{"id":57719,"date":"2024-02-27T17:57:19","date_gmt":"2024-02-27T17:57:19","guid":{"rendered":"https:\/\/medsname.com\/itrotab\/"},"modified":"2026-04-30T10:24:23","modified_gmt":"2026-04-30T10:24:23","slug":"itrotab","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/itrotab\/","title":{"rendered":"Itrotab"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 20px;margin:18px 0;border-radius:6px;\">\n<h3 style=\"margin-top:0;\">\ud83d\udca1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\">Itrotab is itraconazole 100 mg \/ 200 mg oral tablet \u2014 a triazole antifungal for dermatophyte nail and skin infections, oropharyngeal\/oesophageal candidiasis, histoplasmosis, blastomycosis, and aspergillosis (alternative to voriconazole). Capsule absorption requires gastric acid \u2014 take with food and acidic drink; PPIs and H2-blockers reduce absorption substantially. Strong CYP3A4 inhibitor \u2014 many drug interactions. Mandatory ECG \/ heart-failure screening \u2014 itraconazole has a negative inotropic effect.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f5f5;border:1px solid #e1e1e1;padding:18px 22px;margin:24px 0;border-radius:8px;display:flex;flex-wrap:wrap;justify-content:space-around;gap:16px;align-items:center;font-size:0.95em;\">\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udfed<br \/><strong>WHO-GMP<\/strong><br \/>certifikovan\u00fd v\u00fdrobce<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83d\udce6<br \/><strong>Diskr\u00e9tn\u00ed balen\u00ed<\/strong><br \/>oby\u010dejn\u00e1 ob\u00e1lka<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udf0d<br \/><strong>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/strong><br \/>do v\u011bt\u0161iny zem\u00ed<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\u2b50<br \/><strong>1 400+ z\u00e1kazn\u00edk\u016f<\/strong><br \/><a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a><\/div>\n<\/div>\n<h2>\ud83d\udd12 Why order Itrotab from MedsBase<\/h2>\n<ul>\n<li><strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2014 dod\u00e1v\u00e1no z regulovan\u00e9ho za\u0159\u00edzen\u00ed, kompletn\u00ed balen\u00ed s \u010d\u00edslem \u0161ar\u017ee a datem expirace.<\/li>\n<li><strong>Diskr\u00e9tn\u00ed balen\u00ed<\/strong> \u2014 oby\u010dejn\u00e1 ob\u00e1lka, bez uveden\u00ed n\u00e1zvu l\u00e9ku na vn\u011bj\u0161\u00ed stran\u011b.<\/li>\n<li><strong>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/strong> do v\u011bt\u0161iny zem\u00ed s <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a>.<\/li>\n<li><strong>V\u011brnostn\u00ed body<\/strong> \u2014 1 bod za ka\u017ed\u00fd utracen\u00fd 1$ (neplat\u00ed pro peptidy\/dopravu); 100 bod\u016f = 5$ sleva na dal\u0161\u00ed objedn\u00e1vku.<\/li>\n<\/ul>\n<h2 id=\"uses\">Pou\u017eit\u00ed a indikace<\/h2>\n<p>Itrotab (itraconazole 100 mg \/ 200 mg, Pulse Pharmaceuticals) is a broad-spectrum triazole antifungal active against dermatophytes, yeasts (Candida), dimorphic fungi (Histoplasma, Blastomyces, Sporothrix, Paracoccidioides), and most Aspergillus species. The capsule is the standard oral formulation; a separate oral solution exists with different food-rules (taken on an empty stomach) and is the preferred form for oesophageal candidiasis.