{"id":57932,"date":"2024-02-27T18:08:00","date_gmt":"2024-02-27T18:08:00","guid":{"rendered":"https:\/\/medsname.com\/letroheal\/"},"modified":"2026-04-30T10:17:01","modified_gmt":"2026-04-30T10:17:01","slug":"letroheal","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/letroheal\/","title":{"rendered":"Letroheal"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Rychl\u00e1 odpov\u011b\u010f<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Letroheal<\/strong> je <strong>letrozol 2.5 mg<\/strong>, vysoce selektivn\u00ed nesteroidn\u00ed <strong>inhibitor aromat\u00e1zy (AI)<\/strong> pou\u017e\u00edvan\u00fd jako prvn\u00ed volba endokrinn\u00ed terapie u <strong>ER+ karcinomu prsu u postmenopauz\u00e1ln\u00edch \u017een<\/strong>, a pro indukci ovulace p\u0159i neplodnosti (mimo schv\u00e1lenou indikaci \u2014 st\u00e1le \u010dast\u011bji prvn\u00ed volba u anovulace souvisej\u00edc\u00ed s PCOS dle ACOG). Potla\u010duje synt\u00e9zu estrogenu p\u0159ibli\u017en\u011b o 98 %.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 Pro\u010d nakupovat na MedsBase:<\/strong> Ov\u011b\u0159en\u00e9 dod\u00e1vky p\u0159\u00edmo od v\u00fdrobce \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 Bezpe\u010dn\u00e9 platby (kreditn\u00ed karta, kryptom\u011bny) \u00b7 Hodnocen\u00ed 4,9\u2605 od 1 400+ z\u00e1kazn\u00edk\u016f\n<\/div>\n<h2><strong>What Is Letroheal?<\/strong><\/h2>\n<p>Letroheal is a branded generic of <strong>letrozol 2.5 mg<\/strong>, inhibitor aromat\u00e1zy t\u0159et\u00ed generace. Letrozol blokuje enzym aromat\u00e1zu, kter\u00fd p\u0159em\u011b\u0148uje androgeny na estrogeny v perifern\u00edch tk\u00e1n\u00edch, \u010d\u00edm\u017e sni\u017euje cirkuluj\u00edc\u00ed estrogen u postmenopauz\u00e1ln\u00edch \u017een p\u0159ibli\u017en\u011b o 98 %. <strong>Letrozol ne\u00fa\u010dinkuje u premenopauz\u00e1ln\u00edch \u017een<\/strong> because it doesn&#8217;t suppress ovarian estrogen production \u2014 premenopausal ER+ breast cancer uses tamoxifen or tamoxifen + ovarian suppression instead. Manufactured by Healing Pharma.<\/p>\n<h2><strong>Klinick\u00e9 pou\u017eit\u00ed<\/strong><\/h2>\n<ul>\n<li><strong>Adjuvantn\u00ed terapie pro ER+ postmenopauz\u00e1ln\u00ed karcinom prsu<\/strong> \u2014 prvn\u00ed linie; typicky 5 let, \u010dasto prodlou\u017eeno na 10.<\/li>\n<li><strong>Pokro\u010dil\u00fd\/metastatick\u00fd karcinom prsu<\/strong> u postmenopauz\u00e1ln\u00edch \u017een (prvn\u00ed nebo druh\u00e1 linie hormon\u00e1ln\u00ed terapie).<\/li>\n<li><strong>Neoadjuvantn\u00ed terapie<\/strong> (p\u0159edopera\u010dn\u00ed) u vybran\u00fdch p\u0159\u00edpad\u016f ER+.<\/li>\n<li><strong>Indukce ovulace u PCOS<\/strong> (mimo indikaci) \u2014 <strong>2,5\u20137,5 mg denn\u011b po dobu 5 dn\u016f<\/strong> za\u010d\u00ednaj\u00edc\u00ed 2.\u20135. den cyklu. Nyn\u00ed prvn\u00ed volba pro anovulaci u PCOS dle ACOG (vy\u0161\u0161\u00ed m\u00edra \u017eiv\u011b narozen\u00fdch d\u011bt\u00ed ve srovn\u00e1n\u00ed s klomifenem ve studii PPCOS II).<\/li>\n<li><strong>Neplodnost spojen\u00e1 s endometri\u00f3zou<\/strong> (mimo indikaci).