{"id":57690,"date":"2024-02-27T17:55:41","date_gmt":"2024-02-27T17:55:41","guid":{"rendered":"https:\/\/medsname.com\/sorbitrate\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"sorbitrate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/sorbitrate\/","title":{"rendered":"Sorbitrate"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Sorbitrate?<\/h3>\n<p style=\"margin:0;\"><strong>Sorbitrate<\/strong> je <strong>isosorbid dinitr\u00e1t (ISDN)<\/strong> tablety dostupn\u00e9 v <strong>5 mg a 10 mg<\/strong> sil. Je to univerz\u00e1ln\u00ed nitr\u00e1t: p\u0159i pod\u00e1n\u00ed <strong>sublingv\u00e1ln\u011b (pod jazyk)<\/strong> \u00fa\u010dinkuje b\u011bhem <strong>2\u20135 minut<\/strong> k p\u0159eru\u0161en\u00ed akutn\u00ed angin\u00f3zn\u00ed ataky; u\u017e\u00edv\u00e1 se <strong>or\u00e1ln\u011b<\/strong> poskytuje st\u0159edn\u011bdobou profylaxi. Standardn\u00ed profylaktick\u00e1 d\u00e1vka p\u0159i peror\u00e1ln\u00edm pod\u00e1n\u00ed je <strong>10\u201320 mg dvakr\u00e1t a\u017e t\u0159ikr\u00e1t denn\u011b<\/strong> s asymetrick\u00fdm re\u017eimem pro zachov\u00e1n\u00ed 8\u201312 hodinov\u00e9ho intervalu bez nitr\u00e1t\u016f.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<p><strong>Sorbitrate<\/strong> obsahuje <strong>isosorbid dinitr\u00e1t (ISDN)<\/strong>, jeden z nejd\u00e9le pou\u017e\u00edvan\u00fdch nitr\u00e1tov\u00fdch l\u00e9k\u016f v kardiologii. ISDN byl poprv\u00e9 zaveden v 60. letech 20. stolet\u00ed a st\u00e1le je na Seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO pro l\u00e9\u010dbu anginy pectoris. Ka\u017ed\u00e1 tableta Sorbitrate je formulov\u00e1na tak, aby byla stejn\u011b vhodn\u00e1 pro sublingv\u00e1ln\u00ed pou\u017eit\u00ed (pro rychl\u00fd n\u00e1stup \u00fa\u010dinku) i pro peror\u00e1ln\u00ed pod\u00e1n\u00ed (pro pl\u00e1novanou profylaxi) \u2014 tato flexibilita z n\u00ed u\u010dinila pil\u00ed\u0159 antiangin\u00f3zn\u00ed terapie po v\u00edce ne\u017e p\u011bt desetilet\u00ed.<\/p>\n<p>Samotn\u00fd ISDN je v j\u00e1trech metabolizov\u00e1n na dva aktivn\u00ed metabolity: <strong>isosorbid-2-mononitr\u00e1t<\/strong> a <strong>isosorbid-5-mononitr\u00e1t<\/strong>. Metabolit 5-mononitr\u00e1t je \u00fa\u010dinn\u011bj\u0161\u00ed a d\u00e9le p\u016fsob\u00edc\u00ed slo\u017eka, kter\u00e1 zaji\u0161\u0165uje ISDN jeho 4\u20136 hodinovou dobu \u00fa\u010dinku p\u0159i peror\u00e1ln\u00edm pod\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">K \u010demu se Sorbitrate pou\u017e\u00edv\u00e1?