{"id":58686,"date":"2024-02-28T05:23:06","date_gmt":"2024-02-28T05:23:06","guid":{"rendered":"https:\/\/medsname.com\/lurakem\/"},"modified":"2026-04-30T10:24:10","modified_gmt":"2026-04-30T10:24:10","slug":"lurakem","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/lurakem\/","title":{"rendered":"Lurakem"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Lurakem (Lurasidon 40\/80 mg) je atypick\u00e9 antipsychotikum pro l\u00e9\u010dbu schizofrenie a bipol\u00e1rn\u00ed deprese. Mus\u00ed se u\u017e\u00edvat s j\u00eddlem (\u2265 350 kcal)<\/strong> \u2014 nala\u010dno se absorpce sni\u017euje na polovinu a vede k ne\u00fasp\u011bchu l\u00e9\u010dby. Metabolicky pat\u0159\u00ed mezi nej\u010dist\u0161\u00ed atypick\u00e1 antipsychotika.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Lurakem na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Lurakem a jak funguje<\/h2>\n

Lurakem je tableta lurasidonu dod\u00e1van\u00e1 spole\u010dnost\u00ed Alkem. Dostupn\u00e9 s\u00edly: 40 \/ 80 mg<\/strong>. Lurasidon je antagonista D2\/5-HT2A s dodate\u010dnou antagonizac\u00ed 5-HT7 (komponenta 5-HT7 je z\u00e1kladem pro indikaci u bipol\u00e1rn\u00ed deprese). Pat\u0159\u00ed mezi metabolicky nej\u010dist\u0161\u00ed atypick\u00e1 antipsychotika \u2014 minim\u00e1ln\u00ed p\u0159\u00edr\u016fstek hmotnosti, minim\u00e1ln\u00ed vliv na lipidy, minim\u00e1ln\u00ed vliv na gluk\u00f3zu.<\/p>\n

\nKL\u00cd\u010cOV\u00c9 \u2014 mus\u00ed se u\u017e\u00edvat s j\u00eddlem (\u2265 350 kcal)<\/strong><\/p>\n

Biologick\u00e1 dostupnost lurasidonu nala\u010dno je p\u0159ibli\u017en\u011b polovi\u010dn\u00ed<\/strong> oproti stavu po j\u00eddle. Pacienti, kte\u0159\u00ed vynechaj\u00ed j\u00eddlo nebo u\u017eij\u00ed d\u00e1vku s malou sva\u010dinou, dos\u00e1hnou nedostate\u010dn\u00e9 plazmatick\u00e9 hladiny a \u010dasto se zd\u00e1, \u017ee l\u00e9\u010dba \u201cselh\u00e1v\u00e1\u201d. U\u017e\u00edvejte s nejv\u011bt\u0161\u00edm j\u00eddlem dne, ka\u017ed\u00fd den ve stejnou dobu.<\/strong> Sklenice ml\u00e9ka nebo mal\u00e1 su\u0161enka nesta\u010d\u00ed \u2014 c\u00edlem je alespo\u0148 350 kcal potravy se sm\u00ed\u0161en\u00fdmi makro\u017eivinami.<\/p>\n<\/div>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Schizofrenie (dosp\u011bl\u00ed)<\/td>\n40 mg 1\u00d7 denn\u011b s j\u00eddlem<\/td>\n40\u201380 mg 1\u00d7 denn\u011b<\/td>\n160 mg<\/td>\n<\/tr>\n
Schizofrenie (dosp\u00edvaj\u00edc\u00ed \u2265 13 let)<\/td>\n40 mg 1\u00d7 denn\u011b s j\u00eddlem<\/td>\n40\u201380 mg 1\u00d7 denn\u011b<\/td>\n80 mg<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed deprese (dosp\u011bl\u00ed, monoterapie nebo adjuvantn\u00ed l\u00e9\u010dba)<\/td>\n20 mg 1\u00d7 denn\u011b s j\u00eddlem<\/td>\n20\u201360 mg 1\u00d7 denn\u011b<\/td>\n120 mg<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed deprese (d\u011bti \u2265 10 let)<\/td>\n20 mg 1\u00d7 denn\u011b s j\u00eddlem<\/td>\n20\u201380 mg 1\u00d7 denn\u011b<\/td>\n80 mg<\/td>\n<\/tr>\n
Porucha funkce ledvin (CrCl < 50)<\/td>\n20 mg 1\u00d7 denn\u011b s j\u00eddlem<\/td>\na\u017e 80 mg<\/td>\n80 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 psych\u00f3za spojen\u00e1 s demenc\u00ed<\/strong><\/p>\n

V\u0161echna atypick\u00e1 antipsychotika nesou varov\u00e1n\u00ed FDA black-box pro zv\u00fd\u0161enou mortalitu (p\u0159edev\u0161\u00edm kardiovaskul\u00e1rn\u00ed a infek\u010dn\u00ed) p\u0159i pou\u017eit\u00ed k l\u00e9\u010db\u011b behavior\u00e1ln\u00edch poruch u star\u0161\u00edch dosp\u011bl\u00fdch s demenc\u00ed. Atypick\u00e1 antipsychotika nejsou schv\u00e1lena pro psych\u00f3zu nebo agitovanost spojenou s demenc\u00ed<\/strong>. Pou\u017eit\u00ed u t\u00e9to populace je off-label, posledn\u00ed mo\u017enost\u00ed, \u010dasov\u011b omezen\u00e9 a vy\u017eaduje explicitn\u00ed rozhovor o rizic\u00edch a p\u0159\u00ednosech.<\/p>\n<\/div>\n

\nAkathisie a EPS<\/strong><\/p>\n

Akathisie je \u010dast\u011bj\u0161\u00ed p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch. EPS (rigidita, tremor, dystonie) jsou m\u00e9n\u011b \u010dast\u00e9 ne\u017e u antipsychotik prvn\u00ed generace, ale mohou se vyskytnout. \u0158e\u0161\u00ed se sn\u00ed\u017een\u00edm d\u00e1vky nebo pod\u00e1n\u00edm anticholinergik.<\/p>\n<\/div>\n

\nSiln\u00fd substr\u00e1t CYP3A4<\/strong><\/p>\n

Vyvarujte se sou\u010dasn\u00e9ho pod\u00e1v\u00e1n\u00ed siln\u00fdch inhibitor\u016f CYP3A4 (azoly, klarithromycin, ritonavir, grapefruitov\u00fd d\u017eus) \u2013 mohou n\u011bkolikan\u00e1sobn\u011b zv\u00fd\u0161it hladinu lurasidonu. Vyhn\u011bte se siln\u00fdm induktor\u016fm (rifampicin, karbamazepin, fenytoin, t\u0159ezalka te\u010dkovan\u00e1) \u2013 sni\u017euj\u00ed hladinu na ne\u00fa\u010dinnou \u00farove\u0148.<\/p>\n<\/div>\n

\nSebevra\u017eedn\u00e9 tendence (u osob do 25 let s bipol\u00e1rn\u00ed depres\u00ed)<\/strong><\/p>\n

V\u0161echny indikace ze skupiny antidepresiv nesou varov\u00e1n\u00ed o riziku sebevra\u017eedn\u00fdch tendenc\u00ed u osob mlad\u0161\u00edch 25 let.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n