u00ed, pr\u016fjem, horko, intenzivn\u00ed cvi\u010den\u00ed) a pacienti s ji\u017e existuj\u00edc\u00edm CKD. P\u0159esta\u0148te u\u017e\u00edvat NSAID a vyhledejte l\u00e9ka\u0159skou kontrolu, pokud se u v\u00e1s objev\u00ed sn\u00ed\u017een\u00fd v\u00fddej mo\u010di, otoky nebo nevysv\u011btlen\u00fd p\u0159\u00edr\u016fstek hmotnosti.<\/p>\n

              B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky p\u0159\u00edpravku Inmecin<\/h2>\n

              Indomethacin m\u00e1 v\u00fdrazn\u011bj\u0161\u00ed profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f ne\u017e ibuprofen nebo diklofenak, zejm\u00e9na v centr\u00e1ln\u00edm nervov\u00e9m syst\u00e9mu.<\/p>\n

              Velmi \u010dast\u00e9 (>10 %):<\/strong><\/p>\n