{"id":58155,"date":"2024-02-27T18:20:09","date_gmt":"2024-02-27T18:20:09","guid":{"rendered":"https:\/\/medsname.com\/tetrafol\/"},"modified":"2026-04-30T10:24:17","modified_gmt":"2026-04-30T10:24:17","slug":"tetrafol","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/tetrafol\/","title":{"rendered":"Tetrafol"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Tetrafol (L-methylfolate 1 \/ 5 \/ 7,5 \/ 15 mg) je biologicky aktivn\u00ed forma fol\u00e1tu (vitamin B9). Pou\u017e\u00edv\u00e1 se jako augmentace antidepresiv p\u0159i t\u011b\u017ek\u00e9 depresi, u nosi\u010d\u016f polymorfismu MTHFR (asi 30 % populace) a jako n\u00e1hrada p\u0159i nedostatku fol\u00e1tu. Obch\u00e1z\u00ed enzym MTHFR \u2014 u\u017eite\u010dn\u00e9 tam, kde je kyselina listov\u00e1 (syntetick\u00e1) nedostate\u010dn\u011b p\u0159em\u011bn\u011bna.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Tetrafol na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

\nD\u016fle\u017eit\u00e9 \u2014 dopln\u011bk, nikoli n\u00e1hrada prim\u00e1rn\u00ed antidepresivn\u00ed terapie<\/strong><\/p>\n

L-methylfolate je augmenta\u010dn\u00ed terapie. Je n\u00e1hradou<\/strong> k SSRI\/SNRI p\u0159i t\u011b\u017ek\u00e9 depresi. Nejsiln\u011bj\u0161\u00ed d\u016fkazy podporuj\u00ed L-methylfolate jako dopln\u011bk k st\u00e1vaj\u00edc\u00edm antidepresiv\u016fm u \u010d\u00e1ste\u010dn\u00fdch respondent\u016f.<\/p>\n<\/div>\n

Co je Tetrafol a jak funguje<\/h2>\n

Tetrafol je tableta L-methylfol\u00e1tu (5-MTHF) dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: 1 \/ 5 \/ 7,5 \/ 15 mg<\/strong>. L-methylfol\u00e1t je aktivn\u00ed forma fol\u00e1tu, kter\u00e1 p\u0159ekon\u00e1v\u00e1 hematoencefalickou bari\u00e9ru a slou\u017e\u00ed jako donor methylu pro synt\u00e9zu serotoninu, dopaminu a noradrenalinu. Kyselina listov\u00e1 (syntetick\u00e1 forma obsa\u017een\u00e1 ve v\u011bt\u0161in\u011b dopl\u0148k\u016f) vy\u017eaduje p\u0159em\u011bnu enzymem methylentetrahydrofol\u00e1tredukt\u00e1zou (MTHFR) \u2014 polymorfismus (C677T nebo A1298C) sni\u017euje enzymatickou aktivitu u p\u0159ibli\u017en\u011b 30 % populace, co\u017e vede k funk\u010dn\u00edmu nedostatku fol\u00e1tu v CNS navzdory norm\u00e1ln\u00ed hladin\u011b fol\u00e1tu v s\u00e9ru.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nTypick\u00e1 d\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Augmentace antidepresivy u MDD<\/td>\n7,5\u201315 mg\/den<\/td>\nTrivedi 2012, Papakostas 2012<\/td>\n<\/tr>\n
Nositel\u00e9 MTHFR polymorfismu s depres\u00ed<\/td>\n7,5\u201315 mg\/den<\/td>\nN\u011bkdy se pou\u017e\u00edvaj\u00ed vy\u0161\u0161\u00ed d\u00e1vky<\/td>\n<\/tr>\n
Deficit fol\u00e1tu (n\u00e1hrada)<\/td>\n1 mg\/den<\/td>\nPo dobu 3\u20136 m\u011bs\u00edc\u016f<\/td>\n<\/tr>\n
Kardiovaskul\u00e1rn\u00ed zdrav\u00ed (sn\u00ed\u017een\u00ed hladiny homocysteinu)<\/td>\n1\u20135 mg\/den<\/td>\n\u2014<\/td>\n<\/tr>\n
Prevence defekt\u016f neur\u00e1ln\u00ed trubice (t\u011bhotenstv\u00ed)<\/td>\n0,4\u20135 mg\/den<\/td>\nP\u0159ed po\u010det\u00edm a v prvn\u00edm trimestru; kyselina listov\u00e1 je obecn\u011b preferov\u00e1na z d\u016fvodu ceny<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nMaskov\u00e1n\u00ed deficitu vitaminu B12<\/strong><\/p>\n

Vysok\u00e9 d\u00e1vky fol\u00e1tu (jak\u00e9koli formy) mohou korigovat megaloblastickou an\u00e9mii zp\u016fsobenou nedostatkem B12 bez korekce neurologick\u00e9ho deficitu \u2013 maskuj\u00ed tak diagn\u00f3zu a umo\u017e\u0148uj\u00ed vznik nevratn\u00e9ho neurologick\u00e9ho po\u0161kozen\u00ed. V\u017edy zkontrolujte hladinu B12 p\u0159ed pod\u00e1v\u00e1n\u00edm vysok\u00fdch d\u00e1vek fol\u00e1tu.<\/strong><\/p>\n<\/div>\n

\nMo\u017en\u00fd sign\u00e1l souvisej\u00edc\u00ed s rakovinou p\u0159i velmi vysok\u00fdch d\u00e1vk\u00e1ch<\/strong><\/p>\n

N\u011bkter\u00e1 observa\u010dn\u00ed data nazna\u010duj\u00ed, \u017ee velmi vysok\u00fd p\u0159\u00edjem fol\u00e1tu m\u016f\u017ee podporovat progresi ji\u017e existuj\u00edc\u00edch kolorekt\u00e1ln\u00edch adenom\u016f. Klinick\u00fd p\u0159enos: standardn\u00ed d\u00e1vky pro augmentaci antidepresiv (7,5\u201315 mg) se zdaj\u00ed b\u00fdt bezpe\u010dn\u00e9; megad\u00e1vky (> 30 mg\/den) bez indikace se nedoporu\u010duj\u00ed.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n