{"id":58015,"date":"2024-02-27T18:12:30","date_gmt":"2024-02-27T18:12:30","guid":{"rendered":"https:\/\/medsname.com\/etibo\/"},"modified":"2026-04-30T10:17:00","modified_gmt":"2026-04-30T10:17:00","slug":"etibo","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/etibo\/","title":{"rendered":"Etibo"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Rychl\u00e1 odpov\u011b\u010f<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Etibo<\/strong> je <strong>lapatinib 250 mg<\/strong>, , <strong>du\u00e1ln\u00ed inhibitor tyrozinkin\u00e1zy HER2\/EGFR<\/strong> pro pokro\u010dil\u00fd nebo metastatick\u00fd <strong>HER2-pozitivn\u00ed karcinom prsu<\/strong>. Peror\u00e1ln\u00ed terapie jednou denn\u011b v kombinaci s kapecitabinem nebo jin\u00fdmi re\u017eimy, obvykle po selh\u00e1n\u00ed trastuzumabu (Herceptin). V\u00fdznamn\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky zahrnuj\u00ed pr\u016fjem, vyr\u00e1\u017eku a kardiotoxicitu; vy\u017eaduje \u00fazk\u00fd dohled onkologa a monitorov\u00e1n\u00ed EKG.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 Pro\u010d nakupovat na MedsBase:<\/strong> Ov\u011b\u0159en\u00e9 dod\u00e1vky p\u0159\u00edmo od v\u00fdrobce \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 Bezpe\u010dn\u00e9 platby (kreditn\u00ed karta, kryptom\u011bny) \u00b7 Hodnocen\u00ed 4,9\u2605 od 1 400+ z\u00e1kazn\u00edk\u016f\n<\/div>\n<h2><strong>Co je Etibo?<\/strong><\/h2>\n<p>Etibo je zna\u010dkov\u00fd generick\u00fd p\u0159\u00edpravek <strong>lapatinibu<\/strong> 250 mg, mal\u00e1 molekula inhibitoru tyrozinkin\u00e1zy, kter\u00e1 c\u00edl\u00ed na <strong>HER2 (ErbB2)<\/strong> a <strong>EGFR (ErbB1)<\/strong>. Lapatinib blokuje intracelul\u00e1rn\u00ed signalizaci t\u011bchto receptor\u016f, \u010d\u00edm\u017e zastavuje proliferaci HER2-pozitivn\u00edch n\u00e1dorov\u00fdch bun\u011bk. V\u00fdrobce: Natco Pharma.<\/p>\n<p><strong>Kritick\u00e9:<\/strong> Lapatinib je onkologick\u00fd l\u00e9k pou\u017e\u00edvan\u00fd pouze pod odborn\u00fdm dohledem. Nen\u00ed to obecn\u00fd p\u0159\u00edpravek pro zdrav\u00ed \u017een. Pou\u017e\u00edvejte p\u0159\u00edsn\u011b podle protokolu onkologa \u2014 typicky po vzniku rezistence na trastuzumab.<\/p>\n<h2><strong>Klinick\u00e9 pou\u017eit\u00ed<\/strong><\/h2>\n<ul>\n<li><strong>Pokro\u010dil\u00fd\/metastatick\u00fd HER2+ karcinom prsu<\/strong>: 1250 mg denn\u011b (5 tablet) + kapecitabin \u2014 po selh\u00e1n\u00ed trastuzumabu.<\/li>\n<li><strong>HER2+ karcinom prsu s letrozolem<\/strong> u postmenopauz\u00e1ln\u00edch \u017een s ER+\/HER2+ metastatick\u00fdm onemocn\u011bn\u00edm.<\/li>\n<li><strong>Nen\u00ed indikov\u00e1n<\/strong> pro adjuvantn\u00ed (\u010dasn\u00e9 st\u00e1dium s l\u00e9\u010debn\u00fdm z\u00e1m\u011brem) terapii \u2014 trastuzumab \u00b1 pertuzumab z\u016fst\u00e1v\u00e1 standardem.<\/li>\n<\/ul>\n<h2><strong>Jak u\u017e\u00edvat<\/strong><\/h2>\n<ol>\n<li>U\u017eijte <strong>1250 mg (5 tablet) 1\u00d7 denn\u011b<\/strong>, <strong>nejm\u00e9n\u011b 1 hodinu p\u0159ed j\u00eddlem nebo po j\u00eddle<\/strong>. Potrava v\u00fdznamn\u011b zvy\u0161uje absorpci a m\u011bn\u00ed d\u00e1vkovac\u00ed parametry; d\u016fle\u017eit\u00e1 je konzistence.<\/li>\n<li>Typick\u00fd kombinovan\u00fd l\u00e9k: kapecitabin 2000 mg\/m\u00b2\/den ve dnech 1\u201314 v 21denn\u00edm cyklu.<\/li>\n<li>Monitorov\u00e1n\u00ed EKG a LVEF na za\u010d\u00e1tku a ka\u017ed\u00e9 3 m\u011bs\u00edce (riziko kardiotoxicity).<\/li>\n<li>Pr\u016fjem \u0159e\u0161te proaktivn\u011b \u2014 \u010dasto stupe\u0148 1\u20133, b\u011b\u017en\u00fd v prvn\u00edm cyklu. Loperamid, hydratace, sn\u00ed\u017een\u00ed d\u00e1vky podle pot\u0159eby.<\/li>\n<li>Vyhn\u011bte se grapefruitu, sevillsk\u00fdm pomeran\u010d\u016fm a inhibitor\u016fm\/induktor\u016fm CYP3A4.