{"id":58616,"date":"2024-02-28T05:19:40","date_gmt":"2024-02-28T05:19:40","guid":{"rendered":"https:\/\/medsname.com\/onlee-10\/"},"modified":"2026-04-30T10:24:11","modified_gmt":"2026-04-30T10:24:11","slug":"onlee-10","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/onlee-10\/","title":{"rendered":"Onlee-10"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Onlee-10?<\/h3>\n<p style=\"margin:0;\"><strong>Onlee-10<\/strong> je <strong>olanzapin 10 mg<\/strong>, atypick\u00e9 (druh\u00e9 generace) antipsychotikum p\u0159edepisovan\u00e9 pro schizofrenii, akutn\u00ed m\u00e1nii u bipol\u00e1rn\u00ed poruchy I. typu a udr\u017eovac\u00ed terapii bipol\u00e1rn\u00ed poruchy. Obvykl\u00e1 d\u00e1vka: <strong>5\u201310 mg jednou denn\u011b<\/strong>, obvykle p\u0159ed span\u00edm. Hlavn\u00edmi vedlej\u0161\u00edmi \u00fa\u010dinky jsou sedace, p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze a metabolick\u00e9 zm\u011bny \u2014 pravideln\u011b sledujte hmotnost, hladinu gluk\u00f3zy a lipid\u016f b\u011bhem l\u00e9\u010dby.<\/p>\n<\/div>\n<p><strong>Onlee-10<\/strong> je <strong>olanzapin 10 mg tableta<\/strong> \u2014 atypick\u00e9 (druh\u00e9 generace) antipsychotikum pou\u017e\u00edvan\u00e9 k l\u00e9\u010db\u011b <strong>schizofrenie a bipol\u00e1rn\u00ed poruchy I. typu<\/strong>. Je klinicky ekvivalentn\u00ed zna\u010dkov\u00fdm formulac\u00edm olanzapinu, jako je <strong>Zyprexa<\/strong> a pou\u017e\u00edv\u00e1 se po cel\u00e9m sv\u011bt\u011b od konce 90. let 20. stolet\u00ed. Ka\u017ed\u00e1 tableta Onlee-10 obsahuje 10 mg olanzapinu, co\u017e je nej\u010dast\u011bji p\u0159edepisovan\u00e1 denn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 za\u010d\u00ednaj\u00edc\u00ed s antipsychotickou terapi\u00ed.<\/p>\n<p>Olanzapin je \u00fa\u010dinn\u00fd jak pro <strong>pozitivn\u00ed p\u0159\u00edznaky psych\u00f3zy<\/strong> (halucinace, bludy, neuspo\u0159\u00e1dan\u00e9 my\u0161len\u00ed) a <strong>afektivn\u00ed p\u0159\u00edznaky<\/strong> bipol\u00e1rn\u00ed poruchy (akutn\u00ed m\u00e1nie, sm\u00ed\u0161en\u00e9 epizody a dlouhodob\u00e1 stabilizace n\u00e1lady). Obvykle se u\u017e\u00edv\u00e1 jednou denn\u011b ve\u010der a nejl\u00e9pe funguje, kdy\u017e je u\u017e\u00edv\u00e1n pravideln\u011b jako sou\u010d\u00e1st celkov\u00e9ho l\u00e9\u010debn\u00e9ho pl\u00e1nu, kter\u00fd zahrnuje psychoterapii a soci\u00e1ln\u00ed podporu.<\/p>\n<h2 class=\"wp-block-heading\">Co je Onlee-10?<\/h2>\n<p>Onlee-10 je generikum vyr\u00e1b\u011bn\u00e9 v Indii, kter\u00e9 obsahuje <strong>olanzapin<\/strong>, thienobenzodiazepinov\u00fd atypick\u00fd antipsychotikum. Olanzapin je od roku 2017 za\u0159azen na Seznam z\u00e1kladn\u00edch l\u00e9k\u016f Sv\u011btov\u00e9 zdravotnick\u00e9 organizace a z\u016fst\u00e1v\u00e1 jedn\u00edm z nej\u010dast\u011bji p\u0159edepisovan\u00fdch antipsychotik druh\u00e9 generace na sv\u011bt\u011b.