<\/h2>\n<p>Sorbitrate m\u00e1 t\u0159i odli\u0161n\u00e9 klinick\u00e9 pou\u017eit\u00ed, kter\u00e9 by m\u011bl ka\u017ed\u00fd pacient zn\u00e1t:<\/p>\n<h3 class=\"wp-block-heading\">1. Akutn\u00ed z\u00e1chvat anginy pectoris (sublingv\u00e1ln\u00ed pod\u00e1n\u00ed)<\/h3>\n<p>5mg tableta um\u00edst\u011bn\u00e1 pod jazyk se rozpou\u0161t\u00ed a je absorbov\u00e1na p\u0159\u00edmo p\u0159es \u00fastn\u00ed sliznici, obch\u00e1z\u00ed tak prvn\u00ed pr\u016fchod j\u00e1try. N\u00e1stup \u00fa\u010dinku je za 2\u20135 minut, vrchol \u00fa\u010dinku za 15\u201320 minut a doba trv\u00e1n\u00ed 1\u20132 hodiny. Toto je hlavn\u00ed \u201cz\u00e1chrann\u00e9\u201d pou\u017eit\u00ed ISDN a je z\u00e1kladem l\u00e9\u010dby akutn\u00ed anginy pectoris tam, kde nen\u00ed k dispozici sublingv\u00e1ln\u00ed nitroglycerin.<\/p>\n<h3 class=\"wp-block-heading\">2. Profylaxe chronick\u00e9 anginy pectoris (pravideln\u00e9 peror\u00e1ln\u00ed pod\u00e1v\u00e1n\u00ed)<\/h3>\n<p>Tableta 10\u201320 mg u\u017e\u00edvan\u00e1 2 a\u017e 3kr\u00e1t denn\u011b na asymetrick\u00e9m rozvrhu poskytuje trvalou ochranu proti angin\u011b pectoris b\u011bhem dne. P\u0159\u00edklad rozvrhu: 8 hod., 13 hod., 18 hod. \u2014 pot\u00e9 nic p\u0159es noc, aby se zabr\u00e1nilo vzniku tolerance.<\/p>\n<h3 class=\"wp-block-heading\">3. Srde\u010dn\u00ed selh\u00e1n\u00ed (kombinovan\u00e1 terapie)<\/h3>\n<p>ISDN v kombinaci s hydralazinem m\u00e1 d\u016fkazn\u00ed z\u00e1kladnu v l\u00e9\u010db\u011b srde\u010dn\u00edho selh\u00e1n\u00ed se sn\u00ed\u017eenou ejek\u010dn\u00ed frakc\u00ed, zejm\u00e9na u pacient\u016f africk\u00e9ho p\u016fvodu (studie A-HeFT). Toto je specializovan\u00e1 indikace.<\/p>\n<h2 class=\"wp-block-heading\">Jak funguj\u00ed nitr\u00e1ty?<\/h2>\n<p>V\u0161echna nitr\u00e1tov\u00e1 l\u00e9\u010diva maj\u00ed stejn\u00fd z\u00e1kladn\u00ed mechanismus \u00fa\u010dinku. Po vst\u0159eb\u00e1n\u00ed jsou enzymaticky p\u0159em\u011bn\u011bny na <strong>oxid dusnat\u00fd (NO)<\/strong> uvnit\u0159 bun\u011bk hladk\u00e9ho svalstva c\u00e9v. NO aktivuje guanyl\u00e1tcykl\u00e1zu, \u010d\u00edm\u017e zvy\u0161uje intracelul\u00e1rn\u00ed cGMP a uvol\u0148uje hladk\u00e9 svalstvo c\u00e9v. Klinick\u00e9 \u00fa\u010dinky jsou:<\/p>\n<ul>\n<li><strong>\u017diln\u00ed dilatace<\/strong> (dominantn\u00ed p\u0159i n\u00edzk\u00fdch d\u00e1vk\u00e1ch) \u2014 sni\u017euje \u017eiln\u00ed n\u00e1vrat k srdci, \u010d\u00edm\u017e se sni\u017euje <em>p\u0159edt\u00ed\u017een\u00ed<\/em>. Takto nitr\u00e1ty sni\u017euj\u00ed spot\u0159ebu kysl\u00edku myokardem.<\/li>\n<li><strong>Arteri\u00e1ln\u00ed dilatace<\/strong> (vy\u0161\u0161\u00ed d\u00e1vky) \u2014 sni\u017euje syst\u00e9movou c\u00e9vn\u00ed rezistenci a <em>dot\u00ed\u017een\u00ed<\/em>, co\u017e d\u00e1le sni\u017euje srde\u010dn\u00ed pr\u00e1ci.<\/li>\n<li><strong>Dilatace koron\u00e1rn\u00edch tepen<\/strong> \u2014 zlep\u0161uje pr\u016ftok krve do ischemick\u00fdch oblast\u00ed srde\u010dn\u00edho svalu, zejm\u00e9na p\u0159i koron\u00e1rn\u00edm spasmu.