{"id":58445,"date":"2024-02-27T18:36:12","date_gmt":"2024-02-27T18:36:12","guid":{"rendered":"https:\/\/medsname.com\/lomoother\/"},"modified":"2026-04-30T10:24:13","modified_gmt":"2026-04-30T10:24:13","slug":"lomoother","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/lomoother\/","title":{"rendered":"Lomoother"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Lomoother?<\/h3>\n<p style=\"margin:0;\"><strong>Lomoother<\/strong> is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong> &mdash; a nitrosourea alkylating agent that crosses the blood-brain barrier. Used for <strong>recurrent or refractory primary brain tumours<\/strong> (high-grade glioma, ependymoma) and as part of older Hodgkin lymphoma combination regimens. Standard adult monotherapy dose: <strong>100&ndash;130 mg\/m&sup2; orally as a single dose every 6 weeks<\/strong> &mdash; the 6-week interval is mandatory because nadir is delayed (4&ndash;6 weeks) and recovery slow. Mandatory: FBC at baseline, weekly between cycles, and on day 42 before next dose. <strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> because of cumulative myelotoxicity and pulmonary fibrosis risk. Pregnancy contraindication; offer fertility preservation.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Lomoother?<\/h2>\n<p>Lomoother is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong>. Lomustine is a nitrosourea alkylating agent that crosses the blood-brain barrier (CSF concentration ~30&ndash;50% of plasma), making it one of the few oral cytotoxics with meaningful CNS penetration. Used in primary brain tumours, particularly recurrent high-grade glioma after temozolomide failure.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Recurrent or refractory glioblastoma multiforme<\/strong> after temozolomide<\/li>\n<li><strong>Anaplastic astrocytoma, anaplastic oligodendroglioma<\/strong> (PCV regimen)<\/li>\n<li><strong>Hodgkin lymphoma<\/strong> (older CCNU-containing combinations)<\/li>\n<li><strong>Brain metastases (selected)<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>Standard:<\/strong> 100&ndash;130 mg\/m&sup2; PO as a SINGLE dose every 6 weeks<\/li>\n<li><strong>PCV regimen (oligodendroglioma):<\/strong> 110 mg\/m&sup2; day 1 + procarbazine + vincristine, every 6 weeks<\/li>\n<\/ul>\n<ol>\n<li>Take as a single oral dose at bedtime, on an empty stomach (no food 2 hours before or 2 hours after).<\/li>\n<li>Antiemetic (ondansetron 8 mg) 1 hour before dose.<\/li>\n<li>Swallow capsules whole with water. Do NOT open.<\/li>\n<li><strong>Mandatory 6-week interval between doses<\/strong> &mdash; nadir is delayed (typically week 4&ndash;6), recovery slow. Dosing more frequently than every 6 weeks risks cumulative pancytopenia.<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> FBC at baseline, weekly throughout the cycle, and on day 42 before next dose. LFTs and renal function monthly. PFTs (DLCO) baseline and if dyspnoea.<\/li>\n<li><strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> over the lifetime &mdash; cumulative myelotoxicity and pulmonary fibrosis become rate-limiting.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> nausea (significant), vomiting, anorexia.<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Delayed cumulative myelosuppression<\/strong> &mdash; thrombocytopenia and leucopenia at week 4&ndash;6, recovery slow<\/li>\n<li><strong>Pulmonary fibrosis<\/strong> at high cumulative dose &mdash; mandatory PFTs if dyspnoea<\/li>\n<li>Hepatotoxicita<\/li>\n<li>Ren\u00e1ln\u00ed toxicita<\/li>\n<li>Secondary leukaemia (long-term, dose-related)<\/li>\n<li>Trval\u00e1 neplodnost (gonadotoxick\u00fd \u00fa\u010dinek)<\/li>\n<li>Confusion, lethargy, ataxia (high doses)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> teratogenic; strict contraception throughout + 6 months after.<\/li>\n<li><strong>Kojen\u00ed:<\/strong> vyhnout se.<\/li>\n<li><strong>Pre-existing pulmonary disease:<\/strong> baseline DLCO; avoid in severe.<\/li>\n<li><strong>T\u011b\u017ek\u00e9 jatern\u00ed\/ledvinov\u00e9 posti\u017een\u00ed:<\/strong> sni\u017ete d\u00e1vku.<\/li>\n<li><strong>\u017div\u00e9 vakc\u00edny:<\/strong> kontraindikov\u00e1no.<\/li>\n<li><strong>Cumulative dose tracking<\/strong> &mdash; specialist responsibility.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other myelosuppressives<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive prolonged pancytopenia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dohled specialisty.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increases lomustine marrow toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Use ranitidine or famotidine instead.