<\/p>\n<p>Onlee-10 je typicky p\u0159edepisov\u00e1n pro:<\/p>\n<ul>\n<li><strong>Schizofrenii<\/strong> \u2014 jak akutn\u00ed epizody, tak dlouhodobou udr\u017eovac\u00ed l\u00e9\u010dbu<\/li>\n<li><strong>Akutn\u00ed manick\u00e9 nebo sm\u00ed\u0161en\u00e9 epizody<\/strong> bipol\u00e1rn\u00ed poruchy I. typu, jako monoterapie nebo v kombinaci s lithiem\/valpro\u00e1tem<\/li>\n<li><strong>Udr\u017eovac\u00ed l\u00e9\u010dba bipol\u00e1rn\u00ed poruchy I. typu<\/strong> k prevenci recidivy<\/li>\n<li><strong>L\u00e9\u010dba rezistentn\u00ed deprese<\/strong> jako dopln\u011bk (\u010dasto v kombinaci s fluoxetinem)<\/li>\n<li><strong>Siln\u00e9 rozru\u0161en\u00ed<\/strong> v kontextu psych\u00f3zy nebo m\u00e1nie (pou\u017eit\u00ed v l\u016f\u017ekov\u00fdch za\u0159\u00edzen\u00edch)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Jak funguje Onlee-10?<\/h2>\n<p>Olanzapin pat\u0159\u00ed do <strong>atypick\u00fdch antipsychotik<\/strong> t\u0159\u00eddy a p\u016fsob\u00ed na v\u00edce neurotransmiterov\u00fdch syst\u00e9m\u016f v mozku. Tento \u0161ir\u0161\u00ed receptorov\u00fd profil jej odli\u0161uje od star\u0161\u00edch \u201ctypick\u00fdch\u201d antipsychotik, jako je haloperidol.<\/p>\n<ul>\n<li><strong>Antagonismus dopaminov\u00e9ho receptoru D2<\/strong> v mezolimbick\u00e9 dr\u00e1ze sni\u017euje pozitivn\u00ed p\u0159\u00edznaky psych\u00f3zy, jako jsou halucinace a bludy<\/li>\n<li><strong>Antagonismus serotoninov\u00e9ho receptoru 5-HT2A<\/strong> pom\u00e1h\u00e1 s negativn\u00edmi p\u0159\u00edznaky a sni\u017euje z\u00e1t\u011b\u017e extrapyramidov\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f spojen\u00fdch s \u010dist\u011b dopamin-blokuj\u00edc\u00edmi l\u00e9ky<\/li>\n<li><strong>Blok\u00e1da histaminov\u00e9ho receptoru H1<\/strong> p\u0159isp\u00edv\u00e1 k sedativn\u00edmu \u00fa\u010dinku, kter\u00fd m\u016f\u017ee b\u00fdt u\u017eite\u010dn\u00fd p\u0159i nespavosti nebo akutn\u00edm rozru\u0161en\u00ed, ale tak\u00e9 zp\u016fsobuje p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze<\/li>\n<li><strong>Blok\u00e1da muskarinov\u00e9ho receptoru M1<\/strong> vyvol\u00e1v\u00e1 anticholinergn\u00ed \u00fa\u010dinky (sucho v \u00fastech, z\u00e1cpa)<\/li>\n<li><strong>Blok\u00e1da alfa-1 adrenergn\u00edch receptor\u016f<\/strong> p\u0159isp\u00edv\u00e1 k ortostatick\u00e9 hypotenzi, zejm\u00e9na b\u011bhem titrace d\u00e1vky<\/li>\n<\/ul>\n<p>Maxim\u00e1ln\u00ed plazmatick\u00e1 koncentrace je dosa\u017eena p\u0159ibli\u017en\u011b za <strong>5\u20138 hodin<\/strong>, a polo\u010das rozpadu je <strong>21\u201354 hodin<\/strong> \u2014 dostate\u010dn\u011b dlouh\u00fd pro jednodenn\u00ed d\u00e1vkov\u00e1n\u00ed. Stabiln\u00ed hladiny v krvi jsou obvykle dosa\u017eeny b\u011bhem p\u0159ibli\u017en\u011b jednoho t\u00fddne pravideln\u00e9ho u\u017e\u00edv\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Schizofrenie (akutn\u00ed a udr\u017eovac\u00ed l\u00e9\u010dba):<\/strong> olanzapin je pova\u017eov\u00e1n za jeden z \u00fa\u010dinn\u011bj\u0161\u00edch antipsychotik druh\u00e9 generace u l\u00e9\u010debn\u011b rezistentn\u00edch p\u0159\u00edpad\u016f<\/li>\n<li><strong>Bipol\u00e1rn\u00ed porucha I \u2014 akutn\u00ed m\u00e1nie nebo sm\u00ed\u0161en\u00e9 epizody<\/strong> jako monoterapie nebo v kombinaci s thymoprofylaktikem<\/li>\n<li><strong>udr\u017eovac\u00ed l\u00e9\u010dba bipol\u00e1rn\u00ed poruchy I. typu<\/strong> ke sn\u00ed\u017een\u00ed rizika relapsu do m\u00e1nie nebo deprese<\/li>\n<li><strong>deprese s psychotick\u00fdmi rysy<\/strong> v kombinaci s SSRI<\/li>\n<li><strong>farmakorezistentn\u00ed t\u011b\u017ek\u00e1 depresivn\u00ed porucha<\/strong> (\u010dasto kombinov\u00e1n s fluoxetinem