{"id":58482,"date":"2024-02-27T18:38:32","date_gmt":"2024-02-27T18:38:32","guid":{"rendered":"https:\/\/medsname.com\/lukotas\/"},"modified":"2026-04-30T10:24:12","modified_gmt":"2026-04-30T10:24:12","slug":"lukotas","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/lukotas\/","title":{"rendered":"Lukotas"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Lukotas?<\/h3>\n<p><strong>Lukotas<\/strong> obsahuje <strong>montelukast<\/strong>, an oral preventer for asthma and allergic rhinitis. Montelukast blocks <strong>cysteinyl leukotriene receptors (CysLT1)<\/strong>, mediators released by mast cells and eosinophils that drive bronchoconstriction, mucus production, and airway oedema. Used as add-on preventer therapy for asthma, especially exercise-induced and allergy-triggered asthma, and for allergic rhinitis. Each tablet contains <strong>4 \/ 5 \/ 10 mg<\/strong>, vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed <strong>Intas Pharmaceuticals<\/strong>. Taken <strong>once daily in the evening<\/strong>.<\/p>\n<p><strong>Important \u2014 neuropsychiatric warning:<\/strong> the FDA added a black-box warning in 2020 noting reports of mood changes, sleep disturbance, anxiety, depression, and (rarely) suicidal ideation with montelukast. Discuss any new mood symptoms with your prescriber.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00fd n\u00e1kup<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava po cel\u00e9m sv\u011bt\u011b<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2>What Is Lukotas?<\/h2>\n<p>Lukotas is a montelukast (LTRA) preparation manufactured by Intas Pharmaceuticals at WHO-GMP certified facilities. Internationally montelukast is sold as Singulair (MSD). Available as 4 mg, 5 mg, and 10 mg tablets \u2014 strengths chosen by age and indication.<\/p>\n<h2>How Does Lukotas Work?<\/h2>\n<p>Cysteinyl leukotrienes (LTC4, LTD4, LTE4) are inflammatory lipid mediators released by mast cells, eosinophils, and basophils when activated by allergen, exercise, cold air, or aspirin. They bind CysLT1 receptors on airway smooth muscle, eosinophils, and bronchial epithelium \u2014 driving bronchoconstriction, eosinophil recruitment, airway oedema, and mucus hypersecretion. Montelukast selectively blocks CysLT1, breaking this cascade.<\/p>\n<h2>Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Perzistuj\u00edc\u00ed astma<\/strong> \u2014 add-on preventer in patients not controlled by ICS alone (alternative to LABA or LAMA add-on)<\/li>\n<li><strong>Astma vyvolan\u00e9 cvi\u010den\u00edm<\/strong> \u2014 particularly effective; taken 2 hours before exercise<\/li>\n<li><strong>Aspirin-exacerbated respiratory disease (AERD)<\/strong> \u2014 leukotrienes are central to this phenotype<\/li>\n<li><strong>Alergick\u00e1 r\u00fdma<\/strong> \u2014 both seasonal (hay fever) and perennial<\/li>\n<li><strong>Allergic conjunctivitis adjunct<\/strong><\/li>\n<li><strong>Chronick\u00e1 kop\u0159ivka<\/strong> \u2014 montelukast as adjunct to high-dose antihistamine<\/li>\n<\/ul>\n<h2>Lukotas Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pacient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">D\u00e1vka<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frekvence<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults &amp; children &gt;15 yr<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Jednou denn\u011b ve\u010der<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">D\u011bti 6\u201314 let<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>5 mg chewable<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Jednou denn\u011b ve\u010der<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">D\u011bti 2\u20135 let<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>4 mg chewable \/ granules<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Jednou denn\u011b ve\u010der<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Children 6 mo \u2013 2 yr<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>4 mg granules<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Jednou denn\u011b \u2014 pod odborn\u00fdm dohledem<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Lukotas<\/h2>\n<ul>\n<li>Bolest hlavy<\/li>\n<li>M\u00edrn\u00e1 bolest b\u0159icha nebo nevolnost<\/li>\n<li>Sleep disturbance (vivid dreams, insomnia)<\/li>\n<li>Mood changes \u2014 irritability, anxiety, depression (FDA black-box warning, 2020)<\/li>\n<li>Upper respiratory infection symptoms<\/li>\n<li>Vyr\u00e1\u017eka<\/li>\n<\/ul>\n<p><strong>Z\u00e1va\u017en\u00e9 \u2014 p\u0159esta\u0148te u\u017e\u00edvat a vyhledejte pomoc:<\/strong><\/p>\n<ul>\n<li>Z\u00e1va\u017en\u00e1 alergick\u00e1 reakce \/ angioed\u00e9m<\/li>\n<li>Suicidal ideation or severe depression \u2014 STOP and seek urgent psychiatric review<\/li>\n<li>Churg-Strauss syndrome (eosinophilic vasculitis) \u2014 rare; suspect in ICS-tapering patients with new vasculitic features (rash, neuropathy, eosinophilia)<\/li>\n<li>Hepatitis (rare)<\/li>\n<\/ul>\n<h2>Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Black-box warning \u2014 neuropsychiatric events.<\/strong> If new mood changes, anxiety, sleep disturbance, agitation, depression, or suicidal thoughts occur, stop Lukotas and contact your prescriber.<\/li>\n<li><strong>Nen\u00ed ur\u010deno k akutn\u00ed l\u00e9\u010db\u011b.<\/strong> Do not use in acute asthma attacks \u2014 onset is too slow.<\/li>\n<li><strong>Pokra\u010dujte v u\u017e\u00edv\u00e1n\u00ed ICS<\/strong> if previously prescribed; montelukast does not replace inhaled corticosteroids.<\/li>\n<li><strong>Porucha funkce jater:<\/strong> use cautiously in moderate-to-severe disease.<\/li>\n<li><strong>T\u011bhotenstv\u00ed a kojen\u00ed:<\/strong> reasonable safety data; use when benefits outweigh risks.