<\/li>\n<\/ul>\n<p>V\u00fdsledn\u00fdm efektem je m\u00e9n\u011b bolest\u00ed na hrudi, m\u00e9n\u011b angin\u00f3zn\u00edch epizod a lep\u0161\u00ed tolerance z\u00e1t\u011b\u017ee u pacient\u016f se stabiln\u00ed ischemickou chorobou srde\u010dn\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Nitr\u00e1tov\u00e1 tolerance \u2014 kritick\u00e9 d\u00e1vkovac\u00ed pravidlo<\/h2>\n<p>Nitr\u00e1tov\u00e1 tolerance je nejd\u016fle\u017eit\u011bj\u0161\u00edm konceptem pro ka\u017ed\u00e9ho pacienta u\u017e\u00edvaj\u00edc\u00edho nitr\u00e1ty. Pokud se nitr\u00e1t pod\u00e1v\u00e1 nep\u0159etr\u017eit\u011b \u2013 s konstantn\u00ed hladinou v krvi 24 hodin denn\u011b \u2013 antiangin\u00f3zn\u00ed \u00fa\u010dinek se vytr\u00e1c\u00ed b\u011bhem 48 a\u017e 72 hodin. Jedn\u00e1 se o dob\u0159e zdokumentovan\u00fd, reprodukovateln\u00fd farmakologick\u00fd jev, nikoli o domn\u011bl\u00fd efekt.<\/p>\n<p>\u0158e\u0161en\u00ed je jednoduch\u00e9 a nezpochybniteln\u00e9: ka\u017ed\u00fd 24hodinov\u00fd cyklus mus\u00ed zahrnovat <strong>nitr\u00e1tov\u00fd interval alespo\u0148 8\u201312 hodin<\/strong>, obvykle p\u0159es noc. Standardn\u00ed strategie jsou:<\/p>\n<ul>\n<li>Asymetrick\u00e9 d\u00e1vkov\u00e1n\u00ed dvakr\u00e1t denn\u011b (nap\u0159. v 7 hodin r\u00e1no a ve 3 hodiny odpoledne, pot\u00e9 nic a\u017e do n\u00e1sleduj\u00edc\u00edho r\u00e1na)<\/li>\n<li>Jednou denn\u011b pod\u00e1van\u00e9 tablety s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm navr\u017een\u00e9 tak, aby udr\u017eovaly n\u00edzkou hladinu<\/li>\n<li>Odstran\u011bn\u00ed transderm\u00e1ln\u00ed n\u00e1plasti po 12\u201314 hodin\u00e1ch no\u0161en\u00ed<\/li>\n<\/ul>\n<p>Nep\u0159est\u00e1vejte <em>ne<\/em> nep\u0159id\u00e1vejte dal\u0161\u00ed d\u00e1vky \u201cp\u0159ed span\u00edm\u201d nebo b\u011bhem noci, pokud v\u00e1m l\u00e9ka\u0159 v\u00fdslovn\u011b nep\u0159edep\u00ed\u0161e nep\u0159etr\u017eitou terapii z konkr\u00e9tn\u00edho d\u016fvodu.<\/p>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed Sorbitrate<\/h2>\n<p><strong>Akutn\u00ed angina pectoris (sublingv\u00e1ln\u00ed):<\/strong><\/p>\n<ul>\n<li>P\u0159i prvn\u00edch zn\u00e1mk\u00e1ch bolesti na hrudi se posa\u010fte<\/li>\n<li>Um\u00edst\u011bte <strong>jednu tabletu Sorbitrate 5 mg pod jazyk<\/strong> a nechte ji rozpustit \u2014 nepolykejte ji celou<\/li>\n<li>Pokud bolest neustoup\u00ed do 5 minut, lze u\u017e\u00edt druhou tabletu<\/li>\n<li>Pokud bolest p\u0159etrv\u00e1v\u00e1 i po t\u0159et\u00ed d\u00e1vce (celkem 15 minut), volejte z\u00e1chrannou slu\u017ebu \u2014 m\u016f\u017ee se jednat o infarkt myokardu<\/li>\n<\/ul>\n<p><strong>Pl\u00e1novan\u00e1 peror\u00e1ln\u00ed profylaxe:<\/strong><\/p>\n<ul>\n<li><strong>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka:<\/strong> 