jako Symbyax \/ OFC)<\/li>\n<li><strong>kr\u00e1tkodob\u00e1 l\u00e9\u010dba t\u011b\u017ek\u00e9 agitovanosti<\/strong> v l\u016f\u017ekov\u00fdch psychiatrick\u00fdch za\u0159\u00edzen\u00edch<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Onlee-10 D\u00e1vkov\u00e1n\u00ed a pod\u00e1v\u00e1n\u00ed<\/h2>\n<p>Individu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed se li\u0161\u00ed podle diagn\u00f3zy, v\u011bku a odpov\u011bdi. L\u00e9\u010dba obvykle za\u010d\u00edn\u00e1 <strong>ni\u017e\u0161\u00ed po\u010d\u00e1te\u010dn\u00ed d\u00e1vkou<\/strong> a postupn\u011b se zvy\u0161uje podle pot\u0159eby.<\/p>\n<table>\n<thead>\n<tr>\n<th>Indikace \/ Pacient<\/th>\n<th>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\n<th>Obvykl\u00e9 \u00fa\u010dinn\u00e9 rozmez\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Schizofrenie (dosp\u011bl\u00ed)<\/strong><\/td>\n<td>5\u201310 mg jednou denn\u011b<\/td>\n<td>10\u201320 mg denn\u011b<\/td>\n<\/tr>\n<tr>\n<td><strong>Bipol\u00e1rn\u00ed akutn\u00ed m\u00e1nie (monoterapie)<\/strong><\/td>\n<td>10\u201315 mg jednou denn\u011b<\/td>\n<td>10\u201320 mg denn\u011b<\/td>\n<\/tr>\n<tr>\n<td><strong>Bipol\u00e1rn\u00ed akutn\u00ed m\u00e1nie (kombinovan\u00e1 l\u00e9\u010dba)<\/strong><\/td>\n<td>10 mg jednou denn\u011b<\/td>\n<td>5\u201320 mg s lithiem nebo valpro\u00e1tem<\/td>\n<\/tr>\n<tr>\n<td><strong>Bipol\u00e1rn\u00ed udr\u017eovac\u00ed l\u00e9\u010dba<\/strong><\/td>\n<td>Pokra\u010dovat v \u00fa\u010dinn\u00e9 akutn\u00ed d\u00e1vce<\/td>\n<td>5\u201320 mg denn\u011b<\/td>\n<\/tr>\n<tr>\n<td><strong>P\u0159\u00eddavn\u00e1 l\u00e9\u010dba deprese<\/strong><\/td>\n<td>5 mg ve\u010der<\/td>\n<td>5\u201315 mg s fluoxetinem<\/td>\n<\/tr>\n<tr>\n<td><strong>Senio\u0159i (65+) nebo oslaben\u00ed pacienti<\/strong><\/td>\n<td>2,5\u20135 mg denn\u011b<\/td>\n<td>Titrovat opatrn\u011b; nep\u0159ekra\u010dovat 10 mg bez odborn\u00e9ho dohledu<\/td>\n<\/tr>\n<tr>\n<td><strong>Porucha funkce jater<\/strong><\/td>\n<td>5 mg denn\u011b<\/td>\n<td>Opatrn\u00e1 titrace; monitorovat jatern\u00ed testy<\/td>\n<\/tr>\n<tr>\n<td><strong>Maxim\u00e1ln\u00ed denn\u00ed d\u00e1vka<\/strong><\/td>\n<td>20 mg<\/td>\n<td>Vy\u0161\u0161\u00ed d\u00e1vky z\u0159\u00eddka p\u0159in\u00e1\u0161ej\u00ed dal\u0161\u00ed benefit<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Onlee-10<\/h3>\n<ul>\n<li>U\u017e\u00edvejte Onlee-10 <strong>jednou denn\u011b ve stejnou dobu<\/strong> \u2014 v\u011bt\u0161ina pacient\u016f ji u\u017e\u00edv\u00e1 ve\u010der kv\u016fli sedativn\u00edmu \u00fa\u010dinku<\/li>\n<li>Lze u\u017e\u00edvat <strong>s j\u00eddlem nebo nala\u010dno<\/strong> \u2014 j\u00eddlo neovliv\u0148uje v\u00fdznamn\u011b vst\u0159eb\u00e1v\u00e1n\u00ed<\/li>\n<li>Tabletu spolkn\u011bte celou a zapijte sklenic\u00ed vody<\/li>\n<li>Nep\u0159est\u00e1vejte <strong>nep\u0159eru\u0161ujte u\u017e\u00edv\u00e1n\u00ed Onlee-10 n\u00e1hle<\/strong>, ani kdy\u017e se c\u00edt\u00edte l\u00e9pe \u2014 n\u00e1hl\u00e9 vysazen\u00ed m\u016f\u017ee zp\u016fsobit relaps nebo abstinen\u010dn\u00ed p\u0159\u00edznaky (nespavost, nevolnost, pocen\u00ed). V\u017edy sni\u017eujte d\u00e1vku pod l\u00e9ka\u0159sk\u00fdm dohledem<\/li>\n<li>Pokud d\u00e1vku vynech\u00e1te a vzpomenete si do 12 hodin, u\u017eijte