<\/li>\n<li><strong>D\u011bti<\/strong> may show increased risk of behavioural changes \u2014 counsel parents to monitor mood.<\/li>\n<\/ul>\n<h2>Kontraindikace<\/h2>\n<ul>\n<li>Hypersensitivity to montelukast or excipients<\/li>\n<li>Severe hepatic impairment \u2014 relative<\/li>\n<li><\/li>\n<\/ul>\n<h2>Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interaguj\u00edc\u00ed l\u00e9k<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Phenobarbital, phenytoin, rifampicin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induce CYP enzymes \u2014 reduce montelukast levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor asthma control<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Gemfibrozil<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibits CYP2C8 \u2014 increases montelukast levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Pou\u017e\u00edvejte s opatrnost\u00ed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Theoretical INR change reported in case reports<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR after starting\/stopping<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i teplot\u011b do <strong>25\u00b0C<\/strong> na chladn\u00e9m, such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed p\u0159\u00edm\u00fdm slune\u010dn\u00edm z\u00e1\u0159en\u00edm.<\/li>\n<li>Ponechte v p\u016fvodn\u00edm obalu a\u017e do pou\u017eit\u00ed, aby byl chr\u00e1n\u011bn p\u0159ed vlhkost\u00ed a sv\u011btlem.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace uveden\u00e9ho na blistru.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/li>\n<\/ul>\n<h2>Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol \u00falevov\u00fd inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonid preventivn\u00ed ICS inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonid + formoterol ICS-LABA inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA pro CHOPN<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/montair\/\"><strong>Montair \u2014 montelukast LTRA tablety<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>When should I take montelukast?<\/h3>\n<p>Once daily in the evening, with or without food. Evening dosing matches the typical overnight rise in leukotriene mediators and gives best protection against early-morning symptoms.<\/p>\n<h3>How long until montelukast works?<\/h3>\n<p>Some symptom relief within 24\u201348 hours. Full effect on asthma exacerbation rate develops over 4\u20138 weeks.<\/p>\n<h3>Should I worry about the FDA black-box warning?<\/h3>\n<p>The 2020 FDA black-box warning highlighted reports of mood changes, sleep disturbance, anxiety, depression, and rarely suicidal ideation \u2014 particularly in children. The absolute risk is low but real. Watch for any new mood symptoms in yourself or your child; stop the drug and contact your prescriber if they appear.<\/p>\n<h3>Can montelukast replace my inhaler?<\/h3>\n<p>No \u2014 montelukast is an add-on preventer. It does not replace inhaled corticosteroids (Budecort, Beclate, Foracort, Seretide). Continue ICS as prescribed.<\/p>\n<h3>Is montelukast a rescue medication?<\/h3>\n<p>No \u2014 onset is too slow. Use a SABA (Asthalin, Levolin) for acute attacks.<\/p>\n<h3>Can children take montelukast?<\/h3>\n<p>Yes from 6 months of age in age-appropriate strengths (4 mg granules, 4 mg or 5 mg chewable, 10 mg tablet). Counsel parents to monitor mood and behaviour.<\/p>\n<h3>Is montelukast safe in pregnancy?<\/h3>\n<p>Reasonable observational data; use when benefits outweigh risks, particularly in patients whose asthma is well-controlled on it.<\/p>\n<h3>Does montelukast help allergic rhinitis?<\/h3>\n<p>Yes \u2014 montelukast is licensed for both asthma and allergic rhinitis. Particularly useful when both coexist (United Airways disease).<\/p>\n<h3>Should I stop montelukast if I feel better?<\/h3>\n<p>No \u2014 continue daily for as long as your prescriber advises. Stopping leads to gradual return of symptoms over days-to-weeks.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka je vzd\u011bl\u00e1vac\u00ed a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli inhal\u00e1toru nebo respira\u010dn\u00edho l\u00e9ku se v\u017edy pora\u010fte s kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem, zejm\u00e9na pokud m\u00e1te jin\u00e9 zdravotn\u00ed pot\u00ed\u017ee, u\u017e\u00edv\u00e1te jin\u00e9 l\u00e9ky, jste t\u011bhotn\u00e1 nebo koj\u00edte, nebo je v\u00e1m v\u00edce ne\u017e 65 let.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/calpol\/\">Calpol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hivus-lr\/\">Hivus LR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rami-race\/\">Rami Race<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dynapar\/\">Dynapar<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/indicid-75-sr\/\">Indicid-75 SR<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Manages allergies<br \/>\n\u2705 Ulevuje od p\u0159\u00edznak\u016f astmatu<br \/>\n\u2705 Reduces bronchoconstriction<br \/>\n\u2705 Controls wheezing<br \/>\n\u2705 Prevents airway inflammation<\/p>\n<p>Lukotas contains Montelukast.<\/p>","protected":false},"featured_media":58483,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[4501,4499],"class_list":{"0":"post-58482","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-lukotas","10":"product_tag-montelukast","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58482"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58483"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58482"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58482"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58482"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}