<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Indikace<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typick\u00e9 d\u00e1vkov\u00e1n\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomyk\u00f3za (nehty na nohou)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Pulzn\u00ed re\u017eim: 200 mg dvakr\u00e1t denn\u011b \u00d7 1 t\u00fdden m\u011bs\u00ed\u010dn\u011b, opakovat \u00d7 3 pulzy (nebo kontinu\u00e1ln\u011b 200 mg\/denn\u011b \u00d7 12 t\u00fddn\u016f)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomyk\u00f3za (nehty na rukou)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Pulzn\u00ed re\u017eim: 200 mg dvakr\u00e1t denn\u011b \u00d7 1 t\u00fdden m\u011bs\u00ed\u010dn\u011b \u00d7 2 pulzy<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea pedis\/cruris\/corporis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">100 mg\/denn\u011b \u00d7 15 dn\u00ed NEBO 200 mg\/denn\u011b \u00d7 7 dn\u00ed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Pityriasis versicolor<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg\/den \u00d7 7 dn\u00ed<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Orofarynge\u00e1ln\u00ed kandid\u00f3za<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">100\u2013200 mg\/den \u00d7 7\u201314 dn\u00ed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Histoplazm\u00f3za \/ blastomyk\u00f3za<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg dvakr\u00e1t denn\u011b \u00d7 6\u201312 m\u011bs\u00edc\u016f (indukce amfotericinem B u t\u011b\u017ek\u00e9ho onemocn\u011bn\u00ed)<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Aspergil\u00f3za (po vorikonazolu \/ amfotericinu B)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg dvakr\u00e1t denn\u011b, d\u00e9lka pod\u00e1v\u00e1n\u00ed z\u00e1vis\u00ed na odpov\u011bdi<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"how-to-take\">Jak u\u017e\u00edvat \u2014 pravidlo absorpce je d\u016fle\u017eit\u00e9<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:20px 0;border-radius:6px;\"><strong>Absorpce kapsl\u00ed je z\u00e1visl\u00e1 na kysel\u00e9m prost\u0159ed\u00ed<\/strong><\/p>\n<div>U\u017e\u00edvejte itrakonazolov\u00e9 kapsle s pln\u00fdm j\u00eddlem A s kysel\u00fdm n\u00e1pojem (kola, pomeran\u010dov\u00fd d\u017eus). Kysel\u00e9 prost\u0159ed\u00ed je nutn\u00e9 k rozpu\u0161t\u011bn\u00ed obalu kapsle. PPI (omeprazol, pantoprazol) a H2-blok\u00e1tory (famotidin, ranitidin) <strong>sni\u017euj\u00ed absorpci na polovinu<\/strong>. Pokud mus\u00edte pokra\u010dovat v terapii potla\u010duj\u00edc\u00ed kyselost, u\u017e\u00edvejte itrakonazol s kolou; zva\u017ete p\u0159echod na peror\u00e1ln\u00ed roztok (u\u017e\u00edvan\u00fd nala\u010dno) nebo na alternativn\u00ed azol (flukonazol, vorikonazol).<\/div>\n<\/div>\n<ul>\n<li>Polykejte cel\u00e9 \u2014 nedr\u0165te ani ne\u017ev\u00fdkejte.<\/li>\n<li>U\u017e\u00edvejte ve stejnou dobu ka\u017ed\u00fd den pro udr\u017een\u00ed stabiln\u00ed hladiny v krvi.<\/li>\n<li>Nep\u0159eru\u0161ujte p\u0159ed\u010dasn\u011b \u2014 pulzn\u00ed terapie onychomyk\u00f3zy vy\u017eaduje v\u0161ech 3 pulzy, i kdy\u017e neht\u016fm trv\u00e1 m\u011bs\u00edce, ne\u017e vypadaj\u00ed norm\u00e1ln\u011b.<\/li>\n<li>Pokud u\u017e\u00edv\u00e1te antacidum, odd\u011blte pod\u00e1n\u00ed alespo\u0148 o 2 hodiny.