<\/li>\n<\/ol>\n<h2><strong>Vedlej\u0161\u00ed \u00fa\u010dinky<\/strong><\/h2>\n<p><strong>Velmi \u010dast\u00e9:<\/strong> pr\u016fjem (60\u201380%), vyr\u00e1\u017eka (40\u201360%), nevolnost, zvracen\u00ed, \u00fanava, syndrom ruka-noha, palmoplant\u00e1rn\u00ed erytrodysestezie (v kombinaci s kapecitabinem).<\/p>\n<p><strong>V\u00fdznamn\u00e9:<\/strong> <strong>hepatotoxicita<\/strong> (sledujte jatern\u00ed testy), <strong>kardiotoxicita \/ sn\u00ed\u017een\u00e1 LVEF<\/strong> (5\u20136%), prodlou\u017een\u00ed QT intervalu, interstici\u00e1ln\u00ed plicn\u00ed onemocn\u011bn\u00ed (vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9).<\/p>\n<p><strong>Z\u00e1va\u017en\u00e9:<\/strong> z\u00e1va\u017en\u00e9 po\u0161kozen\u00ed jater, srde\u010dn\u00ed selh\u00e1n\u00ed, z\u00e1va\u017en\u00e9 ko\u017en\u00ed reakce (Stevens-Johnson), plicn\u00ed toxicita.<\/p>\n<h2><strong>Kdo by nem\u011bl u\u017e\u00edvat Etibo<\/strong><\/h2>\n<ul>\n<li>HER2-negativn\u00ed karcinom prsu (ne\u00fa\u010dinn\u00e9)<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>Symptomatick\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed nebo z\u00e1va\u017en\u00e1 srde\u010dn\u00ed dysfunkce<\/li>\n<li>T\u011bhotenstv\u00ed \u2014 teratogenn\u00ed \u00fa\u010dinky<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed siln\u00fdch inhibitor\u016f nebo induktor\u016f CYP3A4 bez \u00fapravy d\u00e1vkov\u00e1n\u00ed<\/li>\n<\/ul>\n<h2><strong>Interakce s l\u00e9\u010divy<\/strong><\/h2>\n<ul>\n<li><strong>Siln\u00e9 inhibitory CYP3A4<\/strong> (ketokonazol, ritonavir, klarithromycin, grapefruit): v\u00fdrazn\u011b zvy\u0161uj\u00ed hladinu lapatinibu.<\/li>\n<li><strong>Siln\u00e9 induktory CYP3A4<\/strong> (rifampicin, karbamazepin, fenytoin, t\u0159ezalka te\u010dkovan\u00e1): sni\u017euj\u00ed hladinu a \u00fa\u010dinnost lapatinibu.<\/li>\n<li><strong>PPI, H2 blok\u00e1tory<\/strong>: sni\u017euj\u00ed absorpci \u2014 vyhn\u011bte se nebo \u010dasov\u011b odd\u011blte o n\u011bkolik hodin.<\/li>\n<li><strong>Warfarin, digoxin<\/strong>: m\u016f\u017ee zv\u00fd\u0161it hladiny.<\/li>\n<\/ul>\n<h2><strong>Skladov\u00e1n\u00ed<\/strong><\/h2>\n<p>Skladujte p\u0159i pokojov\u00e9 teplot\u011b (15\u201330 \u00b0C), mimo vlhkost. Uchov\u00e1vejte v p\u016fvodn\u00edm obalu. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Kdy se pou\u017e\u00edv\u00e1 lapatinib?<\/h3>\n<p>Pokro\u010dil\u00fd\/metastatick\u00fd HER2-pozitivn\u00ed karcinom prsu, obvykle po rezistenci na trastuzumab (Herceptin). Nepou\u017e\u00edv\u00e1 se pro \u010dasn\u00e9 st\u00e1dium l\u00e9\u010dby s kurativn\u00edm z\u00e1m\u011brem.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d u\u017e\u00edvat nala\u010dno?<\/h3>\n<p>Potrava zvy\u0161uje absorpci lapatinibu 4\u20135\u00d7, co\u017e \u010din\u00ed d\u00e1vkov\u00e1n\u00ed nep\u0159edv\u00eddateln\u00fdm. Standardem je konzistentn\u00ed p\u016fst \u2014 1 hodinu p\u0159ed j\u00eddlem nebo po j\u00eddle \u2014 ve stejnou dobu ka\u017ed\u00fd den.<\/p>\n<h3 class=\"wp-block-heading\">Jak z\u00e1va\u017en\u00fd je pr\u016fjem?<\/h3>\n<p>\u010cast\u00fd, \u010dasto stupn\u011b 1\u20132; zvl\u00e1dnuteln\u00fd s loperamidem a hydratac\u00ed. Pr\u016fjem stupn\u011b 3+ m\u016f\u017ee vy\u017eadovat p\u0159eru\u0161en\u00ed l\u00e9\u010dby a sn\u00ed\u017een\u00ed d\u00e1vky. Hlaste v\u010das.<\/p>\n<h3 class=\"wp-block-heading\">Po\u0161kod\u00ed lapatinib m\u00e9 srdce?<\/h3>\n<p>Asi 5\u20136 % pacient\u016f m\u00e1 asymptomatick\u00fd pokles LVEF. EKG + echokardiogram na za\u010d\u00e1tku a ka\u017ed\u00e9 3 m\u011bs\u00edce. Obvykle reverzibiln\u00ed po \u00faprav\u011b d\u00e1vky nebo p\u0159eru\u0161en\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat lapatinib s trastuzumabem?