ji. Pokud uplynulo v\u00edce ne\u017e 12 hodin, vynechejte ji a pokra\u010dujte v obvykl\u00e9m re\u017eimu \u2014 nedvojte d\u00e1vku<\/li>\n<li>D\u016fslednost je kl\u00ed\u010dov\u00e1 \u2014 antipsychotick\u00fd \u00fa\u010dinek se pln\u011b rozv\u00edj\u00ed po 2\u20134 t\u00fddnech pravideln\u00e9ho u\u017e\u00edv\u00e1n\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky p\u0159\u00edpravku Onlee-10<\/h2>\n<p>Olanzapin je obecn\u011b dob\u0159e sn\u00e1\u0161en pro psychiatrickou \u00fa\u010dinnost, ale m\u00e1 dob\u0159e zdokumentovan\u00fd metabolick\u00fd profil vedlej\u0161\u00edch \u00fa\u010dink\u016f vy\u017eaduj\u00edc\u00ed pr\u016fb\u011b\u017en\u00e9 monitorov\u00e1n\u00ed.<\/p>\n<table>\n<thead>\n<tr>\n<th>Z\u00e1va\u017enost<\/th>\n<th>Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Velmi \u010dast\u00e9 (\u22651 z 10)<\/strong><\/td>\n<td>Sedace\/ospalost, p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze (pr\u016fm\u011brn\u011b 3\u20137 kg), zv\u00fd\u0161en\u00e1 chu\u0165 k j\u00eddlu, z\u00e1vrat\u011b, m\u00edrn\u00e1 ortostatick\u00e1 hypotenze<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cast\u00e9 (\u22651 ze 100)<\/strong><\/td>\n<td>Sucho v \u00fastech, z\u00e1cpa, zv\u00fd\u0161en\u00e1 hladina gluk\u00f3zy nala\u010dno, zv\u00fd\u0161en\u00fd cholesterol a triglyceridy, m\u00edrn\u00e1 transaminitida, perifern\u00ed ed\u00e9my, m\u00edrn\u00e9 extrapyramidov\u00e9 p\u0159\u00edznaky (t\u0159es, akatizie)<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00e9n\u011b \u010dast\u00e9<\/strong><\/td>\n<td>Nov\u011b vznikl\u00fd diabetes mellitus, hyperprolaktinemie, sexu\u00e1ln\u00ed dysfunkce, retence mo\u010di, tardivn\u00ed dyskineze (p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed)<\/td>\n<\/tr>\n<tr>\n<td><strong>Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9<\/strong><\/td>\n<td>Neuroleptick\u00fd malign\u00ed syndrom, diabetick\u00e1 ketoacid\u00f3za, t\u011b\u017ek\u00e1 hyperglyk\u00e9mie, z\u00e1chvaty, agranulocyt\u00f3za, hepatitida, \u017eiln\u00ed tromboembolie, c\u00e9vn\u00ed mozkov\u00e1 p\u0159\u00edhoda<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Vyhledejte neodkladnou l\u00e9ka\u0159skou pomoc<\/strong> pokud se u v\u00e1s objev\u00ed n\u011bkter\u00fd z n\u00e1sleduj\u00edc\u00edch p\u0159\u00edznak\u016f:<\/p>\n<ul>\n<li>Velmi vysok\u00e1 hore\u010dka, svalov\u00e1 ztuhlost, zmatenost (mo\u017en\u00fd neuroleptick\u00fd malign\u00ed syndrom)<\/li>\n<li>Nekontrolovateln\u00e9 pohyby obli\u010deje, jazyka nebo kon\u010detin<\/li>\n<li>P\u0159\u00edznaky t\u011b\u017ek\u00e9 hyperglyk\u00e9mie \u2014 extr\u00e9mn\u00ed \u017e\u00edze\u0148, \u010dast\u00e9 mo\u010den\u00ed, ovocn\u00fd z\u00e1pach dechu, rychl\u00e9 d\u00fdch\u00e1n\u00ed<\/li>\n<li>P\u0159\u00edznaky krevn\u00ed sra\u017eeniny \u2014 bolest na hrudi, du\u0161nost, jednostrann\u00fd otok nebo bolest nohy<\/li>\n<li>T\u011b\u017ek\u00e1 alergick\u00e1 reakce \u2014 otok obli\u010deje, krku nebo jazyka; obt\u00ed\u017en\u00e9 d\u00fdch\u00e1n\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Pacienti star\u0161\u00edho v\u011bku s psych\u00f3zou souvisej\u00edc\u00ed s demenc\u00ed:<\/strong> olanzapin je <strong>FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. V\u00fdzkumn\u00fd