<\/li>\n<\/ul>\n<h2 id=\"mechanism\">Jak to funguje<\/h2>\n<p>Itrakonazol inhibuje houbov\u00fd CYP51 (14-\u03b1-demethyl\u00e1zu), \u010d\u00edm\u017e blokuje p\u0159em\u011bnu lanosterolu na ergosterol a oslabuje bun\u011b\u010dnou membr\u00e1nu hub. Ve srovn\u00e1n\u00ed s flukonazolem je itrakonazol lipofiln\u011bj\u0161\u00ed \u2013 koncentruje se v k\u016f\u017ei, nehtech a tukov\u00e9 tk\u00e1ni v koncentrac\u00edch 4\u201310\u00d7 vy\u0161\u0161\u00edch ne\u017e v plazm\u011b a p\u0159etrv\u00e1v\u00e1 v nehtov\u00e9m l\u016f\u017eku t\u00fddny po pod\u00e1n\u00ed. To je d\u016fvod, pro\u010d pulzn\u00ed d\u00e1vkov\u00e1n\u00ed funguje u onychomyk\u00f3zy: sta\u010d\u00ed 1 t\u00fdden pod\u00e1v\u00e1n\u00ed m\u011bs\u00ed\u010dn\u011b, proto\u017ee l\u00e9k z\u016fst\u00e1v\u00e1 v nehtu.<\/p>\n<h2 id=\"side-effects\">Ne\u017e\u00e1douc\u00ed \u00fa\u010dinky &amp; monitorov\u00e1n\u00ed<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Frekvence<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typick\u00e9 \u00fa\u010dinky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u010cast\u00e9 (\u22651\/100)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Nevolnost, bolesti b\u0159icha, pr\u016fjem, bolest hlavy, p\u0159echodn\u00e9 zv\u00fd\u0161en\u00ed jatern\u00edch test\u016f, vyr\u00e1\u017eka, perifern\u00ed ed\u00e9m<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">M\u00e9n\u011b \u010dast\u00e9<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hypokal\u00e9mie, z\u00e1vrat\u011b, menstrua\u010dn\u00ed poruchy, alopecie, parestezie<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hepatotoxicita (FDA black-box: p\u0159eru\u0161it l\u00e9\u010dbu p\u0159i \u017eloutence, tmav\u00e9 mo\u010di, p\u0159etrv\u00e1vaj\u00edc\u00ed nevolnosti), m\u011bstnav\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed (FDA black-box: vyvarovat se u symptomatick\u00e9 dysfunkce lev\u00e9 komory), z\u00e1va\u017en\u00e9 ko\u017en\u00ed reakce (SJS\/TEN), perifern\u00ed neuropatie, ztr\u00e1ta sluchu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:20px 0;border-radius:6px;\"><strong>Varov\u00e1n\u00ed p\u0159ed srde\u010dn\u00edm selh\u00e1n\u00edm (FDA black-box)<\/strong><\/p>\n<div>Itrakonazol m\u00e1 d\u00e1vkov\u011b z\u00e1visl\u00fd negativn\u011b inotropn\u00ed \u00fa\u010dinek. Nepod\u00e1vejte itrakonazol pacient\u016fm se sou\u010dasn\u00fdm nebo minul\u00fdm m\u011bstnav\u00fdm srde\u010dn\u00edm selh\u00e1n\u00edm nebo ventrikul\u00e1rn\u00ed dysfunkc\u00ed, pokud p\u0159\u00ednos jasn\u011b nep\u0159ev\u00e1\u017e\u00ed riziko a pacient je monitorov\u00e1n pro p\u0159\u00edznaky CHF (du\u0161nost, otoky nohou, p\u0159\u00edr\u016fstek hmotnosti, \u00fanava). U onychomyk\u00f3zy je itrakonazol kontraindikov\u00e1n u pacient\u016f s prok\u00e1zanou ventrikul\u00e1rn\u00ed dysfunkc\u00ed.<\/div>\n<\/div>\n<h2 id=\"interactions\">L\u00e9kov\u00e9 interakce \u2013 itrakonazol je siln\u00fd inhibitor CYP3A4<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">L\u00e9k<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u00da\u010dinek<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u00da\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">PPI \/ H2-blok\u00e1tory \/ antacida<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Sni\u017euj\u00ed absorpci