<\/h3>\n<p>Kombinace lapatinibu + trastuzumabu se pou\u017e\u00edv\u00e1 v specifick\u00fdch protokolech. Nen\u00ed rutinn\u00ed bez dohledu onkologa.<\/p>\n<h3 class=\"wp-block-heading\">A co plodnost?<\/h3>\n<p>B\u011bhem l\u00e9\u010dby a 1 t\u00fdden po n\u00ed je nutn\u00e1 \u00fa\u010dinn\u00e1 antikoncepce (teratogenn\u00ed). Mu\u017ei by m\u011bli pou\u017e\u00edvat \u00fa\u010dinnou antikoncepci b\u011bhem l\u00e9\u010dby a 3 m\u011bs\u00edce po n\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d je toto v kategorii \u017densk\u00e9 zdrav\u00ed?<\/h3>\n<p>HER2+ karcinom prsu postihuje p\u0159ev\u00e1\u017en\u011b \u017eeny (a\u010dkoli v\u00fdjime\u010dn\u011b se m\u016f\u017ee vyskytnout i u mu\u017e\u016f). Za\u0159azen\u00ed odr\u00e1\u017e\u00ed c\u00edlovou populaci, nikoli striktn\u00ed klinickou klasifikaci.<\/p>\n<h3 class=\"wp-block-heading\">Je lapatinib st\u00e1le l\u00e9kem prvn\u00ed volby?<\/h3>\n<p>U metastatick\u00e9ho HER2+ karcinomu v druh\u00e9 linii l\u00e9\u010dby (po trastuzumabu) byla l\u00e9ta standardem kombinace lapatinibu s kapecitabinem. Nov\u011bj\u0161\u00ed mo\u017enosti (T-DM1\/Kadcyla, T-DXd\/Enhertu, tucatinib) jej v rozvinut\u00fdch zem\u00edch v\u011bt\u0161inou nahradily \u2014 lapatinib z\u016fst\u00e1v\u00e1 d\u016fle\u017eit\u00fd tam, kde nejsou nov\u011bj\u0161\u00ed l\u00e9ky dostupn\u00e9.<\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed produkty pro zdrav\u00ed \u017een<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tamodex\/\">Tamodex (Tamoxifen 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tamilong\/\">Tamilong (Tamoxifen 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/letroheal\/\">Letroheal (Letrozol 2,5 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/duphaston\/\">Duphaston (Dydrogesteron 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/deviry\/\">Deviry (Medroxyprogesteron 10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/naprosyn\/\">Naprosyn (Naproxen 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/candid-v-gel\/\">Candid-V Gel (Clotrimazol)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed:<\/strong> Informace maj\u00ed vzd\u011bl\u00e1vac\u00ed charakter a nenahrazuj\u00ed l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli l\u00e9ku, zejm\u00e9na p\u0159i l\u00e9\u010db\u011b rakoviny, hormon\u00e1ln\u00ed terapii a p\u0159edepsan\u00fdch p\u0159\u00edpravc\u00edch, se pora\u010fte s l\u00e9ka\u0159em.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/verpin\/\">Verpin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/triohale-rotacaps\/\">Triohale Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">Inderal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hydrocl\/\">Hydrocl<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ezedoc\/\">Lipikard<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 C\u00edl\u00ed na rakovinn\u00e9 bu\u0148ky<br \/>\n\u2705 Inhibuje r\u016fst n\u00e1dor\u016f<br \/>\n\u2705 L\u00e9\u010d\u00ed rakovinu prsu<br \/>\n\u2705 Blokuje HER2 receptory<br \/>\n\u2705 Zlep\u0161uje m\u00edru p\u0159e\u017eit\u00ed<\/p>\n<p>Etibo obsahuje Lapatinib.<\/p>","protected":false},"featured_media":58016,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223,3502],"product_tag":[4402,4403],"class_list":{"0":"post-58015","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-womens-health","10":"product_tag-etibo","11":"product_tag-lapatinib","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58015"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58016"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58015"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58015"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58015"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}