10 mg peror\u00e1ln\u011b 2\u20133kr\u00e1t denn\u011b<\/li>\n<li><strong>Udr\u017eovac\u00ed l\u00e9\u010dba:<\/strong> 10\u201340 mg na d\u00e1vku; titrovat podle kontroly p\u0159\u00edznak\u016f<\/li>\n<li><strong>Maxim\u00e1ln\u00ed d\u00e1vka:<\/strong> 120 mg\/den v rozd\u011blen\u00fdch d\u00e1vk\u00e1ch (z\u0159\u00eddka pot\u0159ebn\u00e9)<\/li>\n<li><strong>Na\u010dasov\u00e1n\u00ed:<\/strong> 8 hod., 13 hod. a 18 hod. je b\u011b\u017en\u00fd asymetrick\u00fd re\u017eim. Nikdy ned\u00e1vejte d\u00e1vku po 18 hod., pokud to nedoporu\u010d\u00ed l\u00e9ka\u0159<\/li>\n<li><strong>Potrava:<\/strong> Lze u\u017e\u00edvat s j\u00eddlem i bez j\u00eddla; j\u00eddlo m\u00edrn\u011b oddaluje vrchol \u00fa\u010dinku, ale nesni\u017euje celkovou absorpci<\/li>\n<\/ul>\n<p>Peror\u00e1ln\u00ed tablety by se m\u011bly polykat cel\u00e9. Pokud chcete rychl\u00fd sublingv\u00e1ln\u00ed \u00fa\u010dinek, nechte tabletu rozpustit pod jazykem bez polyk\u00e1n\u00ed \u2014 nerozkous\u00e1vejte ji.<\/p>\n<h2 class=\"wp-block-heading\">Kdo by nem\u011bl u\u017e\u00edvat Sorbitrate?<\/h2>\n<p>Existuje jedna absolutn\u00ed kontraindikace, kterou mus\u00ed ka\u017ed\u00fd pacient pochopit p\u0159ed prvn\u00ed d\u00e1vkou:<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:16px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>Nikdy nekombinujte \u017e\u00e1dn\u00fd nitr\u00e1t s inhibitorem PDE5.<\/strong> Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra) a avanafil (Stendra) zesiluj\u00ed vazodilata\u010dn\u00ed \u00fa\u010dinek nitr\u00e1t\u016f a mohou zp\u016fsobit \u017eivot ohro\u017euj\u00edc\u00ed hypotenzi, kolaps, c\u00e9vn\u00ed mozkovou p\u0159\u00edhodu nebo infarkt myokardu. Po\u010dkejte alespo\u0148 <strong>24 hodiny po pod\u00e1n\u00ed sildenafilu\/vardenafilu<\/strong> a <strong>48 hodin po pod\u00e1n\u00ed tadalafilu<\/strong> ne\u017e u\u017eijete jakoukoli d\u00e1vku nitr\u00e1tu. Toto plat\u00ed pro v\u0161echny formy \u2013 peror\u00e1ln\u00ed, sublingv\u00e1ln\u00ed, transderm\u00e1ln\u00ed a sprej.<\/p>\n<\/div>\n<p>Dal\u0161\u00ed d\u016fle\u017eit\u00e9 kontraindikace:<\/p>\n<ul>\n<li>T\u011b\u017ek\u00e1 hypotenze nebo hypovol\u00e9mie (systolick\u00fd TK &lt; 90 mmHg)<\/li>\n<li>T\u011b\u017ek\u00e1 an\u00e9mie (nitr\u00e1ty mohou zhor\u0161it dod\u00e1vku kysl\u00edku do tk\u00e1n\u00ed)<\/li>\n<li>Hypertrofick\u00e1 obstruk\u010dn\u00ed kardiomyopatie (HOCM) \u2013 nitr\u00e1ty mohou zhor\u0161it v\u00fdtokovou obstrukci<\/li>\n<li>T\u011b\u017ek\u00e1 aort\u00e1ln\u00ed sten\u00f3za \u2013 riziko synkopy<\/li>\n<li>Zv\u00fd\u0161en\u00fd nitrolebn\u00ed tlak nebo ned\u00e1vn\u00e9 poran\u011bn\u00ed hlavy<\/li>\n<li>Infarkt prav\u00e9 komory \u2013 preload je