tobolek<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">U\u017e\u00edvejte s colou; nebo pou\u017eijte peror\u00e1ln\u00ed roztok; nebo p\u0159eru\u0161te kyselou supresi<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Rifampicin \/ rifabutin \/ fenytoin \/ karbamazepin \/ fenobarbital<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Indukce CYP3A4 \u2192 n\u00edzk\u00e9 hladiny itrakonazolu<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Vyhn\u011bte se kombinaci \u2013 zm\u011b\u0148te t\u0159\u00eddu antimykotik<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Simvastatin \/ atorvastatin \/ lovastatin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Zv\u00fd\u0161en\u00ed hladin statin\u016f \u2192 rhabdomyol\u00fdza<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">P\u0159eru\u0161it u\u017e\u00edv\u00e1n\u00ed statinu b\u011bhem l\u00e9\u010dby itrakonazolem; nebo p\u0159ej\u00edt na pravastatin\/rosuvastatin<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Chinidin, dofetilid, pimozid, cisaprid, terfenadin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Prodlou\u017een\u00ed QT intervalu \u2192 torsade de pointes<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Kontraindikov\u00e1no<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Midazolam (peror\u00e1ln\u00ed), triazolam, alprazolam<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Nadm\u011brn\u00e1 sedace<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Vyvarovat se; pou\u017e\u00edt lorazepam (ne-CYP)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tacrolimus \/ cyklosporin \/ sirolimus<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hladiny stoupaj\u00ed \u2014 toxicita<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Sn\u00ed\u017eit d\u00e1vku o 50%; monitorovat hladinu<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Warfarin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Vzestup INR<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitorovat INR; sn\u00ed\u017eit warfarin<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Vinkov\u00e9 alkaloidy (vinkristin, vinblastin)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Neurotoxicita, ileus<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Vyvarujte se kombinace<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Buprenorfin, fentanyl<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Zv\u00fd\u0161en\u00fd \u00fa\u010dinek opioid\u016f<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Sni\u017ete d\u00e1vku opioid\u016f; sledujte sedaci<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Apixaban, rivaroxaban, edoxaban<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hladiny DOAC stoupaj\u00ed \u2014 krv\u00e1cen\u00ed<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Vyhn\u011bte se kombinaci; p\u0159echodn\u011b pou\u017eijte LMWH<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\">Kdo by nem\u011bl u\u017e\u00edvat itrakonazol<\/h2>\n<ul>\n<li>Symptomatick\u00e9 m\u011bstnav\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed nebo ventrikul\u00e1rn\u00ed dysfunkce (zejm\u00e9na pro indikaci onychomyk\u00f3zy).<\/li>\n<li>T\u011bhotenstv\u00ed (teratogenita u zv\u00ed\u0159at, kontraindikov\u00e1no krom\u011b z\u00e1va\u017en\u00fdch syst\u00e9mov\u00fdch myk\u00f3z).