{"id":58668,"date":"2024-02-28T05:22:29","date_gmt":"2024-02-28T05:22:29","guid":{"rendered":"https:\/\/medsname.com\/pantocid-injection\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"pantocid-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/pantocid-injection\/","title":{"rendered":"Pantocid Injection"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je injekce Pantocid?<\/h3>\n

Pantocid Injection<\/strong> je pantoprazol sodn\u00fd 40 mg v jedn\u00e9 lahvi\u010dce<\/strong> pro intraven\u00f3zn\u00ed pou\u017eit\u00ed, vyr\u00e1b\u011bno spole\u010dnost\u00ed Sun Pharma ve v\u00fdrobn\u00edm za\u0159\u00edzen\u00ed certifikovan\u00e9m WHO-GMP. Toto je parenter\u00e1ln\u00ed forma pantoprazolu pou\u017e\u00edvan\u00e1 v nemocnici, kdy\u017e pacient nem\u016f\u017ee u\u017e\u00edvat peror\u00e1ln\u00ed PPI<\/strong> \u2014 nula per os, poopera\u010dn\u00ed stav, intubace nebo aktivn\u00ed krv\u00e1cen\u00ed z horn\u00ed \u010d\u00e1sti tr\u00e1vic\u00edho traktu. Standardn\u00ed d\u00e1vka:<\/strong> 40 mg IV jednou denn\u011b, rekonstituov\u00e1no v 0,9% fyziologick\u00e9m roztoku, pod\u00e1v\u00e1no infuz\u00ed po dobu 15 minut. Pro aktivn\u00ed nevarik\u00f3zn\u00ed krv\u00e1cen\u00ed z horn\u00ed \u010d\u00e1sti tr\u00e1vic\u00edho traktu<\/strong> U pacient\u016f s vysokorizikov\u00fdm endoskopick\u00fdm n\u00e1lezem (Forrest Ia\/Ib\/IIa\/IIb) se pod\u00e1v\u00e1 80 mg intraven\u00f3zn\u011b v bolusu, n\u00e1sledovan\u00e1 kontinu\u00e1ln\u00ed infuz\u00ed 8 mg\/h po dobu 72 hodin. P\u0159echod na peror\u00e1ln\u00ed pantoprazol<\/strong> (nap\u0159. Pantodac 40 mg), jakmile pacient bezpe\u010dn\u011b polyk\u00e1. Pokra\u010dov\u00e1n\u00ed v intraven\u00f3zn\u00edm pod\u00e1v\u00e1n\u00ed PPI po 3\u20135 dnech nem\u00e1 farmakologick\u00fd p\u0159\u00ednos.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

L\u00e9k pro nemocni\u010dn\u00ed pou\u017eit\u00ed.<\/strong> Pantocid Injection je parenter\u00e1ln\u00ed l\u00e9k ur\u010den\u00fd pro l\u016f\u017ekov\u00e9 nebo klinicky sledovan\u00e9 pou\u017eit\u00ed. Dod\u00e1v\u00e1 se jako steriln\u00ed lyofilizovan\u00fd pr\u00e1\u0161ek v lahvi\u010dce, kter\u00fd mus\u00ed b\u00fdt rekonstituov\u00e1n s 0,9% roztokem chloridu sodn\u00e9ho a pod\u00e1v\u00e1n intraven\u00f3zn\u011b kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem. Samopod\u00e1n\u00ed tohoto p\u0159\u00edpravku nen\u00ed vhodn\u00e9. Pokud m\u016f\u017eete u\u017e\u00edvat peror\u00e1ln\u00ed PPI, peror\u00e1ln\u00ed pantoprazol (Pantodac, Pan, Pentab, Walapan-40) nebo jak\u00fdkoli jin\u00fd peror\u00e1ln\u00ed PPI poskytuje ekvivalentn\u00ed supresi kyseliny za zlomek n\u00e1klad\u016f.<\/div>\n

Co je Pantocid Injection<\/h2>\n

Pantocid Injection je zna\u010dka spole\u010dnosti Sun Pharma pro intraven\u00f3zn\u00ed pantoprazol sodn\u00fd<\/strong>. Ka\u017ed\u00e1 lahvi\u010dka obsahuje pantoprazol sodn\u00fd odpov\u00eddaj\u00edc\u00ed 40 mg pantoprazolov\u00e9 b\u00e1ze, dod\u00e1van\u00fd jako steriln\u00ed lyofilizovan\u00fd pr\u00e1\u0161ek k rekonstituci. Jedn\u00e1 se o parenter\u00e1ln\u00ed formu stejn\u00e9 molekuly dostupn\u00e9 peror\u00e1ln\u011b jako Pantodac, Pan, Pentab, Penlip a Walapan-40.<\/p>\n