DSIP prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n<\/strong> pro tuto indikaci a nese \u010dern\u00e9 varov\u00e1n\u00ed ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika mortality v t\u00e9to specifick\u00e9 populaci<\/li>\n<li><strong>Metabolick\u00fd monitoring:<\/strong> doporu\u010duje se z\u00e1kladn\u00ed a pravideln\u00e9 sledov\u00e1n\u00ed hmotnosti, obvodu pasu, hladiny gluk\u00f3zy nala\u010dno, HbA1c a lipidov\u00e9ho profilu \u2014 ide\u00e1ln\u011b na za\u010d\u00e1tku, po 3 m\u011bs\u00edc\u00edch a pot\u00e9 ro\u010dn\u011b<\/li>\n<li><strong>Riziko diabetu:<\/strong> olanzapin m\u016f\u017ee odhalit nebo zhor\u0161it diabetes, a to i bez v\u00fdrazn\u00e9ho p\u0159\u00edr\u016fstku hmotnosti. Sledujte hladinu gluk\u00f3zy nala\u010dno na za\u010d\u00e1tku a pravideln\u011b<\/li>\n<li><strong>Kardiovaskul\u00e1rn\u00ed riziko:<\/strong> bylo pozorov\u00e1no m\u00edrn\u00e9 prodlou\u017een\u00ed QT intervalu; klinicky v\u00fdznamn\u011bj\u0161\u00ed je v\u0161ak metabolick\u00fd dopad<\/li>\n<li><strong>Ortostatick\u00e1 hypotenze:<\/strong> nejv\u00fdrazn\u011bj\u0161\u00ed je b\u011bhem titrace d\u00e1vky \u2014 vst\u00e1vejte pomalu ze sedu nebo lehu<\/li>\n<li><strong>Pr\u00e1h z\u00e1chvat\u016f:<\/strong> olanzapin m\u00edrn\u011b sni\u017euje pr\u00e1h z\u00e1chvat\u016f; pou\u017e\u00edvejte opatrn\u011b u epilepsie nebo u pacient\u016f u\u017e\u00edvaj\u00edc\u00edch prokonvulzivn\u00ed l\u00e9ky<\/li>\n<li><strong>Porucha funkce jater:<\/strong> za\u010dn\u011bte n\u00edzkou d\u00e1vkou (5 mg), sledujte jatern\u00ed testy<\/li>\n<li><strong>T\u011bhotenstv\u00ed (kategorie C):<\/strong> expozice ve t\u0159et\u00edm trimestru byla spojena s neonat\u00e1ln\u00edmi extrapyramidov\u00fdmi p\u0159\u00edznaky a abstinen\u010dn\u00edmi p\u0159\u00edznaky \u2014 zva\u017ete p\u0159\u00ednosy versus rizika se sv\u00fdm specialistou<\/li>\n<li><strong>Kojen\u00ed:<\/strong> olanzapin p\u0159ech\u00e1z\u00ed do mate\u0159sk\u00e9ho ml\u00e9ka; proberte rovnov\u00e1hu se sv\u00fdm p\u0159edepisuj\u00edc\u00edm l\u00e9ka\u0159em<\/li>\n<li><strong>Kou\u0159en\u00ed:<\/strong> kou\u0159en\u00ed indukuje CYP1A2 a sni\u017euje hladiny olanzapinu \u2014 ukon\u010den\u00ed kou\u0159en\u00ed m\u016f\u017ee zv\u00fd\u0161it hladiny v krvi a m\u016f\u017ee vy\u017eadovat revizi d\u00e1vkov\u00e1n\u00ed<\/li>\n<li><strong>Alkohol:<\/strong> zesiluje sedaci; vyvarujte se nebo omezte<\/li>\n<li><strong>Citlivost na teplo:<\/strong> olanzapin naru\u0161uje regulaci t\u011blesn\u00e9 teploty \u2014 bu\u010fte opatrn\u00ed v hork\u00e9m podneb\u00ed a p\u0159i nam\u00e1hav\u00e9m cvi\u010den\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na olanzapin nebo jakoukoli pomocnou l\u00e1tku<\/li>\n<li>T\u011b\u017ek\u00fd uzav\u0159en\u00fd glaukom<\/li>\n<li>T\u011b\u017ek\u00e1 deprese centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu nebo k\u00f3ma jak\u00e9hokoli p\u016fvodu<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f zn\u00e1m\u00fdch pro v\u00fdznamn\u00e9 prodlou\u017een\u00ed QT intervalu by m\u011blo b\u00fdt posuzov\u00e1no individu\u00e1ln\u011b<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table>\n<thead>\n<tr>\n<th>L\u00e9\u010divo \/ T\u0159\u00edda<\/th>\n<th>Interakce<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Fluvoxamin, ciprofloxacin<\/strong><\/td>\n<td>Siln\u00e9 inhibitory CYP1A2 \u2014 mohou zdvojn\u00e1sobit plazmatick\u00e9 hladiny olanzapinu; sni\u017ete d\u00e1vku olanzapinu<\/td>\n<\/tr>\n<tr>\n<td><strong>Karbamazepin, fenytoin, rifampicin<\/strong><\/td>\n<td>Induktory CYP1A2 \u2014 sni\u017euj\u00ed hladiny olanzapinu; m\u016f\u017ee b\u00fdt pot\u0159eba vy\u0161\u0161\u00ed d\u00e1vka olanzapinu<\/td>\n<\/tr>\n<tr>\n<td><strong>Kou\u0159en\u00ed (tab\u00e1k)<\/strong><\/td>\n<td>Indukuje CYP1A2; ukon\u010den\u00ed kou\u0159en\u00ed m\u016f\u017ee v\u00fdrazn\u011b zv\u00fd\u0161it hladiny olanzapinu<\/td>\n<\/tr>\n<tr>\n<td><strong>Benzodiazepiny, opioidy, alkohol<\/strong><\/td>\n<td>Aditivn\u00ed \u00fatlum CNS a d\u00fdch\u00e1n\u00ed; pou\u017e\u00edvejte parenter\u00e1ln\u00ed olanzapin + IM benzodiazepiny s velkou opatrnost\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>Levodopa, agonist\u00e9 dopaminu<\/strong><\/td>\n<td>Antagonistick\u00fd \u00fa\u010dinek \u2014 olanzapin m\u016f\u017ee sn\u00ed\u017eit \u00fa\u010dinnost l\u00e9k\u016f na Parkinsonovu chorobu<\/td>\n<\/tr>\n<tr>\n<td><strong>Antihypertenziva<\/strong><\/td>\n<td>Aditivn\u00ed hypotenzn\u00ed \u00fa\u010dinek \u2014 monitorujte krevn\u00ed tlak<\/td>\n<\/tr>\n<tr>\n<td><strong>Anticholinergika<\/strong><\/td>\n<td>Aditivn\u00ed anticholinergn\u00ed \u00fa\u010dinky (sucho v \u00fastech, z\u00e1cpa, retence mo\u010di)<\/td>\n<\/tr>\n<tr>\n<td><strong>Dal\u0161\u00ed l\u00e9ky prodlu\u017euj\u00edc\u00ed QT interval<\/strong><\/td>\n<td>Kombinovan\u00e9 riziko arytmie \u2014 konzultujte s p\u0159edepisuj\u00edc\u00edm l\u00e9ka\u0159em<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Ukon\u010den\u00ed Onlee-10<\/h2>\n<p>Olanzapin by <strong>nem\u011bl b\u00fdt n\u00e1hle vysazen<\/strong>. N\u00e1hl\u00e9 vysazen\u00ed m\u016f\u017ee zp\u016fsobit:<\/p>\n<ul>\n<li>N\u00e1vratov\u00e1 nespavost, nevolnost, pocen\u00ed, neklid<\/li>\n<li>\u201cSupersenzitivn\u00ed psych\u00f3za\u201d \u2014 rychl\u00fd n\u00e1vrat psychotick\u00fdch nebo manick\u00fdch p\u0159\u00edznak\u016f<\/li>\n<li>Siln\u00e1 \u00fazkost nebo dysforie<\/li>\n<\/ul>\n<p>Standardn\u00ed postup je <strong>postupn\u00e9 sni\u017eov\u00e1n\u00ed d\u00e1vky po dobu minim\u00e1ln\u011b 4 t\u00fddn\u016f<\/strong>, pod dohledem psychiatra. Nikdy neupravujte d\u00e1vkov\u00e1n\u00ed bez p\u0159edchoz\u00ed konzultace s l\u00e9ka\u0159em.<\/p>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i teplot\u011b do 25 \u00b0C na such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9 p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem<\/li>\n<li>Tablety uchov\u00e1vejte v p\u016fvodn\u00edm blistru a\u017e do pou\u017eit\u00ed<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed \u2014 n\u00e1hodn\u00e9 po\u017eit\u00ed d\u00edt\u011btem m\u016f\u017ee m\u00edt v\u00e1\u017en\u00e9 n\u00e1sledky<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed uveden\u00e9ho data expirace<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed produkty na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/synaptol\/\" rel=\"noopener\">Synaptol<\/a> \u2014 kombinace pou\u017e\u00edvan\u00e1 u vybran\u00fdch neuropsychiatrick\u00fdch stav\u016f<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mens-health\/\" rel=\"noopener\">L\u00e9ky na du\u0161evn\u00ed zdrav\u00ed<\/a> \u2014 prohl\u00e9dn\u011bte si souvisej\u00edc\u00ed psychiatrick\u00e9 l\u00e9\u010dby<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Jak dlouho trv\u00e1, ne\u017e Onlee-10 za\u010dne p\u016fsobit?