<\/li>\n<\/ul>\n<h2><strong>Jak u\u017e\u00edvat<\/strong><\/h2>\n<ol>\n<li><strong>Karcinom prsu:<\/strong> 2,5 mg jednou denn\u011b, kontinu\u00e1ln\u011b, s j\u00eddlem nebo bez.<\/li>\n<li><strong>Indukce ovulace:<\/strong> 2,5 mg (po\u010d\u00e1te\u010dn\u00ed d\u00e1vka) nebo 5 mg denn\u011b po dobu 5 dn\u016f, po\u010d\u00ednaje 2., 3., 4. nebo 5. dnem cyklu. Vy\u0161\u0161\u00ed d\u00e1vky (7,5 mg) se pou\u017e\u00edvaj\u00ed p\u0159i absenci odpov\u011bdi. V\u011bt\u0161ina po\u010det\u00ed nast\u00e1v\u00e1 b\u011bhem 3\u20134 cykl\u016f.<\/li>\n<li>U karcinomu prsu: minim\u00e1ln\u011b 5 let; prodlou\u017een\u00e9 pod\u00e1v\u00e1n\u00ed (a\u017e 10 let) p\u0159in\u00e1\u0161\u00ed dal\u0161\u00ed benefit u vybran\u00fdch pacient\u016f.<\/li>\n<li>Vysadit 2\u20134 t\u00fddny p\u0159ed pl\u00e1novanou v\u011bt\u0161\u00ed operac\u00ed kv\u016fli m\u00edrn\u00e9mu trombogenn\u00edmu \u00fa\u010dinku.<\/li>\n<\/ol>\n<h2><strong>Vedlej\u0161\u00ed \u00fa\u010dinky<\/strong><\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> n\u00e1valy horka, artralgie (bolest kloub\u016f \u2014 vyskytuje se u ~30\u201350 %), bolest sval\u016f a kost\u00ed, \u00fanava, nevolnost, bolest hlavy, no\u010dn\u00ed pocen\u00ed.<\/p>\n<p><strong>V\u00fdznamn\u00e9:<\/strong> <strong>\u00fabytek kostn\u00ed hmoty a riziko zlomenin<\/strong> \u2014 letrozol sni\u017euje hustotu kost\u00ed o ~2\u20133 % za 2 roky. DEXA scan na za\u010d\u00e1tku a ka\u017edoro\u010dn\u011b; v\u00e1pn\u00edk + vitamin D; zva\u017ete bisfosfon\u00e1ty u rizikov\u00fdch pacient\u016f.<\/p>\n<p><strong>Specifick\u00e9 pro indukci ovulace:<\/strong> riziko mnoho\u010detn\u00e9ho t\u011bhotenstv\u00ed ~3 % (ni\u017e\u0161\u00ed ne\u017e u klomifenu), ovari\u00e1ln\u00ed hyperstimulace vz\u00e1cn\u00e9.<\/p>\n<p><strong>Z\u00e1va\u017en\u00e9 (vz\u00e1cn\u00e9):<\/strong> kardiovaskul\u00e1rn\u00ed p\u0159\u00edhody, hepatotoxicita, tromboembolie, tendinitida.<\/p>\n<h2><strong>Who Should Not Take Letroheal<\/strong><\/h2>\n<ul>\n<li>Premenopauz\u00e1ln\u00ed \u017eeny k l\u00e9\u010db\u011b karcinomu prsu (ne\u00fa\u010dinn\u00e9; pou\u017eijte tamoxifen nebo tamoxifen + supresi ovari\u00ed)<\/li>\n<li>T\u011bhotenstv\u00ed (u indikace karcinomu prsu) \u2014 teratogenn\u00ed \u00fa\u010dinky<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na letrozol<\/li>\n<\/ul>\n<h2><strong>Interakce s l\u00e9\u010divy<\/strong><\/h2>\n<ul>\n<li><strong>Tamoxifen<\/strong>: sni\u017euje hladiny letrozolu o 37 % \u2014 nem\u011bly by b\u00fdt kombinov\u00e1ny.<\/li>\n<li><strong>Terapie obsahuj\u00edc\u00ed estrogen<\/strong>: antagonizuje letrozol \u2014 vyvarujte se kombinace.<\/li>\n<li>M\u00e1lo dal\u0161\u00edch v\u00fdznamn\u00fdch interakc\u00ed; letrozol je metabolizov\u00e1n p\u0159es CYP3A4 a CYP2A6.<\/li>\n<\/ul>\n<h2><strong>Skladov\u00e1n\u00ed<\/strong><\/h2>\n<p>Skladujte p\u0159i pokojov\u00e9 teplot\u011b (15\u201325 \u00b0C). Uchov\u00e1vejte v p\u016fvodn\u00edm blistru. Chra\u0148te p\u0159ed vlhkost\u00ed a sv\u011btlem.