Jak Pantocid Injection funguje<\/h2>\n

Pantoprazol je benzimidazolov\u00fd inhibitor protonov\u00e9 pumpy. Po intraven\u00f3zn\u00edm pod\u00e1n\u00ed se l\u00e9k koncentruje v kysel\u00fdch sekre\u010dn\u00edch kan\u00e1lc\u00edch pariet\u00e1ln\u00edch bun\u011bk \u017ealudku. Tam je protonov\u00e1n na aktivn\u00ed sulfenamidovou formu, kter\u00e1 vytv\u00e1\u0159\u00ed kovalentn\u00ed disulfidovou vazbu s cysteinov\u00fdmi zbytky na H+<\/sup>\/K+<\/sup>-ATP\u00e1zov\u00e9 pump\u011b. Toto nevratn\u011b blokuje sekreci kyseliny, dokud nejsou syntetizov\u00e1ny nov\u00e9 pumpy, co\u017e poskytuje 24\u201372 hodin farmakodynamick\u00e9ho \u00fa\u010dinku z ka\u017ed\u00e9 d\u00e1vky navzdory kr\u00e1tk\u00e9mu plazmatick\u00e9mu polo\u010dasu ~1 hodina. Kontinu\u00e1ln\u00ed infuze se pou\u017e\u00edv\u00e1 u aktivn\u00edho GI krv\u00e1cen\u00ed, proto\u017ee udr\u017euje zv\u00fd\u0161en\u00e9 intragastrick\u00e9 pH > 6 \u2014 prahovou hodnotu, nad kterou je zachov\u00e1na agregace trombocyt\u016f a zlep\u0161ena stabilita krevn\u00ed sra\u017eeniny.<\/p>\n

Indikace \u2014 Kdy se pou\u017e\u00edv\u00e1 intraven\u00f3zn\u00ed pantoprazol<\/h2>\n

1. Aktivn\u00ed krv\u00e1cen\u00ed z horn\u00ed \u010d\u00e1sti GI traktu z peptick\u00e9ho v\u0159edu (po endoskopii)<\/h3>\n

Nejv\u011bt\u0161\u00ed evidence. Po endoskopick\u00e9 hemost\u00e1ze vysokorizikov\u00e9ho n\u00e1lezu (aktivn\u00ed arteri\u00e1ln\u00ed krv\u00e1cen\u00ed Forrest Ia, prosakov\u00e1n\u00ed Ib, nekrv\u00e1cen\u00ed viditeln\u00e1 c\u00e9va IIa nebo p\u0159ilnav\u00e1 sra\u017eenina IIb) sni\u017euje 72hodinov\u00e1 intraven\u00f3zn\u00ed infuze PPI v d\u00e1vce 80 mg bolus + 8 mg\/h op\u011btovn\u00e9 krv\u00e1cen\u00ed, chirurgick\u00fd z\u00e1krok a 30denn\u00ed mortalitu. Pacienti s n\u00edzkorizikov\u00fdmi n\u00e1lezy (Forrest IIc\/III) nepot\u0159ebuj\u00ed intraven\u00f3zn\u00ed terapii a mohou p\u0159ej\u00edt p\u0159\u00edmo na vysok\u00e9 d\u00e1vky peror\u00e1ln\u00edho pantoprazolu.<\/p>\n

2. Pacienti NPO (nic per os) vy\u017eaduj\u00edc\u00ed supresi kyseliny<\/h3>\n

Poopera\u010dn\u00ed ileus, mechanick\u00e1 ventilace, t\u011b\u017ek\u00e1 pankreatitida, p\u0159etrv\u00e1vaj\u00edc\u00ed zvracen\u00ed nebo dysfagie. Po obnoven\u00ed enter\u00e1ln\u00ed v\u00fd\u017eivy p\u0159ej\u00edt na peror\u00e1ln\u00ed pantoprazol.<\/p>\n

3. Profylaxe stresov\u00fdch v\u0159ed\u016f na JIP<\/h3>\n

Pro pacienty s mechanickou ventilac\u00ed > 48 hodin, s koagulopati\u00ed nebo na vazopresorech. Pozn\u00e1mka: dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed PPI na JIP je spojeno se zv\u00fd\u0161en\u00fdm rizikem C. difficile<\/em> infekce a ventil\u00e1torov\u00e9 pneumonie \u2014 denn\u011b p\u0159ehodnocujte indikaci a vysa\u010fte, kdy\u017e ji\u017e nen\u00ed pot\u0159eba.<\/p>\n