<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f prodlu\u017euj\u00edc\u00edch QT interval uveden\u00fdch v\u00fd\u0161e.<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed simvastatinu\/atorvastatinu\/lovastatinu v pln\u00e9 d\u00e1vce.<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed nebo aktivn\u00ed hepatitida.<\/li>\n<\/ul>\n<h2 id=\"pregnancy\">T\u011bhotenstv\u00ed a kojen\u00ed<\/h2>\n<p>Itrakonazol je kontraindikov\u00e1n v t\u011bhotenstv\u00ed pro onychomyk\u00f3zu (ne\u017eivot ohro\u017euj\u00edc\u00ed indikaci). U syst\u00e9mov\u00fdch myk\u00f3z (histoplazm\u00f3za, blastomyk\u00f3za, aspergil\u00f3za) mohou p\u0159\u00ednosy p\u0159ev\u00e1\u017eit rizika \u2014 konzultujte s odborn\u00edkem. B\u011bhem terapie a po dobu 2 m\u011bs\u00edc\u016f po posledn\u00ed d\u00e1vce je nutn\u00e1 \u00fa\u010dinn\u00e1 antikoncepce. Itrakonazol se v mal\u00e9m mno\u017estv\u00ed vylu\u010duje do mate\u0159sk\u00e9ho ml\u00e9ka \u2014 kr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed m\u016f\u017ee b\u00fdt slu\u010diteln\u00e9; dlouhodob\u00e1 udr\u017eovac\u00ed terapie se b\u011bhem kojen\u00ed nedoporu\u010duje.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Za jak dlouho bude m\u016fj nehet vypadat norm\u00e1ln\u011b?<\/h3>\n<p>L\u00e9k odstran\u00ed pl\u00edse\u0148 za 12 t\u00fddn\u016f, ale mrtv\u00fd nehet dor\u016fst\u00e1 je\u0161t\u011b m\u011bs\u00edce. Nehty na nohou vypadaj\u00ed pln\u011b norm\u00e1ln\u011b za 9\u201312 m\u011bs\u00edc\u016f; nehty na rukou za 4\u20136 m\u011bs\u00edc\u016f. Fotografie v m\u011bs\u00edci 0, 3, 6, 12 pomohou objektivn\u011b sledovat pokrok.<\/p>\n<h3>Co je \u2018pulzn\u00ed terapie\u2019 a pro\u010d funguje?<\/h3>\n<p>Itrakonazol se koncentruje v nehtu 4\u201310\u00d7 v\u00edce ne\u017e v plazm\u011b a p\u0159etrv\u00e1v\u00e1 t\u00fddny po pod\u00e1n\u00ed. Pulzn\u00ed terapie = 200 mg dvakr\u00e1t denn\u011b po dobu 1 t\u00fddne, pot\u00e9 3 t\u00fddny pauza, opakovat \u00d7 3. Kumulativn\u00ed \u00fasp\u011b\u0161nost l\u00e9\u010dby u neht\u016f na nohou je ~70%, podobn\u011b jako p\u0159i kontinu\u00e1ln\u00edm pod\u00e1v\u00e1n\u00ed, ale s men\u0161\u00ed expozic\u00ed l\u00e9ku a ni\u017e\u0161\u00edmi n\u00e1klady.<\/p>\n<h3>Pro\u010d m\u016fj l\u00e9ka\u0159 chce EKG p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby?<\/h3>\n<p>Itrakonazol m\u00e1 negativn\u00ed inotropn\u00ed \u00fa\u010dinek a m\u016f\u017ee prodlou\u017eit QT interval. Pacienti s rizikov\u00fdmi faktory (st\u00e1vaj\u00edc\u00ed srde\u010dn\u00ed selh\u00e1n\u00ed, v\u011bk &gt; 70 let, p\u0159edchoz\u00ed kardiotoxick\u00e1 chemoterapie) by m\u011bli m\u00edt v\u00fdchoz\u00ed EKG. Hledejte prodlou\u017een\u00fd QTc &gt; 500 ms \u2014 itrakonazol by se v takov\u00e9m p\u0159\u00edpad\u011b vynechal.<\/p>\n<h3>M\u016f\u017eu u\u017e\u00edvat itrakonazol s omeprazolem?<\/h3>\n<p>Absorpce itrakonazolu v kapsl\u00edch je sn\u00ed\u017eena o 40\u201360% p\u0159i u\u017e\u00edv\u00e1n\u00ed PPI. Bu\u010f: (a) vysa\u010fte PPI b\u011bhem 1t\u00fddenn\u00edho pulzu, (b) u\u017e\u00edvejte itrakonazol s colou pro dod\u00e1n\u00ed kyseliny, nebo (c) p\u0159ejd\u011bte na peror\u00e1ln\u00ed roztok itrakonazolu (jin\u00e1 forma, u\u017e\u00edvan\u00e1 nala\u010dno), nebo (d) pou\u017eijte terbinafin (nevy\u017eaduje kysel\u00e9 prost\u0159ed\u00ed).