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Je letrozol lep\u0161\u00ed ne\u017e tamoxifen p\u0159i l\u00e9\u010db\u011b rakoviny prsu?<\/h3>\n<p>U postmenopauz\u00e1ln\u00edch \u017een inhibitory aromat\u00e1zy (letrozol, anastrozol, exemestan) poskytuj\u00ed o n\u011bco lep\u0161\u00ed p\u0159e\u017eit\u00ed bez onemocn\u011bn\u00ed ne\u017e samotn\u00fd tamoxifen. Mnoho re\u017eim\u016f pou\u017e\u00edv\u00e1 sekven\u010dn\u00ed l\u00e9\u010dbu tamoxifen \u2192 AI nebo AI \u2192 tamoxifen. U premenopauz\u00e1ln\u00edch \u017een samotn\u00fd letrozol nefunguje \u2014 pou\u017e\u00edv\u00e1 se tamoxifen nebo tamoxifen + potla\u010den\u00ed funkce vaje\u010dn\u00edk\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Jak letrozol pom\u00e1h\u00e1 p\u0159i neplodnosti u PCOS?<\/h3>\n<p>Letrozol potla\u010duje estrogen, co\u017e stimuluje hypotalamus ke zv\u00fd\u0161en\u00ed FSH a podpo\u0159e v\u00fdvoje folikul\u016f. ~85 % pacientek s PCOS ovuluje p\u0159i l\u00e9\u010db\u011b letrozolem, ve srovn\u00e1n\u00ed s ~65 % p\u0159i l\u00e9\u010db\u011b klomifenem. M\u00edra \u017eiv\u011b narozen\u00fdch d\u011bt\u00ed je tak\u00e9 vy\u0161\u0161\u00ed podle studie PPCOS II.<\/p>\n<h3 class=\"wp-block-heading\">Jak dlouho trv\u00e1 ot\u011bhotn\u011bn\u00ed p\u0159i l\u00e9\u010db\u011b letrozolem?<\/h3>\n<p>V\u011bt\u0161ina t\u011bhotenstv\u00ed nast\u00e1v\u00e1 b\u011bhem 3\u20134 cykl\u016f indukce ovulace. Pokud nedojde k \u00fasp\u011bchu po 3\u20136 cyklech, diskutuje se dal\u0161\u00ed vy\u0161et\u0159en\u00ed a eskalace l\u00e9\u010dby (injek\u010dn\u00ed p\u0159\u00edpravky, IVF).<\/p>\n<h3 class=\"wp-block-heading\">A co bolesti kloub\u016f?<\/h3>\n<p>Artralgie je nej\u010dast\u011bj\u0161\u00ed a nejobt\u00ed\u017en\u011bj\u0161\u00ed vedlej\u0161\u00ed \u00fa\u010dinek \u2014 a\u017e u 50 % pacient\u016f. Obvykle nejhor\u0161\u00ed v prvn\u00edch m\u011bs\u00edc\u00edch, pot\u00e9 se stabilizuje. Cvi\u010den\u00ed, hydratace, glukosamin (omezen\u00e9 d\u016fkazy) a NSAID pro symptomatickou \u00falevu. T\u011b\u017ek\u00e1 p\u0159etrv\u00e1vaj\u00edc\u00ed artralgie m\u016f\u017ee vy\u017eadovat p\u0159echod na jin\u00fd AI nebo tamoxifen.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017ee letrozol oslabit m\u00e9 kosti?<\/h3>\n<p>Ano \u2014 zrychlen\u00e1 ztr\u00e1ta kostn\u00ed hmoty je t\u0159\u00eddn\u00edm \u00fa\u010dinkem AI. V\u00fdchoz\u00ed DEXA, v\u00e1pn\u00edk (1200 mg\/den) + vitamin D (800\u20131000 IU), cvi\u010den\u00ed s v\u00e1hou a zva\u017ete bisfosfon\u00e1ty, pokud se objev\u00ed osteopenie\/osteopor\u00f3za.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat letrozol p\u0159i kojen\u00ed?<\/h3>\n<p>Ne \u2014 pro onkologick\u00e9 indikace je to kontraindikov\u00e1no. Pro indukci ovulace se typicky prov\u00e1d\u011bj\u00ed kompletn\u00ed cykly p\u0159ed t\u011bhotenstv\u00edm, ne b\u011bhem n\u011bj.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e mi letrozol zp\u016fsob\u00ed n\u00e1valy horka?