z\u00e1sadn\u00ed, nitr\u00e1ty jej sni\u017euj\u00ed<\/li>\n<li>Konstriktivn\u00ed perikarditida nebo srde\u010dn\u00ed tampon\u00e1da<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na organick\u00e9 nitr\u00e1ty<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed stimul\u00e1tor\u016f solubiln\u00ed guanyl\u00e1tcykl\u00e1zy (riociguat)<\/li>\n<\/ul>\n<p>Pou\u017e\u00edvejte opatrn\u011b v t\u011bhotenstv\u00ed (kategorie C) a konzultujte s odborn\u00edkem. P\u0159i kojen\u00ed je ob\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed obecn\u011b p\u0159ijateln\u00e9, ale rutinn\u00ed terapii by m\u011bl posoudit kardiolog.<\/p>\n<h2 class=\"wp-block-heading\">B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky Sorbitrate<\/h2>\n<p>V\u011bt\u0161ina ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f nitr\u00e1t\u016f je p\u0159\u00edm\u00fdm d\u016fsledkem jejich vazodilata\u010dn\u00edho \u00fa\u010dinku a obvykle ustupuje b\u011bhem prvn\u00edch 1\u20132 t\u00fddn\u016f l\u00e9\u010dby.<\/p>\n<p><strong>Velmi \u010dast\u00e9 (&gt;10 % pacient\u016f):<\/strong><\/p>\n<ul>\n<li><strong>Bolest hlavy<\/strong> \u2014 pulzuj\u00edc\u00ed, \u010deln\u00ed bolesti, \u010dasto nejhor\u0161\u00ed v prvn\u00edch dnech. Paracetamol je bezpe\u010dn\u00fd. Bolest hlavy obvykle ustoup\u00ed b\u011bhem 7\u201314 dn\u016f, jak si t\u011blo zvyk\u00e1; je <em>ne<\/em> zn\u00e1mkou p\u0159ed\u00e1vkov\u00e1n\u00ed.<\/li>\n<li>Z\u00e1vrat\u011b nebo mot\u00e1n\u00ed hlavy, zejm\u00e9na p\u0159i postaven\u00ed<\/li>\n<li>Z\u010derven\u00e1n\u00ed obli\u010deje<\/li>\n<\/ul>\n<p><strong>B\u011b\u017en\u00e9 (1\u201310 %):<\/strong><\/p>\n<ul>\n<li>Postur\u00e1ln\u00ed hypotenze<\/li>\n<li>Reflexn\u00ed tachykardie (zrychlen\u00fd srde\u010dn\u00ed tep)<\/li>\n<li>Nevolnost, ob\u010dasn\u00e9 zvracen\u00ed<\/li>\n<li>Ko\u017en\u00ed vyr\u00e1\u017eka (\u010dast\u011bj\u0161\u00ed u transderm\u00e1ln\u00ed n\u00e1plasti)<\/li>\n<\/ul>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9, ale d\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li>Synkopa (mdloby) \u2014 obvykle po prvn\u00ed d\u00e1vce, p\u0159i postaven\u00ed nebo po alkoholu<\/li>\n<li>Paradoxn\u00ed zhor\u0161en\u00ed anginy pectoris \u2014 vz\u00e1cn\u00e9; vyhledejte neodkladn\u00e9 vy\u0161et\u0159en\u00ed<\/li>\n<li>Methemoglobinemie \u2014 velmi vz\u00e1cn\u00e9 p\u0159i dlouhodob\u00e9 vysokod\u00e1vkov\u00e9 terapii<\/li>\n<\/ul>\n<p>Okam\u017eit\u011b p\u0159eru\u0161te u\u017e\u00edv\u00e1n\u00ed l\u00e9ku a neodkladn\u011b kontaktujte l\u00e9ka\u0159e, pokud se objev\u00ed siln\u00e1 nebo p\u0159etrv\u00e1vaj\u00edc\u00ed bolest hlavy, mdloby, puch\u00fd\u0159ovit\u00e1 vyr\u00e1\u017eka nebo modrav\u00e9 zbarven\u00ed rt\u016f a k\u016f\u017ee.