{"id":57949,"date":"2024-02-27T18:09:12","date_gmt":"2024-02-27T18:09:12","guid":{"rendered":"https:\/\/medsname.com\/atarise\/"},"modified":"2026-04-30T10:24:19","modified_gmt":"2026-04-30T10:24:19","slug":"atarise","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/atarise\/","title":{"rendered":"Atarise"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Atarise (Hydroxyzine 10 \/ 25 mg) je sedativn\u00ed antihistaminikum prvn\u00ed generace s centr\u00e1ln\u00edm anxiolytick\u00fdm \u00fa\u010dinkem. Pou\u017e\u00edv\u00e1 se kr\u00e1tkodob\u011b p\u0159i \u00fazkosti, p\u0159edopera\u010dn\u00ed sedaci, alergick\u00e9m pruritu a kop\u0159ivce, tak\u00e9 jako antiemetikum. Nen\u00ed n\u00e1vykov\u00e9 \u2014 vhodn\u00e1 alternativa, kdy\u017e jsou benzodiazepiny nevhodn\u00e9.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Atarise na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Atarise a jak funguje<\/h2>\n

Atarise je tableta hydroxyzinu 10 \/ 25 mg od Sun Pharma. Hydroxyzin je piperazinov\u00e9 antihistaminikum prvn\u00ed generace se siln\u00fdm centr\u00e1ln\u00edm H1 antagonismem, slab\u00fdm 5-HT2A antagonismem a m\u00edrnou anticholinergn\u00ed aktivitou. H1 slo\u017eka dob\u0159e pronik\u00e1 hematoencefalickou bari\u00e9rou, co\u017e je z\u00e1kladem jeho sedativn\u00edho a anxiolytick\u00e9ho \u00fa\u010dinku.<\/p>\n

Hydroxyzin je jedna z m\u00e1la ne-benzodiazepinov\u00fdch a ne-barbitur\u00e1tov\u00fdch mo\u017enost\u00ed pro skute\u010dnou PRN \u00falevu od \u00fazkosti \u2014 n\u00e1stup \u00fa\u010dinku za 30\u201360 minut, d\u00e9lka \u00fa\u010dinku 4\u20136 hodin.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Akutn\u00ed \u00fazkost \/ agitace<\/td>\n25\u2013100 mg p.o.\/i.m., lze opakovat po 6 h<\/td>\nMax. 400 mg\/den<\/td>\n<\/tr>\n
Pruritus \/ kop\u0159ivka<\/td>\n25 mg 3\u20134\u00d7 denn\u011b<\/td>\nMax. 100 mg 4\u00d7 denn\u011b<\/td>\n<\/tr>\n
P\u0159edopera\u010dn\u00ed sedace<\/td>\n50\u2013100 mg 1 hodinu p\u0159ed v\u00fdkonem<\/td>\n\u2014<\/td>\n<\/tr>\n
Antiemetikum<\/td>\n25\u2013100 mg IM<\/td>\nPouze pro dosp\u011bl\u00e9<\/td>\n<\/tr>\n
Nespavost (mimo indikaci)<\/td>\n25\u201350 mg p\u0159ed span\u00edm<\/td>\nKr\u00e1tkodob\u011b pouze<\/td>\n<\/tr>\n
D\u011btsk\u00fd pruritus\/sedace<\/td>\n0,5\u20131 mg\/kg\/d\u00e1vka ka\u017ed\u00fdch 6 hodin<\/td>\n\u2014<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed (jak\u00e1koliv indikace)<\/td>\nza\u010d\u00edt s 10\u201325 mg<\/td>\nRiziko QT prodlou\u017een\u00ed a p\u00e1d\u016f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nProdlu\u017eov\u00e1n\u00ed QT intervalu \u2014 omezen\u00ed EMA z roku 2015<\/strong><\/p>\n

Hydroxyzin prodlu\u017euje QT interval z\u00e1visle na d\u00e1vce. EMA v roce 2015 omezila d\u00e1vkov\u00e1n\u00ed: maxim\u00e1ln\u011b 100 mg\/den u dosp\u011bl\u00fdch, 50 mg\/den u star\u0161\u00edch dosp\u011bl\u00fdch a 2 mg\/kg\/den u d\u011bt\u00ed<\/strong>. Vyvarujte se u zn\u00e1m\u00e9ho prodlou\u017een\u00ed QT intervalu, hypokal\u00e9mie\/hypomagnez\u00e9mie, ned\u00e1vn\u00e9ho IM, dekompenzovan\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed a sou\u010dasn\u00e9ho u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f prodlu\u017euj\u00edc\u00edch QT interval (azoly, makrolidy, fluorochinolony, metadon, ondansetron, antipsychotika). U star\u0161\u00edch dosp\u011bl\u00fdch se doporu\u010duje EKG p\u0159ed l\u00e9\u010dbou.<\/p>\n<\/div>\n

\nAnticholinergn\u00ed z\u00e1t\u011b\u017e<\/strong><\/p>\n

Hydroxyzin m\u00e1 v\u00fdznamnou anticholinergn\u00ed aktivitu \u2014 zvl\u00e1\u0161t\u011b relevantn\u00ed u star\u0161\u00edch dosp\u011bl\u00fdch (potenci\u00e1ln\u011b nevhodn\u00fd l\u00e9k dle Beersov\u00fdch krit\u00e9ri\u00ed). Vyvarujte se u uzav\u0159en\u00e9ho \u00fahlu glaukomu, BPH s retenc\u00ed, demence, t\u011b\u017ek\u00e9 z\u00e1cpy. Americk\u00e1 geriatrick\u00e1 spole\u010dnost nedoporu\u010duje antihistaminika prvn\u00ed generace jako PRN l\u00e9ky u star\u0161\u00edch dosp\u011bl\u00fdch.<\/p>\n<\/div>\n

\nSedace a \u0159\u00edzen\u00ed vozidel<\/strong><\/p>\n

Sedace po jedn\u00e9 d\u00e1vce m\u016f\u017ee p\u0159etrv\u00e1vat 6+ hodin; vyvarujte se \u0159\u00edzen\u00ed a obsluhy stroj\u016f, dokud nen\u00ed zn\u00e1ma sn\u00e1\u0161enlivost. Zvl\u00e1\u0161t\u011b problematick\u00e9 u pacient\u016f bez p\u0159edchoz\u00ed zku\u0161enosti s opioidy v den propu\u0161t\u011bn\u00ed po operaci.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n