<\/h3>\n<p>Velmi \u010dast\u00e9 \u2014 podobn\u00e9 vazomotorick\u00fdm p\u0159\u00edznak\u016fm menopauzy. Pom\u00e1haj\u00ed SSRI (venlafaxin, paroxetin s opatrnost\u00ed), gabapentin a \u00fapravy \u017eivotn\u00edho stylu. Hormon\u00e1ln\u00ed HRT je kontraindikov\u00e1na.<\/p>\n<h3 class=\"wp-block-heading\">Pot\u0159ebuji k p\u0159edeps\u00e1n\u00ed tohoto l\u00e9ku onkologa?<\/h3>\n<p>Pro indikace rakoviny prsu je v\u017edy p\u0159edepisov\u00e1n a monitorov\u00e1n onkologem. Pro indukci ovulace obvykle \u0159\u00edd\u00ed specialista na plodnost (reproduk\u010dn\u00ed endokrinolog) nebo gynekolog.<\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed produkty pro zdrav\u00ed \u017een<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tamodex\/\">Tamodex (Tamoxifen 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tamilong\/\">Tamilong (Tamoxifen 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/etibo\/\">Etibo (Lapatinib 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/duphaston\/\">Duphaston (Dydrogesteron 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/deviry\/\">Deviry (Medroxyprogesteron 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/naprosyn\/\">Naprosyn (Naproxen 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/candid-v-gel\/\">Candid-V Gel (Clotrimazol)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed:<\/strong> Informace maj\u00ed vzd\u011bl\u00e1vac\u00ed charakter a nenahrazuj\u00ed l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli l\u00e9ku, zejm\u00e9na p\u0159i l\u00e9\u010db\u011b rakoviny, hormon\u00e1ln\u00ed terapii a p\u0159edepsan\u00fdch p\u0159\u00edpravc\u00edch, se pora\u010fte s l\u00e9ka\u0159em.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/betnovate-cream\/\">Betnovate kr\u00e9m<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/naprosyn\/\">Naprosyn<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/trental-400\/\">Trental 400<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dexona-injection\/\">Injekce Dexona<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/pirox-dt\/\">Pirox DT<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Treats breast cancer<br \/>\n\u2705 Inhibits estrogen production<br \/>\n\u2705 Prevents cancer recurrence<br \/>\n\u2705 Sni\u017euje velikost n\u00e1doru<br \/>\n\u2705 Contains Letrozole<\/p>\n<p>Letroheal contains Letrozole.<\/p>","protected":false},"featured_media":57933,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223,3502],"product_tag":[4387,4388],"class_list":{"0":"post-57932","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-womens-health","10":"product_tag-letroheal","11":"product_tag-letrozole","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/57932","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=57932"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/57933"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=57932"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=57932"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=57932"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=57932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}