4. Zollinger\u016fv-Ellison\u016fv syndrom \u2014 p\u0159echodn\u00e1 l\u00e9\u010dba<\/h3>\n

Pro pacienty se stavy hypersekrece kyseliny, kte\u0159\u00ed do\u010dasn\u011b nemohou u\u017e\u00edvat peror\u00e1ln\u00ed PPI.<\/p>\n

D\u00e1vkov\u00e1n\u00ed a pod\u00e1v\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9<\/td>\n40 mg IV 1\u00d7 denn\u011b<\/td>\nRozpustit v 10 ml 0,9% roztoku chloridu sodn\u00e9ho; mo\u017eno d\u00e1le na\u0159edit ve 100 ml 0,9% NaCl; infundovat po dobu 15 minut<\/td>\n<\/tr>\n
Krv\u00e1cen\u00ed do horn\u00ed \u010d\u00e1sti GI traktu (vysoce rizikov\u00e1 l\u00e9ze, po endoskopii)<\/td>\n80 mg IV bolus, pot\u00e9 kontinu\u00e1ln\u00ed infuze 8 mg\/h<\/td>\n72 hodin, pot\u00e9 sn\u00ed\u017eit na peror\u00e1ln\u00ed pod\u00e1n\u00ed 40 mg dvakr\u00e1t denn\u011b po dobu 14 dn\u016f<\/td>\n<\/tr>\n
T\u011b\u017ek\u00fd Zollinger-Ellison\u016fv syndrom<\/td>\n80 mg IV ka\u017ed\u00fdch 8\u201312 hodin (pod veden\u00edm specialisty)<\/td>\nRekonstituce 0,9% NaCl; pod odborn\u00fdm dohledem<\/td>\n<\/tr>\n
Porucha funkce jater<\/td>\nMaxim\u00e1ln\u011b 40 mg\/den<\/td>\nMonitorovat jatern\u00ed testy<\/td>\n<\/tr>\n
Porucha funkce ledvin<\/td>\nNen\u00ed t\u0159eba \u00fapravy d\u00e1vkov\u00e1n\u00ed<\/td>\nStandardn\u00ed re\u017eim<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Kompatibilita:<\/strong> Rekonstituovat pouze s 0,9% chloridem sodn\u00fdm. Nem\u00edchat s jin\u00fdmi IV l\u00e9ky ve stejn\u00e9 linii. Rekonstituovan\u00fd roztok je stabiln\u00ed po dobu 12 hodin p\u0159i pokojov\u00e9 teplot\u011b; nepou\u017eitou \u010d\u00e1st zlikvidujte.<\/p>\n

P\u0159echod na peror\u00e1ln\u00ed PPI<\/strong> jakmile pacient m\u016f\u017ee bezpe\u010dn\u011b polykat. Pokra\u010dov\u00e1n\u00ed IV PPI d\u00e9le ne\u017e 3\u20135 dn\u00ed nem\u00e1 farmakologickou v\u00fdhodu oproti peror\u00e1ln\u00ed terapii a v\u00fdrazn\u011b zvy\u0161uje n\u00e1klady a riziko infekce.<\/p>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n

B\u011b\u017en\u00e9 (1\u201310 %):<\/strong> bolest hlavy, pr\u016fjem, nevolnost, bolesti b\u0159icha, reakce v m\u00edst\u011b vpichu (bolest, tromboflebitida v m\u00edst\u011b kanyly).<\/p>\n

M\u00e9n\u011b \u010dast\u00e9, ale d\u016fle\u017eit\u00e9:<\/strong> p\u0159ecitliv\u011blost (vyr\u00e1\u017eka, angioed\u00e9m; velmi vz\u00e1cn\u011b anafylaxe), akutn\u00ed interstici\u00e1ln\u00ed nefritida, hepatotoxicita (vz\u00e1cn\u011b), t\u011b\u017ek\u00e1 hypomagnez\u00e9mie (p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed), C. difficile<\/em> infekce (zejm\u00e9na u hospitalizovan\u00fdch pacient\u016f) a ventil\u00e1torem asociovan\u00e1 pneumonie.<\/p>\n

Kontraindikace<\/h2>\n