<\/h3>\n<p>N\u011bkter\u00e9 \u00fa\u010dinky \u2014 jako sedace a sn\u00ed\u017een\u00ed neklidu \u2014 se objev\u00ed b\u011bhem prvn\u00edch n\u011bkolika dn\u016f. Pln\u00fd antipsychotick\u00fd nebo stabiliza\u010dn\u00ed \u00fa\u010dinek na n\u00e1ladu se obvykle rozv\u00edj\u00ed postupn\u011b b\u011bhem <strong>2\u20136 t\u00fddn\u016f<\/strong> pravideln\u00e9ho denn\u00edho u\u017e\u00edv\u00e1n\u00ed. Nehodno\u0165te jeho \u00fa\u010dinek pouze v prvn\u00edm t\u00fddnu.<\/p>\n<h3 class=\"wp-block-heading\">Zp\u016fsob\u00ed Onlee-10 p\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze?<\/h3>\n<p>P\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze je jedn\u00edm z nej\u010dast\u011bj\u0161\u00edch vedlej\u0161\u00edch \u00fa\u010dink\u016f, pr\u016fm\u011brn\u011b 3\u20137 kg v prvn\u00edch 6 m\u011bs\u00edc\u00edch. Riziko je nejvy\u0161\u0161\u00ed v prvn\u00edch t\u0159ech m\u011bs\u00edc\u00edch. V\u010dasn\u00e1 dietn\u00ed doporu\u010den\u00ed, sn\u00ed\u017een\u00fd p\u0159\u00edjem sacharid\u016f a pravideln\u00fd pohyb mohou v\u00fdrazn\u011b omezit p\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze. V\u00e1\u0161 l\u00e9ka\u0159 by m\u011bl sledovat v\u00e1hu, obvod pasu, hladinu gluk\u00f3zy nala\u010dno a lipidy na za\u010d\u00e1tku a pravideln\u011b.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Onlee-10?<\/h3>\n<p>Alkohol zesiluje sedativn\u00ed a hypotenzn\u00ed \u00fa\u010dinky olanzapinu a m\u016f\u017ee zhor\u0161it psychiatrick\u00fd stav, kter\u00fd l\u00e9\u010d\u00ed. Je nejlep\u0161\u00ed se mu vyhnout; pokud pijete, udr\u017eujte to na minimu.<\/p>\n<h3 class=\"wp-block-heading\">Je Onlee-10 n\u00e1vykov\u00fd?<\/h3>\n<p>Olanzapin nen\u00ed n\u00e1vykov\u00fd v klasick\u00e9m smyslu \u2013 nevyvol\u00e1v\u00e1 ba\u017een\u00ed ani opojen\u00ed. Av\u0161ak n\u00e1hl\u00e9 vysazen\u00ed m\u016f\u017ee zp\u016fsobit abstinen\u010dn\u00ed p\u0159\u00edznaky a psychiatrick\u00fd relaps, proto se doporu\u010duje postupn\u00fd \u00fatlum.<\/p>\n<h3 class=\"wp-block-heading\">Lze Onlee-10 u\u017e\u00edvat v t\u011bhotenstv\u00ed?<\/h3>\n<p>Olanzapin je kategorie C. Existuj\u00ed situace, kdy p\u0159\u00ednos pokra\u010dov\u00e1n\u00ed l\u00e9\u010dby p\u0159eva\u017euje nad rizikem, ale toto mus\u00ed b\u00fdt individu\u00e1ln\u00ed rozhodnut\u00ed s va\u0161\u00edm psychiatrem a gynekologem. Expozice ve t\u0159et\u00edm trimestru m\u016f\u017ee zp\u016fsobit abstinen\u010dn\u00ed p\u0159\u00edznaky u novorozence.<\/p>\n<h3 class=\"wp-block-heading\">Bude m\u011b Onlee-10 tolik usp\u00e1vat, \u017ee nebudu moci pracovat?<\/h3>\n<p>Sedace je obvykle nejsiln\u011bj\u0161\u00ed v prvn\u00edch n\u011bkolika t\u00fddnech a \u010dasto se zm\u00edrn\u00ed. U\u017e\u00edv\u00e1n\u00ed d\u00e1vky ve\u010der m\u016f\u017ee minimalizovat denn\u00ed ospalost. Ne\u0159i\u010fte ani neobsluhujte t\u011b\u017ek\u00e9 stroje, dokud nev\u00edte, jak na v\u00e1s Onlee-10 p\u016fsob\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Lze tabletu Onlee-10 rozd\u011blit nebo rozdrtit?