<\/p>\n<h2 class=\"wp-block-heading\">Sorbitrate vs Isosorbidmononitr\u00e1t (Monit)<\/h2>\n<p>Isosorbidmononitr\u00e1t (ISMN) \u2014 nap\u0159\u00edklad <strong>Monit<\/strong> \u2014 je aktivn\u00ed 5-mononitr\u00e1tov\u00fd metabolit ISDN. Od Sorbitrate se li\u0161\u00ed dv\u011bma klinicky v\u00fdznamn\u00fdmi zp\u016fsoby:<\/p>\n<ul>\n<li><strong>Biologick\u00e1 dostupnost:<\/strong> ISMN m\u00e1 100% peror\u00e1ln\u00ed biologickou dostupnost (\u017e\u00e1dn\u00fd jatern\u00ed first-pass efekt), zat\u00edmco biologick\u00e1 dostupnost ISDN je asi 25%. ISMN poskytuje p\u0159edv\u00eddateln\u011bj\u0161\u00ed hladiny v krvi.<\/li>\n<li><strong>Sublingv\u00e1ln\u00ed pod\u00e1n\u00ed:<\/strong> ISMN nen\u00ed <em>ne<\/em> \u00fa\u010dinn\u00fd sublingv\u00e1ln\u011b \u2014 mus\u00ed b\u00fdt spolknut. ISDN (Sorbitrate) je jedine\u010dn\u011b u\u017eite\u010dn\u00fd v obou form\u00e1ch.<\/li>\n<\/ul>\n<p>Pro z\u00e1chrannou terapii a flexibilitu z\u016fst\u00e1v\u00e1 ISDN\/Sorbitrate prvn\u00ed volbou. Pro jednoduchou profylaxi jednou\/dvakr\u00e1t denn\u011b se \u010dasto vol\u00ed ISMN\/Monit.<\/p>\n<h2 class=\"wp-block-heading\">Objedn\u00e1vky a dod\u00e1n\u00ed<\/h2>\n<p>MedsBase nab\u00edz\u00ed celosv\u011btovou dopravu na ka\u017edou objedn\u00e1vku. Objedn\u00e1vky jsou odes\u00edl\u00e1ny v diskr\u00e9tn\u00edm balen\u00ed a p\u0159ich\u00e1zej\u00ed v origin\u00e1ln\u00edch balen\u00edch v\u00fdrobce. Peptidy a v\u011bt\u0161ina generick\u00fdch kardiovaskul\u00e1rn\u00edch l\u00e9k\u016f jsou skladem v r\u016fzn\u00fdch sil\u00e1ch; pokud je v\u00e1mi po\u017eadovan\u00e9 balen\u00ed vyprod\u00e1no, kontaktujte z\u00e1kaznickou podporu pro odhad dod\u00e1n\u00ed.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:20px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> Informace na t\u00e9to str\u00e1nce slou\u017e\u00ed pouze pro obecn\u00e9 vzd\u011bl\u00e1n\u00ed. Nejsou n\u00e1hradou za rady va\u0161eho l\u00e9ka\u0159e nebo kardiologa. Nitr\u00e1ty jsou siln\u00e9 kardiovaskul\u00e1rn\u00ed l\u00e9ky se zn\u00e1m\u00fdmi z\u00e1va\u017en\u00fdmi interakcemi. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou l\u00e9\u010dby se pora\u010fte s kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem a vyhledejte okam\u017eitou l\u00e9ka\u0159skou pomoc, pokud je bolest na hrudi nov\u00e1, siln\u011bj\u0161\u00ed nebo trv\u00e1 d\u00e9le ne\u017e 10\u201315 minut.<\/p>\n<\/div>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">M\u016f\u017ee se Sorbitrate pou\u017e\u00edt k zastaven\u00ed z\u00e1chvatu anginy pectoris?<\/h3>\n<p>Ano. 5 mg tableta um\u00edst\u011bn\u00e1 pod jazyk (sublingv\u00e1ln\u011b) se vst\u0159eb\u00e1 za 2\u20135 minut a m\u016f\u017ee zastavit akutn\u00ed z\u00e1chvat. To je jeden ze dvou hlavn\u00edch \u00fa\u010del\u016f Sorbitrate.