<\/p>\n<h3>Itrakonazol vs terbinafin na pl\u00eds\u0148ov\u00e9 onemocn\u011bn\u00ed neht\u016f u nohou \u2014 co je lep\u0161\u00ed?<\/h3>\n<p>U dermatofytick\u00e9 onychomyk\u00f3zy (b\u011b\u017en\u00e1 p\u0159\u00ed\u010dina) m\u00e1 terbinafin 250 mg denn\u011b \u00d7 12 t\u00fddn\u016f m\u00edrn\u011b vy\u0161\u0161\u00ed \u00fasp\u011b\u0161nost l\u00e9\u010dby (~76% vs ~63%) a m\u00e9n\u011b l\u00e9kov\u00fdch interakc\u00ed. Pulzn\u00ed itrakonazol je preferov\u00e1n, kdy\u017e je p\u0159\u00ed\u010dina sm\u00ed\u0161en\u00e1 (dermatofyt + nedermatofytn\u00ed pl\u00edse\u0148 nebo Candida) nebo kdy\u017e je terbinafin kontraindikov\u00e1n.<\/p>\n<h3>Spadne mi nehet?<\/h3>\n<p>Ne \u2014 mrtv\u00fd, pl\u00edsn\u00ed posti\u017een\u00fd nehet odr\u016fst\u00e1 od l\u016f\u017eka. Jak nov\u00fd zdrav\u00fd nehet dor\u016fst\u00e1, star\u00e1 zabarven\u00e1 \u010d\u00e1st se postupn\u011b odst\u0159ih\u00e1v\u00e1 b\u011bhem 9\u201312 m\u011bs\u00edc\u016f.<\/p>\n<h3>M\u016f\u017eu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed itrakonazolu?<\/h3>\n<p>Itrakonazol i alkohol zat\u011b\u017euj\u00ed j\u00e1tra. B\u011bhem l\u00e9\u010dby omezte p\u0159\u00edjem alkoholu, zejm\u00e9na b\u011bhem 12t\u00fddenn\u00edho kontinu\u00e1ln\u00edho pod\u00e1v\u00e1n\u00ed. Vyhn\u011bte se \u00fapln\u011b nadm\u011brn\u00e9mu pit\u00ed. Nedoch\u00e1z\u00ed k akutn\u00ed disulfiramov\u00e9 reakci.<\/p>\n<h3>Co t\u011bhotenstv\u00ed, pokud jsem v reproduk\u010dn\u00edm v\u011bku?<\/h3>\n<p>Itrakonazol je teratogenn\u00ed u zv\u00ed\u0159at. Pou\u017e\u00edvejte \u00fa\u010dinnou antikoncepci b\u011bhem l\u00e9\u010dby a 2 m\u011bs\u00edce po posledn\u00ed d\u00e1vce (polo\u010das z k\u016f\u017ee\/neht\u016f je dlouh\u00fd). Onychomyk\u00f3za se b\u011bhem t\u011bhotenstv\u00ed l\u00e9\u010d\u00ed z\u0159\u00eddka \u2014 po\u010dkejte a\u017e po porodu a kojen\u00ed.<\/p>\n<h3>Pro\u010d pot\u0159ebuji jatern\u00ed testy p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby?<\/h3>\n<p>Itraconazol m\u016f\u017ee zp\u016fsobit hepatotoxicitu v\u010detn\u011b vz\u00e1cn\u00fdch fat\u00e1ln\u00edch p\u0159\u00edpad\u016f. V\u00fdchoz\u00ed testy jatern\u00edch funkc\u00ed (LFT) umo\u017e\u0148uj\u00ed odhalit p\u0159edchoz\u00ed abnormality. Opakujte LFT po 1 m\u011bs\u00edci p\u0159i kontinu\u00e1ln\u00ed l\u00e9\u010db\u011b nebo p\u0159i jak\u00fdchkoli zn\u00e1mk\u00e1ch \u017eloutenky\/tmav\u00e9 mo\u010di\/p\u0159etrv\u00e1vaj\u00edc\u00ed nevolnosti. P\u0159eru\u0161te l\u00e9\u010dbu, pokud AST\/ALT &gt; 3\u00d7 ULN.<\/p>\n<h3>Co d\u011blat, kdy\u017e vynech\u00e1m d\u00e1vku b\u011bhem pulzn\u00ed terapie?<\/h3>\n<p>Vezm\u011bte l\u00e9k co nejd\u0159\u00edve, jakmile si vzpomenete tent\u00fd\u017e den. Pokud vynech\u00e1te cel\u00fd den, ned\u00e1vejte dvojn\u00e1sobnou d\u00e1vku \u2013 n\u00e1sleduj\u00edc\u00ed denn\u00ed d\u00e1vka je dosta\u010duj\u00edc\u00ed. Pokud vynech\u00e1te 2+ dny b\u011bhem t\u00fddenn\u00edho pulzu, dokon\u010dete pulz a pokra\u010dujte podle pl\u00e1novan\u00e9ho sch\u00e9matu.<\/p>\n<h2 id=\"storage\">Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte tobolky p\u0159i 15\u201325 \u00b0C v p\u016fvodn\u00edm blistru, chr\u00e1n\u011bn\u00e9 p\u0159ed sv\u011btlem a vlhkost\u00ed. Nepou\u017e\u00edvejte po uplynut\u00ed doby pou\u017eitelnosti. