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Pentasa \u010d\u00edpky<\/strong> jsou mesalazine 1 g rectal suppositories<\/strong> — a topical 5-aminosalicylate (5-ASA) for distal ulcerative colitis flares (proctitis, distal proctosigmoiditis), Crohn’s proctitis, and post-surgical pouchitis. Mesalazine acts locally on inflamed colonic mucosa with negligible systemic absorption. Standard regimen: 1 suppository at bedtime for 4–8 weeks induction<\/strong> for proctitis flare, then maintenance 1 suppository three times weekly or daily depending on disease pattern. Manufactured under WHO-GMP standards.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Pentasa Suppositories is supplied from a v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> — if it does not arrive within 20 business days, we reship at no cost. Topical mesalazine delivers high local concentration to the rectum with negligible systemic absorption, which makes it the cornerstone of distal UC remission — safer than oral or systemic steroid courses.<\/p>\n Mesalazine (5-aminosalicylic acid, 5-ASA) is the active anti-inflammatory moiety of the older drug sulfasalazine (which is hydrolysed by colonic bacteria into 5-ASA + sulfapyridine; the sulfapyridine accounts for sulfasalazine’s side effects). 5-ASA acts on the colonic mucosa through several mechanisms: PPAR-γ agonism (anti-inflammatory transcription), inhibition of COX\/LOX prostaglandin pathways, scavenging of reactive oxygen species, and inhibition of NF-κB activation. Suppository formulation delivers the drug directly to the rectum (15 cm reach) with very little systemic absorption.<\/p>\n Induction: 1 suppository (1 g) once daily, ideally at bedtime, for 4–8 weeks. Maintenance: 1 suppository three times weekly or daily depending on disease pattern. Children > 12 years: same as adult. Severe hepatic or renal impairment: caution.<\/p>\n Tenesmus and rectal bleeding often improve within 1–2 weeks. Full mucosal healing takes 4–8 weeks. Continue the full induction course even if symptoms resolve sooner.<\/p>\n A bedtime suppository remains in the rectum overnight while you sleep, maximising mucosal contact time. Daytime applications often leak after activity.<\/p>\n Step up to oral mesalazine (Asacol, Mesacol, or Pentasa) added to the suppository, or escalate to topical budesonide foam. If still no response after 8 weeks, gastroenterology review for systemic steroid, immunomodulator, or biologic.<\/p>\n Yes. Topical mesalazine has minimal systemic absorption and is considered safe throughout pregnancy and breastfeeding. Active ulcerative colitis flares are themselves a risk to pregnancy; controlling the flare is the priority.<\/p>\n Many people do for maintenance. Three-times-weekly dosing often suffices once remission is achieved. The aim is to prevent flares, which carry their own risk of complications and surgery.<\/p>\n Yes, the typical regimen for moderate distal UC is oral mesalazine (Asacol\/Mesacol) 2.4–4.8 g\/day plus a topical mesalazine suppository or enema. Adding a topical 5-ASA accelerates remission compared to oral alone.<\/p>\n Interstitial nephritis is rare with oral mesalazine and very rare with topical-only therapy. If you are on chronic oral mesalazine in addition, baseline and annual creatinine and urinalysis are recommended.<\/p>\n No — the suppository is designed to release mesalazine gradually as it dissolves. Cutting changes the surface area and release rate.<\/p>\n Below 30°C in the original sealed packet. Suppositories that have softened or fragmented should not be used.<\/p>\n Insert it as soon as you remember. If close to the next dose, skip and continue. Do not double up.<\/p>\n <\/p>\n Pentasa Suppositories (Mesalazine 1 g rectal) \u2014 topical 5-ASA for ulcerative proctitis, distal UC and Crohn’s proctitis. ECCO \/ ACG first-line for distal UC induction and maintenance. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":58278,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4458,4459],"class_list":{"0":"post-58277","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-mesalazine","10":"product_tag-pentasa-suppositories","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58277"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58278"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58277"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58277"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58277"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Mechanismus \u00fa\u010dinku<\/h2>\n
Indikace<\/h2>\n
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D\u00e1vka<\/h2>\n
Jak pou\u017e\u00edvat<\/h2>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce l\u00e9k\u016f<\/h2>\n
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\u010casto kladen\u00e9 dotazy<\/h2>\n
How quickly will I improve?<\/h3>\n
Why bedtime?<\/h3>\n
I had no improvement after 4 weeks. What now?<\/h3>\n
Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n
Will I need it long term?<\/h3>\n
Can I take other UC medication at the same time?<\/h3>\n
A co moje ledviny?<\/h3>\n
Can I cut it in half?<\/h3>\n
Skladov\u00e1n\u00ed<\/h3>\n
Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n
Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n
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