<\/p>\n<h3 class=\"wp-block-heading\">Jak dlouho bych m\u011bl \u010dekat mezi sublingv\u00e1ln\u00edmi d\u00e1vkami Sorbitrate p\u0159i z\u00e1chvatu?<\/h3>\n<p>P\u0159i prvn\u00edch p\u0159\u00edznac\u00edch bolesti si sedn\u011bte, vlo\u017ete jednu tabletu 5 mg pod jazyk a vy\u010dkejte 5 minut. Pokud bolest p\u0159etrv\u00e1v\u00e1, u\u017eijte druhou tabletu. Po t\u0159et\u00ed tablet\u011b bez \u00falevy \u2013 celkem 15 minut \u2013 volejte z\u00e1chrannou slu\u017ebu. P\u0159etrv\u00e1vaj\u00edc\u00ed bolest d\u00e9le ne\u017e 15 minut m\u016f\u017ee signalizovat infarkt myokardu.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Sorbitrate spole\u010dn\u011b se sildenafilem, tadalafilem nebo vardenafilem?<\/h3>\n<p>Ne. Tato kombinace m\u016f\u017ee zp\u016fsobit \u017eivot ohro\u017euj\u00edc\u00ed hypotenzi. Po sildenafilu\/vardenafilu vy\u010dkejte 24 hodin a po tadalafilu 48 hodin p\u0159ed jakoukoli d\u00e1vkou Sorbitrate.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00fd je rozd\u00edl mezi sublingv\u00e1ln\u00edm a peror\u00e1ln\u00edm u\u017e\u00edv\u00e1n\u00edm Sorbitrate?<\/h3>\n<p>Sublingv\u00e1ln\u00ed: rozpus\u0165te pod jazykem, n\u00e1stup \u00fa\u010dinku za 2\u20135 minut, trv\u00e1n\u00ed 1\u20132 hodiny \u2013 pro akutn\u00ed pou\u017eit\u00ed. Peror\u00e1ln\u00ed: polkn\u011bte cel\u00e9, n\u00e1stup \u00fa\u010dinku za 30\u201345 minut, trv\u00e1n\u00ed 4\u20136 hodin \u2013 pro pl\u00e1novanou profylaxi.<\/p>\n<h3 class=\"wp-block-heading\">Vytvo\u0159\u00edm si na Sorbitrate toleranci?<\/h3>\n<p>Ano, pokud u\u017e\u00edv\u00e1te peror\u00e1ln\u00ed ISDN nep\u0159etr\u017eit\u011b. Tolerance se vyvine b\u011bhem 48\u201372 hodin. Pro prevenci pou\u017e\u00edvejte asymetrick\u00fd re\u017eim s 8\u201312 hodinami bez dusi\u010dnan\u016f p\u0159es noc. P\u0159\u00edle\u017eitostn\u00e9 sublingv\u00e1ln\u00ed u\u017e\u00edv\u00e1n\u00ed p\u0159i z\u00e1chvatech toleranci nezp\u016fsobuje.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d m\u00e1m po Sorbitrate bolesti hlavy?<\/h3>\n<p>Cerebr\u00e1ln\u00ed vazodilatace zp\u016fsobuje pulzuj\u00edc\u00ed bolest \u010dela, zejm\u00e9na v prvn\u00edm t\u00fddnu. Obvykle sama odezn\u00ed. Paracetamol je bezpe\u010dn\u00fd. P\u0159etrv\u00e1vaj\u00edc\u00ed siln\u00e1 bolest hlavy je d\u016fvodem k revizi d\u00e1vkov\u00e1n\u00ed nebo p\u0159echodu na ISMN.<\/p>\n<h3 class=\"wp-block-heading\">Jak dlouho mohu Sorbitrate u\u017e\u00edvat?<\/h3>\n<p>Des\u00edtky let. ISDN se klinicky pou\u017e\u00edv\u00e1 od 60. let 20. stolet\u00ed. Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed je bezpe\u010dn\u00e9 za p\u0159edpokladu dodr\u017eov\u00e1n\u00ed bezdusi\u010dnanov\u00e9ho intervalu a pravideln\u00fdch kontrol pacienta.