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed antifung\u00e1ln\u00ed l\u00e9ky, kter\u00e9 by v\u00e1s mohly zaj\u00edmat<\/h2>\n<p>If Itrotab is unavailable, here are alternatives \u2014 same molecule from a different manufacturer, terbinafine for straightforward dermatophyte nail\/skin infections, or fluconazole for Candida.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zimig\/\"><strong>Zimig (terbinafin 250 mg)<\/strong><\/a> \u2014 L\u00e9\u010dba prvn\u00ed volby u dermatofytn\u00ed onychomyk\u00f3zy; \u00fasp\u011b\u0161nost l\u00e9\u010dby ~76 %.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sporanox-capsule\/\"><strong>Sporanox (itraconazol 100 mg)<\/strong><\/a> \u2014 Pulzn\u00ed terapie pro nedermatofytn\u00ed pl\u00eds\u0148ov\u00e9 nebo sm\u00ed\u0161en\u00e9 kandidov\u00e9 onychomyk\u00f3zy.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/grisovin-fp\/\"><strong>Grisovin FP (griseofulvin)<\/strong><\/a> \u2014 Tinea capitis zp\u016fsoben\u00e1 Microsporum (pediatrick\u00e9 pou\u017eit\u00ed).<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/loceryl-nail-liq\/\"><strong>Loceryl (amorolfin 5%)<\/strong><\/a> \u2014 Top\u00e1ln\u00ed lak pro m\u00edrn\u00e9 pl\u00eds\u0148ov\u00e9 infekce dist\u00e1ln\u00edho okraje nehtu.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zocon\/\"><strong>Zocon (fluconazol 150 mg)<\/strong><\/a> \u2014 Standardn\u00ed peror\u00e1ln\u00ed terapie pro kandid\u00f3zu (vagin\u00e1ln\u00ed, or\u00e1ln\u00ed, j\u00edcnovou formu).<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 18px;margin:24px 0;font-size:0.95em;\"><strong>Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> Tato str\u00e1nka obsahuje informace o produktu pro dosp\u011bl\u00e9, kte\u0159\u00ed si objedn\u00e1vaj\u00ed antifung\u00e1ln\u00ed l\u00e9ky pro osobn\u00ed pot\u0159ebu. Nenahrazuje individu\u00e1ln\u00ed l\u00e9ka\u0159skou radu. Proberte vhodn\u00e9 antifung\u00e1ln\u00ed l\u00e9\u010divo, d\u00e1vkov\u00e1n\u00ed a d\u00e9lku l\u00e9\u010dby s kvalifikovan\u00fdm l\u00e9ka\u0159em \u2013 zejm\u00e9na pokud m\u00e1te onemocn\u011bn\u00ed jater, jste t\u011bhotn\u00e1 nebo koj\u00edte, u\u017e\u00edv\u00e1te warfarin, statiny, imunosupresiva nebo m\u00e1te pl\u00eds\u0148ovou infekci neht\u016f, kter\u00e1 m\u016f\u017ee b\u00fdt jinou diagn\u00f3zou (psori\u00e1za, lichen planus, trauma).<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Fungal infection treatment<br \/>\n\u2705 Oral antifungal medication<br \/>\n\u2705 Targets skin infections<br \/>\n\u2705 Effectively treats candidiasis<br \/>\n\u2705 Alleviates nail fungus<\/p>\n<p>Itrotab contains Itraconazole<\/p>","protected":false},"featured_media":57720,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[3627,4351],"class_list":{"0":"post-57719","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-itraconazole","11":"product_tag-itrotab","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57719"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57720"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57719"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57719"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57719"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}