{"id":58686,"date":"2024-02-28T05:23:06","date_gmt":"2024-02-28T05:23:06","guid":{"rendered":"https:\/\/medsname.com\/lurakem\/"},"modified":"2026-04-30T10:24:10","modified_gmt":"2026-04-30T10:24:10","slug":"lurakem","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/lurakem\/","title":{"rendered":"Lurakem"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Lurakem (Lurasidone 40 \/ 80 mg) is an atypical antipsychotic for schizophrenia and bipolar depression. Must be taken with food (\u2265 350 kcal)<\/strong> \u2014 fasting halves absorption and produces treatment failure. Metabolically among the cleanest atypicals.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Lurakem at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

What Lurakem is and how it works<\/h2>\n

Lurakem is a lurasidone tablet supplied by Alkem. Available strengths: 40 \/ 80 mg<\/strong>. Lurasidone is a D2\/5-HT2A antagonist with additional 5-HT7 antagonism (the 5-HT7 component is the basis for its bipolar-depression indication). It is one of the cleanest atypicals on metabolic markers \u2014 minimal weight gain, minimal lipid effect, minimal glucose effect.<\/p>\n

\nCRITICAL \u2014 must be taken with food (\u2265 350 kcal)<\/strong><\/p>\n

Fasting bioavailability of lurasidone is approximately half<\/strong> the fed bioavailability. Patients who skip a meal or take the dose at a small snack reach inadequate plasma levels and frequently appear to “fail” therapy. Take with the largest meal of the day, every day, at the same time.<\/strong> A glass of milk or a small biscuit is not enough \u2014 aim for at least 350 kcal of mixed-macronutrient food.<\/p>\n<\/div>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Schizophrenia (adult)<\/td>\n40 mg OD with food<\/td>\n40\u201380 mg OD<\/td>\n160 mg<\/td>\n<\/tr>\n
Schizophrenia (adolescent \u2265 13 y)<\/td>\n40 mg OD with food<\/td>\n40\u201380 mg OD<\/td>\n80 mg<\/td>\n<\/tr>\n
Bipolar depression (adult, monotherapy or adjunct)<\/td>\n20 mg OD with food<\/td>\n20\u201360 mg OD<\/td>\n120 mg<\/td>\n<\/tr>\n
Bipolar depression (paediatric \u2265 10 y)<\/td>\n20 mg OD with food<\/td>\n20\u201380 mg OD<\/td>\n80 mg<\/td>\n<\/tr>\n
Porucha funkce ledvin (CrCl < 50)<\/td>\n20 mg OD with food<\/td>\nup to 80 mg<\/td>\n80 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 dementia-related psychosis<\/strong><\/p>\n

All atypical antipsychotics carry an FDA black-box warning for increased mortality (mostly cardiovascular and infectious) when used to treat behavioural disturbance in older adults with dementia. Atypicals are not approved for dementia-related psychosis or agitation<\/strong>. Use in this population is off-label, last-resort, time-limited, and requires explicit risk-benefit conversation.<\/p>\n<\/div>\n

\nAkathisia and EPS<\/strong><\/p>\n

Akathisia is common at higher doses. EPS (rigidity, tremor, dystonia) less common than first-generation antipsychotics but can occur. Manageable with dose reduction or anticholinergic adjunct.<\/p>\n<\/div>\n

\nStrong CYP3A4 substrate<\/strong><\/p>\n

Avoid concurrent strong CYP3A4 inhibitors (azoles, clarithromycin, ritonavir, grapefruit juice) \u2014 they raise lurasidone levels several-fold. Avoid strong inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) \u2014 they reduce levels into the ineffective range.<\/p>\n<\/div>\n

\nSuicidality (under-25, bipolar depression indication)<\/strong><\/p>\n

All antidepressant-class indications carry the under-25 suicidality warning.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n