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u017div\u00e9 vakc\u00edny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diseminovan\u00e1 infekce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindikov\u00e1no.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte v chladu p\u0159i <strong>2\u20138\u00b0C<\/strong>.<\/li>\n<li>Mimo dosah d\u011bt\u00ed, \u017een v reproduk\u010dn\u00edm v\u011bku, dom\u00e1c\u00edch zv\u00ed\u0159at.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endoxan\/\"><strong>Endoxan (cyklofosfamid 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temotero\/\"><strong>Temotero (temozolomid 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Why must doses be 6 weeks apart?<\/h3>\n<p>Lomustine causes <strong>delayed cumulative myelosuppression<\/strong>. The blood count nadir typically occurs at <strong>week 4&ndash;6<\/strong> after a dose, with slow recovery thereafter. Dosing more frequently than every 6 weeks stacks the marrow toxicity and risks severe pancytopenia. The 6-week interval is rigid &mdash; even if you feel well, do not dose-advance without specialist instruction.<\/p>\n<h3 class=\"wp-block-heading\">Why is there a cumulative dose limit?<\/h3>\n<p>Cumulative pulmonary fibrosis and persistent thrombocytopenia become limiting at total exposure above ~1,000 mg\/m&sup2; (lifetime). Specialists track cumulative dose and stop or extend the interval as the limit is approached. Tell every doctor about every previous chemotherapy course.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Lomoother with food?<\/h3>\n<p>No &mdash; take on an empty stomach (no food for 2 hours before or 2 hours after). Most patients take the dose at bedtime &ge; 2 hours after dinner. Pre-medicate with ondansetron 8 mg about 1 hour before to prevent the significant nausea and vomiting characteristic of nitrosoureas.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 krevn\u00ed testy pot\u0159ebuji?<\/h3>\n<p>FBC at baseline, weekly between cycles, and on day 42 before each next dose. LFTs and renal function monthly. PFTs (with DLCO) at baseline and any time you develop new dyspnoea or persistent dry cough.<\/p>\n<h3 class=\"wp-block-heading\">Will Lomoother work for my brain tumour?<\/h3>\n<p>Lomustine has a long history in primary brain tumours. In recurrent glioblastoma after temozolomide failure, lomustine produces modest disease-control benefit in some patients. In oligodendroglioma, the PCV regimen (procarbazine + lomustine + vincristine) has documented overall survival benefit when combined with radiotherapy in 1p\/19q co-deleted disease. Discuss expected benefit specific to your tumour with the neuro-oncologist.<\/p>\n<h3 class=\"wp-block-heading\">Why must Lomoother be refrigerated?<\/h3>\n<p>Lomustine is heat-sensitive and degrades at room temperature, especially in warmer climates. Refrigeration (2&ndash;8&deg;C) preserves potency. Keep in original blister.<\/p>\n<h3 class=\"wp-block-heading\">Caregivers handling Lomoother?<\/h3>\n<p>Wear gloves when handling capsules and patient body fluids in the first 48 hours after a dose. Wash hands afterwards. Pregnant caregivers should avoid handling.<\/p>\n<h3 class=\"wp-block-heading\">Mohu dostat \u017eiv\u00e9 vakc\u00edny?<\/h3>\n<p>No &mdash; contraindicated during lomustine and for at least 6 months after the last dose. Inactivated vaccines safe and recommended.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endoxan\/\">Endoxan (cyklofosfamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\">Celkeran (chlorambucil 2 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\">Temozol 20 (temozolomide 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temotero\/\">Temotero (temozolomide 100\/250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Brain tumor treatment<br \/>\n\u2705 Chemotherapy drug<br \/>\n\u2705 Slows tumor growth<br \/>\n\u2705 Alkylating agent<br \/>\n\u2705 Oral medication<\/p>\n<p>Lomoother contains Lomustine.<\/p>","protected":false},"featured_media":58446,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4493,4494],"class_list":{"0":"post-58445","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-lomoother","10":"product_tag-lomustine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58445"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58446"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58445"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58445"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58445"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}