{"id":57758,"date":"2024-02-27T17:58:59","date_gmt":"2024-02-27T17:58:59","guid":{"rendered":"https:\/\/medsname.com\/impect\/"},"modified":"2026-04-30T10:24:22","modified_gmt":"2026-04-30T10:24:22","slug":"impect","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/impect\/","title":{"rendered":"Impect"},"content":{"rendered":"

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Quick Answer — What is Impect?<\/h3>\n
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Impect<\/strong> je peror\u00e1ln\u00ed ivermectin 12 mg tablet<\/strong> od Sain Medicaments<\/strong>. Ivermectin je prvn\u00ed volbou podle WHO pro strongyloid\u00f3zu, svrab, v\u0161i a onchocerci\u00e1zu (\u0159\u00ed\u010dn\u00ed slepotu)<\/strong>. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 je 200 \u00b5g\/kg jako jednor\u00e1zov\u00e1 d\u00e1vka, opakovan\u00e1 v den 7\u201314<\/strong> u svrabu. U\u017e\u00edvejte nala\u010dno s vodou.<\/p>\n<\/div>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2713 Zdrojeno od WHO-GMP certifikovan\u00fdch v\u00fdrobc\u016f<\/strong> \u00b7 \u2713 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 \u2713 Doprava do cel\u00e9ho sv\u011bta \u00b7 \u2713 1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/strong> na medsbase.com\/reviews<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

What is Impect?<\/h2>\n

Impect<\/strong> je peror\u00e1ln\u00ed p\u0159\u00edpravek ivermectinu vyr\u00e1b\u011bn\u00fd spole\u010dnost\u00ed Sain Medicaments<\/strong>, dostupn\u00fd v sil\u00e1ch 12 mg<\/strong> . Ivermectin je jedn\u00edm z nejd\u016fle\u017eit\u011bj\u0161\u00edch l\u00e9k\u016f v glob\u00e1ln\u00edm zdravotnictv\u00ed \u2014 Nobelova cena za fyziologii nebo medic\u00ednu v roce 2015 ocenila jeho objevitele (William Campbell & Satoshi \u014cmura) za p\u0159\u00ednos v kontrole \u0159\u00ed\u010dn\u00ed slepoty a lymfatick\u00e9 filari\u00f3zy. Dnes je ivermectin na Modelov\u00e9m seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO a z\u016fst\u00e1v\u00e1 prvn\u00ed volbou u n\u011bkolika lidsk\u00fdch parazit\u00e1rn\u00edch a ektoparazit\u00e1rn\u00edch onemocn\u011bn\u00ed.<\/p>\n

Mechanismus \u2014 jak ivermectin zab\u00edj\u00ed parazity<\/h2>\n

Ivermectin se vyzna\u010duje vysokou afinitou k glutam\u00e1tem \u0159\u00edzen\u00fdm chloridov\u00fdm kan\u00e1l\u016fm<\/strong> v nervov\u00fdch a svalov\u00fdch bu\u0148k\u00e1ch bezobratl\u00fdch. T\u00edm doch\u00e1z\u00ed k otev\u0159en\u00ed kan\u00e1lu, hyperpolarizaci bu\u0148ky a paral\u00fdze parazita. Sav\u010d\u00ed bu\u0148ky postr\u00e1daj\u00ed glutam\u00e1tem \u0159\u00edzen\u00e9 chloridov\u00e9 kan\u00e1ly (nejbli\u017e\u0161\u00edmi p\u0159\u00edbuzn\u00fdmi jsou GABA kan\u00e1ly savc\u016f, ale ivermectin v b\u011b\u017en\u00fdch d\u00e1vk\u00e1ch neproch\u00e1z\u00ed neporu\u0161enou hematoencefalickou bari\u00e9rou), co\u017e vysv\u011btluje \u0161irok\u00e9 bezpe\u010dnostn\u00ed rozp\u011bt\u00ed ivermectinu u lid\u00ed.<\/p>\n

Ivermectin je vysoce lipofiln\u00ed, dosahuje maxim\u00e1ln\u00ed plazmatick\u00e9 koncentrace za 4\u20135 hodin a jeho elimina\u010dn\u00ed polo\u010das je 16\u201328 hodin. V\u011bt\u0161ina l\u00e9\u010diva je vylu\u010dov\u00e1na stolic\u00ed.<\/p>\n