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m pl\u00e1novanou peror\u00e1ln\u00ed d\u00e1vku?<\/h3>\n<p>U\u017eijte ji, jakmile si vzpomenete, pokud nen\u00ed dal\u0161\u00ed d\u00e1vka napl\u00e1nov\u00e1na do 2 hodin \u2013 pak ji vynechejte. Nikdy ned\u00e1vejte dvojn\u00e1sobnou d\u00e1vku.<\/p>\n<h3 class=\"wp-block-heading\">Mohu Sorbitrate n\u00e1hle vysadit?<\/h3>\n<p>Ne. N\u00e1hl\u00e9 vysazen\u00ed pravideln\u00e9 nitr\u00e1tov\u00e9 terapie m\u016f\u017ee vyvolat rebound koron\u00e1rn\u00ed vazospazmus a zhor\u0161en\u00ed anginy pectoris. Jak\u00e9koli vysazov\u00e1n\u00ed by m\u011blo b\u00fdt pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Sorbitrate?<\/h3>\n<p>M\u00edrn\u00e9 pit\u00ed alkoholu s j\u00eddlem je obvykle v po\u0159\u00e1dku. Alkohol je vazodilat\u00e1tor a m\u016f\u017ee zes\u00edlit hypotenzi, zejm\u00e9na v prvn\u00ed hodin\u011b po u\u017eit\u00ed d\u00e1vky. Vyhn\u011bte se nadm\u011brn\u00e9mu pit\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Je Sorbitrate bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p>ISDN je podle FDA kategorie C. M\u016f\u017ee b\u00fdt u\u017e\u00edv\u00e1n v t\u011bhotenstv\u00ed, pokud p\u0159\u00ednos jasn\u011b p\u0159eva\u017euje nad rizikem, ale rutinn\u00ed u\u017e\u00edv\u00e1n\u00ed se nedoporu\u010duje. Kojen\u00ed: data jsou omezen\u00e1; proberte s kardiologem.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/app-up\/\">App-Up<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/elocon-cream\/\">Elocon Cream<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sertima\/\">Sertima<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/p-nolol\/\">P-Nolol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/duovir-n\/\">Duovir N<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Ulevuje od anginy pectoris<br \/>\n\u2705 Vazodilata\u010dn\u00ed \u00fa\u010dinek<br \/>\n\u2705 Zlep\u0161uje pr\u016ftok krve<br \/>\n\u2705 Sni\u017euje bolesti na hrudi<br \/>\n\u2705 Peror\u00e1ln\u00ed l\u00e9k<\/p>\n<p>Sorbitrate obsahuje isosorbid.<\/p>","protected":false},"featured_media":57691,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260],"product_tag":[3881,4349],"class_list":{"0":"post-57690","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_tag-isosorbide","10":"product_tag-sorbitrate","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57690","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57690"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57691"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57690"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57690"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57690"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}