<\/h3>\n<p>B\u011b\u017en\u00e9 tablety olanzapinu lze obvykle v p\u0159\u00edpad\u011b pot\u0159eby rozd\u011blit pro \u00fapravu d\u00e1vkov\u00e1n\u00ed, ale drcen\u00ed se obecn\u011b nedoporu\u010duje. Pokud m\u00e1te pot\u00ed\u017ee s polyk\u00e1n\u00edm tablet, po\u017e\u00e1dejte sv\u00e9ho l\u00e9ka\u0159e o orodispergovateln\u00e9 formy olanzapinu.<\/p>\n<h3 class=\"wp-block-heading\">Je Onlee-10 tot\u00e9\u017e co Zyprexa?<\/h3>\n<p>Oba p\u0159\u00edpravky obsahuj\u00ed 10 mg olanzapinu a jsou bioekvivalentn\u00ed. Onlee-10 je indick\u00e1 generick\u00e1 verze; Zyprexa je p\u016fvodn\u00ed zna\u010dka od Eli Lilly. Klinick\u00e1 \u00fa\u010dinnost je stejn\u00e1.<\/p>\n<h3 class=\"wp-block-heading\">Co m\u00e1m d\u011blat, kdy\u017e zapomenu d\u00e1vku?<\/h3>\n<p>Pokud si vzpomenete do 12 hodin, vynechanou d\u00e1vku u\u017eijte. Pokud uplynulo v\u00edce ne\u017e 12 hodin, vynechejte ji a u\u017eijte dal\u0161\u00ed d\u00e1vku v obvyklou dobu. Nikdy neu\u017e\u00edvejte dv\u011b d\u00e1vky najednou, abyste nahradili vynechanou d\u00e1vku.<\/p>\n<h3 class=\"wp-block-heading\">Jak \u010dasto budu pot\u0159ebovat kontroly p\u0159i u\u017e\u00edv\u00e1n\u00ed Onlee-10?<\/h3>\n<p>Typick\u00e9 monitorov\u00e1n\u00ed: vstupn\u00ed fyzik\u00e1ln\u00ed vy\u0161et\u0159en\u00ed a krevn\u00ed testy (hmotnost, obvod pasu, glyk\u00e9mie nala\u010dno, HbA1c, lipidov\u00fd profil, jatern\u00ed testy, krevn\u00ed obraz), opakov\u00e1n\u00ed po 3 m\u011bs\u00edc\u00edch a pot\u00e9 alespo\u0148 ro\u010dn\u011b. V\u00e1\u0161 psychiatr bude \u010dast\u011bji hodnotit du\u0161evn\u00ed stav \u2013 obvykle ka\u017ed\u00e9 2\u20134 t\u00fddny na za\u010d\u00e1tku a ka\u017ed\u00e9 2\u20133 m\u011bs\u00edce po stabilizaci.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Onlee-10 na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em <a href=\"https:\/\/medsbase.com\/cs\/loyalty-points\/\">v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Obecn\u00e9 zdrav\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/pepzol\/\">Pepzol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/olopat-eye-drop\/\">Olopat Eye Drop<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/spectra\/\">Spectra<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/l-glutathione\/\">L-Glutathione<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mirzacan\/\">Mirzacan<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Onlee-10 (Olanzapin 10 mg) \u2014 atypick\u00fd thienobenzodiazepin pro l\u00e9\u010dbu schizofrenie a bipol\u00e1rn\u00ed m\u00e1nie. Pevn\u00e1 d\u00e1vka 10 mg \u2014 b\u011b\u017en\u00e1 udr\u017eovac\u00ed d\u00e1vka.<\/p>","protected":false},"featured_media":58617,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4527,4530],"class_list":{"0":"post-58616","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-olanzapine","10":"product_tag-onlee-10","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58616"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58617"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58616"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58616"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58616"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}