Impect indications<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Strongyloid\u00f3za<\/td>\n200 \u00b5g\/kg jednor\u00e1zov\u00e1 d\u00e1vka<\/td>\nOpakovat za 14 dn\u00ed u imunokompromitovan\u00fdch; preventivn\u00ed screening p\u0159ed pod\u00e1n\u00edm steroid\u016f<\/td>\n<\/tr>\n
Svrab<\/td>\n200 \u00b5g\/kg, opakovat v den 7\u201314<\/td>\nL\u00e9\u010dit v\u0161echny \u010dleny dom\u00e1cnosti sou\u010dasn\u011b; alternativou je topick\u00fd permethrin<\/td>\n<\/tr>\n
V\u0161i hlavov\u00e9<\/td>\n200 \u00b5g\/kg, opakovat v den 7<\/td>\nVhodn\u00e9 p\u0159i selh\u00e1n\u00ed topick\u00fdch pedikulicid\u016f<\/td>\n<\/tr>\n
Onchocerk\u00f3za<\/td>\n150 \u00b5g\/kg jednor\u00e1zov\u00e1 d\u00e1vka, ka\u017ed\u00fdch 6\u201312 m\u011bs\u00edc\u016f<\/td>\nWHO re\u017eim hromadn\u00e9ho pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f<\/td>\n<\/tr>\n
Lymfatick\u00e1 filari\u00f3za<\/td>\n200 \u00b5g\/kg s albendazolem 400 mg<\/td>\nRo\u010dn\u00ed kombinovan\u00e1 terapie MDA<\/td>\n<\/tr>\n
Larva migrans cutanea<\/td>\n200 \u00b5g\/kg jednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n\u010casto jednor\u00e1zov\u00e9 vyl\u00e9\u010den\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Impect dosage — weight-based<\/h2>\n

Ivermektin se d\u00e1vkuje v mno\u017estv\u00ed 200 \u00b5g na kg t\u011blesn\u00e9 hmotnosti<\/strong> pro v\u011bt\u0161inu indikac\u00ed (150 \u00b5g\/kg pro onchocerci\u00e1zu). P\u0159epo\u010det:<\/p>\n\n\n\n\n\n\n\n\n\n\n
T\u011blesn\u00e1 hmotnost<\/th>\nP\u0159ibli\u017en\u00e1 d\u00e1vka<\/th>\nTabletov\u00fd ekvivalent<\/th>\n<\/tr>\n<\/thead>\n
15\u201325 kg<\/td>\n3 mg<\/td>\n1 \u00d7 3 mg<\/td>\n<\/tr>\n
26\u201344 kg<\/td>\n6 mg<\/td>\n1 \u00d7 6 mg nebo 2 \u00d7 3 mg<\/td>\n<\/tr>\n
45\u201364 kg<\/td>\n9 mg<\/td>\n1 \u00d7 6 mg + 1 \u00d7 3 mg<\/td>\n<\/tr>\n
65\u201384 kg<\/td>\n12 mg<\/td>\n1 \u00d7 12 mg<\/td>\n<\/tr>\n
85\u2013104 kg<\/td>\n15 mg<\/td>\n1 \u00d7 12 mg + 1 \u00d7 3 mg<\/td>\n<\/tr>\n
105\u2013120 kg<\/td>\n18 mg<\/td>\n2 \u00d7 6 mg + 2 \u00d7 3 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

U\u017e\u00edvejte nala\u010dno<\/strong> s plnou sklenic\u00ed vody (potrava zvy\u0161uje biologickou dostupnost p\u0159ibli\u017en\u011b 2,5\u00d7, co\u017e m\u016f\u017ee zm\u011bnit bezpe\u010dnostn\u00ed rozp\u011bt\u00ed u pacient\u016f s vysokou mikrofil\u00e1rn\u00ed n\u00e1lo\u017e\u00ed).<\/p>\n

P\u0159edb\u011b\u017en\u00e9 vy\u0161et\u0159en\u00ed na Loa loa (subsaharsk\u00e1 Afrika).<\/strong> U pacient\u016f ze z\u00e1padn\u00ed\/st\u0159edn\u00ed Afriky s mo\u017enou Loa loa<\/em> koinfekc\u00ed m\u016f\u017ee ivermektin vyvolat t\u011b\u017ekou encefalopatii, pokud je mikrofil\u00e1rn\u00ed n\u00e1lo\u017e vysok\u00e1. P\u0159ed l\u00e9\u010dbou je v endemick\u00fdch oblastech povinn\u00fd Nopch test nebo stanoven\u00ed po\u010dtu mikrofili\u00e1ri\u00ed. Mimo Afriku toto nen\u00ed probl\u00e9m.<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n

Ivermektin je obecn\u011b velmi dob\u0159e sn\u00e1\u0161en. Nej\u010dast\u011bj\u0161\u00ed vedlej\u0161\u00ed \u00fa\u010dinky jsou Mazzottiho reakce<\/strong> (hore\u010dka, sv\u011bd\u011bn\u00ed, lymfadenopatie, bolesti kloub\u016f \u2014 zp\u016fsoben\u00e9 odum\u00edraj\u00edc\u00edmi mikrofili\u00e1riemi, nikoli samotn\u00fdm l\u00e9kem) u pacient\u016f s onchocerk\u00f3zou nebo lymfatickou filari\u00e1zou. Dal\u0161\u00ed reakce:<\/p>\n